Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology
Izco, María, Blesa, Javier, Schleef, Martin, Schmeer, Marco, Porcari, Riccardo, Al-Shawi, Raya, Ellmerich, Stephan, de Toro, María, Gardiner, Chris, Seow, Yiqi, Reinares-Sebastian, Alejandro, Forcen, Raquel, Simons, J. Paul, Bellotti, Vittorio, Cooper, J. Mark, Alvarez-Erviti, Lydia
Published in Molecular therapy (04.12.2019)
Published in Molecular therapy (04.12.2019)
Get full text
Journal Article
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis
Slamova, Ivana, Adib, Rozita, Ellmerich, Stephan, Golos, Michal R., Gilbertson, Janet A., Botcher, Nicola, Canetti, Diana, Taylor, Graham W., Rendell, Nigel, Tennent, Glenys A., Verona, Guglielmo, Porcari, Riccardo, Mangione, P. Patrizia, Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio, Hawkins, Philip N., Al-Shawi, Raya, Simons, J. Paul
Published in Nature communications (07.12.2021)
Published in Nature communications (07.12.2021)
Get full text
Journal Article
L444P Gba1 mutation increases formation and spread of α-synuclein deposits in mice injected with mouse α-synuclein pre-formed fibrils
Migdalska-Richards, Anna, Wegrzynowicz, Michal, Harrison, Ian F, Verona, Guglielmo, Bellotti, Vittorio, Spillantini, Maria Grazia, Schapira, Anthony H V
Published in PloS one (24.08.2020)
Published in PloS one (24.08.2020)
Get full text
Journal Article
Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity
Le Marchand, Tanguy, de Rosa, Matteo, Salvi, Nicola, Sala, Benedetta Maria, Andreas, Loren B., Barbet-Massin, Emeline, Sormanni, Pietro, Barbiroli, Alberto, Porcari, Riccardo, Sousa Mota, Cristiano, de Sanctis, Daniele, Bolognesi, Martino, Emsley, Lyndon, Bellotti, Vittorio, Blackledge, Martin, Camilloni, Carlo, Pintacuda, Guido, Ricagno, Stefano
Published in Nature communications (25.04.2018)
Published in Nature communications (25.04.2018)
Get full text
Journal Article
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes
Corazza, Alessandra, Verona, Guglielmo, Waudby, Christopher A, Mangione, P. Patrizia, Bingham, Ryan, Uings, Iain, Canetti, Diana, Nocerino, Paola, Taylor, Graham W, Pepys, Mark B, Christodoulou, John, Bellotti, Vittorio
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
Get full text
Journal Article
Breakdown of supersaturation barrier links protein folding to amyloid formation
Noji, Masahiro, Samejima, Tatsushi, Yamaguchi, Keiichi, So, Masatomo, Yuzu, Keisuke, Chatani, Eri, Akazawa-Ogawa, Yoko, Hagihara, Yoshihisa, Kawata, Yasushi, Ikenaka, Kensuke, Mochizuki, Hideki, Kardos, József, Otzen, Daniel E., Bellotti, Vittorio, Buchner, Johannes, Goto, Yuji
Published in Communications biology (26.01.2021)
Published in Communications biology (26.01.2021)
Get full text
Journal Article
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils
Raimondi, Sara, Mangione, P. Patrizia, Verona, Guglielmo, Canetti, Diana, Nocerino, Paola, Marchese, Loredana, Piccarducci, Rebecca, Mondani, Valentina, Faravelli, Giulia, Taylor, Graham W., Gillmore, Julian D., Corazza, Alessandra, Pepys, Mark B., Giorgetti, Sofia, Bellotti, Vittorio
Published in The Journal of biological chemistry (14.08.2020)
Published in The Journal of biological chemistry (14.08.2020)
Get full text
Journal Article
A Narrative Review of the Role of Transthyretin in Health and Disease
Liz, Marcia Almeida, Coelho, Teresa, Bellotti, Vittorio, Fernandez-Arias, Maria Isabel, Mallaina, Pablo, Obici, Laura
Published in Neurology and therapy (01.12.2020)
Published in Neurology and therapy (01.12.2020)
Get full text
Journal Article
Hereditary Systemic Amyloidosis Due to Asp76Asn Variant β2-Microglobulin
Valleix, Sophie, Gillmore, Julian D, Bridoux, Frank, Mangione, Palma P, Dogan, Ahmet, Nedelec, Brigitte, Boimard, Mathieu, Touchard, Guy, Goujon, Jean-Michel, Lacombe, Corinne, Lozeron, Pierre, Adams, David, Lacroix, Catherine, Maisonobe, Thierry, Planté-Bordeneuve, Violaine, Vrana, Julie A, Theis, Jason D, Giorgetti, Sofia, Porcari, Riccardo, Ricagno, Stefano, Bolognesi, Martino, Stoppini, Monica, Delpech, Marc, Pepys, Mark B, Hawkins, Philip N, Bellotti, Vittorio
Published in The New England journal of medicine (14.06.2012)
Published in The New England journal of medicine (14.06.2012)
Get full text
Journal Article
A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis
Marcoux, Julien, Mangione, P Patrizia, Porcari, Riccardo, Degiacomi, Matteo T, Verona, Guglielmo, Taylor, Graham W, Giorgetti, Sofia, Raimondi, Sara, Sanglier‐Cianférani, Sarah, Benesch, Justin LP, Cecconi, Ciro, Naqvi, Mohsin M, Gillmore, Julian D, Hawkins, Philip N, Stoppini, Monica, Robinson, Carol V, Pepys, Mark B, Bellotti, Vittorio
Published in EMBO molecular medicine (01.10.2015)
Published in EMBO molecular medicine (01.10.2015)
Get full text
Journal Article
Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases
Solomon, Miriam, Foderà, Vito, Langkilde, Annette Eva, Elliott, Perry, Tagliavini, Fabrizio, Forsyth, Trevor, Klementieva, Oxana, Bellotti, Vittorio
Published in Journal of translational medicine (13.05.2022)
Published in Journal of translational medicine (13.05.2022)
Get full text
Journal Article
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis
Mangione, P. Patrizia, Porcari, Riccardo, Gillmore, Julian D., Pucci, Piero, Monti, Maria, Porcari, Mattia, Giorgetti, Sofia, Marchese, Loredana, Raimondi, Sara, Serpell, Louise C., Chen, Wenjie, Relini, Annalisa, Marcoux, Julien, Clatworthy, Innes R., Taylor, Graham W., Tennent, Glenys A., Robinson, Carol V., Hawkins, Philip N., Stoppini, Monica, Wood, Stephen P., Pepys, Mark B., Bellotti, Vittorio
Published in Proceedings of the National Academy of Sciences - PNAS (28.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (28.01.2014)
Get full text
Journal Article
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant
Domanska, Katarzyna, Vanderhaegen, Saskia, Srinivasan, Vasundara, Pardon, Els, Dupeux, Florine, Marquez, Jose A, Giorgetti, Sofia, Stoppini, Monica, Wyns, Lode, Bellotti, Vittorio, Steyaert, Jan
Published in Proceedings of the National Academy of Sciences - PNAS (25.01.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (25.01.2011)
Get full text
Journal Article
Targeting C-reactive protein for the treatment of cardiovascular disease
Ruth Gallimore, J, Pepys, Mark B, Polara, Alessandra, Hirschfield, Gideon M, Smith, Martin D, Wood, Stephen P, Sharif, Isam, Gray, Gillian A, Sabin, Caroline A, Bellotti, Vittorio, Myers, Rebecca M, Andrew Aquilina, J, Ley, Steven V, Thompson, Darren, Hawkins, Philip N, Robinson, Carol V, Kolstoe, Simon E, Kahan, Melvyn C, Cobb, Alexander J. A, Tennent, Glenys A, Jenvey, Michelle C
Published in Nature (27.04.2006)
Published in Nature (27.04.2006)
Get full text
Journal Article
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile
Valleix, Sophie, Verona, Guglielmo, Jourde-Chiche, Noémie, Nédelec, Brigitte, Mangione, P. Patrizia, Bridoux, Frank, Mangé, Alain, Dogan, Ahmet, Goujon, Jean-Michel, Lhomme, Marie, Dauteuille, Carolane, Chabert, Michèle, Porcari, Riccardo, Waudby, Christopher A., Relini, Annalisa, Talmud, Philippa J., Kovrov, Oleg, Olivecrona, Gunilla, Stoppini, Monica, Christodoulou, John, Hawkins, Philip N., Grateau, Gilles, Delpech, Marc, Kontush, Anatol, Gillmore, Julian D., Kalopissis, Athina D., Bellotti, Vittorio
Published in Nature communications (21.01.2016)
Published in Nature communications (21.01.2016)
Get full text
Journal Article
Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin
Cantarutti, Cristina, Raimondi, Sara, Brancolini, Giorgia, Corazza, Alessandra, Giorgetti, Sofia, Ballico, Maurizio, Zanini, Stefano, Palmisano, Giovanni, Bertoncin, Paolo, Marchese, Loredana, Patrizia Mangione, P, Bellotti, Vittorio, Corni, Stefano, Fogolari, Federico, Esposito, Gennaro
Published in Nanoscale (21.03.2017)
Published in Nanoscale (21.03.2017)
Get full text
Journal Article
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro
Ozawa, Daisaku, Nomura, Ryo, Mangione, P. Patrizia, Hasegawa, Kazuhiro, Okoshi, Tadakazu, Porcari, Riccardo, Bellotti, Vittorio, Naiki, Hironobu
Published in Scientific reports (06.07.2016)
Published in Scientific reports (06.07.2016)
Get full text
Journal Article
Clinical Amyloid Typing by Proteomics: Performance Evaluation and Data Sharing Between Two Centres
Canetti, Diana, Brambilla, Francesca, Rendell, Nigel B, Nocerino, Paola, Gilbertson, Janet A, Di Silvestre, Dario, Bergamaschi, Andrea, Lavatelli, Francesca, Merlini, Giampaolo, Gillmore, Julian D, Bellotti, Vittorio, Mauri, Pierluigi, Taylor, Graham W
Published in Molecules (Basel, Switzerland) (29.03.2021)
Published in Molecules (Basel, Switzerland) (29.03.2021)
Get full text
Journal Article
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel
Verona, Guglielmo, Mangione, P. Patrizia, Raimondi, Sara, Giorgetti, Sofia, Faravelli, Giulia, Porcari, Riccardo, Corazza, Alessandra, Gillmore, Julian D., Hawkins, Philip N., Pepys, Mark B., Taylor, Graham W., Bellotti, Vittorio
Published in Scientific reports (15.03.2017)
Published in Scientific reports (15.03.2017)
Get full text
Journal Article