Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir
Belema, Makonen, Nguyen, Van N., Bachand, Carol, Deon, Dan H., Goodrich, Jason T., James, Clint A., Lavoie, Rico, Lopez, Omar D., Martel, Alain, Romine, Jeffrey L., Ruediger, Edward H., Snyder, Lawrence B., Laurent, Denis R. St, Yang, Fukang, Zhu, Juliang, Wong, Henry S., Langley, David R., Adams, Stephen P., Cantor, Glenn H., Chimalakonda, Anjaneya, Fura, Aberra, Johnson, Benjamin M., Knipe, Jay O., Parker, Dawn D., Santone, Kenneth S., Fridell, Robert A., Lemm, Julie A., O’Boyle, Donald R., Colonno, Richard J., Gao, Min, Meanwell, Nicholas A., Hamann, Lawrence G.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization
Qiu, Dike, Lemm, Julie A, O’Boyle, Donald R., II, Sun, Jin-Hua, Nower, Peter T, Nguyen, Van, Hamann, Lawrence G, Snyder, Lawrence B, Deon, Daniel H, Ruediger, Edward, Meanwell, Nicholas A, Belema, Makonen, Gao, Min, Fridell, Robert A
Published in Journal of general virology (01.11.2011)
Published in Journal of general virology (01.11.2011)
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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
Meanwell, Nicholas A, Gao, Min, Nettles, Richard E, Belema, Makonen, Snyder, Lawrence B, Nguyen, Van N, Fridell, Robert A, Serrano-Wu, Michael H, Langley, David R, Sun, Jin-Hua, O’Boyle II, Donald R, Lemm, Julie A, Wang, Chunfu, Knipe, Jay O, Chien, Caly, Colonno, Richard J, Grasela, Dennis M, Hamann, Lawrence G
Published in Nature (London) (06.05.2010)
Published in Nature (London) (06.05.2010)
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Potent Long-Acting Inhibitors Targeting the HIV‑1 Capsid Based on a Versatile Quinazolin-4-one Scaffold
Gillis, Eric P., Parcella, Kyle, Bowsher, Michael, Cook, James H., Iwuagwu, Christiana, Naidu, B. Narasimhulu, Patel, Manoj, Peese, Kevin, Huang, Haichang, Valera, Lourdes, Wang, Chunfu, Kieltyka, Kasia, Parker, Dawn D., Simmermacher, Jean, Arnoult, Eric, Nolte, Robert T., Wang, Liping, Bender, John A., Frennesson, David B., Saulnier, Mark, Wang, Alan Xiangdong, Meanwell, Nicholas A., Belema, Makonen, Hanumegowda, Umesh, Jenkins, Susan, Krystal, Mark, Kadow, John F., Cockett, Mark, Fridell, Robert
Published in Journal of medicinal chemistry (09.02.2023)
Published in Journal of medicinal chemistry (09.02.2023)
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Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyr-idinyl class of HIV-1 allosteric integrase inhibitors
Parcella, Kyle, Patel, Manoj, Tu, Yong, Eastman, Kyle, Peese, Kevin, Gillis, Eric, Belema, Makonen, Dicker, Ira B., McAuliffe, Brian, Ding, Bo, Falk, Paul, Simmermacher, Jean, Parker, Dawn D., Sivaprakasam, Prasanna, Khan, Javed A., Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Jenkins, Susan, Kadow, John F., Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in Bioorganic & medicinal chemistry (01.08.2022)
Published in Bioorganic & medicinal chemistry (01.08.2022)
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Facile Access to 1,4-Disubstituted Pyrrolo[1,2-a ]pyrazines from alpha-Aminoacetonitriles
Karmakar, Ananta, Ramalingam, Sridharan, Basha, Mushkin, Indasi, Gopi Kumar, Belema, Makonen, Meanwell, Nicholas A., Dhar, T. G. Murali, Rampulla, Richard, Mathur, Arvind, Gupta, Anuradha, Gupta, Arun Kumar
Published in Synthesis (Stuttgart) (04.02.2020)
Published in Synthesis (Stuttgart) (04.02.2020)
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Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors
Belema, Makonen, Lopez, Omar D., Bender, John A., Romine, Jeffrey L., St. Laurent, Denis R., Langley, David R., Lemm, Julie A., O’Boyle, Donald R., Sun, Jin-Hua, Wang, Chunfu, Fridell, Robert A., Meanwell, Nicholas A.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors
Parcella, Kyle, Patel, Manoj, Tu, Yong, Eastman, Kyle, Peese, Kevin, Gillis, Eric, Belema, Makonen, Dicker, Ira B., McAuliffe, Brian, Ding, Bo, Falk, Paul, Simmermacher, Jean, Parker, Dawn D., Sivaprakasam, Prasanna, Khan, Javed A., Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Jenkins, Susan, Kadow, John F., Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in Bioorganic & medicinal chemistry (01.08.2022)
Published in Bioorganic & medicinal chemistry (01.08.2022)
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Journal Article
Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A
Sun, Jin-Hua, O’Boyle II, Donald R., Fridell, Robert A., Langley, David R., Wang, Chunfu, Roberts, Susan B., Nower, Peter, Johnson, Benjamin M., Moulin, Frederic, Nophsker, Michelle J., Wang, Ying-Kai, Liu, Mengping, Rigat, Karen, Tu, Yong, Hewawasam, Piyasena, Kadow, John, Meanwell, Nicholas A., Cockett, Mark, Lemm, Julie A., Kramer, Melissa, Belema, Makonen, Gao, Min
Published in Nature (London) (12.11.2015)
Published in Nature (London) (12.11.2015)
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A scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-car b oxylic acid
Wang, Gan, James, Clint, Meanwell, Nicholas, Hamann, Lawrence, Belema, Makonen
Published in Tetrahedron letters (01.12.2013)
Published in Tetrahedron letters (01.12.2013)
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Journal Article
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV‑1 Allosteric Integrase Inhibitor
Parcella, Kyle, Wang, Tao, Eastman, Kyle, Zhang, Zhongxing, Yin, Zhiwei, Patel, Manoj, Tu, Yong, Zheng, Barbara Zhizhen, Walker, Michael A., Saulnier, Mark G., Frennesson, David, Bowsher, Michael, Gillis, Eric, Peese, Kevin, Belema, Makonen, Cianci, Christopher, Dicker, Ira B., McAuliffe, Brian, Ding, Bo, Falk, Paul, Simmermacher, Jean, Parker, Dawn D., Sivaprakasam, Prasanna, Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Jenkins, Susan, Kadow, John F., Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in ACS medicinal chemistry letters (09.06.2022)
Published in ACS medicinal chemistry letters (09.06.2022)
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Journal Article
Characterizations of HCV NS5A replication complex inhibitors
O'Boyle II, Donald R, Sun, Jin-Hua, Nower, Peter T, Lemm, Julie A, Fridell, Robert A, Wang, Chunfu, Romine, Jeffrey L, Belema, Makonen, Nguyen, Van N, Laurent, Denis R. St, Serrano-Wu, Michael, Snyder, Lawrence B, Meanwell, Nicholas A, Langley, David R, Gao, Min
Published in Virology (New York, N.Y.) (01.09.2013)
Published in Virology (New York, N.Y.) (01.09.2013)
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Journal Article
HCV NS5A Replication Complex Inhibitors. Part 4. Optimization for Genotype la Replicon Inhibitory Activity
St Laurent, Denis R., Serrano-Wu, Michael H., Belema, Makonen, Ding, Min, Fang, Hua, Gao, Min, Goodrich, Jason T., Krause, Rudolph G., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O'Boyle, Donald R., Pearce, Bradley C., Romine, Jeffrey L., Valera, Lourdes, Sun, Jin-Hua, Wang, Ying-Kai, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
HCV NS5A Replication Complex Inhibitors. Part 4.1 Optimization for Genotype 1a Replicon Inhibitory Activity
St. Laurent, Denis R., Serrano-Wu, Michael H., Belema, Makonen, Ding, Min, Fang, Hua, Gao, Min, Goodrich, Jason T., Krause, Rudolph G., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald R., Pearce, Bradley C., Romine, Jeffrey L., Valera, Lourdes, Sun, Jin-Hua, Wang, Ying-Kai, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097
Mathur, Arvind, Wang, Bei, Smith, Daniel, Li, Jianqing, Pawluczyk, Joseph, Sun, Jung-Hui, Wong, Michael Kwok, Krishnananthan, Subramaniam, Wu, Dauh-Rurng, Sun, Dawn, Li, Peng, Yip, Shiuhang, Chen, Bang-Chi, Baran, Phil S, Chen, Qi, Lopez, Omar D, Yong, Zhong, Bender, John A, Nguyen, Van N, Romine, Jeffrey L, Laurent, Denis R. St, Wang, Gan, Kadow, John F, Meanwell, Nicholas A, Belema, Makonen, Zhao, Rulin
Published in Journal of organic chemistry (06.10.2017)
Published in Journal of organic chemistry (06.10.2017)
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