Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Milbauer, Liming, Abdulla, Fuad, Alayash, Abdu I., Smith, Ann, Nath, Karl A., Hebbel, Robert P., Vercellotti, Gregory M.
Published in Blood (16.01.2014)
Published in Blood (16.01.2014)
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Journal Article
Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction
Belcher, John D, Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Zhang, Ping, Nguyen, Hao, Nguyen, Phong, Killeen, Trevor, Miescher, Sylvia M, Brinkman, Nathan, Nath, Karl A, Steer, Clifford J, Vercellotti, Gregory M
Published in PloS one (25.04.2018)
Published in PloS one (25.04.2018)
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Journal Article
Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia
Belcher, John D, Gomperts, Edward, Nguyen, Julia, Chen, Chunsheng, Abdulla, Fuad, Kiser, Zachary M, Gallo, David, Levy, Howard, Otterbein, Leo E, Vercellotti, Gregory M
Published in PloS one (11.10.2018)
Published in PloS one (11.10.2018)
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Journal Article
A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease
McArthur, James G, Svenstrup, Niels, Chen, Chunsheng, Fricot, Aurelie, Carvalho, Caroline, Nguyen, Julia, Nguyen, Phong, Parachikova, Anna, Abdulla, Fuad, Vercellotti, Gregory M, Hermine, Olivier, Edwards, Dave, Ribeil, Jean-Antoine, Belcher, John D, Maciel, Thiago T
Published in Haematologica (Roma) (01.03.2020)
Published in Haematologica (Roma) (01.03.2020)
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Journal Article
Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins
Nath, Karl A, Belcher, John D, Nath, Meryl C, Grande, Joseph P, Croatt, Anthony J, Ackerman, Allan W, Katusic, Zvonimir S, Vercellotti, Gregory M
Published in American journal of physiology. Renal physiology (01.05.2018)
Published in American journal of physiology. Renal physiology (01.05.2018)
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Journal Article
Identification of a Heme Activation Site on the MD-2/TLR4 Complex
Belcher, John D, Zhang, Ping, Nguyen, Julia, Kiser, Zachary M, Nath, Karl A, Hu, Jianjun, Trent, John O, Vercellotti, Gregory M
Published in Frontiers in immunology (30.06.2020)
Published in Frontiers in immunology (30.06.2020)
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Journal Article
Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease
Beckman, Joan D, Abdullah, Fuad, Chen, Chunsheng, Kirchner, Rachel, Rivera-Rodriguez, Dormarie, Kiser, Zachary M, Nguyen, Aithanh, Zhang, Ping, Nguyen, Julia, Hebbel, Robert P, Belcher, John D, Vercellotti, Gregory M
Published in Frontiers in immunology (19.01.2021)
Published in Frontiers in immunology (19.01.2021)
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Journal Article
Liver‐targeted gene therapy: Approaches and challenges
Aravalli, Rajagopal N., Belcher, John D., Steer, Clifford J.
Published in Liver transplantation (01.06.2015)
Published in Liver transplantation (01.06.2015)
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Journal Article
Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells
Zhang, Ping, Nguyen, Julia, Abdulla, Fuad, Nelson, Alexander T, Beckman, Joan D, Vercellotti, Gregory M, Belcher, John D
Published in Frontiers in immunology (26.03.2021)
Published in Frontiers in immunology (26.03.2021)
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Journal Article
Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease
Vercellotti, Gregory M, Zhang, Ping, Nguyen, Julia, Abdulla, Fuad, Chen, Chunsheng, Nguyen, Phong, Nowotny, Carlos, Steer, Clifford J, Smith, Ann, Belcher, John D
Published in Molecular medicine (Cambridge, Mass.) (01.01.2016)
Published in Molecular medicine (Cambridge, Mass.) (01.01.2016)
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Journal Article
Inflammation in sickle cell disease
Conran, Nicola, Belcher, John D
Published in Clinical hemorheology and microcirculation (01.01.2018)
Published in Clinical hemorheology and microcirculation (01.01.2018)
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Journal Article
The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease
Belcher, John D, Nataraja, Selvaraj, Abdulla, Fuad, Zhang, Ping, Chen, Chunsheng, Nguyen, Julia, Ruan, Conglin, Singh, Maneet, Demes, Shilpa, Olson, Lyndsay, Stickens, Domi, Stanwix, Jeff, Clarke, Emer, Huang, Yongzhao, Biddle, Margaret, Vercellotti, Gregory M
Published in Frontiers in medicine (18.04.2023)
Published in Frontiers in medicine (18.04.2023)
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Journal Article
The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice
Hebbel, Robert P., Vercellotti, Gregory M., Pace, Betty S., Solovey, Anna N., Kollander, Rahn, Abanonu, Chine F., Nguyen, Julia, Vineyard, Julie V., Belcher, John D., Abdulla, Fuad, Osifuye, Shadé, Eaton, John W., Kelm, Robert J., Slungaard, Arne
Published in Blood (25.03.2010)
Published in Blood (25.03.2010)
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Journal Article
The multifaceted role of ischemia/reperfusion in sickle cell anemia
Hebbel, Robert P, Belcher, John D, Vercellotti, Gregory M
Published in The Journal of clinical investigation (02.03.2020)
Published in The Journal of clinical investigation (02.03.2020)
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Journal Article
The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-ĸB activation in transgenic sickle mice
Belcher, John D, Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Nguyen, Phong, Nguyen, Minh, Okeley, Nicole M, Benjamin, Dennis R, Senter, Peter D, Vercellotti, Gregory M
Published in PloS one (23.02.2015)
Published in PloS one (23.02.2015)
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Journal Article
Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice
Belcher, John D, Mahaseth, Hemchandra, Welch, Thomas E, Vilback, Asa E, Sonbol, Khalid M, Kalambur, Venkatasubramaniam S, Bowlin, Paul R, Bischof, John C, Hebbel, Robert P, Vercellotti, Gregory M
Published in American journal of physiology. Heart and circulatory physiology (01.06.2005)
Published in American journal of physiology. Heart and circulatory physiology (01.06.2005)
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Journal Article
H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice
Vercellotti, Gregory M, Khan, Fatima B, Nguyen, Julia, Chen, Chunsheng, Bruzzone, Carol M, Bechtel, Heather, Brown, Graham, Nath, Karl A, Steer, Clifford J, Hebbel, Robert P, Belcher, John D
Published in Frontiers in pharmacology (17.04.2014)
Published in Frontiers in pharmacology (17.04.2014)
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Journal Article
Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells
Sjeklocha, Lucas M, Park, Chang-Won, Wong, Phillip Y-P, Roney, Mark J, Belcher, John D, Kaufman, Dan S, Vercellotti, Gregory M, Hebbel, Robert P, Steer, Clifford J
Published in PloS one (28.12.2011)
Published in PloS one (28.12.2011)
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