Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells
Kig, Cenk, Beullens, Monique, Beke, Lijs, Van Eynde, Aleyde, Linders, Johannes T., Brehmer, Dirk, Bollen, Mathieu
Published in The Journal of biological chemistry (16.08.2013)
Published in The Journal of biological chemistry (16.08.2013)
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Journal Article
Nucleocytoplasmic Shuttling of the Splicing Factor SIPP1
Llorian, Miriam, Beullens, Monique, Lesage, Bart, Nicolaescu, Emilia, Beke, Lijs, Landuyt, Willy, Ortiz, José-Miguel, Bollen, Mathieu
Published in The Journal of biological chemistry (18.11.2005)
Published in The Journal of biological chemistry (18.11.2005)
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Journal Article
The transcriptional repression by NIPP1 is mediated by Polycomb group proteins
Roy, Nivedita, Van Eynde, Aleyde, Beke, Lijs, Nuytten, Mieke, Bollen, Mathieu
Published in Biochimica et biophysica acta (01.09.2007)
Published in Biochimica et biophysica acta (01.09.2007)
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Journal Article
Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
Brehmer, Dirk, Beke, Lijs, Wu, Tongfei, Millar, Hillary J, Moy, Christopher, Sun, Weimei, Mannens, Geert, Pande, Vineet, Boeckx, An, van Heerde, Erika, Nys, Thomas, Gustin, Emmanuel M, Verbist, Bie, Zhou, Longen, Fan, Yue, Bhargava, Vipul, Safabakhsh, Pegah, Vinken, Petra, Verhulst, Tinne, Gilbert, Angelique, Rai, Sumit, Graubert, Timothy A, Pastore, Friederike, Fiore, Danilo, Gu, Junchen, Johnson, Amy, Philippar, Ulrike, Morschhäuser, Barbara, Walker, David, De Lange, Desiree, Keersmaekers, Vikki, Viellevoye, Marcel, Diels, Gaston, Schepens, Wim, Thuring, Jan Willem, Meerpoel, Lieven, Packman, Kathryn, Lorenzi, Matthew V, Laquerre, Sylvie
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Withdrawal: Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells
Kig, Cenk, Beullens, Monique, Beke, Lijs, Van Eynde, Aleyde, Linders, Johannes T., Brehmer, Dirk, Bollen, Mathieu
Published in The Journal of biological chemistry (04.08.2017)
Published in The Journal of biological chemistry (04.08.2017)
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Journal Article
Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells
Kig, Cenk, Beullens, Monique, Beke, Lijs, Van Eynde, Aleyde, Linders, Johannes T, Brehmer, Dirk, Bollen, Mathieu
Published in The Journal of biological chemistry (04.08.2017)
Published in The Journal of biological chemistry (04.08.2017)
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Journal Article
MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells
Beke, Lijs, Kig, Cenk, Linders, Joannes T M, Boens, Shannah, Boeckx, An, van Heerde, Erika, Parade, Marc, De Bondt, An, Van den Wyngaert, Ilse, Bashir, Tarig, Ogata, Souichi, Meerpoel, Lieven, Van Eynde, Aleyde, Johnson, Christopher N, Beullens, Monique, Brehmer, Dirk, Bollen, Mathieu
Published in Bioscience reports (01.12.2015)
Published in Bioscience reports (01.12.2015)
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Journal Article
A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode
Pande, Vineet, Sun, Weimei, Beke, Lijs, Berthelot, Didier, Brehmer, Dirk, Brown, David, Corbera, Jordi, Irving, Steve, Meerpoel, Lieven, Nys, Thomas, Parade, Marc, Robinson, Colin, Sommen, Cois, Viellevoye, Marcel, Wu, Tongfei, Thuring, Jan Willem
Published in ACS medicinal chemistry letters (12.11.2020)
Published in ACS medicinal chemistry letters (12.11.2020)
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Journal Article
Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models
Wu, Tongfei, Millar, Hillary, Gaffney, Dana, Beke, Lijs, Mannens, Geert, Vinken, Petra, Sommers, Ivan, Thuring, Jan-Willem, Sun, Weimei, Moy, Christopher, Pande, Vineet, Zhou, Junguo, Haddish-Berhane, Nahor, Salvati, Mark, Laquerre, Sylvie, Lorenzi, Matthew V., Brehmer, Dirk
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets
Van Dessel, Nele, Beke, Lijs, Görnemann, Janina, Minnebo, Nikki, Beullens, Monique, Tanuma, Nobuhiro, Shima, Hiroshi, Van Eynde, Aleyde, Bollen, Mathieu
Published in Nucleic acids research (01.11.2010)
Published in Nucleic acids research (01.11.2010)
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Journal Article
Abstract 2936: JNJ-47117096, a selective small molecule inhibitor of the MELK oncogene decreases DNA damage tolerance in highly proliferating cancer cells
Beke, Lijs, Linders, Joannes T.m., Kig, Cenk, Boeckx, An, Heerde, Erika van, Wuyts, Dirk, Parade, Marc, Meerpoel, Lieven, Johnson, Chris, Beullens, Monique, Bollen, Mathieu, Brehmer, Dirk
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract DDT02-04: A novel PRMT5 inhibitor with potent in vitro and in vivo activity in preclinical lung cancer models
Brehmer, Dirk, Wu, Tongfei, Mannens, Geert, Beke, Lijs, Vinken, Petra, Gaffney, Dana, Sun, Weimei, Pande, Vineet, Thuring, Jan-Willem, Millar, Hillary, Poggesi, Italo, Somers, Ivan, Boeckx, An, Parade, Marc, Heerde, Erika van, Nys, Thomas, Yanovich, Carol, Herkert, Barbara, Verhulst, Tinne, Jardin, Marc Du, Meerpoel, Lieven, Moy, Christopher, Diels, Gaston, Viellevoye, Marcel, Schepens, Wim, Poncelet, Alain, Linders, Joannes T., Lawson, Edward C., Edwards, James P., Chetty, Dushen, Laquerre, Sylvie, Lorenzi, Matthew V.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Correction: MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells
Beke, Lijs, Kig, Cenk, Linders, Joannes T M, Boens, Shannah, Boeckx, An, van Heerde, Erika, Parade, Marc, De Bondt, An, Van den Wyngaert, Ilse, Bashir, Tarig, Ogata, Souichi, Meerpoel, Lieven, Van Eynde, Aleyde, Johnson, Christopher N, Beullens, Monique, Brehmer, Dirk, Bollen, Mathieu
Published in Bioscience reports (21.12.2018)
Published in Bioscience reports (21.12.2018)
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Journal Article
Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Johnson, Christopher N, Berdini, Valerio, Beke, Lijs, Bonnet, Pascal, Brehmer, Dirk, Coyle, Joseph E, Day, Phillip J, Frederickson, Martyn, Freyne, Eddy J. E, Gilissen, Ron A. H. J, Hamlett, Christopher C. F, Howard, Steven, Meerpoel, Lieven, McMenamin, Rachel, Patel, Sahil, Rees, David C, Sharff, Andrew, Sommen, François, Wu, Tongfei, Linders, Joannes T. M
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Journal Article
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase
Johnson, Christopher N, Adelinet, Christophe, Berdini, Valerio, Beke, Lijs, Bonnet, Pascal, Brehmer, Dirk, Calo, Frederick, Coyle, Joseph E, Day, Phillip J, Frederickson, Martyn, Freyne, Eddy J. E, Gilissen, Ron A. H. J, Hamlett, Christopher C. F, Howard, Steven, Meerpoel, Lieven, Mevellec, Laurence, McMenamin, Rachel, Pasquier, Elisabeth, Patel, Sahil, Rees, David C, Linders, Joannes T. M
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Journal Article
PRMT5 억제제로서 사용하기 위한 신규의 모노사이클릭 및 바이사이클릭 고리 시스템 치환된 카르바뉴클레오시드 유사체
PANDE VINEET, SUN WEIMEI, PARADE MARCUS CORNELIS BERNARDUS CATHARINA, DIELS GASTON STANISLAS MARCELLA, VIELLEVOYE MARCEL, MEERPOEL LIEVEN, BOECKX AN, BEKE LIJS, THURING JOHANNES WILHELMUS JOHN F, WU TONGFEI, SCHEPENS WIM BERT GRIET, BREHMER DIRK, LAWSON EDWARD CHARLES
Year of Publication 24.05.2019
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Year of Publication 24.05.2019
Patent
PRMT5 저해제로 사용하기 위한 치환 뉴클레오사이드 유사체
PANDE VINEET, SHOOK BRIAN CHRISTOPHER, SUN WEIMEI, PARADE MARCUS CORNELIS BERNARDUS CATHARINA, DIELS GASTON STANISLAS MARCELLA, VIELLEVOYE MARCEL, MEERPOEL LIEVEN, BERTHELOT DIDIER JEAN CLAUDE, BOECKX AN, BEKE LIJS, THURING JOHANNES WILHELMUS JOHN F, WU TONGFEI, SCHEPENS WIM BERT GRIET, BREHMER DIRK, GILISSEN RONALDUS ARNODUS HENDRIKA JOSEPH, LAWSON EDWARD CHARLES
Year of Publication 24.10.2018
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Year of Publication 24.10.2018
Patent
PRMT5 저해제로서 사용하기 위한 신규한 6-6 이환식 방향족 고리 치환 뉴클레오시드 유사체
PANDE VINEET, SUN WEIMEI, PARADE MARCUS CORNELIS BERNARDUS CATHARINA, DIELS GASTON STANISLAS MARCELLA, VIELLEVOYE MARCEL, MEERPOEL LIEVEN, BOECKX AN, BEKE LIJS, THURING JOHANNES WILHELMUS JOHN F, WU TONGFEI, SCHEPENS WIM BERT GRIET, BREHMER DIRK, GILISSEN RONALDUS ARNODUS HENDRIKA JOSEPH, LAWSON EDWARD CHARLES
Year of Publication 23.04.2018
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Year of Publication 23.04.2018
Patent