Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
Mullarky, Edouard, Lucki, Natasha C., Zavareh, Reza Beheshti, Anglin, Justin L., Gomes, Ana P., Nicolay, Brandon N., Wong, Jenny C. Y., Christen, Stefan, Takahashi, Hidenori, Singh, Pradeep K., Blenis, John, Warren, J. David, Fendt, Sarah-Maria, Asara, John M., DeNicola, Gina M., Lyssiotis, Costas A., Lairson, Luke L., Cantley, Lewis C.
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2016)
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Journal Article
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
Xu, G. Wei, Ali, Mohsin, Wood, Tabitha E., Wong, Derek, Maclean, Neil, Wang, Xiaoming, Gronda, Marcela, Skrtic, Marko, Li, Xiaoming, Hurren, Rose, Mao, Xinliang, Venkatesan, Meenakshi, Zavareh, Reza Beheshti, Ketela, Troy, Reed, John C., Rose, David, Moffat, Jason, Batey, Robert A., Dhe-Paganon, Sirano, Schimmer, Aaron D.
Published in Blood (18.03.2010)
Published in Blood (18.03.2010)
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Journal Article
The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma
Spagnuolo, Paul A., Hu, Jiayi, Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, Sukhai, Mahadeo A., Di Meo, Ashley, Boss, Jonathan, Ashali, Iman, Beheshti Zavareh, Reza, Fine, Noah, Simpson, Craig D., Sharmeen, Sumaiya, Rottapel, Rob, Schimmer, Aaron D.
Published in Blood (10.06.2010)
Published in Blood (10.06.2010)
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Journal Article
Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation
SIMPSON, Craig D, MAWJI, Imtiaz A, BEHESHTI ZAVAREH, Reza, DATTI, Alessandro, WRANA, Jeffrey L, EZZAT, Shereen, SCHIMMER, Aaron D, ANYIWE, Kika, WILLIAMS, Moyo A, XIAOMING WANG, VENUGOPAL, Amudha L, GRONDA, Marcela, HURREN, Rose, CHENG, Sonia, SERRA, Stefano
Published in Cancer research (Chicago, Ill.) (01.04.2009)
Published in Cancer research (Chicago, Ill.) (01.04.2009)
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Journal Article
Suppression of cancer progression by MGAT1 shRNA knockdown
Beheshti Zavareh, Reza, Sukhai, Mahadeo A, Hurren, Rose, Gronda, Marcela, Wang, Xiaoming, Simpson, Craig D, Maclean, Neil, Zih, Francis, Ketela, Troy, Swallow, Carol J, Moffat, Jason, Rose, David R, Schachter, Harry, Schimmer, Aaron D, Dennis, James W
Published in PloS one (05.09.2012)
Published in PloS one (05.09.2012)
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Journal Article
Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function
Beheshti Zavareh, Reza, Lau, Ken S, Hurren, Rose, Datti, Alessandro, Ashline, David J, Gronda, Marcela, Cheung, Pam, Simpson, Craig D, Liu, Wei, Wasylishen, Amanda R, Boutros, Paul C, Shi, Hui, Vengopal, Amudha, Jurisica, Igor, Penn, Linda Z, Reinhold, Vern N, Ezzat, Shereen, Wrana, Jeff, Rose, David R, Schachter, Harry, Dennis, James W, Schimmer, Aaron D
Published in Cancer research (Chicago, Ill.) (15.08.2008)
Published in Cancer research (Chicago, Ill.) (15.08.2008)
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Journal Article
JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma
Zak, Jaroslav, Pratumchai, Isaraphorn, Marro, Brett S, Marquardt, Kristi L, Zavareh, Reza Beheshti, Lairson, Luke L, Oldstone, Michael B A, Varner, Judith A, Hegerova, Livia, Cao, Qing, Farooq, Umar, Kenkre, Vaishalee P, Bachanova, Veronika, Teijaro, John R
Published in Science (American Association for the Advancement of Science) (21.06.2024)
Published in Science (American Association for the Advancement of Science) (21.06.2024)
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Journal Article
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors
Holt, Melissa C, Assar, Zahra, Beheshti Zavareh, Reza, Lin, Lin, Anglin, Justin, Mashadova, Oksana, Haldar, Daniel, Mullarky, Edouard, Kremer, Daniel M, Cantley, Lewis C, Kimmelman, Alec C, Stein, Adam J, Lairson, Luke L, Lyssiotis, Costas A
Published in Biochemistry (Easton) (27.11.2018)
Published in Biochemistry (Easton) (27.11.2018)
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Journal Article
Discovery of Small Molecules for the Reversal of T Cell Exhaustion
Marro, Brett S., Zak, Jaroslav, Zavareh, Reza Beheshti, Teijaro, John R., Lairson, Luke L., Oldstone, Michael B.A.
Published in Cell reports (Cambridge) (03.12.2019)
Published in Cell reports (Cambridge) (03.12.2019)
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Journal Article
Protocol for high-throughput compound screening using flow cytometry in THP-1 cells
Spangenberg, Stephan H., Zavareh, Reza Beheshti, Lairson, Luke L.
Published in STAR protocols (18.06.2021)
Published in STAR protocols (18.06.2021)
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Journal Article
Molecular characterization of type I IFN-induced cytotoxicity in bladder cancer cells reveals biomarkers of resistance
Green, Jennifer L., Osterhout, Robin E., Klova, Amy L., Merkwirth, Carsten, McDonnell, Scott R.P., Zavareh, Reza Beheshti, Fuchs, Bryan C., Kamal, Adeela, Jakobsen, Jørn S.
Published in Molecular therapy. Oncolytics (17.12.2021)
Published in Molecular therapy. Oncolytics (17.12.2021)
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Journal Article
Cyproheptadine displays preclinical activity in myeloma and leukemia
Mao, Xinliang, Liang, Sheng-ben, Hurren, Rose, Gronda, Marcela, Chow, Sue, Xu, G. Wei, Wang, Xiaoming, Zavareh, Reza Beheshti, Jamal, Nazir, Messner, Hans, Hedley, David W., Datti, Alessandro, Wrana, Jeff L., Zhu, Yuanxiao, Shi, Chang-xin, Lee, Kyle, Tiedemann, Rodger, Trudel, Suzanne, Stewart, A. Keith, Schimmer, Aaron D.
Published in Blood (01.08.2008)
Published in Blood (01.08.2008)
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Journal Article
Involvement of ApoE E4 and H63D in Sporadic Alzheimer's Disease in a Folate-Supplemented Ontario Population
Percy, Maire, Moalem, Sharon, Garcia, Angeles, Somerville, Martin J., Hicks, Mark, Andrews, David, Azad, Azar, Schwarz, Peter, Zavareh, Reza Beheshti, Birkan, Rivka, Choo, Clara, Chow, Vinca, Dhaliwal, Sandeep, Duda, Victoria, Kupferschmidt, Anthony L., Lam, Kyla, Lightman, Deborah, Machalek, Karolina, Mar, Wanna, Nguyen, Frank, Rytwinski, Piotr J., Svara, Erin, Tran, Maithy, Yeung, Lisa, Zanibbi, Katherine, Zener, Rebecca, Ziraldo, Melissa, Freedman, Morris
Published in Journal of Alzheimer's disease (01.05.2008)
Published in Journal of Alzheimer's disease (01.05.2008)
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Journal Article
novel diquinolonium displays preclinical anti-cancer activity and induces caspase-independent cell death
Hurren, Rose, Zavareh, Reza Beheshti, Dalili, Shadi, Wood, Tabitha, Rose, David, Chang, Hong, Jamal, Nazir, Messner, Hans, Batey, Robert A, Schimmer, Aaron D
Published in Apoptosis (London) (01.06.2008)
Published in Apoptosis (London) (01.06.2008)
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Journal Article
HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins
Zavareh, Reza Beheshti, Spangenberg, Stephan H., Woods, Ashley, Martínez-Peña, Francisco, Lairson, Luke L.
Published in Cell chemical biology (18.02.2021)
Published in Cell chemical biology (18.02.2021)
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Journal Article
Reversing T cell Exhaustion Through Discovery of Small Molecules
Marro, Brett S., Zavareh, Reza Beheshti, Teijaro, John R., Lairson, Luke L., Oldstone, Michael B.A.
Published in The Journal of immunology (1950) (01.05.2018)
Published in The Journal of immunology (1950) (01.05.2018)
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Journal Article
Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma
Anglin, Justin, Zavareh, Reza Beheshti, Sander, Philipp N., Haldar, Daniel, Mullarky, Edouard, Cantley, Lewis C., Kimmelman, Alec C., Lyssiotis, Costas A., Lairson, Luke L.
Published in Bioorganic & medicinal chemistry letters (01.09.2018)
Published in Bioorganic & medicinal chemistry letters (01.09.2018)
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Journal Article
Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78
Ambrose, Andrew J., Sivinski, Jared, Zerio, Christopher J., Zhu, Xiaoyi, Godek, Jack, Kumirov, Vlad K., Coma Brujas, Teresa, Torra Garcia, Joan, Annadurai, Anandhan, Schmidlin, Cody J., Werner, Alyssa, Shi, Taoda, Zavareh, Reza Beheshti, Lairson, Luke, Zhang, Donna D., Chapman, Eli
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Journal Article
Identification of small-molecule protein-protein interaction inhibitors for NKG2D
Thompson, Aaron A, Harbut, Michael B, Kung, Pei-Pei, Karpowich, Nathan K, Branson, Jeffrey D, Grant, Joanna C, Hagan, Deborah, Pascual, Heather A, Bai, Guoyun, Zavareh, Reza Beheshti, Coate, Heather R, Collins, Bernard C, Côte, Marjorie, Gelin, Christine F, Damm-Ganamet, Kelly L, Gholami, Hadi, Huff, Adam R, Limon, Luis, Lumb, Kevin J, Mak, Puiying A, Nakafuku, Kohki M, Price, Edmund V, Shih, Amy Y, Tootoonchi, Mandana, Vellore, Nadeem A, Wang, Jocelyn, Wei, Na, Ziff, Jeannie, Berger, Scott B, Edwards, James P, Gardet, Agnès, Sun, Siquan, Towne, Jennifer E, Venable, Jennifer D, Shi, Zhicai, Venkatesan, Hariharan, Rives, Marie-Laure, Sharma, Sujata, Shireman, Brock T, Allen, Samantha J
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2023)
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Journal Article
Abstract 1484: Inhibition of the glycosylation enzyme Mgat1 blocks migration, invasion and metastasis of malignant cells
Zavareh, Reza Beheshti, Hurren, Rose, Gronda, Marcela, Sukhai, Mahadeo A., Simpson, Craig D., Wang, Xiaoming, MacLean, Neil A., Ketela, Troy, Moffat, Jason, Rose, David R., Schachter, Harry, Dennis, James W., Schimmer, Aaron D.
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article