Submicron Size Particles of a Murine Monoclonal Antibody Are More Immunogenic Than Soluble Oligomers or Micron Size Particles Upon Subcutaneous Administration in Mice
Kijanka, Grzegorz, Bee, Jared S., Korman, Samuel A., Wu, Yuling, Roskos, Lorin K., Schenerman, Mark A., Slütter, Bram, Jiskoot, Wim
Published in Journal of pharmaceutical sciences (01.11.2018)
Published in Journal of pharmaceutical sciences (01.11.2018)
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Journal Article
Gelation of a Monoclonal Antibody at the Silicone Oil–Water Interface and Subsequent Rupture of the Interfacial Gel Results in Aggregation and Particle Formation
Mehta, Shyam B., Lewus, Rachael, Bee, Jared S., Randolph, Theodore W., Carpenter, John F.
Published in Journal of pharmaceutical sciences (01.04.2015)
Published in Journal of pharmaceutical sciences (01.04.2015)
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Journal Article
Quantitation of Trace Levels of DNA Released from Disrupted Adeno-Associated Virus Gene Therapy Vectors
Bee, Jared S., O'Berry, Kristin, Zhang, Yu (Zoe), Phillippi, Megan Kuhn, Kaushal, Akanksha, DePaz, Roberto A., Marshall, Tristan
Published in Journal of pharmaceutical sciences (01.09.2021)
Published in Journal of pharmaceutical sciences (01.09.2021)
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Journal Article
Comparative Thermodynamics of the Reversible Self-Association of Therapeutic mAbs Reveal Opposing Roles for Linked Proton- and Ion-Binding Events
Hopkins, Mandi M., Antonopoulos, Ioanna H., Parupudi, Arun, Bee, Jared S., Bain, David L.
Published in Pharmaceutical research (01.06.2023)
Published in Pharmaceutical research (01.06.2023)
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Journal Article
Ionic Strength Affects Tertiary Structure and Aggregation Propensity of a Monoclonal Antibody Adsorbed to Silicone Oil–Water Interfaces
Gerhardt, Alana, Bonam, Kurt, Bee, Jared S., Carpenter, John F., Randolph, Theodore W.
Published in Journal of pharmaceutical sciences (01.02.2013)
Published in Journal of pharmaceutical sciences (01.02.2013)
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Journal Article
Response of a concentrated monoclonal antibody formulation to high shear
Bee, Jared S, Stevenson, Jennifer L, Mehta, Bhavya, Svitel, Juraj, Pollastrini, Joey, Platz, Robert, Freund, Erwin, Carpenter, John F, Randolph, Theodore W
Published in Biotechnology and bioengineering (01.08.2009)
Published in Biotechnology and bioengineering (01.08.2009)
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Journal Article
Analytical characterization of coformulated antibodies as combination therapy
Kim, Jun, Kim, Yoen Joo, Cao, Mingyan, De Mel, Niluka, Albarghouthi, Methal, Miller, Kenneth, Bee, Jared S, Wang, Jihong, Wang, Xiangyang
Published in mAbs (01.01.2020)
Published in mAbs (01.01.2020)
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Journal Article
Aggregation of a monoclonal antibody induced by adsorption to stainless steel
Bee, Jared S, Davis, Michele, Freund, Erwin, Carpenter, John F, Randolph, Theodore W
Published in Biotechnology and bioengineering (01.01.2010)
Published in Biotechnology and bioengineering (01.01.2010)
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Journal Article
Identification of an IgG CDR sequence contributing to co‐purification of the host cell protease cathepsin D
Bee, Jared S., Machiesky, LeeAnn M., Peng, Li, Jusino, Kristin C., Dickson, Matthew, Gill, Jeffrey, Johnson, Douglas, Lin, Hung‐Yu, Miller, Kenneth, Heidbrink Thompson, Jenny, Remmele, Richard L.
Published in Biotechnology progress (01.01.2017)
Published in Biotechnology progress (01.01.2017)
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Journal Article
Generation and Characterization of an IgG4 Monomeric Fc Platform
Shan, Lu, Colazet, Magali, Rosenthal, Kim L, Yu, Xiang-Qing, Bee, Jared S, Ferguson, Andrew, Damschroder, Melissa M, Wu, Herren, Dall'Acqua, William F, Tsui, Ping, Oganesyan, Vaheh
Published in PloS one (01.08.2016)
Published in PloS one (01.08.2016)
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Journal Article
Development of a stable lyophilized adeno-associated virus gene therapy formulation
Zhang, Yu (Zoe), DePaz, Roberto A., Bee, Jared S., Marshall, Tristan
Published in International journal of pharmaceutics (05.09.2021)
Published in International journal of pharmaceutics (05.09.2021)
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Journal Article
Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product
Bee, Jared S., Tie, Liu, Johnson, Douglas, Dimitrova, Mariana N., Jusino, Kristin C., Afdahl, Christopher D.
Published in Biotechnology progress (01.09.2015)
Published in Biotechnology progress (01.09.2015)
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Journal Article
Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody
Oganesyan, Vaheh, Peng, Li, Bee, Jared S., Li, John, Perry, Samuel R., Comer, Frank, Xu, Linda, Cook, Kimberly, Senthil, Kannaki, Clarke, Lori, Rosenthal, Kim, Gao, Changshou, Damschroder, Melissa, Wu, Herren, Dall’Acqua, William
Published in The Journal of biological chemistry (01.06.2018)
Published in The Journal of biological chemistry (01.06.2018)
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Journal Article
Impact of Time Out of Intended Storage and Freeze-thaw Rates on the Stability of Adeno-associated Virus 8 and 9
Bee, Jared S., Zhang, Yu (Zoe), Phillippi, Megan Kuhn, Finkner, Sheyla, Mezghebe, Tesfu, Webber, Keith, Cheung, Win Den, Marshall, Tristan
Published in Journal of pharmaceutical sciences (01.05.2022)
Published in Journal of pharmaceutical sciences (01.05.2022)
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Journal Article
Mechanistic Studies and Formulation Mitigations of Adeno-associated Virus Capsid Rupture During Freezing and Thawing: Mechanisms of Freeze/Thaw Induced AAV Rupture
Bee, Jared S, Zhang, Yu, Finkner, Sheyla, O'Berry, Kristin, Kaushal, Akanksha, Phillippi, Megan Kuhn, DePaz, Roberto A, Webber, Keith, Marshall, Tristan
Published in Journal of pharmaceutical sciences (01.07.2022)
Published in Journal of pharmaceutical sciences (01.07.2022)
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Journal Article
Monoclonal Antibody Dimers Induced by Low pH, Heat, or Light Exposure Are Not Immunogenic Upon Subcutaneous Administration in a Mouse Model
Kijanka, Grzegorz, Bee, Jared S., Schenerman, Mark A., Korman, Samuel A., Wu, Yuling, Slütter, Bram, Jiskoot, Wim
Published in Journal of pharmaceutical sciences (01.01.2020)
Published in Journal of pharmaceutical sciences (01.01.2020)
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Journal Article
Energetic Dissection of Mab-Specific Reversible Self-Association Reveals Unique Thermodynamic Signatures
Hopkins, Mandi M., Parupudi, Arun, Bee, Jared S., Bain, David L.
Published in Pharmaceutical research (01.02.2021)
Published in Pharmaceutical research (01.02.2021)
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Journal Article