Therapeutics based on stop codon readthrough
Keeling, Kim M, Xue, Xiaojiao, Gunn, Gwen, Bedwell, David M
Published in Annual review of genomics and human genetics (01.01.2014)
Published in Annual review of genomics and human genetics (01.01.2014)
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Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression
Roy, Bijoyita, Friesen, Westley J., Tomizawa, Yuki, Leszyk, John D., Zhuo, Jin, Johnson, Briana, Dakka, Jumana, Trotta, Christopher R., Xue, Xiaojiao, Mutyam, Venkateshwar, Keeling, Kim M., Mobley, James A., Rowe, Steven M., Bedwell, David M., Welch, Ellen M., Jacobson, Allan
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2016)
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Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats
Tuggle, Katherine L, Birket, Susan E, Cui, Xiaoxia, Hong, Jeong, Warren, Joe, Reid, Lara, Chambers, Andre, Ji, Diana, Gamber, Kevin, Chu, Kengyeh K, Tearney, Guillermo, Tang, Li Ping, Fortenberry, James A, Du, Ming, Cadillac, Joan M, Bedwell, David M, Rowe, Steven M, Sorscher, Eric J, Fanucchi, Michelle V
Published in PloS one (07.03.2014)
Published in PloS one (07.03.2014)
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Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression
Keeling, Kim M, Wang, Dan, Dai, Yanying, Murugesan, Srinivasan, Chenna, Balachandra, Clark, Jeremy, Belakhov, Valery, Kandasamy, Jeyakumar, Velu, Sadanandan E, Baasov, Timor, Bedwell, David M
Published in PloS one (10.04.2013)
Published in PloS one (10.04.2013)
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Journal Article
PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model
Du, Ming, Liu, Xiaoli, Welch, Ellen M, Hirawat, Samit, Peltz, Stuart W, Bedwell, David M
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2008)
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Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells
Li, Chao, Liu, Zhong, Anderson, Justin, Liu, Zhongyu, Tang, Liping, Li, Yao, Peng, Ning, Chen, Jianguo, Liu, Xueming, Fu, Lianwu, Townes, Tim M, Rowe, Steven M, Bedwell, David M, Guimbellot, Jennifer, Zhao, Rui
Published in PloS one (29.11.2023)
Published in PloS one (29.11.2023)
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Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor
Xue, Xiaojiao, Mutyam, Venkateshwar, Tang, Liping, Biswas, Silpak, Du, Ming, Jackson, Laura A, Dai, Yanying, Belakhov, Valery, Shalev, Moran, Chen, Fuquan, Schacht, Jochen, J Bridges, Robert, Baasov, Timor, Hong, Jeong, Bedwell, David M, Rowe, Steven M
Published in American journal of respiratory cell and molecular biology (01.04.2014)
Published in American journal of respiratory cell and molecular biology (01.04.2014)
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Journal Article
Suppression of premature termination codons as a therapeutic approach
Keeling, Kim M., Wang, Dan, Conard, Sara E., Bedwell, David M.
Published in Critical reviews in biochemistry and molecular biology (01.09.2012)
Published in Critical reviews in biochemistry and molecular biology (01.09.2012)
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Mutation-Directed Therapeutics for Neurofibromatosis Type I
Leier, Andre, Bedwell, David M., Chen, Ann T., Dickson, George, Keeling, Kim M., Kesterson, Robert A., Korf, Bruce R., Marquez Lago, Tatiana T., Müller, Ulrich F., Popplewell, Linda, Zhou, Jiangbing, Wallis, Deeann
Published in Molecular therapy. Nucleic acids (05.06.2020)
Published in Molecular therapy. Nucleic acids (05.06.2020)
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Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I
Li, Kairong, Turner, Ashley N, Chen, Min, Brosius, Stephanie N, Schoeb, Trenton R, Messiaen, Ludwine M, Bedwell, David M, Zinn, Kurt R, Anastasaki, Corina, Gutmann, David H, Korf, Bruce R, Kesterson, Robert A
Published in Disease models & mechanisms (01.07.2016)
Published in Disease models & mechanisms (01.07.2016)
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Distinct eRF3 Requirements Suggest Alternate eRF1 Conformations Mediate Peptide Release during Eukaryotic Translation Termination
Fan-Minogue, Hua, Du, Ming, Pisarev, Andrey V., Kallmeyer, Adam K., Salas-Marco, Joe, Keeling, Kim M., Thompson, Sunnie R., Pestova, Tatyana V., Bedwell, David M.
Published in Molecular cell (06.06.2008)
Published in Molecular cell (06.06.2008)
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Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model
Du, Ming, Keeling, Kim M, Fan, Liming, Liu, Xiaoli, Kovaçs, Timea, Sorscher, Eric, Bedwell, David M
Published in Journal of molecular medicine (Berlin, Germany) (01.07.2006)
Published in Journal of molecular medicine (Berlin, Germany) (01.07.2006)
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