Preparation and biological evaluation of conformationally constrained BACE1 inhibitors
Winneroski, Leonard L., Schiffler, Matthew A., Erickson, Jon A., May, Patrick C., Monk, Scott A., Timm, David E., Audia, James E., Beck, James P., Boggs, Leonard N., Borders, Anthony R., Boyer, Robert D., Brier, Richard A., Hudziak, Kevin J., Klimkowski, Valentine J., Garcia Losada, Pablo, Mathes, Brian M., Stout, Stephanie L., Watson, Brian M., Mergott, Dustin J.
Published in Bioorganic & medicinal chemistry (01.07.2015)
Published in Bioorganic & medicinal chemistry (01.07.2015)
Get full text
Journal Article
Mutual Cooperativity of Three Allosteric Sites on the Dopamine D1 Receptor
Wang, Xushan, Hembre, Erik J, Goldsmith, Paul J, Beck, James P, Svensson, Kjell A, Willard, Francis S, Bruns, Robert F
Published in Molecular pharmacology (01.03.2023)
Published in Molecular pharmacology (01.03.2023)
Get full text
Journal Article
Ensemble Docking Approach to Mitigate Pregnane X Receptor-Mediated CYP3A4 Induction Risk
Chen, Qi, Zhou, Xin, Rehmel, Jessica, Steele, James P., Svensson, Kjell A., Beck, James P., Hembre, Erik J., Hao, Junliang
Published in Journal of chemical information and modeling (09.01.2023)
Published in Journal of chemical information and modeling (09.01.2023)
Get full text
Journal Article
Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor
Wang, Xushan, Heinz, Beverly A, Qian, Yue-Wei, Carter, Joan H, Gadski, Robert A, Beavers, Lisa S, Little, Sheila P, Yang, Charles R, Beck, James P, Hao, Junliang, Schaus, John M, Svensson, Kjell A, Bruns, Robert F
Published in Molecular pharmacology (01.10.2018)
Published in Molecular pharmacology (01.10.2018)
Get full text
Journal Article
In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection
Williams, Dustin L, Haymond, Bryan S, Beck, James P, Savage, Paul B, Chaudhary, Vinod, Epperson, Richard T, Kawaguchi, Brooke, Bloebaum, Roy D
Published in Biomaterials (01.11.2012)
Published in Biomaterials (01.11.2012)
Get full text
Journal Article
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor
McKinzie, David L, Winneroski, Leonard L, Green, Steven J, Hembre, Erik J, Erickson, Jon A, Willis, Brian A, Monk, Scott A, Aluise, Christopher D, Baker, Thomas K, Lopez, Jose E, Hendle, Jörg, Beck, James P, Brier, Richard A, Boggs, Leonard N, Borders, Anthony R, Cocke, Patrick J, Garcia-Losada, Pablo, Lowe, Stephen L, Mathes, Brian M, May, Patrick C, Porter, Warren J, Stout, Stephanie L, Timm, David E, Watson, Brian M, Yang, Zhixiang, Mergott, Dustin J
Published in Journal of medicinal chemistry (24.06.2021)
Published in Journal of medicinal chemistry (24.06.2021)
Get full text
Journal Article
Epidermal growth factor receptor genes are overexpressed within the periprosthetic soft‐tissue around percutaneous devices: A pilot study
Jeyapalina, Sujee, Colombo, John S., Beck, James P., Agarwal, Jayant P., Schmidt, Linda A., Bachus, Kent N.
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01.02.2020)
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01.02.2020)
Get full text
Journal Article
Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders
Bruns, Robert F., Mitchell, Stephen N., Wafford, Keith A., Harper, Alex J., Shanks, Elaine A., Carter, Guy, O'Neill, Michael J., Murray, Tracey K., Eastwood, Brian J., Schaus, John M., Beck, James P., Hao, Junliang, Witkin, Jeffrey M., Li, Xia, Chernet, Eyassu, Katner, Jason S., Wang, Hong, Ryder, John W., Masquelin, Meghane E., Thompson, Linda K., Love, Patrick L., Maren, Deanna L., Falcone, Julie F., Menezes, Michelle M., Zhang, Linli, Yang, Charles R., Svensson, Kjell A.
Published in Neuropharmacology (01.01.2018)
Published in Neuropharmacology (01.01.2018)
Get full text
Journal Article
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints
Winneroski, Leonard L., Erickson, Jon A., Green, Steven J., Lopez, Jose E., Stout, Stephanie L., Porter, Warren J., Timm, David E., Audia, James E., Barberis, Mario, Beck, James P., Boggs, Leonard N., Borders, Anthony R., Boyer, Robert D., Brier, Richard A., Hembre, Erik J., Hendle, Jörg, Garcia-Losada, Pablo, Minguez, Jose Miguel, Mathes, Brian M., May, Patrick C., Monk, Scott A., Rankovic, Zoran, Shi, Yuan, Watson, Brian M., Yang, Zhixiang, Mergott, Dustin J.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
Get full text
Journal Article
An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis
Svensson, Kjell A, Heinz, Beverly A, Schaus, John M, Beck, James P, Hao, Junliang, Krushinski, Joseph H, Reinhard, Matthew R, Cohen, Michael P, Hellman, Sarah L, Getman, Brian G, Wang, Xushan, Menezes, Michelle M, Maren, Deanna L, Falcone, Julie F, Anderson, Wesley H, Wright, Rebecca A, Morin, S Michelle, Knopp, Kelly L, Adams, Benjamin L, Rogovoy, Borys, Okun, Ilya, Suter, Todd M, Statnick, Michael A, Gehlert, Donald R, Nelson, David L, Lucaites, Virginia L, Emkey, Renee, DeLapp, Neil W, Wiernicki, Todd R, Cramer, Jeffrey W, Yang, Charles R, Bruns, Robert F
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)
Get full text
Journal Article
Human β-Secretase (BACE) and BACE Inhibitors
John, Varghese, Beck, James P, Bienkowski, Michael J, Sinha, Sukanto, Heinrikson, Robert L
Published in Journal of medicinal chemistry (23.10.2003)
Published in Journal of medicinal chemistry (23.10.2003)
Get full text
Journal Article
An evaluation of electrical stimulation for improving periprosthetic attachment
Isaacson, Brad M., Brunker, Lucille B., Brown, Amalia A., Beck, James P., Burns, Gregory L., Bloebaum, Roy D.
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01.04.2011)
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01.04.2011)
Get full text
Journal Article
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors
Pechulis, Anthony D., Beck, James P., Curry, Matt A., Wolf, Mark A., Harms, Arthur E., Xi, Ning, Opalka, Chet, Sweet, Mark P., Yang, Zhicai, Vellekoop, A. Samuel, Klos, Andrew M., Crocker, Peter J., Hassler, Carla, Laws, Mia, Kitchen, Douglas B., Smith, Mark A., Olson, Richard E., Liu, Shuang, Molino, Bruce F.
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Get full text
Journal Article
Characterization of Bacterial Isolates Collected from a Sheep Model of Osseointegration
Williams, Dustin L, Bloebaum, Roy D, Beck, James P, Petti, Cathy A
Published in Current microbiology (01.12.2010)
Published in Current microbiology (01.12.2010)
Get full text
Journal Article