New approaches for the treatment of Alzheimer’s disease
Fish, Paul V., Steadman, David, Bayle, Elliott D., Whiting, Paul
Published in Bioorganic & medicinal chemistry letters (15.01.2019)
Published in Bioorganic & medicinal chemistry letters (15.01.2019)
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Journal Article
Systematic Investigation of the Permeability of Androgen Receptor PROTACs
Scott, Duncan E, Rooney, Timothy P. C, Bayle, Elliott D, Mirza, Tashfina, Willems, Henriette M. G, Clarke, Jonathan H, Andrews, Stephen P, Skidmore, John
Published in ACS medicinal chemistry letters (13.08.2020)
Published in ACS medicinal chemistry letters (13.08.2020)
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Journal Article
Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins
Igoe, Niall, Bayle, Elliott D, Tallant, Cynthia, Fedorov, Oleg, Meier, Julia C, Savitsky, Pavel, Rogers, Catherine, Morias, Yannick, Scholze, Sarah, Boyd, Helen, Cunoosamy, Danen, Andrews, David M, Cheasty, Anne, Brennan, Paul E, Müller, Susanne, Knapp, Stefan, Fish, Paul V
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Journal Article
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent
Willis, Nicky J, Bayle, Elliott D, Papageorgiou, George, Steadman, David, Atkinson, Benjamin N, Mahy, William, Fish, Paul V
Published in Beilstein journal of organic chemistry (19.11.2019)
Published in Beilstein journal of organic chemistry (19.11.2019)
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Journal Article
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling
Bayle, Elliott D, Svensson, Fredrik, Atkinson, Benjamin N, Steadman, David, Willis, Nicky J, Woodward, Hannah L, Whiting, Paul, Vincent, Jean-Paul, Fish, Paul V
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms
Spurr, Sophie S., Bayle, Elliott D., Yu, Wenyu, Li, Fengling, Tempel, Wolfram, Vedadi, Masoud, Schapira, Matthieu, Fish, Paul V.
Published in Bioorganic & medicinal chemistry letters (15.09.2016)
Published in Bioorganic & medicinal chemistry letters (15.09.2016)
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Journal Article
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit
Willis, Nicky J., Mahy, William, Sipthorp, James, Zhao, Yuguang, Woodward, Hannah L., Atkinson, Benjamin N., Bayle, Elliott D., Svensson, Fredrik, Frew, Sarah, Jeganathan, Fiona, Monaghan, Amy, Benvegnù, Stefano, Jolly, Sarah, Vecchia, Luca, Ruza, Reinis R., Kjær, Svend, Howell, Steven, Snijders, Ambrosius P., Bictash, Magda, Salinas, Patricia C., Vincent, Jean-Paul, Jones, E. Yvonne, Whiting, Paul, Fish, Paul V.
Published in Journal of medicinal chemistry (26.05.2022)
Published in Journal of medicinal chemistry (26.05.2022)
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Journal Article
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors
Atkinson, Benjamin N., Steadman, David, Mahy, William, Zhao, Yuguang, Sipthorp, James, Bayle, Elliott D., Svensson, Fredrik, Papageorgiou, George, Jeganathan, Fiona, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
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Journal Article
Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies
Igoe, Niall, Bayle, Elliott D, Fedorov, Oleg, Tallant, Cynthia, Savitsky, Pavel, Rogers, Catherine, Owen, Dafydd R, Deb, Gauri, Somervaille, Tim C. P, Andrews, David M, Jones, Neil, Cheasty, Anne, Ryder, Hamish, Brennan, Paul E, Müller, Susanne, Knapp, Stefan, Fish, Paul V
Published in Journal of medicinal chemistry (26.01.2017)
Published in Journal of medicinal chemistry (26.01.2017)
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Journal Article
Structural Analysis and Development of Notum Fragment Screening Hits
Zhao, Yuguang, Mahy, William, Willis, Nicky J, Woodward, Hannah L, Steadman, David, Bayle, Elliott D, Atkinson, Benjamin N, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R, Harlos, Karl, Jeganathan, Fiona, Constantinou, Stefan, Costa, Artur, Kjær, Svend, Bictash, Magda, Salinas, Patricia C, Whiting, Paul, Vincent, Jean-Paul, Fish, Paul V, Jones, E Yvonne
Published in ACS chemical neuroscience (06.07.2022)
Published in ACS chemical neuroscience (06.07.2022)
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Journal Article
Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation
Meier, Julia C, Tallant, Cynthia, Fedorov, Oleg, Witwicka, Hanna, Hwang, Sung-Yong, van Stiphout, Ruud G, Lambert, Jean-Philippe, Rogers, Catherine, Yapp, Clarence, Gerstenberger, Brian S, Fedele, Vita, Savitsky, Pavel, Heidenreich, David, Daniels, Danette L, Owen, Dafydd R, Fish, Paul V, Igoe, Niall M, Bayle, Elliott D, Haendler, Bernard, Oppermann, Udo C.T, Buffa, Francesca, Brennan, Paul E, Müller, Susanne, Gingras, Anne Claude, Odgren, Paul R, Birnbaum, Mark J, Knapp, Stefan
Published in ACS chemical biology (20.10.2017)
Published in ACS chemical biology (20.10.2017)
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Journal Article
Design of a Biased Potent Small Molecule Inhibitor of the Bromodonnain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies
Igoe, Niall, Bayle, Elliott D., Fedorov, Oleg, Tallant, Cynthia, Savitsky, Pavel, Rogers, Catherine, Owen, Dafydd R., Deb, Gauri, Somervaille, Tim C. P., Andrews, David M., Jones, Neil, Cheasty, Anne, Ryder, Hamish, Brennan, Paul E., Mueller, Susanne, Knapp, Stefan, Fish, Paul V.
Published in Journal of medicinal chemistry (26.01.2017)
Published in Journal of medicinal chemistry (26.01.2017)
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Journal Article
COMPOUNDS
WILLIS, Nicky, John, MAHY, William, FISH, Paul, Vincent, WOODWARD, Hannah, ZHAO, Yuguang, VECCHIA, Luca, SIPTHORP, James, BAYLE, Elliott, D, ATKINSON, Benjamin, N, JONES, Edith, Yvonne, RUZA, Reinis, Reinholds
Year of Publication 28.08.2024
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Year of Publication 28.08.2024
Patent
Compounds which are inhibitors of Notum
Willis, Nicky John, Sipthorp, James, Woodward, Hannah, Fish, Paul Vincent, Ruza, Reinis Reinholds, Vecchia, Luca, Mahy, William, Jones, Edith Yvonne, Atkinson, Benjamin N, Bayle, Elliott D, Zhao, Yuguang
Year of Publication 25.04.2023
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Year of Publication 25.04.2023
Patent
COMPOUNDS
WILLIS, Nicky, John, MAHY, William, FISH, Paul, Vincent, WOODWARD, Hannah, ZHAO, Yuguang, VECCHIA, Luca, SIPTHORP, James, BAYLE, Elliott, D, ATKINSON, Benjamin, N, JONES, Edith, Yvonne, RUZA, Reinis, Reinholds
Year of Publication 07.07.2021
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Year of Publication 07.07.2021
Patent
COMPOUNDS
Willis, Nicky John, Sipthorp, James, Woodward, Hannah, Fish, Paul Vincent, Ruza, Reinis Reinholds, Vecchia, Luca, Mahy, William, Jones, Edith Yvonne, Atkinson, Benjamin N, Bayle, Elliott D, Zhao, Yuguang
Year of Publication 10.06.2021
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Year of Publication 10.06.2021
Patent