Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876
Siebeneicher, Holger, Cleve, Arwed, Rehwinkel, Hartmut, Neuhaus, Roland, Heisler, Iring, Müller, Thomas, Bauser, Marcus, Buchmann, Bernd
Published in ChemMedChem (19.10.2016)
Published in ChemMedChem (19.10.2016)
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Journal Article
Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
Quanz, Maria, Bender, Eckhard, Kopitz, Charlotte, Grünewald, Sylvia, Schlicker, Andreas, Schwede, Wolfgang, Eheim, Ashley, Toschi, Luisella, Neuhaus, Roland, Richter, Carmen, Toedling, Joern, Merz, Claudia, Lesche, Ralf, Kamburov, Atanas, Siebeneicher, Holger, Bauser, Marcus, Hägebarth, Andrea
Published in Molecular cancer therapeutics (01.11.2018)
Published in Molecular cancer therapeutics (01.11.2018)
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Journal Article
Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol: Safe Generation and Use of an Explosive Intermediate under Continuous-Flow Conditions
Cantillo, David, Damm, Markus, Dallinger, Doris, Bauser, Marcus, Berger, Markus, Kappe, C. Oliver
Published in Organic process research & development (21.11.2014)
Published in Organic process research & development (21.11.2014)
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Journal Article
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
Christian, Sven, Merz, Claudia, Evans, Laura, Gradl, Stefan, Seidel, Henrik, Friberg, Anders, Eheim, Ashley, Lejeune, Pascale, Brzezinka, Krzysztof, Zimmermann, Katja, Ferrara, Steven, Meyer, Hanna, Lesche, Ralf, Stoeckigt, Detlef, Bauser, Marcus, Haegebarth, Andrea, Sykes, David B, Scadden, David T, Losman, Julie-Aurore, Janzer, Andreas
Published in Leukemia (01.10.2019)
Published in Leukemia (01.10.2019)
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Journal Article
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design
Rahm, Fredrik, Viklund, Jenny, Trésaugues, Lionel, Ellermann, Manuel, Giese, Anja, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Günther, Judith, Hallberg, Kenth, Lindström, Johan, Persson, Lars Boukharta, Silvander, Camilla, Talagas, Antoine, Díaz-Sáez, Laura, Fedorov, Oleg, Huber, Kilian V. M, Panagakou, Ioanna, Siejka, Paulina, Gorjánácz, Mátyás, Bauser, Marcus, Andersson, Martin
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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Journal Article
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target
Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás
Published in ACS chemical biology (18.08.2017)
Published in ACS chemical biology (18.08.2017)
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Journal Article
Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179
Mowat, Jeffrey, Ehrmann, Alexander H. M, Christian, Sven, Sperl, Carolyn, Menz, Stephan, Günther, Judith, Hillig, Roman C, Bauser, Marcus, Schwede, Wolfgang
Published in ACS medicinal chemistry letters (10.03.2022)
Published in ACS medicinal chemistry letters (10.03.2022)
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Journal Article
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models
Lemos, Clara, Schulze, Volker K., Baumgart, Simon J., Nevedomskaya, Ekaterina, Heinrich, Tobias, Lefranc, Julien, Bader, Benjamin, Christ, Clara D., Briem, Hans, Kuhnke, Lara P., Holton, Simon J., Bömer, Ulf, Lienau, Philip, von Nussbaum, Franz, Nising, Carl F., Bauser, Marcus, Hägebarth, Andrea, Mumberg, Dominik, Haendler, Bernard
Published in Cellular oncology (Dordrecht) (01.06.2021)
Published in Cellular oncology (Dordrecht) (01.06.2021)
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Journal Article
Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability
Müller, Adrienne, Krämer, Stefanie D, Meletta, Romana, Beck, Katharina, Selivanova, Svetlana V, Rancic, Zoran, Kaufmann, Philipp A, Vos, Bernhard, Meding, Jörg, Stellfeld, Timo, Heinrich, Tobias K, Bauser, Marcus, Hütter, Joachim, Dinkelborg, Ludger M, Schibli, Roger, Ametamey, Simon M
Published in Nuclear medicine and biology (01.08.2014)
Published in Nuclear medicine and biology (01.08.2014)
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Journal Article
New Class of Bacterial Phenylalanyl-tRNA Synthetase Inhibitors with High Potency and Broad-Spectrum Activity
Beyer, Dieter, Kroll, Hein-Peter, Endermann, Rainer, Schiffer, Guido, Siegel, Stephan, Bauser, Marcus, Pohlmann, Jens, Brands, Michael, Ziegelbauer, Karl, Haebich, Dieter, Eymann, Christine, Brötz-Oesterhelt, Heike
Published in Antimicrobial Agents and Chemotherapy (01.02.2004)
Published in Antimicrobial Agents and Chemotherapy (01.02.2004)
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Journal Article
Preclinical Profile of Gadoquatrane: A Novel Tetrameric, Macrocyclic High Relaxivity Gadolinium-Based Contrast Agent
Lohrke, Jessica, Berger, Markus, Frenzel, Thomas, Hilger, Christoph-Stephan, Jost, Gregor, Panknin, Olaf, Bauser, Marcus, Ebert, Wolfgang, Pietsch, Hubertus
Published in Investigative radiology (01.10.2022)
Published in Investigative radiology (01.10.2022)
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Journal Article
Hafnium-Based Contrast Agents for X‑ray Computed Tomography
Berger, Markus, Bauser, Marcus, Frenzel, Thomas, Hilger, Christoph Stephan, Jost, Gregor, Lauria, Silvia, Morgenstern, Bernd, Neis, Christian, Pietsch, Hubertus, Sülzle, Detlev, Hegetschweiler, Kaspar
Published in Inorganic chemistry (15.05.2017)
Published in Inorganic chemistry (15.05.2017)
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Journal Article
Abstract 3790: Targeting the one-carbon metabolism protein MTHFD2 for cancer therapy: Exploiting the unique redox status of cancer cells
Glasauer, Andrea, Steckel, Michael, Haegebarth, Andrea, Bauser, Marcus, Toschi, Luisella
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2‑d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5
Nguyen, Duy, Lemos, Clara, Wortmann, Lars, Eis, Knut, Holton, Simon J, Boemer, Ulf, Moosmayer, Dieter, Eberspaecher, Uwe, Weiske, Joerg, Lechner, Christian, Prechtl, Stefan, Suelzle, Detlev, Siegel, Franziska, Prinz, Florian, Lesche, Ralf, Nicke, Barbara, Nowak-Reppel, Katrin, Himmel, Herbert, Mumberg, Dominik, von Nussbaum, Franz, Nising, Carl F, Bauser, Marcus, Haegebarth, Andrea
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
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Journal Article
Discovery of an Oral, Beyond-Rule-of-Five Mcl‑1 Protein–Protein Interaction Modulator with the Potential of Treating Hematological Malignancies
Romanov-Michailidis, Fedor, Hsiao, Chien-Chi, Urner, Lorenz M., Jerhaoui, Soufyan, Surkyn, Michel, Miller, Bradley, Vos, Ann, Dominguez Blanco, Maria, Bueters, Ruud, Vinken, Petra, Bekkers, Mariette, Walker, David, Pietrak, Beth, Eyckmans, Werner, Dores-Sousa, José Luís, Joo Koo, Seong, Lento, William, Bauser, Marcus, Philippar, Ulrike, Rombouts, Frederik J. R.
Published in Journal of medicinal chemistry (11.05.2023)
Published in Journal of medicinal chemistry (11.05.2023)
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Journal Article
Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A
Wortmann, Lars, Bräuer, Nico, Holton, Simon J, Irlbacher, Horst, Weiske, Jörg, Lechner, Christian, Meier, Robin, Karén, Jakob, Siöberg, Catrine Berthold, Pütter, Vera, Christ, Clara D, ter Laak, Antonius, Lienau, Philip, Lesche, Ralf, Nicke, Barbara, Cheung, Shing-Hu, Bauser, Marcus, Haegebarth, Andrea, von Nussbaum, Franz, Mumberg, Dominik, Lemos, Clara
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
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Journal Article
Identification of novel GLUT inhibitors
Siebeneicher, Holger, Bauser, Marcus, Buchmann, Bernd, Heisler, Iring, Müller, Thomas, Neuhaus, Roland, Rehwinkel, Hartmut, Telser, Joachim, Zorn, Ludwig
Published in Bioorganic & medicinal chemistry letters (01.04.2016)
Published in Bioorganic & medicinal chemistry letters (01.04.2016)
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Journal Article
Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS(G12C)
Mortier, Jeremie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.
Published in ChemMedChem (19.05.2020)
Published in ChemMedChem (19.05.2020)
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Journal Article
Abstract 3599: BAY 2402234: Preclinical evaluation of a novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of colorectal carcinomas
Merz, Claudia, Christian, Sven, Eheim, Ashley, Seidel, Henrik, Lesche, Ralf, Eversloh, Merlin Luetke, Meyer, Hanna, Ferrara, Steven, Bauser, Marcus, Haegebarth, Andrea, Gradl, Stefan, Janzer, Andreas
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 3597: BAY 2402234: Preclinical evaluation of a novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of diffuse large B-cell lymphoma (DLBCL)
Eheim, Ashley, Christian, Sven, Meyer, Hanna, Stoeckigt, Detlef, Merz, Claudia, Zimmermann, Katja, Bauser, Marcus, Haegebarth, Andrea, Ferrara, Steven, Sykes, David B., Scadden, David T., Gradl, Stefan, Janzer, Andreas
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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