Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
Simonetta, Kyle R, Taygerly, Joshua, Boyle, Kathleen, Basham, Stephen E, Padovani, Chris, Lou, Yan, Cummins, Thomas J, Yung, Stephanie L, von Soly, Szerenke Kiss, Kayser, Frank, Kuriyan, John, Rape, Michael, Cardozo, Mario, Gallop, Mark A, Bence, Neil F, Barsanti, Paul A, Saha, Anjanabha
Published in Nature communications (29.03.2019)
Published in Nature communications (29.03.2019)
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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic
Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
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Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5‑a]pyrazines as ATR Inhibitors
Barsanti, Paul A, Aversa, Robert J, Jin, Xianming, Pan, Yue, Lu, Yipin, Elling, Robert, Jain, Rama, Knapp, Mark, Lan, Jiong, Lin, Xiaodong, Rudewicz, Patrick, Sim, Janet, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors
Barsanti, Paul A, Pan, Yue, Lu, Yipin, Jain, Rama, Cox, Matthew, Aversa, Robert J, Dillon, Michael P, Elling, Robert, Hu, Cheng, Jin, Xianming, Knapp, Mark, Lan, Jiong, Ramurthy, Savithri, Rudewicz, Patrick, Setti, Lina, Subramanian, Sharadha, Mathur, Michelle, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Journal Article
Total Synthesis of (+)-Zaragozic Acid C
Armstrong, Alan, Barsanti, Paul A, Jones, Lyn H, Ahmed, Ghafoor
Published in Journal of organic chemistry (20.10.2000)
Published in Journal of organic chemistry (20.10.2000)
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Synthesis of the C1-side chain of zaragozic acid D and progress towards a total synthesis
Armstrong, Alan, Barsanti, Paul A, Blench, Toby J, Ogilvie, Ron
Published in Tetrahedron (13.01.2003)
Published in Tetrahedron (13.01.2003)
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Journal Article
Preparation of Chlorosilyl Enolates
Denmark, Scott E, Stavenger, Robert A, Winter, Stephen B. D, Wong, Ken-Tsung, Barsanti, Paul A
Published in Journal of organic chemistry (11.12.1998)
Published in Journal of organic chemistry (11.12.1998)
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Journal Article
A synthetic lethal screen reveals enhanced sensitivity to ATR inhibitor treatment in mantle cell lymphoma with ATM loss-of-function
Menezes, Daniel L, Holt, Jenny, Tang, Yan, Feng, Jiajia, Barsanti, Paul, Pan, Yue, Ghoddusi, Majid, Zhang, Wei, Thomas, George, Holash, Jocelyn, Lees, Emma, Taricani, Lorena
Published in Molecular cancer research (01.01.2015)
Published in Molecular cancer research (01.01.2015)
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Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors
Lu, Yipin, Knapp, Mark, Crawford, Kenneth, Warne, Robert, Elling, Robert, Yan, Kelly, Doyle, Michael, Pardee, Gwynn, Zhang, Li, Ma, Sylvia, Mamo, Mulugeta, Ornelas, Elizabeth, Pan, Yue, Bussiere, Dirksen, Jansen, Johanna, Zaror, Isabel, Lai, Albert, Barsanti, Paul, Sim, Janet
Published in Journal of molecular biology (02.06.2017)
Published in Journal of molecular biology (02.06.2017)
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Abstract 2696: Genetic and pharmacologic evaluation of the ubiquitin ligase CBL-B as a small-molecule, tumor immunotherapy target
Gosling, Jennifa, Rountree, Ryan, Taherbhoy, Asad, Wang, Chenbo, Cummins, Thomas, Cohen, Frederick, Tanaka, Hiroko, Weiss, Dahlia, Cardozo, Mario, Karim, Christopher, Tan, May, Juan, Joseph, Tenn-McClellan, Austin, Soly, Szerenke Kiss von, Sheung, Julie, Boyle, Kathleen, Dhamnaskar, Ketki, Kurylo, Katherine, Bruffey, Jilliane, McKinnell, Jennifer, Karr, Dane, Christianson, Andria, Vries, Anne-Renee Van Der Vuurst de, Sivakumar, Pallavur, Gallop, Mark, Barsanti, Paul A., Saha, Anjanabha, Bence, Neil F., Zapf, Christoph W.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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DNA 폴리머라제 세타 억제제로서의 O-연결된 티아디아졸릴 화합물
ADAMS NICHOLAS DAVID, MARTYR CUTHBERT, SEVERANCE DANIEL LEE, DUFFY KEVIN J, DARCY MICHAEL G, WANG CHENBO, BOTYANSZKI JANOS, TIAN XINRONG, BARSANTI PAUL A, KIESOW TERENCE J, LAWHORN BRIAN G, JAIPURI FIROZ ALI, MCATEE JOHN J, BUITRAGO SANTANILLA ALEXANDER
Year of Publication 04.04.2024
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Year of Publication 04.04.2024
Patent
Design, Structure–Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990
McBride, Christopher M, Levine, Barry, Xia, Yi, Bellamacina, Cornelia, Machajewski, Timothy, Gao, Zhenhai, Renhowe, Paul, Antonios-McCrea, William, Barsanti, Paul, Brinner, Kristin, Costales, Abran, Doughan, Brandon, Lin, Xiaodong, Louie, Alicia, McKenna, Maureen, Mendenhall, Kris, Poon, Daniel, Rico, Alice, Wang, Michael, Williams, Teresa E, Abrams, Tinya, Fong, Susan, Hendrickson, Thomas, Lei, Dachuan, Lin, Julie, Menezes, Daniel, Pryer, Nancy, Taverna, Pietro, Xu, Yongjin, Zhou, Yasheen, Shafer, Cynthia M
Published in Journal of medicinal chemistry (13.11.2014)
Published in Journal of medicinal chemistry (13.11.2014)
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Abstract 1628: A small-molecule inhibitor of WRN selectively kills MSI-H cancer cells and phenocopies WRN genetic defects
Rao, Yanhua, Srivatsan, Anjana, Liimatta, Marya, Munoz, Diana, Quirit, Jeanne, Shi, Jianxia, Nguyen, An, Linghu, Xin, Federowicz, Federowicz, Jones, Brian, Fleury, Melissa, Newby, Zach, Dillon, Michael P., Barsanti, Paul A., Lackner, Mark R., White, Michael A., Lee, Yang, Landis, Phil, Peng, Yang, Cicchini, Michelle, Cottom, Josh, Nickels, Leng, Brnardic, Ed, DeMartino, Michael, Taygerly, Josh
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors
Ni, Zhi-Jie, Barsanti, Paul, Brammeier, Nathan, Diebes, Anthony, Poon, Daniel J., Ng, Simon, Pecchi, Sabina, Pfister, Keith, Renhowe, Paul A., Ramurthy, Savithri, Wagman, Allan S., Bussiere, Dirksen E., Le, Vincent, Zhou, Yasheen, Jansen, Johanna M., Ma, Sylvia, Gesner, Thomas G.
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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Journal Article
Ketone-directed peracid epoxidation of cyclic alkenes
Armstrong, A, Barsanti, PA, Clarke, PA, Wood, A
Published in Journal of the Chemical Society, Perkin Transactions 1 (21.06.1996)
Published in Journal of the Chemical Society, Perkin Transactions 1 (21.06.1996)
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