The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
Barrett, Stephen D., Bridges, Alexander J., Dudley, David T., Saltiel, Alan R., Fergus, James H., Flamme, Cathlin M., Delaney, Amy M., Kaufman, Michael, LePage, Sophie, Leopold, Wilbur R., Przybranowski, Sally A., Sebolt-Leopold, Judith, Van Becelaere, Keri, Doherty, Annette M., Kennedy, Robert M., Marston, Dan, Howard, W. Allen, Smith, Yvonne, Warmus, Joseph S., Tecle, Haile
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
Sebolt-Leopold, Judith S, Dudley, David T, Herrera, Roman, Becelaere, Keri Van, Wiland, Amy, Gowan, Richard C, Tecle, Haile, Barrett, Stephen D, Bridges, Alexander, Przybranowski, Sally, Leopold, W.R, Saltiel, Alan R
Published in Nature medicine (01.07.1999)
Published in Nature medicine (01.07.1999)
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Improved homology modeling of the human & rat EP4 prostanoid receptors
Holt, Melissa C., Ho, Chi S., Morano, M. Inés, Barrett, Stephen D., Stein, Adam J.
Published in BMC cell biology (27.08.2019)
Published in BMC cell biology (27.08.2019)
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Difluoromethylene at the γ‑Lactam α‑Position Improves 11-Deoxy-8-aza-PGE1 Series EP4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE1 Analog (KMN-159) as a Potent EP4 Agonist
Barrett, Stephen D, Holt, Melissa C, Kramer, James B, Germain, Bradlee, Ho, Chi S, Ciske, Fred L, Kornilov, Andrei, Colombo, Joseph M, Uzieblo, Adam, O’Malley, James P, Owen, Thomas A, Stein, Adam J, Morano, Maria I
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Novel amide and imidazole compounds as potent hematopoietic prostaglandin D-2 synthase inhibitors
Olson, Kirk L., Holt, Melissa C., Ciske, Fred L., Kramer, James B., Heiple, Paige E., Collins, Margaret L., Johnson, Carrie M., Ho, Chi S., Morano, M. Ines, Barrett, Stephen D.
Published in Bioorganic & medicinal chemistry letters (15.02.2021)
Published in Bioorganic & medicinal chemistry letters (15.02.2021)
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Journal Article
Novel amide and imidazole compounds as potent hematopoietic prostaglandin D2 synthase inhibitors
Olson, Kirk L., Holt, Melissa C., Ciske, Fred L., Kramer, James B., Heiple, Paige E., Collins, Margaret L., Johnson, Carrie M., Ho, Chi S., Morano, M. Ines, Barrett, Stephen D.
Published in Bioorganic & medicinal chemistry letters (15.02.2021)
Published in Bioorganic & medicinal chemistry letters (15.02.2021)
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KMN-159, a novel EP4 receptor selective agonist, stimulates osteoblastic differentiation in cultured whole rat bone marrow
Owen, Thomas A., Patel, Chandni, Wei, Shanqiao, Ho, Chi S., Birmingham, Kaylah, Sanchez, Samuel, Chung, Natalie, Cahill, Alexa, O'Malley, James P., Barrett, Stephen D., Morano, María Inés
Published in Gene (20.07.2020)
Published in Gene (20.07.2020)
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Journal Article
Difluoromethylene at the γ-Lactam α-Position Improves 11-Deoxy-8-aza-PGE 1 Series EP 4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE 1 Analog (KMN-159) as a Potent EP 4 Agonist
Barrett, Stephen D, Holt, Melissa C, Kramer, James B, Germain, Bradlee, Ho, Chi S, Ciske, Fred L, Kornilov, Andrei, Colombo, Joseph M, Uzieblo, Adam, O'Malley, James P, Owen, Thomas A, Stein, Adam J, Morano, Maria I
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase
Spicer, Julie A, Rewcastle, Gordon W, Kaufman, Michael D, Black, Shannon L, Plummer, Mark S, Denny, William A, Quin, John, Shahripour, Aurash B, Barrett, Stephen D, Whitehead, Christopher E, Milbank, Jared B. J, Ohren, Jeffrey F, Gowan, Richard C, Omer, Charles, Camp, Heidi S, Esmaeil, Nadia, Moore, Kelley, Sebolt-Leopold, Judith S, Pryzbranowski, Sally, Merriman, Ronald L, Ortwine, Daniel F, Warmus, Joseph S, Flamme, Cathlin M, Pavlovsky, Alexander G, Tecle, Haile
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
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Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring
Boys, Mark L., Bian, Feng, Kramer, James B., Chio, Christopher L., Ren, Xiao-Dan, Chen, Huifen, Barrett, Stephen D., Sexton, Karen E., Iula, Donna M., Filzen, Gary F., Nguyen, Maria N., Angell, Paul, Downs, Victoria L., Wang, Zhi, Raheja, Neil, Ellsworth, Edmund L., Fakhoury, Stephen, Bratton, Larry D., Keller, Paul R., Gowan, Richard, Drummond, Elena M., Maiti, Samarendra N., Hena, Mostofa A., Lu, Leroy, McConnell, Patrick, Knafels, John D., Thanabal, Venkataraman, Sun, Fang, Alessi, Diane, McCarthy, Ann, Zhang, Erli, Finzel, Barry C., Patel, Sneha, Ciotti, Susan M., Eisma, Rone, Payne, N.A., Gilbertsen, Richard B., Kostlan, Catherine R., Pocalyko, David J., Lala, Deepak S.
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
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Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: Potential proinflammatory mechanisms
Thiel, Melissa J., Schaefer, Caralee J., Lesch, Mark E., Mobley, James L., Dudley, David T., Tecle, Haile, Barrett, Stephen D., Schrier, Denis J., Flory, Craig M.
Published in Arthritis and rheumatism (01.10.2007)
Published in Arthritis and rheumatism (01.10.2007)
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Journal Article
Difluoromethylene at the gamma-Lactam alpha-Position Improves 11-Deoxy-8-aza-PGE(1) Series EP4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE(1) Analog (KMN-159) as a Potent EP4 Agonist
Barrett, Stephen D., Holt, Melissa C., Kramer, James B., Germain, Bradlee, Ho, Chi S., Ciske, Fred L., Kornilov, Andrei, Colombo, Joseph M., Uzieblo, Adam, O'Malley, James P., Owen, Thomas A., Stein, Adam J., Morano, Maria I.
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Improved homology modeling of the human & rat EP 4 prostanoid receptors
Holt, Melissa C, Ho, Chi S, Morano, M Inés, Barrett, Stephen D, Stein, Adam J
Published in BMC molecular and cell biology (27.08.2019)
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Published in BMC molecular and cell biology (27.08.2019)
Journal Article
KMN-159, a novel EP 4 receptor selective agonist, stimulates osteoblastic differentiation in cultured whole rat bone marrow
Owen, Thomas A, Patel, Chandni, Wei, Shanqiao, Ho, Chi S, Birmingham, Kaylah, Sanchez, Samuel, Chung, Natalie, Cahill, Alexa, O'Malley, James P, Barrett, Stephen D, Morano, María Inés
Published in Gene (20.07.2020)
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Published in Gene (20.07.2020)
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Design and Synthesis of m1-Selective Muscarinic Agonists: (R)-(−)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3‘-Methoxyphenyl)-2-propynyl)- oxime Maleate (CI-1017), a Functionally m1-Selective Muscarinic Agonist
Tecle, Haile, Barrett, Stephen D, Lauffer, David J, Augelli-Szafran, Corinne, Brann, Mark R, Callahan, Michael J, Caprathe, Bradley. W, Davis, Robert E, Doyle, Patricia D, Eubanks, David, Lipiniski, William, Mirzadegan, Tara, Moos, Walter H, Moreland, D. W, Nelson, Carrie B, Pavia, Michael R, Raby, Charlotte, Schwarz, Roy D, Spencer, Carolyn J, Thomas, Anthony J, Jaen, Juan C
Published in Journal of medicinal chemistry (02.07.1998)
Published in Journal of medicinal chemistry (02.07.1998)
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