BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling‐dependent tumor growth in mouse models
Politz, Oliver, Siegel, Franziska, Bärfacker, Lars, Bömer, Ulf, Hägebarth, Andrea, Scott, William J., Michels, Martin, Ince, Stuart, Neuhaus, Roland, Meyer, Kirstin, Fernández‐Montalván, Amaury Ernesto, Liu, Ningshu, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl
Published in International journal of cancer (15.01.2017)
Published in International journal of cancer (15.01.2017)
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Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases
Bärfacker, Lars, Kuhl, Alexander, Hillisch, Alexander, Grosser, Rolf, Figueroa-Pérez, Santiago, Heckroth, Heike, Nitsche, Adam, Ergüden, Jens-Kerim, Gielen-Haertwig, Heike, Schlemmer, Karl-Heinz, Mittendorf, Joachim, Paulsen, Holger, Platzek, Johannes, Kolkhof, Peter
Published in ChemMedChem (01.08.2012)
Published in ChemMedChem (01.08.2012)
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Cover Picture: Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases (ChemMedChem 8/2012)
Bärfacker, Lars, Kuhl, Alexander, Hillisch, Alexander, Grosser, Rolf, Figueroa-Pérez, Santiago, Heckroth, Heike, Nitsche, Adam, Ergüden, Jens-Kerim, Gielen-Haertwig, Heike, Schlemmer, Karl-Heinz, Mittendorf, Joachim, Paulsen, Holger, Platzek, Johannes, Kolkhof, Peter
Published in ChemMedChem (01.08.2012)
Published in ChemMedChem (01.08.2012)
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A New Mode of Mineralocorticoid Receptor Antagonism by a Potent and Selective Nonsteroidal Molecule
Fagart, Jérôme, Hillisch, Alexander, Huyet, Jessica, Bärfacker, Lars, Fay, Michel, Pleiss, Ulrich, Pook, Elisabeth, Schäfer, Stefan, Rafestin-Oblin, Marie-Edith, Kolkhof, Peter
Published in The Journal of biological chemistry (24.09.2010)
Published in The Journal of biological chemistry (24.09.2010)
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Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases
von Nussbaum, Franz, Li, Volkhart M. -J., Allerheiligen, Swen, Anlauf, Sonja, Baerfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F., Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schaefer, Martina, Schaefer, Stefan, Schamberger, Jens, Telan, Leila A., Tersteegen, Adrian
Published in ChemMedChem (01.07.2015)
Published in ChemMedChem (01.07.2015)
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The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents
van der Staay, F. Josef, Rutten, Kris, Bärfacker, Lars, DeVry, Jean, Erb, Christina, Heckroth, Heike, Karthaus, Dagmar, Tersteegen, Adrian, van Kampen, Marja, Blokland, Arjan, Prickaerts, Jos, Reymann, Klaus G., Schröder, Ulrich H., Hendrix, Martin
Published in Neuropharmacology (01.10.2008)
Published in Neuropharmacology (01.10.2008)
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Tandem Reaction Sequences under Hydroformylation Conditions: New Synthetic Applications of Transition Metal Catalysis
Eilbracht, Peter, Bärfacker, Lars, Buss, Christian, Hollmann, Christoph, Kitsos-Rzychon, Beate E, Kranemann, Christian L, Rische, Thorsten, Roggenbuck, Rafael, Schmidt, Andreas
Published in Chemical reviews (10.11.1999)
Published in Chemical reviews (10.11.1999)
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Finerenone, a novel selective nonsteroidal mineralocorticoid receptor antagonist protects from rat cardiorenal injury
Kolkhof, Peter, Delbeck, Martina, Kretschmer, Axel, Steinke, Wolfram, Hartmann, Elke, Bärfacker, Lars, Eitner, Frank, Albrecht-Küpper, Barbara, Schäfer, Stefan
Published in Journal of cardiovascular pharmacology (01.07.2014)
Published in Journal of cardiovascular pharmacology (01.07.2014)
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Cover Picture: Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases
vonNussbaum, Franz, Li, Volkhart M-J, Allerheiligen, Swen, Anlauf, Sonja, Barfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F, Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schafer, Martina, Schafer, Stefan, Schamberger, Jens, Telan, Leila A, Tersteegen, Adrian
Published in ChemMedChem (01.07.2015)
Published in ChemMedChem (01.07.2015)
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Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists
Griebenow, Nils, Bärfacker, Lars, Meier, Heinrich, Schneider, Dirk, Teusch, Nicole, Lustig, Klemens, Kast, Raimund, Kolkhof, Peter
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
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SUBSTITUTED S-ALANINATE DERIVATIVES
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Year of Publication 09.03.2023
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Year of Publication 09.03.2023
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N-MENTHYLBENZIMIDAZOLES AS MIDH1 INHIBITORS
BARFACKER, LARS, RING, SVEN, ZIMMERMANN, KATJA, GUNTHER, JUDITH, PANKNIN, OLAF
Year of Publication 15.12.2016
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Year of Publication 15.12.2016
Patent
Cover Picture: Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases (ChemMedChem 7/2015)
von Nussbaum, Franz, Li, Volkhart M.-J., Allerheiligen, Swen, Anlauf, Sonja, Bärfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F., Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens, Telan, Leila A., Tersteegen, Adrian
Published in ChemMedChem (01.07.2015)
Published in ChemMedChem (01.07.2015)
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Journal Article
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases
von Nussbaum, Franz, Li, Volkhart M.-J., Allerheiligen, Swen, Anlauf, Sonja, Bärfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F., Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens, Telan, Leila A., Tersteegen, Adrian
Published in ChemMedChem (01.07.2015)
Published in ChemMedChem (01.07.2015)
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Imidazopyridazines as Akt kinase inhibitors
Rehwinkel, Hartmut, Briem, Hans, Neuhaus, Roland, Scott, William Johnston, Hagebarth, Andrea, Ince, Stuart, Bomer, Ulf, Barfacker, Lars, Politz, Oliver
Year of Publication 16.02.2017
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Year of Publication 16.02.2017
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