Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial
Geletneky, Karsten, Hajda, Jacek, Angelova, Assia L., Leuchs, Barbara, Capper, David, Bartsch, Andreas J., Neumann, Jan-Oliver, Schöning, Tilman, Hüsing, Johannes, Beelte, Birgit, Kiprianova, Irina, Roscher, Mandy, Bhat, Rauf, von Deimling, Andreas, Brück, Wolfgang, Just, Alexandra, Frehtman, Veronika, Löbhard, Stephanie, Terletskaia-Ladwig, Elena, Fry, Jeremy, Jochims, Karin, Daniel, Volker, Krebs, Ottheinz, Dahm, Michael, Huber, Bernard, Unterberg, Andreas, Rommelaere, Jean
Published in Molecular therapy (06.12.2017)
Published in Molecular therapy (06.12.2017)
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Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis
Singhal, Mahak, Gengenbacher, Nicolas, Abdul Pari, Ashik Ahmed, Kamiyama, Miki, Hai, Ling, Kuhn, Bianca J, Kallenberg, David M, Kulkarni, Shubhada R, Camilli, Carlotta, Preuß, Stephanie F, Leuchs, Barbara, Mogler, Carolin, Espinet, Elisa, Besemfelder, Eva, Heide, Danijela, Heikenwalder, Mathias, Sprick, Martin R, Trumpp, Andreas, Krijgsveld, Jeroen, Schlesner, Matthias, Hu, Junhao, Moss, Stephen E, Greenwood, John, Augustin, Hellmut G
Published in Science translational medicine (01.09.2021)
Published in Science translational medicine (01.09.2021)
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Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase
Werfel, Stanislas, Jungmann, Andreas, Lehmann, Lorenz, Ksienzyk, Jan, Bekeredjian, Raffi, Kaya, Ziya, Leuchs, Barbara, Nordheim, Alfred, Backs, Johannes, Engelhardt, Stefan, Katus, Hugo A, Müller, Oliver J
Published in Cardiovascular research (01.10.2014)
Published in Cardiovascular research (01.10.2014)
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Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model
Pleger, Sven T, Shan, Changguang, Ksienzyk, Jan, Bekeredjian, Raffi, Boekstegers, Peter, Hinkel, Rabea, Schinkel, Stefanie, Leuchs, Barbara, Ludwig, Jochen, Qiu, Gang, Weber, Christophe, Raake, Philip, Koch, Walter J, Katus, Hugo A, Müller, Oliver J, Most, Patrick
Published in Science translational medicine (20.07.2011)
Published in Science translational medicine (20.07.2011)
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Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol
Geletneky, Karsten, Huesing, Johannes, Rommelaere, Jean, Schlehofer, Joerg R, Leuchs, Barbara, Dahm, Michael, Krebs, Ottheinz, von Knebel Doeberitz, Magnus, Huber, Bernard, Hajda, Jacek
Published in BMC cancer (21.03.2012)
Published in BMC cancer (21.03.2012)
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Adeno-Associated Virus Type 2 Capsids with Externalized VP1/VP2 Trafficking Domains Are Generated prior to Passage through the Cytoplasm and Are Maintained until Uncoating Occurs in the Nucleus
SONNTAG, Florian, BLEKER, Svenja, LEUCHS, Barbara, FISCHER, Roger, KLEINSCHMIDT, Jürgen A
Published in Journal of Virology (01.11.2006)
Published in Journal of Virology (01.11.2006)
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A novel scalable, robust downstream process for oncolytic rat parvovirus: isoelectric point-based elimination of empty particles
Leuchs, Barbara, Frehtman, Veronika, Riese, Markus, Müller, Marcus, Rommelaere, Jean
Published in Applied microbiology and biotechnology (01.04.2017)
Published in Applied microbiology and biotechnology (01.04.2017)
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WIPO PUBLISHES PATENT OF DEUTSCHES KREBSFORSCHUNGSZENTRUM, JEANINNE LACROIX, BARBARA LEUCHS, MONIKA FRANK-STOHR, JORG SCHLEHOFER, JEAN ROMMELAERE, ZOLTAN KIS FOR "ONCOLYTIC VIROTHERAPY FOR THE THERAPY OF SARCOMA" (GERMAN, ROMANIAN INVENTORS)
Published in US Fed News Service, Including US State News
(28.12.2012)
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A non-controlled, single arm, open label, phase II study of intravenous and intratumoral administration of ParvOryx in patients with metastatic, inoperable pancreatic cancer: ParvOryx02 protocol
Hajda, Jacek, Lehmann, Monika, Krebs, Ottheinz, Kieser, Meinhard, Geletneky, Karsten, Jäger, Dirk, Dahm, Michael, Huber, Bernard, Schöning, Tilman, Sedlaczek, Oliver, Stenzinger, Albrecht, Halama, Niels, Daniel, Volker, Leuchs, Barbara, Angelova, Assia, Rommelaere, Jean, Engeland, Christine E, Springfeld, Christoph, Ungerechts, Guy
Published in BMC cancer (29.08.2017)
Published in BMC cancer (29.08.2017)
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Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses
Ungerechts, Guy, Bossow, Sascha, Leuchs, Barbara, Holm, Per S, Rommelaere, Jean, Coffey, Matt, Coffin, Rob, Bell, John, Nettelbeck, Dirk M
Published in Molecular therapy. Methods & clinical development (01.01.2016)
Published in Molecular therapy. Methods & clinical development (01.01.2016)
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Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material
Lock, Martin, McGorray, Susan, Auricchio, Alberto, Ayuso, Eduard, Beecham, E Jeffrey, Blouin-Tavel, Véronique, Bosch, Fatima, Bose, Mahuya, Byrne, Barry J, Caton, Tina, Chiorini, John A, Chtarto, Abdelwahed, Clark, K Reed, Conlon, Thomas, Darmon, Christophe, Doria, Monica, Douar, Anne, Flotte, Terence R, Francis, Joyce D, Francois, Achille, Giacca, Mauro, Korn, Michael T, Korytov, Irina, Leon, Xavier, Leuchs, Barbara, Lux, Gabriele, Melas, Catherine, Mizukami, Hiroaki, Moullier, Philippe, Müller, Marcus, Ozawa, Keiya, Philipsberg, Tina, Poulard, Karine, Raupp, Christina, Rivière, Christel, Roosendaal, Sigrid D, Samulski, R Jude, Soltys, Steven M, Surosky, Richard, Tenenbaum, Liliane, Thomas, Darby L, van Montfort, Bart, Veres, Gabor, Wright, J Fraser, Xu, Yili, Zelenaia, Olga, Zentilin, Lorena, Snyder, Richard O
Published in Human gene therapy (01.10.2010)
Published in Human gene therapy (01.10.2010)
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Improvement of Gemcitabine-Based Therapy of Pancreatic Carcinoma by Means of Oncolytic Parvovirus H-1PV
ANGELOVA, Assia L, APRAHAMIAN, Marc, RAYKOV, Zahari, GREKOVA, Svitlana P, HAJRI, Amor, LEUCHS, Barbara, GIESE, Nathalia A, DINSART, Christiane, HERRMANN, Alexia, BALBONI, Ginette, ROMMELAERE, Jean
Published in Clinical cancer research (15.01.2009)
Published in Clinical cancer research (15.01.2009)
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Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening
Alonso, Angelika, Reinz, Eileen, Leuchs, Barbara, Kleinschmidt, Jürgen, Fatar, Marc, Geers, Bart, Lentacker, Ine, Hennerici, Michael G., de Smedt, Stefaan C., Meairs, Stephen
Published in Molecular therapy. Nucleic acids (01.02.2013)
Published in Molecular therapy. Nucleic acids (01.02.2013)
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Human Retrotransposons and the Global Shutdown of Homeostatic Innate Immunity by Oncolytic Parvovirus H-1PV in Pancreatic Cancer
Neulinger-Muñoz, Matthias, Schaack, Dominik, Grekova, Svetlana P., Bauer, Andrea S., Giese, Thomas, Salg, Gabriel A., Espinet, Elisa, Leuchs, Barbara, Heller, Anette, Nüesch, Jürg P. F., Schenk, Miriam, Volkmar, Michael, Giese, Nathalia A.
Published in Viruses (28.05.2021)
Published in Viruses (28.05.2021)
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Preclinical Testing of an Oncolytic Parvovirus: Standard Protoparvovirus H-1PV Efficiently Induces Osteosarcoma Cell Lysis In Vitro
Geiss, Carsten, Kis, Zoltán, Leuchs, Barbara, Frank-Stöhr, Monika, Schlehofer, Jörg R, Rommelaere, Jean, Dinsart, Christiane, Lacroix, Jeannine
Published in Viruses (17.10.2017)
Published in Viruses (17.10.2017)
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Preclinical Testing of an Oncolytic Parvovirus in Ewing Sarcoma: Protoparvovirus H-1 Induces Apoptosis and Lytic Infection In Vitro but Fails to Improve Survival In Vivo
Lacroix, Jeannine, Kis, Zoltán, Josupeit, Rafael, Schlund, Franziska, Stroh-Dege, Alexandra, Frank-Stöhr, Monika, Leuchs, Barbara, Schlehofer, Jörg R, Rommelaere, Jean, Dinsart, Christiane
Published in Viruses (03.06.2018)
Published in Viruses (03.06.2018)
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Retargeting of Rat Parvovirus H-1PV to Cancer Cells through Genetic Engineering of the Viral Capsid
Allaume, Xavier, El-Andaloussi, Nazim, Leuchs, Barbara, Bonifati, Serena, Kulkarni, Amit, Marttila, Tiina, Kaufmann, Johanna K, Nettelbeck, Dirk M, Kleinschmidt, Jürgen, Rommelaere, Jean, Marchini, Antonio
Published in Journal of Virology (01.04.2012)
Published in Journal of Virology (01.04.2012)
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Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1
Josupeit, Rafael, Bender, Sebastian, Kern, Sonja, Leuchs, Barbara, Hielscher, Thomas, Herold-Mende, Christel, Schlehofer, Jörg R, Dinsart, Christiane, Witt, Olaf, Rommelaere, Jean, Lacroix, Jeannine
Published in Viruses (19.05.2016)
Published in Viruses (19.05.2016)
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TSC22D4 is a molecular output of hepatic wasting metabolism
Jones, Allan, Friedrich, Kilian, Rohm, Maria, Schäfer, Michaela, Algire, Carolyn, Kulozik, Philipp, Seibert, Oksana, Müller‐Decker, Karin, Sijmonsma, Tjeerd, Strzoda, Daniela, Sticht, Carsten, Gretz, Norbert, Dallinga‐Thie, Geesje M., Leuchs, Barbara, Kögl, Manfred, Stremmel, Wolfgang, Diaz, Mauricio Berriel, Herzig, Stephan
Published in EMBO molecular medicine (01.02.2013)
Published in EMBO molecular medicine (01.02.2013)
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Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells
Lacroix, Jeannine, Leuchs, Barbara, Li, Junwei, Hristov, Georgi, Deubzer, Hedwig E., Kulozik, Andreas E., Rommelaere, Jean, Schlehofer, Jörg R., Witt, Olaf
Published in International journal of cancer (01.09.2010)
Published in International journal of cancer (01.09.2010)
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