Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy [J. Am. Chem. Soc. 2006, 128, 11916−11920]
Singh, Sheo B, Jayasuriya, Hiranthi, Ondeyka, John G, Herath, Kithsiri B, Zhang, Chaowei, Zink, Deborah L, Tsou, Nancy N, Ball, Richard G, Basilio, Angela, Genilloud, Olga, Diez, Maria Teresa, Vicente, Francisca, Pelaez, Fernando, Young, Katherine, Wang, Jun
Published in Journal of the American Chemical Society (06.12.2006)
Published in Journal of the American Chemical Society (06.12.2006)
Get full text
Journal Article
Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β₃ adrenergic receptor agonists
Morriello, Gregori J, Wendt, Harvey R, Bansal, Alka, Salvo, Jerry Di, Feighner, Scott, He, Jiafang, Hurley, Amanda L, Hreniuk, Donna L, Salituro, Gino M, Reddy, Marat Vijay, Galloway, Sheila M, McGettigan, Katherine K, Laws, George, McKnight, Crystal, Doss, George A, Tsou, Nancy N, Black, Regina M, Morris, Judy, Ball, Richard G, Sanfiz, Anthony T, Streckfuss, Eric, Struthers, Mary, Edmondson, Scott D
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Get full text
Journal Article
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist
He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Lai, Yingjie, Franklin, Christopher L., Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, Tsou, Nancy N., Ball, Richard G., Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Get full text
Journal Article
The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes
He, Shuwen, Ye, Zhixiong, Truong, Quang, Shah, Shrenik, Du, Wu, Guo, Liangqin, Dobbelaar, Peter H, Lai, Zhong, Liu, Jian, Jian, Tianying, Qi, Hongbo, Bakshi, Raman K, Hong, Qingmei, Dellureficio, James, Pasternak, Alexander, Feng, Zhe, deJesus, Reynalda, Yang, Lihu, Reibarkh, Mikhail, Bradley, Scott A, Holmes, Mark A, Ball, Richard G, Ruck, Rebecca T, Huffman, Mark A, Wong, Frederick, Samuel, Koppara, Reddy, Vijay B, Mitelman, Stan, Tong, Sharon X, Chicchi, Gary G, Tsao, Kwei-Lan, Trusca, Dorina, Wu, Margaret, Shao, Qing, Trujillo, Maria E, Eiermann, George J, Li, Cai, Zhang, Bei B, Howard, Andrew D, Zhou, Yun-Ping, Nargund, Ravi P, Hagmann, William K
Published in ACS medicinal chemistry letters (14.06.2012)
Published in ACS medicinal chemistry letters (14.06.2012)
Get full text
Journal Article
Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists
Li, Derun, Wu, Zhicai, Yu, Yang, Ball, Richard G, Guo, Liangqin, Sherer, Edward, He, Shuwen, Hong, Qingmei, Lai, Zhong, Qi, Hongbo, Truong, Quang, Yang, David X, Chicchi, Gary G, Tsao, Kwei-Lan, Trusca, Dorina, Trujillo, Maria, Pachanski, Michele, Eiermann, George J, Howard, Andrew D, Zhou, Yun-Ping, Zhang, Bei B, Nargund, Ravi P, Hagmann, William K
Published in ACS medicinal chemistry letters (12.06.2014)
Published in ACS medicinal chemistry letters (12.06.2014)
Get full text
Journal Article
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists
LIANGQIN GUO, ZHIXIONG YE, TSOU, Nancy N, BALL, Richard G, WEINBERG, David H, MACNEIL, Tanya, RUI TANG, TAMVAKOPOULOS, Constantin, QIANPING PENG, CHEN, Howard Y, CHEN, Airu S, MARTIN, William J, JIAN LIU, EUAN MACINTYRE, D, STRACK, Alison M, FONG, Tung M, WYVRATT, Matthew J, NARGUND, Ravi P, SHUWEN HE, BAKSHI, Raman K, SEBHAT, Iyassu K, DOBBELAAR, Peter H, QINGMEI HONG, TIANYING JIAN, DELLUREFICIO, James P
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Get full text
Journal Article
1-Sulfonyl-4-acylpiperazines as Selective Cannabinoid-1 Receptor (CB1R) Inverse Agonists for the Treatment of Obesity
Vachal, Petr, Fletcher, Joan M, Fong, Tung M, Huang, Cathy C. R.-R, Lao, Julie, Xiao, Jing C, Shen, Chun-Pyn, Strack, Alison M, Shearman, Lauren, Stribling, Sloan, Chen, Richard Z, Frassetto, Andrea, Tong, Xinchun, Wang, Junying, Ball, Richard G, Tsou, Nancy N, Hickey, Gerard J, Thompson, Donald F, Faidley, Terry D, Nicolich, Susan, Achanfuo-Yeboah, Joana, Hora, Donald F, Hale, Jeffrey J, Hagmann, William K
Published in Journal of medicinal chemistry (23.04.2009)
Published in Journal of medicinal chemistry (23.04.2009)
Get full text
Journal Article
Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity
Friesen, Richard W, Ducharme, Yves, Ball, Richard G, Blouin, Marc, Boulet, Louise, Côté, Bernard, Frenette, Richard, Girard, Mario, Guay, Daniel, Huang, Zheng, Jones, Thomas R, Laliberté, France, Lynch, Joseph J, Mancini, Joseph, Martins, Evelyn, Masson, Paul, Muise, Eric, Pon, Douglas J, Siegl, Peter K. S, Styhler, Angela, Tsou, Nancy N, Turner, Mervyn J, Young, Robert N, Girard, Yves
Published in Journal of medicinal chemistry (05.06.2003)
Published in Journal of medicinal chemistry (05.06.2003)
Get full text
Journal Article
Synthesis, molecular modeling, 2-D NMR, and biological evaluation of ILV mimics as potential modulators of protein kinase C
Kozikowski, Alan P, Ma, Dawei, Pang, Yuan Ping, Shum, Patrick, Likic, Vladimir, Mishra, Prasanna K, Macura, Slobodan, Basu, Alakananda, Lazo, John S, Ball, Richard G
Published in Journal of the American Chemical Society (01.05.1993)
Published in Journal of the American Chemical Society (01.05.1993)
Get full text
Journal Article
Preparation of 2,5,7-Trithiabicyclo[2.2.1]heptane from 1,2-Bis-triisopropylsilanylsulfanyl Alkenes
Gareau, Yves, Juteau, Hélène, Tsou, Nancy N, Ball, Richard G
Published in Organic letters (05.01.2006)
Published in Organic letters (05.01.2006)
Get full text
Journal Article
Cover Picture: Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties (ChemMedChem 3/2012)
Coleman, Paul J., Schreier, John D., Cox, Christopher D., Breslin, Michael J., Whitman, David B., Bogusky, Michael J., McGaughey, Georgia B., Bednar, Rodney A., Lemaire, Wei, Doran, Scott M., Fox, Steven V., Garson, Susan L., Gotter, Anthony L., Harrell, C. Meacham, Reiss, Duane R., Cabalu, Tamara D., Cui, Donghui, Prueksaritanont, Thomayant, Stevens, Joanne, Tannenbaum, Pamela L., Ball, Richard G., Stellabott, Joyce, Young, Steven D., Hartman, George D., Winrow, Christopher J., Renger, John J.
Published in ChemMedChem (05.03.2012)
Published in ChemMedChem (05.03.2012)
Get full text
Journal Article
A straightforward approach to the synthesis of the tricyclic core of taxol
Wang, Zhaoyin, Warder, Scott E, Perrier, Helene, Grimm, Erich L, Bernstein, Michael A, Ball, Richard G
Published in Journal of organic chemistry (01.05.1993)
Published in Journal of organic chemistry (01.05.1993)
Get full text
Journal Article
An Efficient Preparation of Vinamidinium Hexafluorophosphate Salts
Davies, Ian W, Marcoux, Jean-Francois, Wu, Jimmy, Palucki, Michael, Corley, Edward G, Robbins, Michael A, Tsou, Nancy, Ball, Richard G, Dormer, Peter, Larsen, Robert D, Reider, Paul J
Published in Journal of organic chemistry (28.07.2000)
Published in Journal of organic chemistry (28.07.2000)
Get full text
Journal Article
Neighboring Group Participation of the Indole Nucleus: An Unusual DAST-Mediated Rearrangement Reaction
Hallett, David J, Gerhard, Ute, Goodacre, Simon C, Hitzel, Laure, Sparey, Timothy J, Thomas, Steven, Rowley, Michael, Ball, Richard G
Published in Journal of organic chemistry (11.08.2000)
Published in Journal of organic chemistry (11.08.2000)
Get full text
Journal Article
A Novel 3-Substituted Benzazepinone Growth Hormone Secretagogue (L-692,429)
Schoen, William R, Pisano, Judith M, Prendergast, Kristine, Wyvratt, Matthew J, Fisher, Michael H, Cheng, Kang, Chan, Wanda W.-S, Butler, Bridget, Smith, Roy G, Ball, Richard G
Published in Journal of medicinal chemistry (01.04.1994)
Published in Journal of medicinal chemistry (01.04.1994)
Get full text
Journal Article
Preussomerins and Deoxypreussomerins: Novel Inhibitors of Ras Farnesyl-Protein Transferase
Singh, Sheo B, Zink, Deborah L, Liesch, Jerrold M, Ball, Richard G, Goetz, Michael A, Bolessa, Evon A, Giacobbe, Robert A, Silverman, Keith C, Bills, Gerald F
Published in Journal of organic chemistry (01.10.1994)
Published in Journal of organic chemistry (01.10.1994)
Get full text
Journal Article