Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro
Jones, Caroline N, Ellett, Felix, Robertson, Anne L, Forrest, Kevin M, Judice, Kevin, Balkovec, James M, Springer, Martin, Markmann, James F, Vyas, Jatin M, Warren, H Shaw, Irimia, Daniel
Published in Frontiers in immunology (09.04.2019)
Published in Frontiers in immunology (09.04.2019)
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Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin
Ong, Voon, Hough, Grayson, Schlosser, Michael, Bartizal, Ken, Balkovec, James M, James, Kenneth D, Krishnan, B Radha
Published in Antimicrobial agents and chemotherapy (01.11.2016)
Published in Antimicrobial agents and chemotherapy (01.11.2016)
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The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species
McLaren, David G., He, Timothy, Wang, Sheng-Ping, Mendoza, Vivienne, Rosa, Raymond, Gagen, Karen, Bhat, Gowri, Herath, Kithsiri, Miller, Paul L., Stribling, Sloan, Taggart, Andrew, Imbriglio, Jason, Liu, Jinqi, Chen, Dunlu, Pinto, Shirly, Balkovec, James M., DeVita, Robert J., Marsh, Donald J., Castro-Perez, Jose M., Strack, Alison, Johns, Douglas G., Previs, Stephen F., Hubbard, Brian K., Roddy, Thomas P.
Published in Journal of lipid research (01.06.2011)
Published in Journal of lipid research (01.06.2011)
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The First Stereoselective Total Synthesis of Quinine
Stork, Gilbert, Niu, Deqiang, Fujimoto, A, Koft, Emil R, Balkovec, James M, Tata, James R, Dake, Gregory R
Published in Journal of the American Chemical Society (11.04.2001)
Published in Journal of the American Chemical Society (11.04.2001)
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Journal Article
Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor: Receptor Binding and in Vivo Activity
Ali, Amjad, Thompson, Christopher F, Balkovec, James M, Graham, Donald W, Hammond, Milton L, Quraishi, Nazia, Tata, James R, Einstein, Monica, Ge, Lan, Harris, Georgianna, Kelly, Terri M, Mazur, Paul, Pandit, Shilpa, Santoro, Joseph, Sitlani, Ayesha, Wang, Chuanlin, Williamson, Joanne, Miller, Douglas K, Thompson, Chris M, Zaller, Dennis M, Forrest, Michael J, Carballo-Jane, Ester, Luell, Silvi
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Journal Article
Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor
Apgar, James M., Wilkening, Robert R., Parker, Dann L., Meng, Dongfang, Wildonger, Kenneth J., Sperbeck, Donald, Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, Andrew M., Giacobbe, Robert A., Gill, Charles J., Hsu, Ming-Jo, Liberator, Paul, Misura, Andrew S., Motyl, Mary, Nielsen Kahn, Jennifer, Powles, Maryann, Racine, Fred, Dragovic, Jasminka, Fan, Weiming, Kirwan, Robin, Lee, Shu, Liu, Hao, Mamai, Ahmed, Nelson, Kingsley, Peel, Michael
Published in Bioorganic & medicinal chemistry letters (15.01.2021)
Published in Bioorganic & medicinal chemistry letters (15.01.2021)
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Journal Article
Development of Novel Immunoprophylactic Agents against Multidrug-Resistant Gram-Negative Bacterial Infections
Lovey, Arianne, Krel, Mila, Borchardt, Allen, Brady, Thomas, Cole, Jason N, Do, Quyen-Quyen, Fortier, Joanne, Hough, Grayson, Jiang, Wanlong, Noncovich, Alain, Tari, Les, Zhao, Qiping, Balkovec, James M, Zhao, Yanan, Perlin, David S
Published in Antimicrobial agents and chemotherapy (18.10.2021)
Published in Antimicrobial agents and chemotherapy (18.10.2021)
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Journal Article
CTC-177, a novel drug–Fc conjugate, shows promise as an immunoprophylactic agent against multidrug-resistant Gram-negative bacterial infections
Lovey, Arianne, Lee, Annie, Yu, Allison, Krel, Mila, Wang, Mingming, Paderu, Padmaja, Brady, Thomas, Hough, Grayson, Zhao, Qiping, Balkovec, James M, Perlin, David S, Zhao, Yanan
Published in JAC-antimicrobial resistance (01.08.2024)
Published in JAC-antimicrobial resistance (01.08.2024)
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Journal Article
11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
Hermanowski-Vosatka, Anne, Balkovec, James M., Cheng, Kang, Chen, Howard Y., Hernandez, Melba, Koo, Gloria C., Le Grand, Cheryl B., Li, Zhihua, Metzger, Joseph M., Mundt, Steven S., Noonan, Heather, Nunes, Christian N., Olson, Steven H., Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M., Shah, Kashmira, Springer, Martin S., Strack, Alison M., Strowski, Matthias, Wu, Kenneth, Wu, TsueiJu, Xiao, Jianying, Zhang, Bei B., Wright, Samuel D., Thieringer, Rolf
Published in The Journal of experimental medicine (15.08.2005)
Published in The Journal of experimental medicine (15.08.2005)
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Journal Article
MK-5204: An orally active β-1,3-glucan synthesis inhibitor
Apgar, James M., Wilkening, Robert R., Parker, Dann L., Meng, Dongfang, Wildonger, Kenneth J., Sperbeck, Donald, Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, Andrew M., Giacobbe, Robert A., Gill, Charles J., Hsu, Ming-Jo, Liberator, Paul, Misura, Andrew S., Motyl, Mary, Kahn, Jennifer Nielsen, Powles, Maryann, Racine, Fred, Dragovic, Jasminka, Fan, Weiming, Kirwan, Robin, Lee, Shu, Liu, Hao, Mamai, Ahmed, Nelson, Kingsley, Peel, Michael
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)
Yu, Yang, Wu, Zhicai, Shi, Zhi-Cai, He, Shuwen, Lai, Zhong, Cernak, Timothy A., Vachal, Petr, Liu, Min, Liu, Jian, Hong, Qingmei, Jian, Tianying, Guiadeen, Deodial, Krikorian, Arto, Sperbeck, Donald M., Verras, Andreas, Sonatore, Lisa M., Murphy, Beth A., Wiltsie, Judyann, Chung, Christine C., Gorski, Judith N., Liu, Jinqi, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., De Vita, Robert J., Pinto, Shirly, Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.06.2019)
Published in Bioorganic & medicinal chemistry letters (01.06.2019)
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Journal Article
Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety
He, Shuwen, Lai, Zhong, Hong, Qingmei, Shang, Jackie, Reibarkh, Mikhail, Kuethe, Jeffrey T., Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Cernak, Timothy A., Dykstra, Kevin D., Sperbeck, Donald M., Wu, Zhicai, Yu, Yang, Yang, Ginger X., Jian, Tianying, Verras, Andreas, Sonatore, Lisa M., Wiltsie, Judyann, Chung, Christine C., Murphy, Beth A., Gorski, Judith N., Liu, Jinqi, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., Pinto, Shirly, Nargund, Ravi P., DeVita, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.05.2019)
Published in Bioorganic & medicinal chemistry letters (15.05.2019)
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Journal Article
Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin
Apgar, James M., Wilkening, Robert R., Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, Andrew M., Giacobbe, Robert A., Gill, Charles J., Hsu, Ming Jo, Liberator, Paul, Misura, Andrew S., Motyl, Mary, Nielsen Kahn, Jennifer, Powles, Maryann, Racine, Fred, Dragovic, Jasminka, Habulihaz, Bahanu, Fan, Weiming, Kirwan, Robin, Lee, Shu, Liu, Hao, Mamai, Ahmed, Nelson, Kingsley, Peel, Michael
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
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Journal Article
Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase
Heasley, Brian H., Pacofsky, Gregory J., Mamai, Ahmed, Liu, Hao, Nelson, Kingsley, Coti, Ghjuvanni, Peel, Michael R., Balkovec, James M., Greenlee, Mark L., Liberator, Paul, Meng, Dongfang, Parker, Dann L., Wilkening, Robert R., Apgar, James M., Racine, F., Hsu, Ming Jo, Giacobbe, Robert A., Kahn, Jennifer Nielsen
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
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Journal Article
11 beta -HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
Luo, Mingjuan J, Thieringer, Rolf, Springer, Martin S, Wright, Samuel D, Hermanowski-Vosatka, Anne, Plump, Andrew, Balkovec, James M, Cheng, Kang, Ding, Gloria J, Kawka, Douglas W
Published in Physiological genomics (01.01.2013)
Published in Physiological genomics (01.01.2013)
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Journal Article
Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
Zhu, Yuping, Olson, Steven H., Graham, Donald, Patel, Gool, Hermanowski-Vosatka, Anne, Mundt, Steven, Shah, Kashmira, Springer, Marty, Thieringer, Rolf, Wright, Samuel, Xiao, Jianying, Zokian, Hratch, Dragovic, Jasminka, Balkovec, James M.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Journal Article
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
Luo, Mingjuan J, Thieringer, Rolf, Springer, Martin S, Wright, Samuel D, Hermanowski-Vosatka, Anne, Plump, Andrew, Balkovec, James M, Cheng, Kang, Ding, Gloria J, Kawka, Douglas W, Koo, Gloria C, Grand, Cheryl B Le, Luo, Qi, Maletic, Milana M, Malkowitz, Lorraine, Shah, Kashmira, Singer, Irwin, Waddell, Sherman T, Wu, Kenneth K, Yuan, Jeffrey, Zhu, Jun, Stepaniants, Serguei, Yang, Xia, Lum, Pek Yee, Wang, I-Ming
Published in Physiological genomics (07.01.2013)
Published in Physiological genomics (07.01.2013)
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Journal Article
On the use of the O-methylmandelate ester for establishment of absolute configuration of secondary alcohols
Trost, Barry M, Belletire, John L, Godleski, Stephen, McDougal, Patrick G, Balkovec, James M, Baldwin, John J, Christy, Marcia E, Ponticello, Gerald S, Varga, Sandor L, Springer, James P
Published in Journal of organic chemistry (01.06.1986)
Published in Journal of organic chemistry (01.06.1986)
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Journal Article
Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Olson, Steven, Aster, Susan D., Brown, Kai, Carbin, Linda, Graham, Donald W., Hermanowski-Vosatka, Anne, LeGrand, Cheryl B., Mundt, Steven S., Robbins, Michael A., Schaeffer, James M., Slossberg, Llnon H., Szymonifka, Michael J., Thieringer, Rolf, Wright, Samuel D., Balkovec, James M.
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
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