Chemical optimization of Pneumocandin B0 and selection of the pre-clinical candidate Caspofungin
Balkovec, JM, Black, RM, Bouffard, FA, Dropinski, JF, Hammond, ML, Zambias, RA
Published in Planta Medica (01.07.2012)
Published in Planta Medica (01.07.2012)
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Conference Proceeding
11 beta -HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
Hermanowski-Vosatka, Anne, Balkovec, James M, Cheng, Kang, Chen, Howard Y, Hernandez, Melba, Koo, Gloria C, Le Grand, Cheryl B, Li, Zhihua, Metzger, Joseph M, Mundt, Steven S, Noonan, Heather, Nunes, Christian N, Olson, Steven H, Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M, Shah, Kashmira, Springer, Martin S, Strack, Alison M, Strowski, Matthias, Wu, Kenneth, Wu, TsueiJu, Xiao, Jianying, Zhang, Bei B, Wright, Samuel D, Thieringer, Rolf
Published in The Journal of experimental medicine (15.08.2005)
Published in The Journal of experimental medicine (15.08.2005)
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Journal Article
Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase
Toney, J H, Hammond, G G, Fitzgerald, P M, Sharma, N, Balkovec, J M, Rouen, G P, Olson, S H, Hammond, M L, Greenlee, M L, Gao, Y D
Published in The Journal of biological chemistry (24.08.2001)
Published in The Journal of biological chemistry (24.08.2001)
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Journal Article
Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Olson, Steven, Aster, Susan D., Brown, Kai, Carbin, Linda, Graham, Donald W., Hermanowski-Vosatka, Anne, LeGrand, Cheryl B., Mundt, Steven S., Robbins, Michael A., Schaeffer, James M., Slossberg, Llnon H., Szymonifka, Michael J., Thieringer, Rolf, Wright, Samuel D., Balkovec, James M.
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
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Journal Article
The First Stereoselective Total Synthesis of Quinine
Stork, Gilbert, Niu, Deqiang, Fujimoto, A, Koft, Emil R, Balkovec, James M, Tata, James R, Dake, Gregory R
Published in Journal of the American Chemical Society (11.04.2001)
Published in Journal of the American Chemical Society (11.04.2001)
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Journal Article
Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome
Gu, Xin, Dragovic, Jasminka, Koo, Gloria C., Koprak, Sam L., LeGrand, Cheryl, Mundt, Steven S., Shah, Kashmira, Springer, Marty S., Tan, Eugene Y., Thieringer, Rolf, Hermanowski-Vosatka, Anne, Zokian, Hratch J., Balkovec, James M., Waddell, Sherman T.
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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Journal Article
Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis
ABRUZZO, G. K, FLATTERY, A. M, KROPP, H, BARTIZAL, K, GILL, C. J, KONG, L, SMITH, J. G, PIKOUNIS, V. B, BALKOVEC, J. M, BOUFFARD, A. F, DROPINSKI, J. F, ROSEN, H
Published in Antimicrobial Agents and Chemotherapy (01.11.1997)
Published in Antimicrobial Agents and Chemotherapy (01.11.1997)
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Journal Article
Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor: Receptor Binding and in Vivo Activity
Ali, Amjad, Thompson, Christopher F, Balkovec, James M, Graham, Donald W, Hammond, Milton L, Quraishi, Nazia, Tata, James R, Einstein, Monica, Ge, Lan, Harris, Georgianna, Kelly, Terri M, Mazur, Paul, Pandit, Shilpa, Santoro, Joseph, Sitlani, Ayesha, Wang, Chuanlin, Williamson, Joanne, Miller, Douglas K, Thompson, Chris M, Zaller, Dennis M, Forrest, Michael J, Carballo-Jane, Ester, Luell, Silvi
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Journal Article
Efficacy of MK-991 (L-743,872), a semisynthetic pneumocandin, in murine models of Pneumocystis carinii
POWLES, M. A, LIBERATOR, P, SCHMATZ, D, ANDERSON, J, KARKHANIS, Y, DROPINSKI, J. F, BOUFFARD, F. A, BALKOVEC, J. M, FUJIOKA, H, AIKAWA, M, MCFADDEN, D
Published in Antimicrobial agents and chemotherapy (01.08.1998)
Published in Antimicrobial agents and chemotherapy (01.08.1998)
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Journal Article
Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy
Thompson, Christopher F., Quraishi, Nazia, Ali, Amjad, Tata, James R., Hammond, Milton L., Balkovec, James M., Einstein, Monica, Ge, Lan, Harris, Georgianna, Kelly, Theresa M., Mazur, Paul, Pandit, Shilpa, Santoro, Joseph, Sitlani, Ayesha, Wang, Chuanlin, Williamson, Joanne, Miller, Douglas K., Yamin, Ting-ting D., Thompson, Chris M., O’Neill, Edward A., Zaller, Dennis, Forrest, Michael J., Carballo-Jane, Ester, Luell, Silvi
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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Journal Article
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity
Smith, Cameron J., Ali, Amjad, Balkovec, James M., Graham, Donald W., Hammond, Milton L., Patel, Gool F., Rouen, Gregory P., Smith, Scott K., Tata, James R., Einstein, Monica, Ge, Lan, Harris, Georgianna S., Kelly, Theresa M., Mazur, Paul, Thompson, Chris M., Wang, Chuanlin F., Williamson, Joanne M., Miller, Douglas K., Pandit, Shilpa, Santoro, Joseph C., Sitlani, Ayesha, Yamin, Ting-ting D., O’Neill, Edward A., Zaller, Dennis M., Carballo-Jane, Ester, Forrest, Michael J., Luell, Silvi
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Journal Article
Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase
Greenlee, Mark L., Laub, Joanne B., Balkovec, James M., Hammond, Milton L., Hammond, Gail G., Pompliano, David L., Epstein-Toney, Jeffrey H.
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
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Journal Article
SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NOVEL CATIONIC PNEUMOCANDIN B-O DERIVATIVES
BOUFFARD, FA, ZAMBIAS, RA, DROPINSKI, JF, BALKOVEC, JM, HAMMOND, ML, ABRUZZO, GK, BARTIZAL, KF, MARRINAN, JA, KURTZ, MB, MCFADDEN, DC, NOLLSTADT, KH, POWLES, MA, SCHMATZ, DM
Published in Journal of medicinal chemistry (21.01.1994)
Published in Journal of medicinal chemistry (21.01.1994)
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Journal Article
On the use of the O-methylmandelate ester for establishment of absolute configuration of secondary alcohols
Trost, Barry M, Belletire, John L, Godleski, Stephen, McDougal, Patrick G, Balkovec, James M, Baldwin, John J, Christy, Marcia E, Ponticello, Gerald S, Varga, Sandor L, Springer, James P
Published in Journal of organic chemistry (01.06.1986)
Published in Journal of organic chemistry (01.06.1986)
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Journal Article
The First Stereoselective Total Synthesis of Quinine [J. Am. Chem. Soc. 2001, 123 (14), 3239−3242]
Stork, Gilbert, Niu, Deqiang, Fujimoto, Roger A, Koft, Emil R, Balkovec, James M, Tata, James R, Dake, Gregory R
Published in Journal of the American Chemical Society (05.09.2001)
Published in Journal of the American Chemical Society (05.09.2001)
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Journal Article
Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis
KURTZ, M. B, DOUGLAS, C, BOUFFARD, F. A, DROPINSKI, J. F, HAMMOND, M. L, ZAMBIAS, R. A, ABRUZZO, G, BARTIZAL, K, MCMANUS, O. B, GARCIA, M. L, MARRINAN, J, NOLLSTADT, K, ONISHI, J, DREIKORN, S, MILLIGAN, J, MANDALA, S, THOMPSON, J, BALKOVEC, J. M
Published in Antimicrobial Agents and Chemotherapy (01.12.1994)
Published in Antimicrobial Agents and Chemotherapy (01.12.1994)
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Journal Article
Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP)
Balkovec, James M, Black, Regina M, Hammond, Milton L, Heck, James V, Zambias, Robert A, Abruzzo, George, Bartizal, Ken, Kropp, Helmut, Trainor, Charlotte
Published in Journal of medicinal chemistry (01.01.1992)
Published in Journal of medicinal chemistry (01.01.1992)
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Journal Article