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Craig-Schapiro, Rebecca, Kuhn, Max, Xiong, Chengjie, Pickering, Eve H, Liu, Jingxia, Misko, Thomas P, Perrin, Richard J, Bales, Kelly R, Soares, Holly, Fagan, Anne M, Holtzman, David M
Published in PloS one (19.04.2011)
Published in PloS one (19.04.2011)
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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
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Published in Science translational medicine (29.06.2011)
Published in Science translational medicine (29.06.2011)
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Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion
Dresselhaus, Erica, Duerr, James M, Vincent, Fabien, Sylvain, Emily K, Beyna, Mercedes, Lanyon, Lorraine F, LaChapelle, Erik, Pettersson, Martin, Bales, Kelly R, Ramaswamy, Gayathri
Published in PloS one (26.03.2018)
Published in PloS one (26.03.2018)
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Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice
Bales, Kelly R, Liu, Feng, Wu, Su, Lin, Suizhen, Koger, Deanna, DeLong, Cynthia, Hansen, Jeffrey C, Sullivan, Patrick M, Paul, Steven M
Published in The Journal of neuroscience (27.05.2009)
Published in The Journal of neuroscience (27.05.2009)
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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
Wahrle, Suzanne E, Jiang, Hong, Parsadanian, Maia, Kim, Jungsu, Li, Aimin, Knoten, Amanda, Jain, Sanjay, Hirsch-Reinshagen, Veronica, Wellington, Cheryl L, Bales, Kelly R, Paul, Steven M, Holtzman, David M
Published in The Journal of clinical investigation (01.02.2008)
Published in The Journal of clinical investigation (01.02.2008)
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γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin
Pozdnyakov, Nikolay, Murrey, Heather E., Crump, Christina J., Pettersson, Martin, Ballard, T.Eric, am Ende, Christopher W., Ahn, Kwangwook, Li, Yue-Ming, Bales, Kelly R., Johnson, Douglas S.
Published in The Journal of biological chemistry (05.04.2013)
Published in The Journal of biological chemistry (05.04.2013)
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Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, John R., Yamada, Kelvin A., Finn, Mary Beth, Sloviter, Robert S., Bales, Kelly R., May, Patrick C., Schoepp, Darryle D., Paul, Steven M., Mennerick, Steven, Holtzman, David M.
Published in Neuron (Cambridge, Mass.) (22.12.2005)
Published in Neuron (Cambridge, Mass.) (22.12.2005)
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Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity
Bales, Kelly R, O'Neill, Sharon M, Pozdnyakov, Nikolay, Pan, Feng, Caouette, David, Pi, YeQing, Wood, Kathleen M, Volfson, Dmitri, Cirrito, John R, Han, Byung-Hee, Johnson, Andrew W, Zipfel, Gregory J, Samad, Tarek A
Published in Brain (London, England : 1878) (01.02.2016)
Published in Brain (London, England : 1878) (01.02.2016)
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Neuronal Sorting Protein-Related Receptor sorLA/LR11 Regulates Processing of the Amyloid Precursor Protein
Andersen, Olav M., Reiche, Juliane, Schmidt, Vanessa, Gotthardt, Michael, Spoelgen, Robert, Behlke, Joachim, Christine A. F. von Arnim, Breiderhoff, Tilman, Jansen, Pernille, Wu, Xin, Bales, Kelly R., Cappai, Roberto, Masters, Colin L., Gliemann, Jørgen, Mufson, Elliott J., Hyman, Bradley T., Paul, Steven M., Nykjær, Anders, Willnow, Thomas E., Ingram, Vernon Martin
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2005)
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Discovery of Clinical Candidate PF-06648671: A Potent γ‑Secretase Modulator for the Treatment of Alzheimer’s Disease
Pettersson, Martin, Johnson, Douglas S., Humphrey, John M., am Ende, Christopher W., Butler, Todd W., Dorff, Peter H., Efremov, Ivan V., Evrard, Edelweiss, Green, Michael E., Helal, Christopher J., Kauffman, Gregory W., Mullins, Patrick B., Navaratnam, Thayalan, O’Donnell, Christopher J., O’Sullivan, Theresa J., Patel, Nandini C., Stepan, Antonia F., Stiff, Cory M., Subramanyam, Chakrapani, Trapa, Patrick, Tran, Tuan P., Vetelino, Beth Cooper, Yang, Eddie, Xie, Longfei, Pustilnik, Leslie R., Steyn, Stefanus J., Wood, Kathleen M., Bales, Kelly R., Hajos-Korcsok, Eva, Verhoest, Patrick R.
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
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Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms
Costa, David A, Cracchiolo, Jennifer R, Bachstetter, Adam D, Hughes, Tiffany F, Bales, Kelly R, Paul, Steven M, Mervis, Ronald F, Arendash, Gary W, Potter, Huntington
Published in Neurobiology of aging (01.06.2007)
Published in Neurobiology of aging (01.06.2007)
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P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
Cirrito, John R, Deane, Rashid, Fagan, Anne M, Spinner, Michael L, Parsadanian, Maia, Finn, Mary Beth, Jiang, Hong, Prior, Julie L, Sagare, Abhay, Bales, Kelly R, Paul, Steven M, Zlokovic, Berislav V, Piwnica-Worms, David, Holtzman, David M
Published in The Journal of clinical investigation (01.11.2005)
Published in The Journal of clinical investigation (01.11.2005)
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Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation
Kauwe, John S K, Bailey, Matthew H, Ridge, Perry G, Perry, Rachel, Wadsworth, Mark E, Hoyt, Kaitlyn L, Staley, Lyndsay A, Karch, Celeste M, Harari, Oscar, Cruchaga, Carlos, Ainscough, Benjamin J, Bales, Kelly, Pickering, Eve H, Bertelsen, Sarah, Fagan, Anne M, Holtzman, David M, Morris, John C, Goate, Alison M
Published in PLoS genetics (01.10.2014)
Published in PLoS genetics (01.10.2014)
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The roles of inflammation and immune mechanisms in Alzheimer's disease
Van Eldik, Linda J, Carrillo, Maria C, Cole, Patricia E, Feuerbach, Dominik, Greenberg, Barry D, Hendrix, James A, Kennedy, Matthew, Kozauer, Nick, Margolin, Richard A, Molinuevo, José L, Mueller, Reinhold, Ransohoff, Richard M, Wilcock, Donna M, Bain, Lisa, Bales, Kelly
Published in Alzheimer's & dementia : translational research & clinical interventions (01.06.2016)
Published in Alzheimer's & dementia : translational research & clinical interventions (01.06.2016)
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Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
Paul, Steven M, Koistinaho, Milla, Lin, Suizhen, Wu, Xin, Esterman, Michail, Koger, Deanna, Hanson, Jeffrey, Higgs, Richard, Liu, Feng, Malkani, Seema, Bales, Kelly R
Published in Nature medicine (01.07.2004)
Published in Nature medicine (01.07.2004)
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Phosphorylated Tau-Aβ42 Ratio as a Continuous Trait for Biomarker Discovery for Early-Stage Alzheimer’s Disease in Multiplex Immunoassay Panels of Cerebrospinal Fluid
Harari, Oscar, Cruchaga, Carlos, Kauwe, John S.K, Ainscough, Benjamin J, Bales, Kelly, Pickering, Eve H, Bertelsen, Sarah, Fagan, Anne M, Holtzman, David M, Morris, John C, Goate, Alison M
Published in Biological psychiatry (1969) (01.05.2014)
Published in Biological psychiatry (1969) (01.05.2014)
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Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease
Wahrle, Suzanne E., Jiang, Hong, Parsadanian, Maia, Hartman, Richard E., Bales, Kelly R., Paul, Steven M., Holtzman, David M.
Published in The Journal of biological chemistry (30.12.2005)
Published in The Journal of biological chemistry (30.12.2005)
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