Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes
Gudernova, Iva, Vesela, Iva, Balek, Lukas, Buchtova, Marcela, Dosedelova, Hana, Kunova, Michaela, Pivnicka, Jakub, Jelinkova, Iva, Roubalova, Lucie, Kozubik, Alois, Krejci, Pavel
Published in Human molecular genetics (01.01.2016)
Published in Human molecular genetics (01.01.2016)
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Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation
Krejci, Pavel, Aklian, Anie, Kaucka, Marketa, Sevcikova, Eva, Prochazkova, Jirina, Masek, Jan Kukla, Mikolka, Pavol, Pospisilova, Tereza, Spoustova, Tereza, Weis, MaryAnn, Paznekas, William A, Wolf, Joshua H, Gutkind, J Silvio, Wilcox, William R, Kozubik, Alois, Jabs, Ethylin Wang, Bryja, Vitezslav, Salazar, Lisa, Vesela, Iva, Balek, Lukas
Published in PloS one (27.04.2012)
Published in PloS one (27.04.2012)
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The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases
Fafilek, Bohumil, Balek, Lukas, Bosakova, Michaela Kunova, Varecha, Miroslav, Nita, Alexandru, Gregor, Tomas, Gudernova, Iva, Krenova, Jitka, Ghosh, Somadri, Piskacek, Martin, Jonatova, Lucie, Cernohorsky, Nicole H, Zieba, Jennifer T, Kostas, Michal, Haugsten, Ellen Margrethe, Wesche, Jørgen, Erneux, Christophe, Trantirek, Lukas, Krakow, Deborah, Krejci, Pavel
Published in Science signaling (18.09.2018)
Published in Science signaling (18.09.2018)
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Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling
Bosakova, Michaela, Abraham, Sara P, Nita, Alexandru, Hruba, Eva, Buchtova, Marcela, Taylor, S Paige, Duran, Ivan, Martin, Jorge, Svozilova, Katerina, Barta, Tomas, Varecha, Miroslav, Balek, Lukas, Kohoutek, Jiri, Radaszkiewicz, Tomasz, Pusapati, Ganesh V, Bryja, Vitezslav, Rush, Eric T, Thiffault, Isabelle, Nickerson, Deborah A, Bamshad, Michael J, Rohatgi, Rajat, Cohn, Daniel H, Krakow, Deborah, Krejci, Pavel
Published in EMBO molecular medicine (06.11.2020)
Published in EMBO molecular medicine (06.11.2020)
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Decrease in Abundance of Apurinic/Apyrimidinic Endonuclease Causes Failure of Base Excision Repair in Culture‐Adapted Human Embryonic Stem Cells
Krutá, Miriama, Bálek, Lukáš, Hejnová, Renata, Dobšáková, Zuzana, Eiselleová, Livia, Matulka, Kamil, Bárta, Tomáš, Fojtík, Petr, Fajkus, Jiří, Hampl, Aleš, Dvořák, Petr, Rotrekl, Vladimír
Published in Stem cells (Dayton, Ohio) (01.04.2013)
Published in Stem cells (Dayton, Ohio) (01.04.2013)
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One reporter for in-cell activity profiling of majority of protein kinase oncogenes
Gudernova, Iva, Foldynova-Trantirkova, Silvie, Ghannamova, Barbora El, Fafilek, Bohumil, Varecha, Miroslav, Balek, Lukas, Hruba, Eva, Jonatova, Lucie, Jelinkova, Iva, Kunova Bosakova, Michaela, Trantirek, Lukas, Mayer, Jiri, Krejci, Pavel
Published in eLife (15.02.2017)
Published in eLife (15.02.2017)
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A novel variant of FGFR3 causes proportionate short stature
Kant, Sarina G, Cervenkova, Iveta, Balek, Lukas, Trantirek, Lukas, Santen, Gijs W E, de Vries, Martine C, van Duyvenvoorde, Hermine A, van der Wielen, Michiel J R, Verkerk, Annemieke J M H, Uitterlinden, André G, Hannema, Sabine E, Wit, Jan M, Oostdijk, Wilma, Krejci, Pavel, Losekoot, Monique
Published in European journal of endocrinology (01.06.2015)
Published in European journal of endocrinology (01.06.2015)
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Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480
Gudernova, Iva, Balek, Lukas, Varecha, Miroslav, Kucerova, Jana Fialova, Bosakova, Michaela Kunova, Fafilek, Bohumil, Palusova, Veronika, Uldrijan, Stjepan, Trantirek, Lukas, Krejci, Pavel
Published in Oncotarget (12.12.2017)
Published in Oncotarget (12.12.2017)
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Effect of FGFR inhibitors on chicken limb development
Horakova, Dana, Cela, Petra, Krejci, Pavel, Balek, Lukas, Moravcova Balkova, Simona, Matalova, Eva, Buchtova, Marcela
Published in Development, growth & differentiation (01.10.2014)
Published in Development, growth & differentiation (01.10.2014)
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Nanodiamonds as “artificial proteins”: Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals
Balek, Lukas, Buchtova, Marcela, Kunova Bosakova, Michaela, Varecha, Miroslav, Foldynova-Trantirkova, Silvie, Gudernova, Iva, Vesela, Iva, Havlik, Jan, Neburkova, Jitka, Turner, Stuart, Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Klimaschewski, Lars, Claus, Peter, Trantirek, Lukas, Cigler, Petr, Krejci, Pavel
Published in Biomaterials (01.09.2018)
Published in Biomaterials (01.09.2018)
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Computer‐assisted engineering of hyperstable fibroblast growth factor 2
Dvorak, Pavel, Bednar, David, Vanacek, Pavel, Balek, Lukas, Eiselleova, Livia, Stepankova, Veronika, Sebestova, Eva, Kunova Bosakova, Michaela, Konecna, Zaneta, Mazurenko, Stanislav, Kunka, Antonin, Vanova, Tereza, Zoufalova, Karolina, Chaloupkova, Radka, Brezovsky, Jan, Krejci, Pavel, Prokop, Zbynek, Dvorak, Petr, Damborsky, Jiri
Published in Biotechnology and bioengineering (01.04.2018)
Published in Biotechnology and bioengineering (01.04.2018)
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ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3
Balek, Lukas, Gudernova, Iva, Vesela, Iva, Hampl, Marek, Oralova, Veronika, Kunova Bosakova, Michaela, Varecha, Miroslav, Nemec, Pavel, Hall, Terence, Abbadessa, Giovanni, Hatch, Nan, Buchtova, Marcela, Krejci, Pavel
Published in Bone (New York, N.Y.) (01.12.2017)
Published in Bone (New York, N.Y.) (01.12.2017)
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Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase
Bosakova, Michaela Kunova, Nita, Alexandru, Gregor, Tomas, Varecha, Miroslav, Gudernova, Iva, Fafilek, Bohumil, Barta, Tomas, Basheer, Neha, Abraham, Sara P., Balek, Lukas, Tomanova, Marketa, Kucerova, Jana Fialova, Bosak, Juraj, Potesil, David, Zieba, Jennifer, Song, Jieun, Konik, Peter, Park, Sohyun, Duran, Ivan, Zdrahal, Zbynek, Smajs, David, Jansen, Gert, Fu, Zheng, Ko, Hyuk Wan, Hampl, Ales, Trantirek, Lukas, Krakow, Deborah, Krejci, Pavel
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2019)
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Proteomic analyses of signalling complexes associated with receptor tyrosine kinase identify novel members of fibroblast growth factor receptor 3 interactome
Balek, Lukas, Nemec, Pavel, Konik, Peter, Kunova Bosakova, Michaela, Varecha, Miroslav, Gudernova, Iva, Medalova, Jirina, Krakow, Deborah, Krejci, Pavel
Published in Cellular signalling (01.01.2018)
Published in Cellular signalling (01.01.2018)
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An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome
Paige Taylor, S, Kunova Bosakova, Michaela, Varecha, Miroslav, Balek, Lukas, Barta, Tomas, Trantirek, Lukas, Jelinkova, Iva, Duran, Ivan, Vesela, Iva, Forlenza, Kimberly N, Martin, Jorge H, Hampl, Ales, Bamshad, Michael, Nickerson, Deborah, Jaworski, Margie L, Song, Jieun, Ko, Hyuk Wan, Cohn, Daniel H, Krakow, Deborah, Krejci, Pavel
Published in Human molecular genetics (15.09.2016)
Published in Human molecular genetics (15.09.2016)
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Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage
Buchtova, Marcela, Oralova, Veronika, Aklian, Anie, Masek, Jan, Vesela, Iva, Ouyang, Zhufeng, Obadalova, Tereza, Konecna, Zaneta, Spoustova, Tereza, Pospisilova, Tereza, Matula, Petr, Varecha, Miroslav, Balek, Lukas, Gudernova, Iva, Jelinkova, Iva, Duran, Ivan, Cervenkova, Iveta, Murakami, Shunichi, Kozubik, Alois, Dvorak, Petr, Bryja, Vitezslav, Krejci, Pavel
Published in Biochimica et biophysica acta (01.05.2015)
Published in Biochimica et biophysica acta (01.05.2015)
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Journal Article
Cover Image, Volume 115, Number 4, April 2018
Dvorak, Pavel, Bednar, David, Vanacek, Pavel, Balek, Lukas, Eiselleova, Livia, Stepankova, Veronika, Sebestova, Eva, Kunova Bosakova, Michaela, Konecna, Zaneta, Mazurenko, Stanislav, Kunka, Antonin, Vanova, Tereza, Zoufalova, Karolina, Chaloupkova, Radka, Brezovsky, Jan, Krejci, Pavel, Prokop, Zbynek, Dvorak, Petr, Damborsky, Jiri
Published in Biotechnology and bioengineering (01.04.2018)
Published in Biotechnology and bioengineering (01.04.2018)
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Receptor Tyrosine Kinases Activate Canonical WNT/[beta]-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct [beta]-Catenin Phosphorylation
Krejci, Pavel, Aklian, Anie, Kaucka, Marketa, Sevcikova, Eva, Prochazkova, Jirina, Masek, Jan Kukla, Mikolka, Pavol, Pospisilova, Tereza, Spoustova, Tereza, Weis, MaryAnn, Paznekas, William A, Wolf, Joshua H, Gutkind, J. Silvio, Wilcox, William R, Kozubik, Alois, Jabs, Ethylin Wang, Bryja, Vitezslav, Salazar, Lisa, Vesela, Iva, Balek, Lukas
Published in PloS one (27.04.2012)
Published in PloS one (27.04.2012)
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내열성 FGF2 폴리펩타이드 및 그 용도
DVORAK PETR, DVORAK PAVEL, KREJCI PAVEL, STEPANKOVA VERONIKA, CHALOUPKOVA RADKA, BEDNAR DAVID, PROKOP ZBYNEK, BOSAKOVA MICHAELA, DAMBORSKY JIRI, VANACEK PAVEL, BREZOVSKY JAN, SEBESTOVA EVA, BALEK LUKAS, EISELLEOVA LIVIA, KONECNA ZANETA
Year of Publication 11.07.2018
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Year of Publication 11.07.2018
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