Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design
Sharma, Shailendra Kumar, de Val, Natalia, Bale, Shridhar, Guenaga, Javier, Tran, Karen, Feng, Yu, Dubrovskaya, Viktoriya, Ward, Andrew B, Wyatt, Richard T
Published in Cell reports (Cambridge) (28.04.2015)
Published in Cell reports (Cambridge) (28.04.2015)
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Journal Article
Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies
Feng, Yu, Tran, Karen, Bale, Shridhar, Kumar, Shailendra, Guenaga, Javier, Wilson, Richard, de Val, Natalia, Arendt, Heather, DeStefano, Joanne, Ward, Andrew B, Wyatt, Richard T
Published in PLoS pathogens (01.08.2016)
Published in PLoS pathogens (01.08.2016)
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Journal Article
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase
Chatterjee, Abhishek, Abeydeera, N. Dinuka, Bale, Shridhar, Pai, Pei-Jing, Dorrestein, Pieter C., Russell, David H., Ealick, Steven E., Begley, Tadhg P.
Published in Nature (London) (27.10.2011)
Published in Nature (London) (27.10.2011)
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Journal Article
Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies
Bornholdt, Zachary A, Ndungo, Esther, Fusco, Marnie L, Bale, Shridhar, Flyak, Andrew I, Crowe, Jr, James E, Chandran, Kartik, Saphire, Erica Ollmann
Published in mBio (23.02.2016)
Published in mBio (23.02.2016)
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Journal Article
Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
Sarkar, Anita, Bale, Shridhar, Behrens, Anna-Janina, Kumar, Sonu, Sharma, Shailendra Kumar, de Val, Natalia, Pallesen, Jesper, Irimia, Adriana, Diwanji, Devan C., Stanfield, Robyn L., Ward, Andrew B., Crispin, Max, Wyatt, Richard T., Wilson, Ian A.
Published in Nature communications (16.05.2018)
Published in Nature communications (16.05.2018)
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Journal Article
A shared structural solution for neutralizing ebolaviruses
Dias, João M, Kuehne, Ana I, Abelson, Dafna M, Bale, Shridhar, Wong, Anthony C, Halfmann, Peter, Muhammad, Majidat A, Fusco, Marnie L, Zak, Samantha E, Kang, Eugene, Kawaoka, Yoshihiro, Chandran, Kartik, Dye, John M, Saphire, Erica Ollmann
Published in Nature structural & molecular biology (01.12.2011)
Published in Nature structural & molecular biology (01.12.2011)
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Journal Article
mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies
Guenaga, Javier, Alirezaei, Mehrdad, Feng, Yu, Alameh, Mohamad-Gabriel, Lee, Wen-Hsin, Baboo, Sabyasachi, Cluff, Jocelyn, Wilson, Richard, Bale, Shridhar, Ozorowski, Gabriel, Lin, Paulo, Tam, Ying, Diedrich, Jolene K, Yates, 3rd, John R, Paulson, James C, Ward, Andrew B, Weissman, Drew, Wyatt, Richard T
Published in Frontiers in immunology (25.07.2024)
Published in Frontiers in immunology (25.07.2024)
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Journal Article
Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response
Bale, Shridhar, Yang, Lifei, Alirezaei, Mehrdad, Wilson, Richard, Ota, Takayuki, Doyle, Esmeralda D, Cottrell, Christopher A, Guenaga, Javier, Tran, Karen, Li, Wenjuan, Stamatatos, Leonidas, Nemazee, David, Ward, Andrew B, Wyatt, Richard T
Published in Frontiers in immunology (22.05.2023)
Published in Frontiers in immunology (22.05.2023)
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Journal Article
Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies
Bale, Shridhar, Martiné, Alexandra, Wilson, Richard, Behrens, Anna-Janina, Le Fourn, Valérie, de Val, Natalia, Sharma, Shailendra K, Tran, Karen, Torres, Jonathan L, Girod, Pierre-Alain, Ward, Andrew B, Crispin, Max, Wyatt, Richard T
Published in Frontiers in immunology (24.05.2018)
Published in Frontiers in immunology (24.05.2018)
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Journal Article
Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism
Bale, Shridhar, Julien, Jean-Philippe, Bornholdt, Zachary A, Kimberlin, Christopher R, Halfmann, Peter, Zandonatti, Michelle A, Kunert, John, Kroon, Gerard J A, Kawaoka, Yoshihiro, MacRae, Ian J, Wilson, Ian A, Saphire, Erica Ollmann
Published in PLoS pathogens (01.09.2012)
Published in PLoS pathogens (01.09.2012)
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Journal Article
Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion
Bale, Shridhar, Liu, Tong, Li, Sheng, Wang, Yuhao, Abelson, Dafna, Fusco, Marnie, Woods, Jr, Virgil L, Saphire, Erica Ollmann
Published in PLoS neglected tropical diseases (01.11.2011)
Published in PLoS neglected tropical diseases (01.11.2011)
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Journal Article
Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus
OLAL, Daniel, KUEHNE, Ana I, OLLMANN SAPHIRE, Erica, BALE, Shridhar, HALFMANN, Peter, HASHIGUCHI, Takao, FUSCO, Marnie L, LEE, Jeffrey E, KING, Liam B, KAWAOKA, Yoshihiro, DYE, John M
Published in Journal of Virology (01.03.2012)
Published in Journal of Virology (01.03.2012)
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Journal Article
Crystal Structure and Mechanism of Tryptophan 2,3-Dioxygenase, a Heme Enzyme Involved in Tryptophan Catabolism and in Quinolinate Biosynthesis
Zhang, Yang, Kang, Seong A, Mukherjee, Tathagata, Bale, Shridhar, Crane, Brian R, Begley, Tadhg P, Ealick, Steven E
Published in Biochemistry (Easton) (09.01.2007)
Published in Biochemistry (Easton) (09.01.2007)
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Journal Article
HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization
Navis, Marjon, Tran, Karen, Bale, Shridhar, Phad, Ganesh E, Guenaga, Javier, Wilson, Richard, Soldemo, Martina, McKee, Krisha, Sundling, Christopher, Mascola, John, Li, Yuxing, Wyatt, Richard T, Karlsson Hedestam, Gunilla B
Published in PLoS pathogens (01.08.2014)
Published in PLoS pathogens (01.08.2014)
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Journal Article
Structural basis for differential neutralization of ebolaviruses
Bale, Shridhar, Dias, Joao M, Fusco, Marnie L, Hashiguchi, Takao, Wong, Anthony C, Liu, Tong, Keuhne, Ana I, Li, Sheng, Woods, Jr, Virgil L, Chandran, Kartik, Dye, John M, Saphire, Erica Ollmann
Published in Viruses (01.04.2012)
Published in Viruses (01.04.2012)
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Journal Article
Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses
Bale, Shridhar, Goebrecht, Geraldine, Stano, Armando, Wilson, Richard, Ota, Takayuki, Tran, Karen, Ingale, Jidnyasa, Zwick, Michael B, Wyatt, Richard T
Published in Journal of virology (15.08.2017)
Published in Journal of virology (15.08.2017)
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Journal Article
Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
Dubrovskaya, Viktoriya, Tran, Karen, Ozorowski, Gabriel, Guenaga, Javier, Wilson, Richard, Bale, Shridhar, Cottrell, Christopher A., Turner, Hannah L., Seabright, Gemma, O’Dell, Sijy, Torres, Jonathan L., Yang, Lifei, Feng, Yu, Leaman, Daniel P., Vázquez Bernat, Néstor, Liban, Tyler, Louder, Mark, McKee, Krisha, Bailer, Robert T., Movsesyan, Arlette, Doria-Rose, Nicole A., Pancera, Marie, Karlsson Hedestam, Gunilla B., Zwick, Michael B., Crispin, Max, Mascola, John R., Ward, Andrew B., Wyatt, Richard T.
Published in Immunity (Cambridge, Mass.) (19.11.2019)
Published in Immunity (Cambridge, Mass.) (19.11.2019)
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Journal Article
Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach
Martinez-Murillo, Paola, Tran, Karen, Guenaga, Javier, Lindgren, Gustaf, Àdori, Monika, Feng, Yu, Phad, Ganesh E., Vázquez Bernat, Néstor, Bale, Shridhar, Ingale, Jidnyasa, Dubrovskaya, Viktoriya, O’Dell, Sijy, Pramanik, Lotta, Spångberg, Mats, Corcoran, Martin, Loré, Karin, Mascola, John R., Wyatt, Richard T., Karlsson Hedestam, Gunilla B.
Published in Immunity (Cambridge, Mass.) (16.05.2017)
Published in Immunity (Cambridge, Mass.) (16.05.2017)
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