Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3‑Kinase δ for the Treatment of Respiratory Disease
Down, Kenneth, Amour, Augustin, Baldwin, Ian R, Cooper, Anthony W. J, Deakin, Angela M, Felton, Leigh M, Guntrip, Stephen B, Hardy, Charlotte, Harrison, Zoë A, Jones, Katherine L, Jones, Paul, Keeling, Suzanne E, Le, Joelle, Livia, Stefano, Lucas, Fiona, Lunniss, Christopher J, Parr, Nigel J, Robinson, Ed, Rowland, Paul, Smith, Sarah, Thomas, Daniel A, Vitulli, Giovanni, Washio, Yoshiaki, Hamblin, J. Nicole
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Journal Article
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism
Wellaway, Christopher R, Baldwin, Ian R, Bamborough, Paul, Barker, Daniel, Bartholomew, Michelle A, Chung, Chun-wa, Dümpelfeld, Birgit, Evans, John P, Fazakerley, Neal J, Homes, Paul, Keeling, Steven P, Lewell, Xiao Q, McNab, Finlay W, Morley, Joanne, Needham, Deborah, Neu, Margarete, van Oosterhout, Antoon J. M, Pal, Anshu, Reinhard, Friedrich B. M, Rianjongdee, Francesco, Robertson, Craig M, Rowland, Paul, Shah, Rishi R, Sherriff, Emma B, Sloan, Lisa A, Teague, Simon, Thomas, Daniel A, Wellaway, Natalie, Wojno-Picon, Justyna, Woolven, James M, Coe, Diane M
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Journal Article
Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3‑Kinase δ
Spencer, Jonathan A, Baldwin, Ian R, Barton, Nick, Chung, Chun-Wa, Convery, Máire A, Edwards, Christopher D, Jamieson, Craig, Mallett, David N, Rowedder, James E, Rowland, Paul, Thomas, Daniel A, Hardy, Charlotte J
Published in ACS medicinal chemistry letters (09.07.2020)
Published in ACS medicinal chemistry letters (09.07.2020)
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Journal Article
From PIM1 to PI3Kδ via GSK3β: Target Hopping through the Kinome
Henley, Zoë A, Bax, Benjamin D, Inglesby, Laura M, Champigny, Aurélie, Gaines, Simon, Faulder, Paul, Le, Joelle, Thomas, Daniel A, Washio, Yoshiaki, Baldwin, Ian R
Published in ACS medicinal chemistry letters (12.10.2017)
Published in ACS medicinal chemistry letters (12.10.2017)
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Journal Article
The Synthesis of (−)-Isodomoic Acid C
Clayden, Jonathan, Knowles, Faye E, Baldwin, Ian R
Published in Journal of the American Chemical Society (02.03.2005)
Published in Journal of the American Chemical Society (02.03.2005)
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Journal Article
A practical drug discovery project at the undergraduate level
Jonathan Fray, M., Macdonald, Simon J.F., Baldwin, Ian R., Barton, Nick, Brown, Jack, Campbell, Ian B., Churcher, Ian, Coe, Diane M., Cooper, Anthony W.J., Craven, Andrew P., Fisher, Gail, Inglis, Graham G.A., Kelly, Henry A., Liddle, John, Maxwell, Aoife C., Patel, Vipulkumar K., Swanson, Stephen, Wellaway, Natalie
Published in Drug discovery today (01.12.2013)
Published in Drug discovery today (01.12.2013)
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Journal Article
3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β
Miller, David D., Bamborough, Paul, Christopher, John A., Baldwin, Ian R., Champigny, Aurelie C., Cutler, Geoffrey J., Kerns, Jeffrey K., Longstaff, Timothy, Mellor, Geoffrey W., Morey, James V., Morse, Mary A., Nie, Hong, Rumsey, William L., Taggart, John J.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Journal Article
3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IIK-β
MILLER, David D, BAMBOROUGH, Paul, MORSE, Mary A, HONG NIE, RUMSEY, William L, TAGGART, John J, CHRISTOPHER, John A, BALDWIN, Ian R, CHAMPIGNY, Aurelie C, CUTLER, Geoffrey J, KERNS, Jeffrey K, LONGSTAFF, Timothy, MELLOR, Geoffrey W, MOREY, James V
Published in Bioorganic & medicinal chemistry letters (2011)
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Published in Bioorganic & medicinal chemistry letters (2011)
Journal Article
Hemodialysis membrane with a high-molecular-weight cutoff and cytokine levels in sepsis complicated by acute renal failure: a phase 1 randomized trial
Haase, Michael, Bellomo, Rinaldo, Baldwin, Ian, Haase-Fielitz, Anja, Fealy, Nigel, Davenport, Piers, Morgera, Stanislao, Goehl, Hermann, Storr, Markus, Boyce, Neil, Neumayer, Hans-Hellmut
Published in American journal of kidney diseases (01.08.2007)
Published in American journal of kidney diseases (01.08.2007)
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Journal Article
HETEROARYLSUBSTITUIERTE BIPHENYLDERIVATE ALS INHIBITOREN VON P38-KINASE
WALKER, ANN LOUISE, ANGELL, RICHARD M, LI-KWAIUNG, ANNE-MARIE, SWANSON, STEPHEN, SMITH, KATHRYN JANE, BAMBOROUGH, PAUL, BALDWIN, IAN R, MERRICK, SUZANNE, JOY, LONGSTAFF, TIMOTHY
Year of Publication 17.04.2008
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Year of Publication 17.04.2008
Patent
HETEROARYLSUBSTITUIERTE BIPHENYLDERIVATE ALS INHIBITOREN VON P38-KINASE
WALKER, ANN LOUISE, ANGELL, RICHARD M, LI-KWAIUNG, ANNE-MARIE, SWANSON, STEPHEN, MERRICK, SUZANNE JOY, SMITH, KATHRYN JANE, BAMBOROUGH, PAUL, BALDWIN, IAN R, LONGSTAFF, TIMOTHY
Year of Publication 15.08.2007
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Year of Publication 15.08.2007
Patent
Quinoline derivatives as phosphodiesterase inhibitors
HOLMAN STUART, EVANS BRIAN, DEAN ANTHONY W, HAMBLIN JULIE N, BALDWIN IAN R, BARKER MICHAEL D, ROBINSON JOHN E, LUNNISS CHRISTOPHER J, LINDVALL MIKA K, ELDRED COLIN D, JONES PAUL, REDFERN TRACY J, REDGRAVE ALISON J, WOODROW MICHAEL, GOUGH SHARON L, GUNTRIP STEPHEN B
Year of Publication 21.06.2007
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Year of Publication 21.06.2007
Patent