Discovery and Preclinical Characterization of 1‑Methyl‑3-(4‑methylpyridin‑3‑yl)‑6‑(pyridin‑2‑ylmethoxy)‑1H‑pyrazolo-[3,4‑b]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator
Zhang, Lei, Balan, Gayatri, Barreiro, Gabriela, Boscoe, Brian P, Chenard, Lois K, Cianfrogna, Julie, Claffey, Michelle M, Chen, Laigao, Coffman, Karen J, Drozda, Susan E, Dunetz, Joshua R, Fonseca, Kari R, Galatsis, Paul, Grimwood, Sarah, Lazzaro, John T, Mancuso, Jessica Y, Miller, Emily L, Reese, Matthew R, Rogers, Bruce N, Sakurada, Isao, Skaddan, Marc, Smith, Deborah L, Stepan, Antonia F, Trapa, Patrick, Tuttle, Jamison B, Verhoest, Patrick R, Walker, Daniel P, Wright, Ann S, Zaleska, Margaret M, Zasadny, Kenneth, Shaffer, Christopher L
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists
Humphries, Paul S., Benbow, John W., Bonin, Paul D., Boyer, David, Doran, Shawn D., Frisbie, Richard K., Piotrowski, David W., Balan, Gayatri, Bechle, Bruce M., Conn, Edward L., Dirico, Kenneth J., Oliver, Robert M., Soeller, Walter C., Southers, James A., Yang, Xiaojing
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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이카로스 아연 핑거 패밀리 분해제 및 이의 용도
KIM MUSONG, TUDESCO MICHAEL T, BLOMGREN PETER A, DU ZHIMIN, BALAN GAYATRI, CODELLI JULIAN A, THOMAS TRAN RHIANNON, VENKATARAMANI CHANDRASEKAR
Year of Publication 14.08.2024
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Year of Publication 14.08.2024
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피리디진-3(2H)-온 유도체
CHANDRASEKHAR JAYARAMAN, KROPF JEFFREY E, LEE SEUNG H, WEAVER HEATH A, JACOBSEN JESSE M, BALAN GAYATRI, CHANG JONAH J, CURRIE KEVIN S, PAUL THOMAS J, SALVO PATRICK J, MOAZAMI YASAMIN, TREIBERG JENNIFER A, PATEL LEENA B, PERREAULT STEPHANE, HOLMBO STEPHEN D
Year of Publication 21.06.2024
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Year of Publication 21.06.2024
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Expedient Synthesis of Sulfinamides from Sulfonyl Chlorides
Harmata, Michael, Zheng, Pinguan, Huang, Chaofeng, Gomes, Maria G, Ying, Weijiang, Ranyanil, Kanok-On, Balan, Gayatri, Calkins, Nathan L
Published in Journal of organic chemistry (19.01.2007)
Published in Journal of organic chemistry (19.01.2007)
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Cot COT MODULATORS AND METHODS OF USE THEREOF
CLARK CHRISTOPHER T, KIM MUSONG, WATKINS WILLIAM J, KIRSCHBERG THORSTEN A, WRIGHT NATHAN E, LINK JOHN O, BACON ELIZABETH M, COTTELL JEROMY J, SCHROEDER SCOTT D, SQUIRES NEIL H, TAYLOR JAMES G, STEVENS KIRK L, BALAN GAYATRI, CHOU CHIEN HUNG, PHILLIPS GARY, ZIPFEL SHEILA M
Year of Publication 18.01.2024
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Year of Publication 18.01.2024
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Discovery and Characterization of (R)‑6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1‑c][1,4]oxazin-4(9H)‑one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates
Stepan, Antonia F, Claffey, Michelle M, Reese, Matthew R, Balan, Gayatri, Barreiro, Gabriela, Barricklow, Jason, Bohanon, Michael J, Boscoe, Brian P, Cappon, Gregg D, Chenard, Lois K, Cianfrogna, Julie, Chen, Laigao, Coffman, Karen J, Drozda, Susan E, Dunetz, Joshua R, Ghosh, Somraj, Hou, Xinjun, Houle, Christopher, Karki, Kapil, Lazzaro, John T, Mancuso, Jessica Y, Marcek, John M, Miller, Emily L, Moen, Mark A, O’Neil, Steven, Sakurada, Isao, Skaddan, Marc, Parikh, Vinod, Smith, Deborah L, Trapa, Patrick, Tuttle, Jamison B, Verhoest, Patrick R, Walker, Daniel P, Won, Annie, Wright, Ann S, Whritenour, Jessica, Zasadny, Kenneth, Zaleska, Margaret M, Zhang, Lei, Shaffer, Christopher L
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Cot COT MODULATORS AND METHODS OF USE THEREOF
CLARK CHRISTOPHER T, KIM MUSONG, WATKINS WILLIAM J, KIRSCHBERG THORSTEN A, WRIGHT NATHAN E, LINK JOHN O, BACON ELIZABETH M, COTTELL JEROMY J, SCHROEDER SCOTT D, SQUIRES NEIL H, TAYLOR JAMES G, STEVENS KIRK L, BALAN GAYATRI, CHOU CHIEN HUNG, PHILLIPS GARY, ZIPFEL SHEILA M
Year of Publication 23.09.2022
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Year of Publication 23.09.2022
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The synthesis and in vivo evaluation of [18 F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)
Skaddan, Marc B, Zhang, Lei, Johnson, Douglas S, Zhu, Aijun, Zasadny, Kenneth R, Coelho, Richard V, Kuszpit, Kyle, Currier, Gwen, Fan, Kuo-Hsien, Beck, Elizabeth M, Chen, Laigao, Drozda, Susan E, Balan, Gayatri, Niphakis, Micah, Cravatt, Benjamin F, Ahn, Kay, Bocan, Thomas, Villalobos, Anabella
Published in Nuclear medicine and biology (01.10.2012)
Published in Nuclear medicine and biology (01.10.2012)
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HPK1 억제제로서의 치환된 6-아자벤즈이미다졸 화합물
ZABLOCKI JEFF, KIM MUSONG, CHANDRASEKHAR JAYARAMAN, LEE SEUNG H, SWAMINATHAN SUNDARAMOORTHI, MITCHELL SCOTT A, BALAN GAYATRI, LOYER DREW JENNIFER A, COSMAN JENNIFER L, LO JENNIFER R, SALVO PATRICK J, KASUN ZACHARY A, CONWAY JOHN H, VAN VELDHUIZEN JOSHUA J, PHILLIPS GARY B, PERRY THAO D, YEUNG SUET C, BARTLETT MARK J, KALLA RAO V, CODELLI JULIAN A
Year of Publication 08.07.2021
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Year of Publication 08.07.2021
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HPK1 억제 활성을 갖는 치환된 6-아자벤즈이미다졸 화합물
ZABLOCKI JEFF, KIM MUSONG, CHANDRASEKHAR JAYARAMAN, LEE SEUNG H, MITCHELL SCOTT A, BALAN GAYATRI, LOYER DREW JENNIFER A, COSMAN JENNIFER L, LO JENNIFER R, SALVO PATRICK J, CONWAY JOHN H, VAN VELDHUIZEN JOSHUA J, PHILLIPS GARY B, PERRY THAO D, YEUNG SUET C, BARTLETT MARK J, KALLA RAO V, CODELLI JULIAN A
Year of Publication 07.07.2021
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Year of Publication 07.07.2021
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Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3- d]pyrimidine core
Dow, Robert L., Andrews, Melissa, Aspnes, Gary E., Balan, Gayatri, Michael Gibbs, E., Guzman-Perez, Angel, Karki, Kapil, LaPerle, Jennifer L., Li, Jian-Cheng, Litchfield, John, Munchhof, Michael J., Perreault, Christian, Patel, Leena
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
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Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1 H -pyrazolo-[3,4- b ]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator
Zhang, Lei, Balan, Gayatri, Barreiro, Gabriela, Boscoe, Brian P., Chenard, Lois K., Cianfrogna, Julie, Claffey, Michelle M., Chen, Laigao, Coffman, Karen J., Drozda, Susan E., Dunetz, Joshua R., Fonseca, Kari R., Galatsis, Paul, Grimwood, Sarah, Lazzaro, John T., Mancuso, Jessica Y., Miller, Emily L., Reese, Matthew R., Rogers, Bruce N., Sakurada, Isao, Skaddan, Marc, Smith, Deborah L., Stepan, Antonia F., Trapa, Patrick, Tuttle, Jamison B., Verhoest, Patrick R., Walker, Daniel P., Wright, Ann S., Zaleska, Margaret M., Zasadny, Kenneth, Shaffer, Christopher L.
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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The discovery of novel calcium sensing receptor negative allosteric modulators
Balan, Gayatri, Bauman, Jonathan, Bhattacharya, Samit, Castrodad, Mayda, Healy, David R., Herr, Michael, Humphries, Paul, Jennings, Sandra, Kalgutkar, Amit S., Kapinos, Brendon, Khot, Vishal, Lazarra, Kimberly, Li, Mei, Li, Yan, Neagu, Constantin, Oliver, Robert, Piotrowski, David W., Price, David, Qi, Hong, Simmons, Holly A., Southers, James, Wei, Liuqing, Zhang, Yan, Paralkar, Vishwas M.
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
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Cot 6---3-6-AMINO-QUINOLINE-3-CARBONITRILS AS COT MODULATORS
CLARK CHRISTOPHER T, KIM MUSONG, WATKINS WILLIAM J, KIRSCHBERG THORSTEN A, WRIGHT NATHAN E, LINK JOHN O, BACON ELIZABETH M, COTTELL JEROMY J, SCHROEDER SCOTT D, SQUIRES NEIL H, TAYLOR JAMES G, STEVENS KIRK L, BALAN GAYATRI, CHOU CHIEN HUNG, PHILLIPS GARY, ZIPFEL SHEILA M
Year of Publication 03.03.2020
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Year of Publication 03.03.2020
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Cot COT MODULATORS AND METHODS OF USE THEREOF
CLARK CHRISTOPHER T, KIM MUSONG, WATKINS WILLIAM J, KIRSCHBERG THORSTEN A, WRIGHT NATHAN E, LINK JOHN O, BACON ELIZABETH M, COTTELL JEROMY J, SCHROEDER SCOTT D, SQUIRES NEIL H, TAYLOR JAMES G, STEVENS KIRK L, BALAN GAYATRI, CHOU CHIEN HUNG, PHILLIPS GARY, ZIPFEL SHEILA M
Year of Publication 05.02.2020
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Year of Publication 05.02.2020
Patent
Chemically-enabled synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones
Humphries, Paul S., Balan, Gayatri, Bechle, Bruce M., Conn, Edward L., Dirico, Kenneth J., Hui, Yu, Oliver, Robert M., Southers, James A., Yang, Xiaojing
Published in Tetrahedron letters (06.05.2009)
Published in Tetrahedron letters (06.05.2009)
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Cot COT MODULATORS AND METHODS OF USE THEREOF
CLARK CHRISTOPHER T, KIM MUSONG, WATKINS WILLIAM J, KIRSCHBERG THORSTEN A, WRIGHT NATHAN E, LINK JOHN O, BACON ELIZABETH M, COTTELL JEROMY J, SCHROEDER SCOTT D, SQUIRES NEIL H, TAYLOR JAMES G, STEVENS KIRK L, BALAN GAYATRI, CHOU CHIEN HUNG, PHILLIPS GARY, ZIPFEL SHEILA M
Year of Publication 02.05.2019
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Year of Publication 02.05.2019
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Cot 조정제 및 그의 사용 방법
CLARK CHRISTOPHER T, KIM MUSONG, WATKINS WILLIAM J, KIRSCHBERG THORSTEN A, WRIGHT NATHAN E, LINK JOHN O, BACON ELIZABETH M, COTTELL JEROMY J, SCHROEDER SCOTT D, SQUIRES NEIL H, TAYLOR JAMES G, STEVENS KIRK L, BALAN GAYATRI, CHOU CHIEN HUNG, PHILLIPS GARY, ZIPFEL SHEILA M
Year of Publication 06.03.2018
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Year of Publication 06.03.2018
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