In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy
Becker, Kolja, Klein, Holger, Simon, Eric, Viollet, Coralie, Haslinger, Christian, Leparc, German, Schultheis, Christian, Chong, Victor, Kuehn, Markus H, Fernandez-Albert, Francesc, Bakker, Remko A
Published in Scientific reports (18.05.2021)
Published in Scientific reports (18.05.2021)
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The histamine H3 receptor: from gene cloning to H3 receptor drugs
Leurs, Rob, Bakker, Remko A, Timmerman, Henk, de Esch, Iwan J P
Published in Nature reviews. Drug discovery (01.02.2005)
Published in Nature reviews. Drug discovery (01.02.2005)
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Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes
Becker, Kolja, Weigelt, Carina M, Fuchs, Holger, Viollet, Coralie, Rust, Werner, Wyatt, Hannah, Huber, Jochen, Lamla, Thorsten, Fernandez-Albert, Francesc, Simon, Eric, Zippel, Nina, Bakker, Remko A, Klein, Holger, Redemann, Norbert H
Published in Scientific reports (12.11.2022)
Published in Scientific reports (12.11.2022)
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Journal Article
A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein
Schnapp, Gisela, Hoevels, Yvette, Bakker, Remko A., Schreiner, Patrick, Klein, Thomas, Nar, Herbert
Published in ChemMedChem (17.02.2021)
Published in ChemMedChem (17.02.2021)
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Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity
Smit, Martine J, Vischer, Henry F, Bakker, Remko A, Jongejan, Aldo, Timmerman, Henk, Pardo, Leonardo, Leurs, Rob
Published in Annual review of pharmacology and toxicology (01.01.2007)
Published in Annual review of pharmacology and toxicology (01.01.2007)
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Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells
Markert, Elke K, Klein, Holger, Viollet, Coralie, Rust, Werner, Strobel, Benjamin, Kauschke, Stefan G, Makovoz, Bar, Neubauer, Heike, Bakker, Remko A, Blenkinsop, Timothy A
Published in Frontiers in cell and developmental biology (26.08.2022)
Published in Frontiers in cell and developmental biology (26.08.2022)
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Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy
Lebon, Cecile, Neubauer, Heike, Berdugo, Marianne, Delaunay, Kimberley, Markert, Elke, Becker, Kolja, Baum-Kroker, Katja S., Prestle, Jürgen, Fuchs, Holger, Bakker, Remko A., Behar-Cohen, Francine
Published in Pharmaceutics (21.07.2021)
Published in Pharmaceutics (21.07.2021)
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Characterization of the Histamine H4 Receptor Binding Site. Part 1. Synthesis and Pharmacological Evaluation of Dibenzodiazepine Derivatives
Smits, Rogier A, Lim, Herman D, Stegink, Bart, Bakker, Remko A, de Esch, Iwan J. P, Leurs, Rob
Published in Journal of medicinal chemistry (27.07.2006)
Published in Journal of medicinal chemistry (27.07.2006)
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Molecular determinants of ligand binding to H4R species variants
Lim, Herman D, de Graaf, Chris, Jiang, Wen, Sadek, Payman, McGovern, Patricia M, Istyastono, Enade P, Bakker, Remko A, de Esch, Iwan J P, Thurmond, Robin L, Leurs, Rob
Published in Molecular pharmacology (01.05.2010)
Published in Molecular pharmacology (01.05.2010)
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Phenylalanine 169 in the Second Extracellular Loop of the Human Histamine H4 Receptor Is Responsible for the Difference in Agonist Binding between Human and Mouse H4 Receptors
Lim, Herman D, Jongejan, Aldo, Bakker, Remko A, Haaksma, Eric, de Esch, Iwan J P, Leurs, Rob
Published in The Journal of pharmacology and experimental therapeutics (01.10.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2008)
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BI-Y, an Neuropilin-1 Antagonist, Enhances Revascularization and Prevents Vascular Endothelial Growth Factor-A Induced Retinal Hyperpermeability in Rodent Models of Retinopathies
Thomas, Leo, Low, Sarah, Hansen, Gale, Bakker, Remko A, Zippel, Nina
Published in The Journal of pharmacology and experimental therapeutics (01.06.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2023)
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Journal Article
Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor
van Rijn, Richard M, van Marle, André, Chazot, Paul L, Langemeijer, Ellen, Qin, Yongjun, Shenton, Fiona C, Lim, Herman D, Zuiderveld, Obbe P, Sansuk, Kamonchanok, Dy, Michel, Smit, Martine J, Tensen, Cornelis P, Bakker, Remko A, Leurs, Rob
Published in Biochemical journal (15.08.2008)
Published in Biochemical journal (15.08.2008)
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Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists
BAKKER, R. A, WIELAND, K, TIMMERMAN, H, LEURS, R
Published in European journal of pharmacology (01.11.2000)
Published in European journal of pharmacology (01.11.2000)
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Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model
Nakamura, Shinsuke, Nishinaka, Anri, Hidaka, Yae, Shimazawa, Masamitsu, Thomas, Leo, Bakker, Remko A., Hara, Hideaki
Published in Investigative ophthalmology & visual science (13.07.2022)
Published in Investigative ophthalmology & visual science (13.07.2022)
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Journal Article
Domain Swapping in the Human Histamine H1 Receptor
Bakker, Remko A, Dees, Guido, Carrillo, Juan J, Booth, Raymond G, López-Gimenez, Juan F, Milligan, Graeme, Strange, Philip G, Leurs, Rob
Published in The Journal of pharmacology and experimental therapeutics (01.10.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2004)
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Journal Article
Discovery of Naturally Occurring Splice Variants of the Rat Histamine H3 Receptor That Act as Dominant-Negative Isoforms
Bakker, Remko A, Lozada, Adrian Flores, van Marle, André, Shenton, Fiona C, Drutel, Guillaume, Karlstedt, Kaj, Hoffmann, Marcel, Lintunen, Minnamaija, Yamamoto, Yumiko, van Rijn, Richard M, Chazot, Paul L, Panula, Pertti, Leurs, Rob
Published in Molecular pharmacology (01.04.2006)
Published in Molecular pharmacology (01.04.2006)
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An 80-Amino Acid Deletion in the Third Intracellular Loop of a Naturally Occurring Human Histamine H3 Isoform Confers Pharmacological Differences and Constitutive Activity
Bongers, Gerold, Krueger, Kathleen M, Miller, Thomas R, Baranowski, John L, Estvander, Brian R, Witte, David G, Strakhova, Marina I, van Meer, Peter, Bakker, Remko A, Cowart, Marlon D, Hancock, Arthur A, Esbenshade, Timothy A, Leurs, Rob
Published in The Journal of pharmacology and experimental therapeutics (01.12.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2007)
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Journal Article
GPCR Proteomics: Mass Spectrometric and Functional Analysis of Histamine H1 Receptor after Baculovirus-Driven and in Vitro Cell Free Expression
Sansuk, Kamonchanok, Balog, Crina I. A, van der Does, Anne M, Booth, Raymond, de Grip, Willem J, Deelder, André M, Bakker, Remko A, Leurs, Rob, Hensbergen, Paul J
Published in Journal of proteome research (01.02.2008)
Published in Journal of proteome research (01.02.2008)
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Journal Article
A Selective Human H4-Receptor Agonist: (−)-2-Cyano-1-methyl-3-{(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine
Hashimoto, Takeshi, Harusawa, Shinya, Araki, Lisa, Zuiderveld, Obbe P, Smit, Martine J, Imazu, Tomonari, Takashima, Seiichiroh, Yamamoto, Yumiko, Sakamoto, Yasuhiko, Kurihara, Takushi, Leurs, Rob, Bakker, Remko A, Yamatodani, Atsushi
Published in Journal of medicinal chemistry (03.07.2003)
Published in Journal of medicinal chemistry (03.07.2003)
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