Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition
Nakagawa, Shigeki, Wei, Lan, Song, Won Min, Higashi, Takaaki, Ghoshal, Sarani, Kim, Rosa S., Bian, C. Billie, Yamada, Suguru, Sun, Xiaochen, Venkatesh, Anu, Goossens, Nicolas, Bain, Gretchen, Lauwers, Gregory Y., Koh, Anna P., El-Abtah, Mohamed, Ahmad, Noor B., Hoshida, Hiroki, Erstad, Derek J., Gunasekaran, Ganesh, Lee, Youngmin, Yu, Ming-Lung, Chuang, Wan-Long, Dai, Chia-Yen, Kobayashi, Masahiro, Kumada, Hiromitsu, Beppu, Toru, Baba, Hideo, Mahajan, Milind, Nair, Venugopalan D., Lanuti, Michael, Villanueva, Augusto, Sangiovanni, Angelo, Iavarone, Massimo, Colombo, Massimo, Llovet, Josep M., Subramanian, Aravind, Tager, Andrew M., Friedman, Scott L., Baumert, Thomas F., Schwarz, Myron E., Chung, Raymond T., Tanabe, Kenneth K., Zhang, Bin, Fuchs, Bryan C., Hoshida, Yujin
Published in Cancer cell (12.12.2016)
Published in Cancer cell (12.12.2016)
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An Autotaxin/Lysophosphatidic Acid/Interleukin‐6 Amplification Loop Drives Scleroderma Fibrosis
Castelino, Flavia V., Bain, Gretchen, Pace, Veronica A., Black, Katharine E., George, Leaya, Probst, Clemens K., Goulet, Lance, Lafyatis, Robert, Tager, Andrew M.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.12.2016)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.12.2016)
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Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma
Castelino, Flavia V., Seiders, Jon, Bain, Gretchen, Brooks, Sarah F., King, Christopher D., Swaney, James S., Lorrain, Daniel S., Chun, Jerold, Luster, Andrew D., Tager, Andrew M.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2011)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2011)
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Identification of 4‑(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)
Rowbottom, Martin W, Bain, Gretchen, Calderon, Imelda, Lasof, Taylor, Lonergan, David, Lai, Andiliy, Huang, Fei, Darlington, Janice, Prodanovich, Patricia, Santini, Angelina M, King, Christopher D, Goulet, Lance, Shannon, Kristen E, Ma, Gina L, Nguyen, Katherine, MacKenna, Deidre A, Evans, Jilly F, Hutchinson, John H
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders
Ambrus-Aikelin, Geza, Takeda, Katsuyuki, Joetham, Anthony, Lazic, Milos, Povero, Davide, Santini, Angelina M., Pranadinata, Rama, Johnson, Casey D., McGeough, Matthew D., Beasley, Federico C., Stansfield, Ryan, McBride, Christopher, Trzoss, Lynnie, Hoffman, Hal M., Feldstein, Ariel E., Stafford, Jeffrey A., Veal, James M., Bain, Gretchen, Gelfand, Erwin W.
Published in Scientific reports (19.08.2023)
Published in Scientific reports (19.08.2023)
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Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis
Bain, Gretchen, Shannon, Kristen E, Huang, Fei, Darlington, Janice, Goulet, Lance, Prodanovich, Patricia, Ma, Gina L, Santini, Angelina M, Stein, Adam J, Lonergan, Dave, King, Christopher D, Calderon, Imelda, Lai, Andiliy, Hutchinson, John H, Evans, Jilly F
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)
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Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders
Ambrus-Aikelin, Geza, Takeda, Katsuyuki, Joetham, Anthony, Lazic, Milos, Povero, Davide, Santini, Angelina M., Pranadinata, Rama, Johnson, Casey D., McGeough, Matthew D., Beasley, Federico C., Stansfield, Ryan, McBride, Christopher, Trzoss, Lynnie, Hoffman, Hal M., Feldstein, Ariel E., Stafford, Jeffrey A., Veal, James M., Bain, Gretchen, Gelfand, Erwin W.
Published in Scientific reports (16.11.2023)
Published in Scientific reports (16.11.2023)
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The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage
Sakai, Norihiko, Bain, Gretchen, Furuichi, Kengo, Iwata, Yasunori, Nakamura, Miki, Hara, Akinori, Kitajima, Shinji, Sagara, Akihiro, Miyake, Taito, Toyama, Tadashi, Sato, Koichi, Nakagawa, Shiori, Shimizu, Miho, Kaneko, Shuichi, Wada, Takashi
Published in Scientific reports (15.05.2019)
Published in Scientific reports (15.05.2019)
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Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade
Murre, Cornelis, Bain, Gretchen, Cravatt, Celia B, Loomans, Cindy, Alberola-Ila, Jose, Hedrick, Stephen M
Published in Nature immunology (01.02.2001)
Published in Nature immunology (01.02.2001)
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Early thymocyte development is regulated by modulation of E2A protein activity
Engel, I, Johns, C, Bain, G, Rivera, R R, Murre, C
Published in The Journal of experimental medicine (17.09.2001)
Published in The Journal of experimental medicine (17.09.2001)
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Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2
Schaffhauser, Hervé, Rowe, Blake A, Morales, Sylvia, Chavez-Noriega, Laura E, Yin, Ruoyuan, Jachec, Christine, Rao, Sara P, Bain, Gretchen, Pinkerton, Anthony B, Vernier, Jean-Michel, Bristow, Linda J, Varney, Mark A, Daggett, Lorrie P
Published in Molecular pharmacology (01.10.2003)
Published in Molecular pharmacology (01.10.2003)
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Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung
Stebbins, Karin J, Broadhead, Alex R, Baccei, Christopher S, Scott, Jill M, Truong, Yen P, Coate, Heather, Stock, Nicholas S, Santini, Angelina M, Fagan, Patrick, Prodanovich, Patricia, Bain, Gretchen, Stearns, Brian A, King, Christopher D, Hutchinson, John H, Prasit, Peppi, Evans, Jilly F, Lorrain, Daniel S
Published in The Journal of pharmacology and experimental therapeutics (01.03.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2010)
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5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-(( S)-1-Acetyl-2,3-dihydro-1 H-indol-2-ylmethoxy)-3- tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1 H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)—A potent FLAP inhibitor
Stock, Nicholas, Baccei, Christopher, Bain, Gretchen, Broadhead, Alex, Chapman, Charles, Darlington, Janice, King, Christopher, Lee, Catherine, Li, Yiwei, Lorrain, Daniel S., Prodanovich, Pat, Rong, Haojing, Santini, Angelina, Zunic, Jasmine, Evans, Jilly F., Hutchinson, John H., Prasit, Peppi
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Pharmacological Characterization of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic Acid (AM103), a Novel Selective 5-Lipoxygenase-Activating Protein Inhibitor That Reduces Acute and Chronic Inflammation
Lorrain, Daniel S, Bain, Gretchen, Correa, Lucia D, Chapman, Charles, Broadhead, Alex R, Santini, Angelina M, Prodanovich, Pat, Darlington, Janice V, Hutchinson, John H, King, Christopher, Lee, Catherine, Baccei, Christopher, Li, Yiwei, Arruda, Jeannie M, Evans, Jilly F
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
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A Novel 5-Lipoxygenase-Activating Protein Inhibitor, AM679, Reduces Inflammation in the Respiratory Syncytial Virus-Infected Mouse Eye
Musiyenko, Alla, Correa, Lucia, Stock, Nicholas, Hutchinson, John H, Lorrain, Daniel S, Bain, Gretchen, Evans, Jilly F, Barik, Sailen
Published in Clinical and Vaccine Immunology (01.11.2009)
Published in Clinical and Vaccine Immunology (01.11.2009)
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Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47
Bain, G, Quong, M W, Soloff, R S, Hedrick, S M, Murre, C
Published in The Journal of experimental medicine (06.12.1999)
Published in The Journal of experimental medicine (06.12.1999)
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Positive and negative regulation of V(D)J recombination by the E2A proteins
Bain, G, Romanow, W J, Albers, K, Havran, W L, Murre, C
Published in The Journal of experimental medicine (18.01.1999)
Published in The Journal of experimental medicine (18.01.1999)
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Both E12 and E47 Allow Commitment to the B Cell Lineage
Bain, Gretchen, Maandag, Els C.Robanus, Riele, Hein P.J.te, Feeney, Ann J, Sheehy, Ann, Schlissel, Mark, Shinton, Susan A, Hardy, Richard R, Murre, Cornelis
Published in Immunity (Cambridge, Mass.) (01.02.1997)
Published in Immunity (Cambridge, Mass.) (01.02.1997)
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DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection
Friedrich, Monica L., Wen, Ben G., Bain, Gretchen, Kee, Barbara L., Katayama, Carol, Murre, Cornelis, Hedrick, Stephen M., Walsh, Craig M.
Published in International immunology (01.11.2005)
Published in International immunology (01.11.2005)
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Overcoming Preclinical Safety Obstacles to Discover (S)‑N‑((1,2,3,5,6,7-Hexahydro‑s‑indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro‑5H‑pyrazolo[5,1‑b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor
McBride, Christopher, Trzoss, Lynnie, Povero, Davide, Lazic, Milos, Ambrus-Aikelin, Geza, Santini, Angelina, Pranadinata, Rama, Bain, Gretchen, Stansfield, Ryan, Stafford, Jeffrey A., Veal, James, Takahashi, Ryan, Ly, Justin, Chen, Shu, Liu, Liling, Nespi, Marika, Blake, Robert, Katewa, Arna, Kleinheinz, Tracy, Sujatha-Bhaskar, Swathi, Ramamoorthi, Nandhini, Sims, Jessica, McKenzie, Brent, Chen, Mark, Ultsch, Mark, Johnson, Matthew, Murray, Jeremy, Ciferri, Claudio, Staben, Steven T., Townsend, Michael J., Stivala, Craig E.
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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