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Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation

Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation

by Bain, Gretchen, Lorrain, Daniel S, Stebbins, Karin J, Broadhead, Alex R, Santini, Angelina M, Prodanovich, Pat, Darlington, Janice, King, Christopher D, Lee, Catherine, Baccei, Christopher, Stearns, Brian, Troung, Yen, Hutchinson, John H, Prasit, Peppi, Evans, Jilly F
Published in The Journal of pharmacology and experimental therapeutics (01.07.2011)

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Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis

Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis

by STEARNS, Brian A, BACCEI, Christopher, LEE, Catherine, LORRAIN, Daniel S, PRASIT, Peppi, PRODANOVICH, Pat, SANTINI, Angelina, SCOTT, Jill M, STOCK, Nicholas S, TRUONG, Yen P, BAIN, Gretchen, BROADHEAD, Alex, CLARK, Ryan C, COATE, Heather, EVANS, Jilly F, FAGAN, Patrick, HUTCHINSON, John H, KING, Christopher
Published in Bioorganic & medicinal chemistry letters (15.08.2009)

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Pharmacodynamics, pharmacokinetics and safety of GSK 2190915, a novel oral anti‐inflammatory 5‐lipoxygenase‐activating protein inhibitor

Pharmacodynamics, pharmacokinetics and safety of GSK 2190915, a novel oral anti‐inflammatory 5‐lipoxygenase‐activating protein inhibitor

by Bain, Gretchen, King, Christopher D., Schaab, Kevin, Rewolinski, Melissa, Norris, Virginia, Ambery, Claire, Bentley, Jane, Yamada, Masanori, Santini, Angelina M., van de Wetering de Rooij, Jeroen, Stock, Nicholas, Zunic, Jasmine, Hutchinson, John H., Evans, Jilly F.
Published in British journal of clinical pharmacology (01.03.2013)

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Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation

Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation

by Lorrain, Daniel S., Bain, Gretchen, Correa, Lucia D., Chapman, Charles, Broadhead, Alex R., Santini, Angelina M., Prodanovich, Patricia P., Darlington, Janice V., Stock, Nicholas S., Zunic, Jasmine, King, Christopher D., Lee, Catherine, Baccei, Christopher S., Stearns, Brian, Roppe, Jeffrey, Hutchinson, John H., Prasit, Peppi, Evans, Jilly F.
Published in European journal of pharmacology (25.08.2010)

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Discovery and optimization of a biphenylacetic acid series of prostaglandin D 2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis

Discovery and optimization of a biphenylacetic acid series of prostaglandin D 2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis

by Scott, Jill M., Baccei, Christopher, Bain, Gretchen, Broadhead, Alex, Evans, Jilly F., Fagan, Patrick, Hutchinson, John H., King, Christopher, Lorrain, Daniel S., Lee, Catherine, Prasit, Peppi, Prodanovich, Pat, Santini, Angelina, Stearns, Brian A.
Published in Bioorganic & medicinal chemistry letters (01.11.2011)

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Sodium [2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D 2 receptor antagonist

Sodium [2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D 2 receptor antagonist

by Stock, Nicholas, Volkots, Deborah, Stebbins, Karin, Broadhead, Alex, Stearns, Brian, Roppe, Jeffrey, Parr, Timothy, Baccei, Christopher, Bain, Gretchen, Chapman, Charles, Correa, Lucia, Darlington, Janice, King, Christopher, Lee, Catherine, Lorrain, Daniel S., Prodanovich, Pat, Santini, Angelina, Evans, Jilly F., Hutchinson, John H., Prasit, Peppi
Published in Bioorganic & medicinal chemistry letters (01.02.2011)

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Sodium [2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D₂ receptor antagonist

Sodium [2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D₂ receptor antagonist

by Stock, Nicholas, Volkots, Deborah, Stebbins, Karin, Broadhead, Alex, Stearns, Brian, Roppe, Jeffrey, Parr, Timothy, Baccei, Christopher, Bain, Gretchen, Chapman, Charles, Correa, Lucia, Darlington, Janice, King, Christopher, Lee, Catherine, Lorrain, Daniel S, Prodanovich, Pat, Santini, Angelina, Evans, Jilly F, Hutchinson, John H, Prasit, Peppi
Published in Bioorganic & medicinal chemistry letters (01.02.2011)

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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

by Bain, Gretchen, Maandag, Els C.Robanus, Izon, David J., Amsen, Derk, Kruisbeek, Ada M., Weintraub, Bennett C., Krop, Ian, Schlissel, Mark S., Feeney, Ann J., van Roon, Marian, van der Valk, Martin, te Riele, Hein P.J., Berns, Anton, Murre, Cornelis
Published in Cell (02.12.1994)

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Discovery and optimization of a biphenylacetic acid series of prostaglandin D sub(2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis)

Discovery and optimization of a biphenylacetic acid series of prostaglandin D sub(2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis)

by Scott, Jill M, Baccei, Christopher, Bain, Gretchen, Broadhead, Alex, Evans, Jilly F, Fagan, Patrick, Hutchinson, John H, King, Christopher, Lorrain, Daniel S, Lee, Catherine, Prasit, Peppi, Prodanovich, Pat, Santini, Angelina, Stearns, Brian A
Published in Bioorganic & medicinal chemistry letters (01.11.2011)

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5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)—A potent FLAP inhibitor suitable for topical administration

5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)—A potent FLAP inhibitor suitable for topical administration

by Stock, Nicholas, Baccei, Christopher, Bain, Gretchen, Chapman, Charles, Correa, Lucia, Darlington, Janice, King, Christopher, Lee, Catherine, Lorrain, Daniel S., Prodanovich, Pat, Santini, Angelina, Schaab, Kevin, Evans, Jilly F., Hutchinson, John H., Prasit, Peppi
Published in Bioorganic & medicinal chemistry letters (01.08.2010)

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Discovery and optimization of a biphenylacetic acid series of prostaglandin D₂ receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis

Discovery and optimization of a biphenylacetic acid series of prostaglandin D₂ receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis

by Scott, Jill M, Baccei, Christopher, Bain, Gretchen, Broadhead, Alex, Evans, Jilly F, Fagan, Patrick, Hutchinson, John H, King, Christopher, Lorrain, Daniel S, Lee, Catherine, Prasit, Peppi, Prodanovich, Pat, Santini, Angelina, Stearns, Brian A
Published in Bioorganic & medicinal chemistry letters (01.11.2011)

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The role of E-proteins in B- and T-lymphocyte development

The role of E-proteins in B- and T-lymphocyte development

by Bain, Gretchen, Murre, Cornelis
Published in Seminars in immunology (01.04.1998)

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Pharmacological Characterization of 3-[3- tert -Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1 H -indol-2-yl]-2,2-dimethyl-propionic Acid (AM103), a Novel Selective 5-Lipoxygenase-Activating Protein Inhibitor That Reduces Acute and Chronic Inflammation

Pharmacological Characterization of 3-[3- tert -Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1 H -indol-2-yl]-2,2-dimethyl-propionic Acid (AM103), a Novel Selective 5-Lipoxygenase-Activating Protein Inhibitor That Reduces Acute and Chronic Inflammation

by Lorrain, Daniel S., Bain, Gretchen, Correa, Lucia D., Chapman, Charles, Broadhead, Alex R., Santini, Angelina M., Prodanovich, Pat, Darlington, Janice V., Hutchinson, John H., King, Christopher, Lee, Catherine, Baccei, Christopher, Li, Yiwei, Arruda, Jeannie M., Evans, Jilly F.
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)

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5-Lipoxygenase-Activating Protein Inhibitors: Development of 3-[3- tert -Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1 H -indol-2-yl]-2,2-dimethyl-propionic Acid (AM103)

5-Lipoxygenase-Activating Protein Inhibitors: Development of 3-[3- tert -Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1 H -indol-2-yl]-2,2-dimethyl-propionic Acid (AM103)

by Hutchinson, John H., Li, Yiwei, Arruda, Jeannie M., Baccei, Christopher, Bain, Gretchen, Chapman, Charles, Correa, Lucia, Darlington, Janice, King, Christopher D., Lee, Catherine, Lorrain, Dan, Prodanovich, Pat, Rong, Haojing, Santini, Angelina, Stock, Nicholas, Prasit, Peppi, Evans, Jilly F.
Published in Journal of medicinal chemistry (08.10.2009)

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IL-7Rα and E47: independent pathways required for development of multipotent lymphoid progenitors

IL-7Rα and E47: independent pathways required for development of multipotent lymphoid progenitors

by Kee, Barbara L., Bain, Gretchen, Murre, Cornelis
Published in The EMBO journal (15.01.2002)

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Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'- (6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D sub(2) receptor antagonist

Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'- (6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D sub(2) receptor antagonist

by Stock, Nicholas, Volkots, Deborah, Stebbins, Karin, Broadhead, Alex, Stearns, Brian, Roppe, Jeffrey, Parr, Timothy, Baccei, Christopher, Bain, Gretchen, Chapman, Charles, Correa, Lucia, Darlington, Janice, King, Christopher, Lee, Catherine, Lorrain, Daniel S, Prodanovich, Pat, Santini, Angelina, Evans, Jilly F, Hutchinson, John H, Prasit, Peppi
Published in Bioorganic & medicinal chemistry letters (01.02.2011)

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Journal Article

5-Lipoxygenase-activating protein inhibitors. Part 3: 3-[3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)—A potent FLAP inhibitor suitable for topical administration

5-Lipoxygenase-activating protein inhibitors. Part 3: 3-[3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)—A potent FLAP inhibitor suitable for topical administration

by STOCK, Nicholas, BACCEI, Christopher, SANTINI, Angelina, SCHAAB, Kevin, EVANS, Jilly F, HUTCHINSON, John H, PRASIT, Peppi, BAIN, Gretchen, CHAPMAN, Charles, CORREA, Lucia, DARLINGTON, Janice, KING, Christopher, LEE, Catherine, LORRAIN, Daniel S, PRODANOVICH, Pat
Published in Bioorganic & medicinal chemistry letters (2010)

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The geminal dimethyl analogue of Flurbiprofen as a novel Aβ42 inhibitor and potential Alzheimer's disease modifying agent

The geminal dimethyl analogue of Flurbiprofen as a novel Aβ42 inhibitor and potential Alzheimer's disease modifying agent

by STOCK, Nicholas, MUNOZ, Benito, ST-JACQUES, René, PRASIT, Peppi, WRIGLEY, Jonathan D. J, SHEARMAN, Mark S, BEHER, Dirk, PEACHEY, James, WILLIAMSON, Toni L, BAIN, Gretchen, WEICHAO CHEN, XIAOHUI JIANG
Published in Bioorganic & medicinal chemistry letters (15.04.2006)

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IL-7R[alpha] and E47: independent pathways required for development of multipotent lymphoid progenitors

IL-7R[alpha] and E47: independent pathways required for development of multipotent lymphoid progenitors

by Kee, Barbara L, Bain, Gretchen, Murre, Cornelis
Published in The EMBO journal (15.01.2002)

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IL-7Ra and E47: independent pathways required for development of multipotent lymphoid progenitors

IL-7Ra and E47: independent pathways required for development of multipotent lymphoid progenitors

by Kee, Barbara L, Bain, Gretchen, Murre, Cornelis
Published in The EMBO journal (15.01.2002)

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