Discovery of 2‑(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)‑yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases
Ruggeri, Roger B, Buckbinder, Leonard, Bagley, Scott W, Carpino, Philip A, Conn, Edward L, Dowling, Matthew S, Fernando, Dilinie P, Jiao, Wenhua, Kung, Daniel W, Orr, Suvi T. M, Qi, Yingmei, Rocke, Benjamin N, Smith, Aaron, Warmus, Joseph S, Zhang, Yan, Bowles, Daniel, Widlicka, Daniel W, Eng, Heather, Ryder, Tim, Sharma, Raman, Wolford, Angela, Okerberg, Carlin, Walters, Karen, Maurer, Tristan S, Zhang, Yanwei, Bonin, Paul D, Spath, Samantha N, Xing, Gang, Hepworth, David, Ahn, Kay, Kalgutkar, Amit S
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors
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Published in Journal of organic chemistry (16.11.2012)
Published in Journal of organic chemistry (16.11.2012)
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Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates
Li, Qi Yukki, Gockel, Samuel N., Lutovsky, Grace A., DeGlopper, Kimberly S., Baldwin, Neil J., Bundesmann, Mark W., Tucker, Joseph W., Bagley, Scott W., Yoon, Tehshik P.
Published in Nature chemistry (01.01.2022)
Published in Nature chemistry (01.01.2022)
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Application of Fundamental Organometallic Chemistry to the Development of a Gold-Catalyzed Synthesis of Sulfinate Derivatives
Johnson, Miles W., Bagley, Scott W., Mankad, Neal P., Bergman, Robert G., Mascitti, Vincent, Toste, F. Dean
Published in Angewandte Chemie International Edition (22.04.2014)
Published in Angewandte Chemie International Edition (22.04.2014)
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Synthesis of 2‑Arylpiperidines via Pd-Catalyzed Arylation of Aza-Achmatowicz Rearrangement Products with Arylboronic Acids
Zhao, Guodong, Canterbury, Daniel P, Taylor, Alexandria P, Cheng, Xiayun, Mikochik, Peter, Bagley, Scott W, Tong, Rongbiao
Published in Organic letters (17.01.2020)
Published in Organic letters (17.01.2020)
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A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide‑1 Receptor
Griffith, David A., Edmonds, David J., Fortin, Jean-Philippe, Kalgutkar, Amit S., Kuzmiski, J. Brent, Loria, Paula M., Saxena, Aditi R., Bagley, Scott W., Buckeridge, Clare, Curto, John M., Derksen, David R., Dias, João M., Griffor, Matthew C., Han, Seungil, Jackson, V. Margaret, Landis, Margaret S., Lettiere, Daniel, Limberakis, Chris, Liu, Yuhang, Mathiowetz, Alan M., Patel, Jayesh C., Piotrowski, David W., Price, David A., Ruggeri, Roger B., Tess, David A.
Published in Journal of medicinal chemistry (23.06.2022)
Published in Journal of medicinal chemistry (23.06.2022)
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Convergent Syntheses of Isomeric Imidazolospiroketones as Templates for Acetyl-CoA Carboxylase (ACC) Inhibitors
Limberakis, Chris, Smith, Aaron C., Bagley, Scott W., Yayla, Hatice G., Kung, Daniel W., Griffith, David A.
Published in Journal of organic chemistry (06.10.2023)
Published in Journal of organic chemistry (06.10.2023)
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Iron-mediated modular decarboxylative cross-nucleophile coupling
Lutovsky, Grace A., Gockel, Samuel N., Bundesmann, Mark W., Bagley, Scott W., Yoon, Tehshik P.
Published in Chem (08.06.2023)
Published in Chem (08.06.2023)
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6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor
Aspnes, Gary E., Bagley, Scott W., Coffey, Steven B., Conn, Edward L., Curto, John M., Edmonds, David J., Genovino, Julien, Griffith, David A., Ingle, Gajendra, Jiao, Wenhua, Limberakis, Chris, Mathiowetz, Alan M., Piotrowski, David W., Rose, Colin R., Ruggeri, Roger B., Wei, Liuqing
Published in Bioorganic & medicinal chemistry letters (01.10.2023)
Published in Bioorganic & medicinal chemistry letters (01.10.2023)
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Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes
Griffith, David A, Kung, Daniel W, Esler, William P, Amor, Paul A, Bagley, Scott W, Beysen, Carine, Carvajal-Gonzalez, Santos, Doran, Shawn D, Limberakis, Chris, Mathiowetz, Alan M, McPherson, Kirk, Price, David A, Ravussin, Eric, Sonnenberg, Gabriele E, Southers, James A, Sweet, Laurel J, Turner, Scott M, Vajdos, Felix F
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Huard, Kim, Smith, Aaron C, Cappon, Gregg, Dow, Robert L, Edmonds, David J, El-Kattan, Ayman, Esler, William P, Fernando, Dilinie P, Griffith, David A, Kalgutkar, Amit S, Ross, Trenton T, Bagley, Scott W, Beebe, David, Bi, Yi-An, Cabral, Shawn, Crowley, Collin, Doran, Shawn D, Dowling, Matthew S, Liras, Spiros, Mascitti, Vincent, Niosi, Mark, Pfefferkorn, Jeffrey A, Polivkova, Jana, Préville, Cathy, Price, David A, Shavnya, Andre, Shirai, Norimitsu, Smith, Andrew H, Southers, James R, Tess, David A, Thuma, Benjamin A, Varma, Manthena V, Yang, Xiaojing
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Discovery of a Novel Small-Molecule Modulator of C–X–C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis
Menhaji-Klotz, Elnaz, Hesp, Kevin D, Londregan, Allyn T, Kalgutkar, Amit S, Piotrowski, David W, Boehm, Markus, Song, Kun, Ryder, Tim, Beaumont, Kevin, Jones, Rhys M, Atkinson, Karen, Brown, Janice A, Litchfield, John, Xiao, Jun, Canterbury, Daniel P, Burford, Kristen, Thuma, Benjamin A, Limberakis, Chris, Jiao, Wenhua, Bagley, Scott W, Agarwal, Saket, Crowell, Danielle, Pazdziorko, Stephen, Ward, Jessica, Price, David A, Clerin, Valerie
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
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2‑Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety
Dow, Robert L, Ammirati, Mark, Bagley, Scott W, Bhattacharya, Samit K, Buckbinder, Leonard, Cortes, Christian, El-Kattan, Ayman F, Ford, Kristen, Freeman, Gary B, Guimarães, Cristiano R. W, Liu, Shenping, Niosi, Mark, Skoura, Athanasia, Tess, David
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems
Smith, Aaron C, Cabral, Shawn, Kung, Daniel W, Rose, Colin R, Southers, James A, García-Irizarry, Carmen N, Damon, David B, Bagley, Scott W, Griffith, David A
Published in Journal of organic chemistry (06.05.2016)
Published in Journal of organic chemistry (06.05.2016)
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Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure
Griffith, David A, Dow, Robert L, Huard, Kim, Edmonds, David J, Bagley, Scott W, Polivkova, Jana, Zeng, Dongxiang, Garcia-Irizarry, Carmen N, Southers, James A, Esler, William, Amor, Paul, Loomis, Kathrine, McPherson, Kirk, Bahnck, Kevin B, Préville, Cathy, Banks, Tereece, Moore, Dianna E, Mathiowetz, Alan M, Menhaji-Klotz, Elnaz, Smith, Aaron C, Doran, Shawn D, Beebe, David A, Dunn, Matthew F
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase
Kung, Daniel W., Griffith, David A., Esler, William P., Vajdos, Felix F., Mathiowetz, Alan M., Doran, Shawn D., Amor, Paul A., Bagley, Scott W., Banks, Tereece, Cabral, Shawn, Ford, Kristen, Garcia-Irizarry, Carmen N., Landis, Margaret S., Loomis, Kathrine, McPherson, Kirk, Niosi, Mark, Rockwell, Kristin L., Rose, Colin, Smith, Aaron C., Southers, James A., Tapley, Susan, Tu, Meihua, Valentine, James J.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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