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Published in American journal of physiology. Heart and circulatory physiology (01.02.2006)
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Inhibition of Vascular Endothelial Growth Factor (VEGF) Signaling in Cancer Causes Loss of Endothelial Fenestrations, Regression of Tumor Vessels, and Appearance of Basement Membrane Ghosts
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Published in The American journal of pathology (01.07.2004)
Published in The American journal of pathology (01.07.2004)
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Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent
Andraos, Rita, Qian, Zhiyan, Bonenfant, Débora, Rubert, Joëlle, Vangrevelinghe, Eric, Scheufler, Clemens, Marque, Fanny, Régnier, Catherine H, De Pover, Alain, Ryckelynck, Hugues, Bhagwat, Neha, Koppikar, Priya, Goel, Aviva, Wyder, Lorenza, Tavares, Gisele, Baffert, Fabienne, Pissot-Soldermann, Carole, Manley, Paul W, Gaul, Christoph, Voshol, Hans, Levine, Ross L, Sellers, William R, Hofmann, Francesco, Radimerski, Thomas
Published in Cancer discovery (01.06.2012)
Published in Cancer discovery (01.06.2012)
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Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor
Harding, James J., Bauer, Todd M., Tan, Daniel S. W., Bedard, Philippe L., Rodon, Jordi, Doi, Toshihiko, Schnell, Christian, Iyer, Varsha, Baffert, Fabienne, Radhakrishnan, Rajkumar, Fabre, Claire, Juric, Dejan
Published in Investigational new drugs (01.04.2019)
Published in Investigational new drugs (01.04.2019)
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A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression
Chapeau, Emilie A, Mandon, Emeline, Gill, Jason, Romanet, Vincent, Ebel, Nicolas, Powajbo, Violetta, Andraos-Rey, Rita, Qian, Zhiyan, Kininis, Miltos, Zumstein-Mecker, Sabine, Ito, Moriko, Hynes, Nancy E, Tiedt, Ralph, Hofmann, Francesco, Eshkind, Leonid, Bockamp, Ernesto, Kinzel, Bernd, Mueller, Matthias, Murakami, Masato, Baffert, Fabienne, Radimerski, Thomas
Published in PloS one (2019)
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Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period
Thurston, Gavin, Wang, Quan, Baffert, Fabienne, Rudge, John, Papadopoulos, Nicholas, Jean-Guillaume, Danielle, Wiegand, Stanley, Yancopoulos, George D, McDonald, Donald M
Published in Development (Cambridge) (01.07.2005)
Published in Development (Cambridge) (01.07.2005)
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Long-Term and Sustained COMP-Ang1 Induces Long-Lasting Vascular Enlargement and Enhanced Blood Flow
Cho, Chung-Hyun, Kim, Kyung Eun, Byun, Jonghoe, Jang, Hyung-Suk, Kim, Duk-Kyung, Baluk, Peter, Baffert, Fabienne, Lee, Gyun Min, Mochizuki, Naoki, Kim, Jin, Jeon, Byeong Hwa, McDonald, Donald M, Koh, Gou Young
Published in Circulation research (08.07.2005)
Published in Circulation research (08.07.2005)
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The Antiangiogenic Agent Neovastat (Æ-941) Inhibits Vascular Endothelial Growth Factor-mediated Biological Effects
BELIVEAU, Richard, GINGRAS, Denis, DIMITRIADOU, Violetta, PEPIN, Marie-Claude, COURJAL, Frank, RICARD, Isabelle, POYET, Patrick, FALARDEAU, Pierre, FIGG, William D, KRUGER, Erwin A, LAMY, Sylvie, SIROIS, Pierre, SIMARD, Bryan, SIROIS, Martin G, TRANQUI, Leone, BAFFERT, Fabienne, BEAULIEU, Edith
Published in Clinical cancer research (01.04.2002)
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Published in Clinical cancer research (01.04.2002)
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First-in-human study of naporafenib (LXH254) with or without spartalizumab in adult patients with advanced solid tumors harboring MAPK signaling pathway alterations
Janku, Filip, Kim, Tae Min, Iyer, Gopakumar, Spreafico, Anna, Elez, Elena, de Jonge, Maja, Yamamoto, Noboru, van der Wekken, Anthonie J, Ascierto, Paolo Antonio, Maur, Michela, Marmé, Frederik, Kiladjian, Jean-Jacques, Basu, Sumit, Baffert, Fabienne, Buigues, Amparo, Chen, Chi, Cooke, Vesselina, Giorgetti, Elisa, Kim, Jaeyeon, McCarthy, Fiona, Moschetta, Michele, Dummer, Reinhard
Published in European journal of cancer (1990) (01.01.2024)
Published in European journal of cancer (1990) (01.01.2024)
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Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia
Wu, Shuo-Chieh, Li, Loretta S., Kopp, Nadja, Montero, Joan, Chapuy, Bjoern, Yoda, Akinori, Christie, Amanda L., Liu, Huiyun, Christodoulou, Alexandra, van Bodegom, Diederik, van der Zwet, Jordy, Layer, Jacob V., Tivey, Trevor, Lane, Andrew A., Ryan, Jeremy A., Ng, Samuel Y., DeAngelo, Daniel J., Stone, Richard M., Steensma, David, Wadleigh, Martha, Harris, Marian, Mandon, Emeline, Ebel, Nicolas, Andraos, Rita, Romanet, Vincent, Dölemeyer, Arno, Sterker, Dario, Zender, Michael, Rodig, Scott J., Murakami, Masato, Hofmann, Francesco, Kuo, Frank, Eck, Michael J., Silverman, Lewis B., Sallan, Stephen E., Letai, Anthony, Baffert, Fabienne, Vangrevelinghe, Eric, Radimerski, Thomas, Gaul, Christoph, Weinstock, David M.
Published in Cancer cell (13.07.2015)
Published in Cancer cell (13.07.2015)
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Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition
Weigert, Oliver, Lane, Andrew A, Bird, Liat, Kopp, Nadja, Chapuy, Bjoern, van Bodegom, Diederik, Toms, Angela V, Marubayashi, Sachie, Christie, Amanda L, McKeown, Michael, Paranal, Ronald M, Bradner, James E, Yoda, Akinori, Gaul, Christoph, Vangrevelinghe, Eric, Romanet, Vincent, Murakami, Masato, Tiedt, Ralph, Ebel, Nicolas, Evrot, Emeline, De Pover, Alain, Régnier, Catherine H, Erdmann, Dirk, Hofmann, Francesco, Eck, Michael J, Sallan, Stephen E, Levine, Ross L, Kung, Andrew L, Baffert, Fabienne, Radimerski, Thomas, Weinstock, David M
Published in The Journal of experimental medicine (13.02.2012)
Published in The Journal of experimental medicine (13.02.2012)
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Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805
Baffert, Fabienne, Régnier, Catherine H, De Pover, Alain, Pissot-Soldermann, Carole, Tavares, Gisele A, Blasco, Francesca, Brueggen, Josef, Chène, Patrick, Drueckes, Peter, Erdmann, Dirk, Furet, Pascal, Gerspacher, Marc, Lang, Marc, Ledieu, David, Nolan, Lynda, Ruetz, Stephan, Trappe, Joerg, Vangrevelinghe, Eric, Wartmann, Markus, Wyder, Lorenza, Hofmann, Francesco, Radimerski, Thomas
Published in Molecular cancer therapeutics (01.07.2010)
Published in Molecular cancer therapeutics (01.07.2010)
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A conditional inducible JAK2.sup.V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression
Chapeau, Emilie A, Mandon, Emeline, Gill, Jason, Romanet, Vincent, Ebel, Nicolas, Powajbo, Violetta, Andraos-Rey, Rita, Qian, Zhiyan, Kininis, Miltos, Zumstein-Mecker, Sabine, Ito, Moriko, Hynes, Nancy E, Tiedt, Ralph, Hofmann, Francesco, Eshkind, Leonid, Bockamp, Ernesto, Kinzel, Bernd, Mueller, Matthias, Murakami, Masato, Baffert, Fabienne, Radimerski, Thomas
Published in PloS one (10.10.2019)
Published in PloS one (10.10.2019)
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CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms
Meyer, Sara C., Keller, Matthew D., Chiu, Sophia, Koppikar, Priya, Guryanova, Olga A., Rapaport, Franck, Xu, Ke, Manova, Katia, Pankov, Dmitry, O’Reilly, Richard J., Kleppe, Maria, McKenney, Anna Sophia, Shih, Alan H., Shank, Kaitlyn, Ahn, Jihae, Papalexi, Eftymia, Spitzer, Barbara, Socci, Nick, Viale, Agnes, Mandon, Emeline, Ebel, Nicolas, Andraos, Rita, Rubert, Joëlle, Dammassa, Ernesta, Romanet, Vincent, Dölemeyer, Arno, Zender, Michael, Heinlein, Melanie, Rampal, Raajit, Weinberg, Rona Singer, Hoffman, Ronald, Sellers, William R., Hofmann, Francesco, Murakami, Masato, Baffert, Fabienne, Gaul, Christoph, Radimerski, Thomas, Levine, Ross L.
Published in Cancer cell (13.07.2015)
Published in Cancer cell (13.07.2015)
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Type II Inhibition of JAK2 with NVP-CHZ868 Reverses Type I JAK Inhibitor Persistence and Demonstrates Increased Efficacy in MPN Models
Meyer, Sara C, Keller, Matthew D, Koppikar, Priya, Guryanova, Olga A, Kleppe, Maria, McKenney, Anna Sophia, Sellers, William R, Hofmann, Francesco, Baffert, Fabienne, Gaul, Christoph, Radimerski, Thomas, Levine, Ross L
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Age-Related Changes in Vascular Endothelial Growth Factor Dependency and Angiopoietin-1–Induced Plasticity of Adult Blood Vessels
Baffert, Fabienne, Thurston, Gavin, Rochon-Duck, Michael, Le, Tom, Brekken, Rolf, McDonald, Donald M
Published in Circulation research (16.04.2004)
Published in Circulation research (16.04.2004)
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Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors
Pissot-Soldermann, Carole, Gerspacher, Marc, Furet, Pascal, Gaul, Christoph, Holzer, Philipp, McCarthy, Clive, Radimerski, Thomas, Regnier, Catherine H., Baffert, Fabienne, Drueckes, Peter, Tavares, Gisele A., Vangrevelinghe, Eric, Blasco, Francesca, Ottaviani, Giorgio, Ossola, Flavio, Scesa, Julien, Reetz, Janitha
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Improved Efficacy Upon Combined JAK1/2 and Pan-Deacetylase Inhibition Using Ruxolitinib (INC424) and Panobinostat (LBH589) in Preclinical Mouse Models of JAK2V617F-Driven Disease
Baffert, Fabienne, Evrot, Emeline, Ebel, Nicolas, Roelli, Claudia, Andraos, Rita, Qian, Zhiyan, Romanet, Vincent, Murakami, Masato, Radimerski, Thomas
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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