Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
Tully, David C, Rucker, Paul V, Chianelli, Donatella, Williams, Jennifer, Vidal, Agnès, Alper, Phil B, Mutnick, Daniel, Bursulaya, Badry, Schmeits, James, Wu, Xiangdong, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Seidel, H. Martin, Molteni, Valentina, Liu, Bo, Phimister, Andrew, Joseph, Sean B, Laffitte, Bryan
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Journal Article
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
Bursulaya, Badry, Patapoutian, Ardem, Bandell, Michael, Kim, Sung Eun, Uzzell, Valerie, Petrus, Matt, Grandl, Jörg
Published in Nature neuroscience (01.06.2010)
Published in Nature neuroscience (01.06.2010)
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Journal Article
Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels
Xiao, Bailong, Dubin, Adrienne E, Bursulaya, Badry, Viswanath, Veena, Jegla, Timothy J, Patapoutian, Ardem
Published in The Journal of neuroscience (24.09.2008)
Published in The Journal of neuroscience (24.09.2008)
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Journal Article
Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
Marsilje, Thomas H, Pei, Wei, Chen, Bei, Lu, Wenshuo, Uno, Tetsuo, Jin, Yunho, Jiang, Tao, Kim, Sungjoon, Li, Nanxin, Warmuth, Markus, Sarkisova, Yelena, Sun, Frank, Steffy, Auzon, Pferdekamper, AnneMarie C, Li, Allen G, Joseph, Sean B, Kim, Young, Liu, Bo, Tuntland, Tove, Cui, Xiaoming, Gray, Nathanael S, Steensma, Ruo, Wan, Yongqin, Jiang, Jiqing, Chopiuk, Greg, Li, Jie, Gordon, W. Perry, Richmond, Wendy, Johnson, Kevin, Chang, Jonathan, Groessl, Todd, He, You-Qun, Phimister, Andrew, Aycinena, Alex, Lee, Christian C, Bursulaya, Badry, Karanewsky, Donald S, Seidel, H. Martin, Harris, Jennifer L, Michellys, Pierre-Yves
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
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Journal Article
EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor
Jia, Yong, Juarez, Jose, Li, Jie, Manuia, Mari, Niederst, Matthew J, Tompkins, Celin, Timple, Noelito, Vaillancourt, Mei-Ting, Pferdekamper, AnneMarie Culazzo, Lockerman, Elizabeth L, Li, Chun, Anderson, Jennifer, Costa, Carlotta, Liao, Debbie, Murphy, Eric, DiDonato, Michael, Bursulaya, Badry, Lelais, Gerald, Barretina, Jordi, McNeill, Matthew, Epple, Robert, Marsilje, Thomas H, Pathan, Nuzhat, Engelman, Jeffrey A, Michellys, Pierre-Yves, McNamara, Peter, Harris, Jennifer, Bender, Steven, Kasibhatla, Shailaja
Published in Cancer research (Chicago, Ill.) (15.03.2016)
Published in Cancer research (Chicago, Ill.) (15.03.2016)
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Journal Article
Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197
Malito, Enrico, Bursulaya, Badry, Chen, Connie, Surdo, Paola Lo, Picchianti, Monica, Balducci, Enrico, Biancucci, Marco, Brock, Ansgar, Berti, Francesco, Bottomley, Matthew James, Nissum, Mikkel, Costantino, Paolo, Rappuoli, Rino, Spraggon, Glen
Published in Proceedings of the National Academy of Sciences - PNAS (03.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (03.04.2012)
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Journal Article
Pore region of TRPV3 ion channel is specifically required for heat activation
Patapoutian, Ardem, Grandl, Jörg, Hu, Hongzhen, Bandell, Michael, Bursulaya, Badry, Schmidt, Manuela, Petrus, Matt
Published in Nature neuroscience (01.09.2008)
Published in Nature neuroscience (01.09.2008)
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Journal Article
Tuning a Protein‐Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation
Pham, Grace H., Ou, Weijia, Bursulaya, Badry, DiDonato, Michael, Herath, Ananda, Jin, Yunho, Hao, Xueshi, Loren, Jon, Spraggon, Glen, Brock, Ansgar, Uno, Tetsuo, Geierstanger, Bernhard H., Cellitti, Susan E.
Published in Chembiochem : a European journal of chemical biology (16.04.2018)
Published in Chembiochem : a European journal of chemical biology (16.04.2018)
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Journal Article
Efficient Preparation of Site-Specific Antibody–Drug Conjugates Using Phosphopantetheinyl Transferases
Grünewald, Jan, Klock, Heath E, Cellitti, Susan E, Bursulaya, Badry, McMullan, Daniel, Jones, David H, Chiu, Hsien-Po, Wang, Xing, Patterson, Paula, Zhou, Huanfang, Vance, Julie, Nigoghossian, Edward, Tong, Hung, Daniel, Dylan, Mallet, William, Ou, Weijia, Uno, Tetsuo, Brock, Ansgar, Lesley, Scott A, Geierstanger, Bernhard H
Published in Bioconjugate chemistry (16.12.2015)
Published in Bioconjugate chemistry (16.12.2015)
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Journal Article
In vivo Incorporation of Unnatural Amino Acids to Probe Structure, Dynamics, and Ligand Binding in a Large Protein by Nuclear Magnetic Resonance Spectroscopy
Cellitti, Susan E, Jones, David H, Lagpacan, Leanna, Hao, Xueshi, Zhang, Qiong, Hu, Huiyong, Brittain, Scott M, Brinker, Achim, Caldwell, Jeremy, Bursulaya, Badry, Spraggon, Glen, Brock, Ansgar, Ryu, Youngha, Uno, Tetsuo, Schultz, Peter G, Geierstanger, Bernhard H
Published in Journal of the American Chemical Society (23.07.2008)
Published in Journal of the American Chemical Society (23.07.2008)
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Journal Article
Comparative study of several algorithms for flexible ligand docking
Bursulaya, Badry D, Totrov, Maxim, Abagyan, Ruben, Brooks, 3rd, Charles L
Published in Journal of computer-aided molecular design (01.11.2003)
Published in Journal of computer-aided molecular design (01.11.2003)
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Journal Article
Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I
Jiang, Tao, Kuhen, Kelli L., Wolff, Karen, Yin, Hong, Bieza, Kimberly, Caldwell, Jeremy, Bursulaya, Badry, Wu, Tom Yao-Hsing, He, Yun
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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Journal Article
Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2
Jiang, Tao, Kuhen, Kelli L., Wolff, Karen, Yin, Hong, Bieza, Kimberly, Caldwell, Jeremy, Bursulaya, Badry, Tuntland, Tove, Zhang, Kanyin, Karanewsky, Donald, He, Yun
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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Journal Article
A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor
Nam, Tae-gyu, McNamara, Case W, Bopp, Selina, Dharia, Neekesh V, Meister, Stephan, Bonamy, Ghislain M. C, Plouffe, David M, Kato, Nobutaka, McCormack, Susan, Bursulaya, Badry, Ke, Hangjun, Vaidya, Akhil B, Schultz, Peter G, Winzeler, Elizabeth A
Published in ACS chemical biology (18.11.2011)
Published in ACS chemical biology (18.11.2011)
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Journal Article
Discovery of Trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as Potent, Orally Bioavailable TGR5 (GPBAR1) Agonists: Structure–Activity Relationships, Lead Optimization, and Chronic In Vivo Efficacy
Phillips, Dean P, Gao, Wenqi, Yang, Yang, Zhang, Guobao, Lerario, Isabelle K, Lau, Thomas L, Jiang, Jiqing, Wang, Xia, Nguyen, Deborah G, Bhat, B. Ganesh, Trotter, Carol, Sullivan, Heather, Welzel, Gustav, Landry, Jannine, Chen, Yali, Joseph, Sean B, Li, Chun, Gordon, W. Perry, Richmond, Wendy, Johnson, Kevin, Bretz, Angela, Bursulaya, Badry, Pan, Shifeng, McNamara, Peter, Seidel, H. Martin
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Journal Article
Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids
Gauba, Varun, Grünewald, Jan, Gorney, Vanessa, Deaton, Lisa M, Kang, Mingchao, Bursulaya, Badry, Ou, Weijia, Lerner, Richard A, Schmedt, Christian, Geierstanger, Bernhard H, Schultz, Peter G, Ramirez-Montagut, Teresa
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2011)
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Journal Article
Expanding the Diversity of Allosteric Bcr-Abl Inhibitors
Deng, Xianming, Okram, Barun, Ding, Qiang, Zhang, Jianming, Choi, Yongmun, Adrián, Francisco J, Wojciechowski, Amy, Zhang, Guobao, Che, Jianwei, Bursulaya, Badry, Cowan-Jacob, Sandra W, Rummel, Gabriele, Sim, Taebo, Gray, Nathanael S
Published in Journal of medicinal chemistry (14.10.2010)
Published in Journal of medicinal chemistry (14.10.2010)
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Journal Article
Golgicide A reveals essential roles for GBF1 in Golgi assembly and function
Sáenz, José B, Sun, William J, Chang, Jae Won, Li, Jinmei, Bursulaya, Badry, Gray, Nathanael S, Haslam, David B
Published in Nature chemical biology (01.02.2009)
Published in Nature chemical biology (01.02.2009)
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Journal Article
Selective Incorporation of 5-Hydroxytryptophan into Proteins in Mammalian Cells
Zhang, Zhiwen, Alfonta, Lital, Tian, Feng, Bursulaya, Badry, Uryu, Sean, King, David S., Schultz, Peter G., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2004)
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Journal Article
Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations
Spraggon, Glen, Hornsby, Michael, Shipway, Aaron, Tully, David C., Bursulaya, Badry, Danahay, Henry, Harris, Jennifer L., Lesley, Scott A.
Published in Protein science (01.05.2009)
Published in Protein science (01.05.2009)
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