Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
Eaton, John K., Furst, Laura, Ruberto, Richard A., Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J., Zimmermann, Katja, Cai, Luke L., Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C., Clemons, Paul A., Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E., Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L., Viswanathan, Vasanthi S., Schreiber, Stuart L.
Published in Nature chemical biology (01.05.2020)
Published in Nature chemical biology (01.05.2020)
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Structural analysis of human KDM5B guides histone demethylase inhibitor development
Johansson, Catrine, Velupillai, Srikannathasan, Tumber, Anthony, Szykowska, Aleksandra, Hookway, Edward S, Nowak, Radoslaw P, Strain-Damerell, Claire, Gileadi, Carina, Philpott, Martin, Burgess-Brown, Nicola, Wu, Na, Kopec, Jola, Nuzzi, Andrea, Steuber, Holger, Egner, Ursula, Badock, Volker, Munro, Shonagh, LaThangue, Nicholas B, Westaway, Sue, Brown, Jack, Athanasou, Nick, Prinjha, Rab, Brennan, Paul E, Oppermann, Udo
Published in Nature chemical biology (01.07.2016)
Published in Nature chemical biology (01.07.2016)
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A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition
Falkenstern, Lilia, Georgi, Victoria, Bunse, Stefanie, Badock, Volker, Husemann, Manfred, Roehn, Ulrike, Stellfeld, Timo, Fitzgerald, Mark, Ferrara, Steven, Stöckigt, Detlef, Stresemann, Carlo, Hartung, Ingo V., Fernández-Montalván, Amaury
Published in Scientific reports (19.01.2024)
Published in Scientific reports (19.01.2024)
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Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2
Eggert, Erik, Hillig, Roman C, Koehr, Silke, Stöckigt, Detlef, Weiske, Jörg, Barak, Naomi, Mowat, Jeffrey, Brumby, Thomas, Christ, Clara D, ter Laak, Antonius, Lang, Tina, Fernandez-Montalvan, Amaury E, Badock, Volker, Weinmann, Hilmar, Hartung, Ingo V, Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena, Kennedy, Steven, Li, Fengling, Vedadi, Masoud, Brown, Peter J, Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H, Stellfeld, Timo, Stresemann, Carlo
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication
Koo, Seong Joo, Fernández-Montalván, Amaury E, Badock, Volker, Ott, Christopher J, Holton, Simon J, von Ahsen, Oliver, Toedling, Joern, Vittori, Sarah, Bradner, James E, Gorjánácz, Mátyás
Published in Oncotarget (25.10.2016)
Published in Oncotarget (25.10.2016)
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Cleavage and Shedding of E-cadherin after Induction of Apoptosis
Steinhusen, Ulrike, Weiske, Jörg, Badock, Volker, Tauber, Rudolf, Bommert, Kurt, Huber, Otmar
Published in The Journal of biological chemistry (16.02.2001)
Published in The Journal of biological chemistry (16.02.2001)
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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction
Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmanna, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, Julia, Petersen, Kirstin, Siemeister, Gerhard, Kahmann, Jan D., Wegener, Dennis, Böhnke, Niels, Eis, Knut, Graham, Keith, Wortmann, Lars, von Nussbaum, Franz, Bader, Benjamin
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2019)
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Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162
Moosmayer, Dieter, Hilpmann, André, Hoffmann, Jutta, Schnirch, Lennart, Zimmermann, Katja, Badock, Volker, Furst, Laura, Eaton, John K., Viswanathan, Vasanthi S., Schreiber, Stuart L., Gradl, Stefan, Hillig, Roman C.
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2021)
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2021)
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Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1
Jung, Marie, Philpott, Martin, Müller, Susanne, Schulze, Jessica, Badock, Volker, Eberspächer, Uwe, Moosmayer, Dieter, Bader, Benjamin, Schmees, Norbert, Fernández-Montalván, Amaury, Haendler, Bernard
Published in The Journal of biological chemistry (28.03.2014)
Published in The Journal of biological chemistry (28.03.2014)
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Discovery and Characterization of BAY-184: A New Potent and Selective Acylsulfonamide-Benzofuran In Vivo -Active KAT6AB Inhibitor
Ter Laak, Antonius, Hillig, Roman C, Ferrara, Steven J, Korr, Daniel, Barak, Naomi, Lienau, Philip, Herbert, Simon, Fernández-Montalván, Amaury Ernesto, Neuhaus, Roland, Gorjánácz, Mátyás, Puetter, Vera, Badock, Volker, Bone, Wilhelm, Strathdee, Craig, Siegel, Franziska, Schatz, Christoph, Nowak-Reppel, Katrin, Doehr, Olaf, Gradl, Stefan, Hartung, Ingo V, Meyerson, Matthew, Bouché, Léa
Published in Journal of medicinal chemistry (25.10.2024)
Published in Journal of medicinal chemistry (25.10.2024)
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Critical Evaluation of Native Electrospray Ionization Mass Spectrometry for Fragment‐Based Screening
Göth, Melanie, Badock, Volker, Weiske, Jörg, Pagel, Kevin, Kuropka, Benno
Published in ChemMedChem (08.08.2017)
Published in ChemMedChem (08.08.2017)
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Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS(G12C)
Mortier, Jeremie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.
Published in ChemMedChem (19.05.2020)
Published in ChemMedChem (19.05.2020)
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Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action
Fernández-Montalván, Amaury E, Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Puetter, Vera, Holton, Simon J, Stöckigt, Detlef, ter Laak, Antonius, Centrella, Paolo A, Clark, Matthew A, Dumelin, Christoph E, Sigel, Eric A, Soutter, Holly H, Troast, Dawn M, Zhang, Ying, Cuozzo, John W, Keefe, Anthony D, Roche, Didier, Rodeschini, Vincent, Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James M, Fedorov, Oleg, Huber, Kilian V. M, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V, Gorjánácz, Mátyás
Published in ACS chemical biology (17.11.2017)
Published in ACS chemical biology (17.11.2017)
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Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C
Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C, Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D
Published in ChemMedChem (19.05.2020)
Published in ChemMedChem (19.05.2020)
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Journal Article
Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C
Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.
Published in ChemMedChem (19.05.2020)
Published in ChemMedChem (19.05.2020)
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Front Cover: Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C (ChemMedChem 10/2020)
Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.
Published in ChemMedChem (19.05.2020)
Published in ChemMedChem (19.05.2020)
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Front Cover: Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C (ChemMedChem 10/2020)
Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.
Published in ChemMedChem (19.05.2020)
Published in ChemMedChem (19.05.2020)
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Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor
Gradl, Stefan, Steuber, Holger, Weiske, Jörg, Schmees, Norbert, Siegel, Stephan, Stoeckigt, Detlef, Christ, Clara D., Li, Fengling, Organ, Shawna, Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena M., Kennedy, Steven, Trush, Viacheslav, Vedadi, Masoud, Arrowsmith, Cheryl H., Brown, Peter J., Husemann, Manfred, Fernandez-Montalvan, Amaury E., Badock, Volker, Bauser, Marcus, Haegebarth, Andrea, Hartung, Ingo V., Stresemann, Carlo
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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