The metabolic fate of izencitinib, a gut-selective pan-JAK inhibitor, in humans. Identification of unusual fecal metabolites and implications for MIST evaluation
Yeola, Suresh, Badagnani, Ilaria, Huang, Xiaojun, Segraves, Nathanial L., Rapta, Miroslav, Borin, Marie T., Obedencio, Glenmar P., Fitch, William L., Baillie, Thomas A., Bourdet, David L.
Published in Medicinal chemistry research (01.09.2023)
Published in Medicinal chemistry research (01.09.2023)
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Journal Article
Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors
Wilsbacher, Julie L, Cheng, Min, Cheng, Dong, Trammell, Samuel A J, Shi, Yan, Guo, Jun, Koeniger, Stormy L, Kovar, Peter J, He, Yupeng, Selvaraju, Sujatha, Heyman, H Robin, Sorensen, Bryan K, Clark, Richard F, Hansen, T Matthew, Longenecker, Kenton L, Raich, Diana, Korepanova, Alla V, Cepa, Steven, Towne, Danli L, Abraham, Vivek C, Tang, Hua, Richardson, Paul L, McLoughlin, Shaun M, Badagnani, Ilaria, Curtin, Michael L, Michaelides, Michael R, Maag, David, Buchanan, F Gregory, Chiang, Gary G, Gao, Wenqing, Rosenberg, Saul H, Brenner, Charles, Tse, Chris
Published in Molecular cancer therapeutics (01.07.2017)
Published in Molecular cancer therapeutics (01.07.2017)
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Journal Article
Interaction of Methotrexate with Organic-Anion Transporting Polypeptide 1A2 and Its Genetic Variants
Badagnani, Ilaria, Castro, Richard A, Taylor, Travis R, Brett, Claire M, Huang, Conrad C, Stryke, Douglas, Kawamoto, Michiko, Johns, Susan J, Ferrin, Thomas E, Carlson, Elaine J, Burchard, Esteban G, Giacomini, Kathleen M
Published in The Journal of pharmacology and experimental therapeutics (01.08.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2006)
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Journal Article
A High Throughput, 384-Well, Semi-Automated, Hepatocyte Intrinsic Clearance Assay for Screening New Molecular Entities in Drug Discovery
Heinle, Lance, Peterkin, Vincent, de Morais, Sonia M, Jenkins, Gary J, Badagnani, Ilaria
Published in Combinatorial chemistry & high throughput screening (01.01.2015)
Published in Combinatorial chemistry & high throughput screening (01.01.2015)
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Journal Article
Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate
Singh, Shweta, Serwer, Laura, DuPage, Amy, Elkins, Kristi, Chauhan, Niharika, Ravn, Matthew, Buchanan, Fritz, Wang, Leyu, Krimm, Michael, Wong, Ken, Sagert, Jason, Tipton, Kimberly, Moore, Stephen J, Huang, Yuanhui, Jang, Andrew, Ureno, Eric, Miller, Adam, Patrick, Sarah, Duvur, Shanti, Liu, Shouchun, Vasiljeva, Olga, Li, Yingchun, Henriques, Tracy, Badagnani, Ilaria, Jeffries, Shawn, Schleyer, Siew, Leanna, Rob, Krebber, Claus, Viswanathan, Sridhar, Desnoyers, Luc, Terrett, Jonathan, Belvin, Marcia, Morgan-Lappe, Susan, Kavanaugh, W Michael, Richardson, Jennifer
Published in Molecular cancer therapeutics (02.08.2022)
Published in Molecular cancer therapeutics (02.08.2022)
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Journal Article
Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species
Hardwick, Rhiannon N, Brassil, Patrick, Badagnani, Ilaria, Perkins, Kimberly, Obedencio, Glenmar P, Kim, Andrea S, Conner, Michael W, Bourdet, David L, Harstad, Eric B
Published in Toxicological sciences (28.03.2022)
Published in Toxicological sciences (28.03.2022)
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Journal Article
Abstract B103: A multi-analyte HPLC-MS/MS approach to assessing exposure of a Probody drug conjugate in preclinical studies
Serwer, Laura, Singh, Shweta, Krebber, Claus, Liu, Shouchun, Chauhan, Niharika, Leanna, Robert, Lu, Hong, Badagnani, Ilaria, Henriques, Tracy, Morgan-Lappe, Susan, Mylott, William, Viswanathan, Sridhar, Richardson, Jennifer, Kavanaugh, Michael
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
CD71 ANTI-CD71 ACTIVATABLE ANTIBODY DRUG CONJUGATES AND METHODS OF USE THEREOF
SINGH SHWETA, TERRETT JONATHAN ALEXANDER, BOSE SAHANA, RICHARDSON JENNIFER HOPE, HENRIQUES TRACY, SERWER LAURA PATTERSON, LEANNA MARVIN ROBERT, BADAGNANI ILARIA, MORGAN LAPPE SUSAN E, RALSTON SHERRY L
Year of Publication 19.05.2023
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Year of Publication 19.05.2023
Patent
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)
Curtin, Michael L., Heyman, H. Robin, Clark, Richard F., Sorensen, Bryan K., Doherty, George A., Hansen, T. Matthew, Frey, Robin R., Sarris, Kathy A., Aguirre, Ana L., Shrestha, Anurupa, Tu, Noah, Woller, Kevin, Pliushchev, Marina A., Sweis, Ramzi F., Cheng, Min, Wilsbacher, Julie L., Kovar, Peter J., Guo, Jun, Cheng, Dong, Longenecker, Kenton L., Raich, Diana, Korepanova, Alla V., Soni, Nirupama B., Algire, Mikkel A., Richardson, Paul L., Marin, Violeta L., Badagnani, Ilaria, Vasudevan, Anil, Buchanan, F. Greg, Maag, David, Chiang, Gary G., Tse, Chris, Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
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Journal Article
Abstract B116: Optimizing a CD71-targeting Probody drug conjugate (PDC) for activity in multiple solid tumor and lymphoma models and for tolerability in nonhuman primates
Singh, Shweta, Serwer, Laura, Chauhan, Niharika, DuPage, Amy, Krimm, Michael, Wong, Ken, Huang, Yuanhui, Jang, Andrew, Ureno, Eric, Miller, Adam, Patrick, Sarah, Duvur, Shanti, Buchanan, Fritz, Ravn, Matthew M., Leanna, Rob, Badagnani, Ilaria, Henriques, Tracy, Liu, Shouchun, Krebber, Claus, Viswanathan, Sridhar, Richardson, Jennifer, Morgan-Lappe, Susan, Kavanaugh, Michael
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
CD71 ANTI-CD71 ACTIVATABLE ANTIBODY DRUG CONJUGATES AND METHODS OF USE THEREOF
SINGH SHWETA, TERRETT JONATHAN ALEXANDER, BOSE SAHANA, RICHARDSON JENNIFER HOPE, HENRIQUES TRACY, SERWER LAURA PATTERSON, LEANNA MARVIN ROBERT, BADAGNANI ILARIA, MORGAN LAPPE SUSAN E, RALSTON SHERRY L
Year of Publication 12.04.2022
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Year of Publication 12.04.2022
Patent
SLC19A1 pharmacogenomics summary
Yee, Sook Wah, Gong, Li, Badagnani, Ilaria, Giacomini, Kathleen M, Klein, Teri E, Altman, Russ B
Published in Pharmacogenetics and genomics (01.11.2010)
Published in Pharmacogenetics and genomics (01.11.2010)
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Journal Article
Functional genomics of membrane transporters in human populations
Urban, Thomas J, Sebro, Ronnie, Hurowitz, Evan H, Leabman, Maya K, Badagnani, Ilaria, Lagpacan, Leah L, Risch, Neil, Giacomini, Kathleen M
Published in Genome Research (01.02.2006)
Published in Genome Research (01.02.2006)
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Journal Article
Corrigendum to “Nucleoside transporters in the disposition and targeting of nucleoside 2 analogs in the kidney” [Eur. J. Pharmacol. 479/1–3 (2003) 269–281]
Mangravite, Lara M., Badagnani, Ilaria, Giacomini, Kathleen M.
Published in European journal of pharmacology (01.02.2004)
Published in European journal of pharmacology (01.02.2004)
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Journal Article