Discovery and Characterization of 6-{4-[3-(R)-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H3 Receptor Inverse Agonist
Hudkins, Robert L, Raddatz, Rita, Tao, Ming, Mathiasen, Joanne R, Aimone, Lisa D, Becknell, Nadine C, Prouty, Catherine P, Knutsen, Lars J. S, Yazdanian, Mehran, Moachon, Gilbert, Ator, Mark A, Mallamo, John P, Marino, Michael J, Bacon, Edward R, Williams, Michael
Published in Journal of medicinal chemistry (14.07.2011)
Published in Journal of medicinal chemistry (14.07.2011)
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Structure-guided identification of novel VEGFR-2 kinase inhibitors via solution phase parallel synthesis
Tripathy, Rabindranath, Reiboldt, Alyssa, Messina, Patricia A., Iqbal, Mohamed, Singh, Jasbir, Bacon, Edward R., Angeles, Thelma S., Yang, Shi X., Albom, Mark S., Robinson, Candy, Chang, Hong, Ruggeri, Bruce A., Mallamo, John P.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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Wake promoting agents: Search for next generation modafinil, lessons learned: Part III
Dunn, Derek, Hostetler, Greg, Iqbal, Mohamed, Marcy, Val R., Lin, Yin Guo, Jones, Bruce, Aimone, Lisa D., Gruner, John, Ator, Mark A., Bacon, Edward R., Chatterjee, Sankar
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: Identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test
Tripathy, Rabindranath, McHugh, Robert J., Bacon, Edward R., Salvino, Joseph M., Morton, George C., Aimone, Lisa D., Huang, Zeck, Mathiasen, Joanne R., DiCamillo, Amy, Huffman, Mark J., McKenna, Beth A., Kopec, Karla, Lu, Lily D., Qian, Jie, Angeles, Thelma S., Connors, Thomas, Spais, Chrysanthe, Holskin, Beverly, Duzic, Emir, Schaffhauser, Hervé, Rossé, Gerard C.
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
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Synthesis and Biological Profile of the pan-Vascular Endothelial Growth Factor Receptor/Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor-Like Homology Domains 2 (VEGF-R/TIE-2) Inhibitor 11-(2-Methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): A Novel Oncology Therapeutic Agent
Hudkins, Robert L, Becknell, Nadine C, Zulli, Allison L, Underiner, Ted L, Angeles, Thelma S, Aimone, Lisa D, Albom, Mark S, Chang, Hong, Miknyoczki, Sheila J, Hunter, Kathryn, Jones-Bolin, Susan, Zhao, Hugh, Bacon, Edward R, Mallamo, John P, Ator, Mark A, Ruggeri, Bruce A
Published in Journal of medicinal chemistry (26.01.2012)
Published in Journal of medicinal chemistry (26.01.2012)
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3-(1′-Cyclobutylspiro[4H-1,3-benzodioxine-2,4′-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist
Hudkins, Robert L., Gruner, John A., Raddatz, Rita, Mathiasen, Joanne R., Aimone, Lisa D., Marino, Michael J., Bacon, Edward R., Williams, Michael, Ator, Mark A.
Published in Neuropharmacology (01.07.2016)
Published in Neuropharmacology (01.07.2016)
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1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors
Tripathy, Rabindranath, Ghose, Arup, Singh, Jasbir, Bacon, Edward R., Angeles, Thelma S., Yang, Shi X., Albom, Mark S., Aimone, Lisa D., Herman, Joseph L., Mallamo, John P.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists
Zulli, Allison L., Aimone, Lisa D., Mathiasen, Joanne R., Gruner, John A., Raddatz, Rita, Bacon, Edward R., Hudkins, Robert L.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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From an Atypical Wake-promoting Agent to Potent Histamine-3 Receptor Inverse Agonists
Dunn, Derek, Raddatz, Rita, Ator, Mark A., Bacon, Edward R., Chatterjee, Sankar
Published in Chemical biology & drug design (01.03.2013)
Published in Chemical biology & drug design (01.03.2013)
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Wake-promoting agents: Search for next generation modafinil: Part I
Dunn, Derek, Hostetler, Greg, Iqbal, Mohamed, Messina-McLaughlin, Patricia, Reiboldt, Alyssa, Lin, Yin Guo, Gruner, John, Bacon, Edward R., Ator, Mark A., Chatterjee, Sankar
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
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Journal Article
Wake-promoting agents: Search for next generation modafinil: Part II
Dunn, Derek, Hostetler, Greg, Iqbal, Mohamed, Messina-McLaughlin, Patricia, Reiboldt, Alyssa, Lin, Yin Guo, Gruner, John, Bacon, Edward R., Ator, Mark A., Chatterjee, Sankar
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
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Wake-promoting agents: Search for next generation modafinil: Part IV
Louvet, Philippe, Schweizer, Dominique, Gourdel, Marie-Edith, Riguet, Eric, Yue, Christoph, Marcy, Val R., Lin, Yin Guo, Gruner, John, Lesur, Brigitte, Bacon, Edward R., Chatterjee, Sankar
Published in European journal of medicinal chemistry (01.08.2012)
Published in European journal of medicinal chemistry (01.08.2012)
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Novel morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity
Sundar, Babu G., Bailey, Thomas R., Dunn, Derek, Hostetler, Greg A., Chatterjee, Sankar, Bacon, Edward R., Yue, Christoph, Schweizer, Dominique, Aimone, Lisa D., Gruner, John A., Lyons, Jacquelyn, Raddatz, Rita, Lesur, Brigitte
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Aryl-Heteroaryl Derivatives as Novel Wake-Promoting Agents
Lesur, Brigitte, Lin, Yin G., Marcy, Val R., Aimone, Lisa D., Gruner, John, Bacon, Edward R., Chatterjee, Sankar
Published in Chemical biology & drug design (01.03.2013)
Published in Chemical biology & drug design (01.03.2013)
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Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists
Sundar, Babu G., Bailey, Thomas R., Dunn, Derek D., Bacon, Edward R., Salvino, Joseph M., Morton, George C., Aimone, Lisa D., Zeqi, Huang, Mathiasen, Joanne R., Dicamillo, Amy, Huffman, Mark J., McKenna, Beth A., Kopec, Karla, Lu, Lily D., Brown, Rebecca, Qian, Jie, Angeles, Thelma, Connors, Thomas, Spais, Chrysanthe, Holskin, Beverly, Galinis, Deborah, Duzic, Emir, Schaffhauser, Herve, Rosse, Gerard C.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Identification of pyridazin-3-one derivatives as potent, selective histamine H3 receptor inverse agonists with robust wake activity
Hudkins, Robert L., Aimone, Lisa D., Bailey, Thomas R., Bendesky, Robert J., Dandu, Reddeppa reddy, Dunn, Derek, Gruner, John A., Josef, Kurt A., Lin, Yin-Guo, Lyons, Jacquelyn, Marcy, Val R., Mathiasen, Joanne R., Sundar, Babu G., Tao, Ming, Zulli, Allison L., Raddatz, Rita, Bacon, Edward R.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Design and synthesis of dihydroindazolo[5,4- a]pyrrolo[3,4- c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases
Dandu, Reddeppareddy, Zulli, Allison L., Bacon, Edward R., Underiner, Ted, Robinson, Candy, Chang, Hong, Miknyoczki, Sheila, Grobelny, Jennifer, Ruggeri, Bruce A., Yang, Shi, Albom, Mark S., Angeles, Thelma S., Aimone, Lisa D., Hudkins, Robert L.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Journal Article
Discovery and Characterization of 6-{4[3-(R)-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H-3 Receptor Inverse Agonist
Hudkins, Robert L., Raddatz, Rita, Tao, Ming, Mathiasen, Joanne R., Aimone, Lisa D., Becknell, Nadine C., Prouty, Catherine P., Knutsen, Lars J. S., Yazdanian, Mehran, Moachon, Gilbert, Ator, Mark A., Mallamo, John P., Marino, Michael J., Bacon, Edward R., Williams, Michael
Published in Journal of medicinal chemistry (14.07.2011)
Published in Journal of medicinal chemistry (14.07.2011)
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Time course of nodal enhancement with CT X-ray nanoparticle contrast agents: effect of particle size and chemical structure
McIntire, G L, Bacon, E R, Illig, K J, Coffey, S B, Singh, B, Bessin, G, Shore, M T, Wolf, G L
Published in Investigative radiology (01.02.2000)
Published in Investigative radiology (01.02.2000)
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1,3,5-Trialkyl-2,4,6-triiodobenzenes: Novel X-ray Contrast Agents for Gastrointestinal Imaging
Estep, Kimberly G, Josef, Kurt A, Bacon, Edward R, Illig, Carl R, Toner, John L, Mishra, Dinesh, Blazak, William F, Miller, Dennis M, Johnson, David K, Allen, Jack M, Spencer, Andy, Wilson, Susan A
Published in Journal of medicinal chemistry (18.05.2000)
Published in Journal of medicinal chemistry (18.05.2000)
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