Synthetic and Structure/Activity Studies on Acid-Substituted 2-Arylphenols: Discovery of 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]- propoxy]phenoxy]benzoic Acid, a High-Affinity Leukotriene B4 Receptor Antagonist
Sawyer, J. Scott, Bach, Nicholas J, Baker, S. Richard, Baldwin, Ronald F, Borromeo, Peter S, Cockerham, Sandra L, Fleisch, Jerome H, Floreancig, Paul, Froelich, Larry L
Published in Journal of medicinal chemistry (01.10.1995)
Published in Journal of medicinal chemistry (01.10.1995)
Get full text
Journal Article
Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. 1. Indole-3-acetamides
Dillard, Robert D., Bach, Nicholas J., Draheim, Susan E., Berry, Dennis R., Carlson, Donald G., Chirgadze, Nickolay Y., Clawson, David K., Hartley, Lawrence W., Johnson, Lea M., Jones, Noel D., McKinney, Emma R., Mihelich, Edward D., Olkowski, Jennifer L., Schevitz, Richard W., Smith, Amy C., Snyder, David W., Sommers, Cynthia D., Wery, Jean-Pierre
Published in Journal of medicinal chemistry (20.12.1996)
Published in Journal of medicinal chemistry (20.12.1996)
Get full text
Journal Article
Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. 3. Indole-3-glyoxamides
Draheim, Susan E., Bach, Nicholas J., Dillard, Robert D., Berry, Dennis R., Carlson, Donald G., Chirgadze, Nickolay Y., Clawson, David K., Hartley, Lawrence W., Johnson, Lea M., Jones, Noel D., McKinney, Emma R., Mihelich, Edward D., Olkowski, Jennifer L., Schevitz, Richard W., Smith, Amy C., Snyder, David W., Sommers, Cynthia D., Wery, Jean-Pierre
Published in Journal of medicinal chemistry (20.12.1996)
Published in Journal of medicinal chemistry (20.12.1996)
Get full text
Journal Article
Transgenic model for the discovery of novel human secretory non-pancreatic phospholipase A2 inhibitors
FOX, N, SONG, M, DRAHEIM, S. E, BOBBITT, J. L, FISHER, L, MIHELICH, E. D, SCHREMENTI, J, SHARP, J. D, WHITE, D. L, SNYDER, D. W, HARTLEY, L. W, CARLSON, D. G, BACH, N. J, DILLARD, R. D
Published in European journal of pharmacology (18.07.1996)
Published in European journal of pharmacology (18.07.1996)
Get full text
Journal Article
o-Phenylphenols: potent and orally active leukotriene B4 receptor antagonists
Sofia, Michael J, Floreancig, Paul, Bach, Nicholas J, Baker, S. Richard, Cockerham, Sandra L, Fleisch, Jerome H, Froelich, Larry L, Jackson, William T, Marder, Philip
Published in Journal of medicinal chemistry (01.11.1993)
Published in Journal of medicinal chemistry (01.11.1993)
Get full text
Journal Article
Bicyclic and tricyclic ergoline partial structures. Rigid 3-(2-aminoethyl)pyrroles and 3- and 4-(2-aminoethyl)pyrazoles as dopamine agonists
Bach, Nicholas J, Kornfeld, Edmund C, Jones, Noel D, Chaney, Michael O, Dorman, Douglas E, Paschal, Jonathan W, Clemens, James A, Smalstig, E. Barry
Published in Journal of medicinal chemistry (01.05.1980)
Published in Journal of medicinal chemistry (01.05.1980)
Get full text
Journal Article
Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI
Snyder, D W, Bach, N J, Dillard, R D, Draheim, S E, Carlson, D G, Fox, N, Roehm, N W, Armstrong, C T, Chang, C H, Hartley, L W, Johnson, L M, Roman, C R, Smith, A C, Song, M, Fleisch, J H
Published in The Journal of pharmacology and experimental therapeutics (01.03.1999)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.03.1999)
Journal Article
Preparation and biological evaluation of 2-azaergolines
Bach, Nicholas J, Kornfeld, Edmund C, Clemens, James A, Smalstig, E. Barry, Frederickson, Robert C. A
Published in Journal of medicinal chemistry (01.05.1980)
Published in Journal of medicinal chemistry (01.05.1980)
Get full text
Journal Article
Descarboxylysergic acid (9,10-didehydro-6-methylergoline)
Bach, Nicholas J, Hall, David A, Kornfeld, Edmund C
Published in Journal of medicinal chemistry (01.03.1974)
Published in Journal of medicinal chemistry (01.03.1974)
Get full text
Journal Article
Synthesis and biological activity of 8-arylergolines
Bach, Nicholas J, Kornfeld, Edmund C, Dorman, Douglas E
Published in Journal of medicinal chemistry (01.08.1977)
Published in Journal of medicinal chemistry (01.08.1977)
Get full text
Journal Article
Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. 2. Indole-3-acetamides with Additional Functionality
Dillard, Robert D., Bach, Nicholas J., Draheim, Susan E., Berry, Dennis R., Carlson, Donald G., Chirgadze, Nickolay Y., Clawson, David K., Hartley, Lawrence W., Johnson, Lea M., Jones, Noel D., McKinney, Emma R., Mihelich, Edward D., Olkowski, Jennifer L., Schevitz, Richard W., Smith, Amy C., Snyder, David W., Sommers, Cynthia D., Wery, Jean-Pierre
Published in Journal of medicinal chemistry (20.12.1996)
Published in Journal of medicinal chemistry (20.12.1996)
Get full text
Journal Article
Pharmacology of LY315920/S-5920,[[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetate, a Potent and Selective Secretory Phospholipase A2Inhibitor: A New Class of Anti-Inflammatory Drugs, SPI
David W. Snyder, Nicholas J. Bach, Robert D. Dillard, Susan E. Draheim, Donald G. Carlson, Niles Fox, Neal W. Roehm, Christopher T. Armstrong, Chan H. Chang, Lawrence W. Hartley, Lea M. Johnson, Carlos R. Roman, Amy C. Smith, Min Song, Jerome H. Fleisch
Published in The Journal of pharmacology and experimental therapeutics (01.03.1999)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.03.1999)
Journal Article
Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor
Fleisch, J H, Armstrong, C T, Roman, C R, Mihelich, E D, Spaethe, S M, Jackson, W T, Bobbitt, J L, Draheim, S, Bach, N J, Dillard, R D, Martinelli, M, Fouts, R, Snyder, D W
Published in The Journal of pharmacology and experimental therapeutics (01.07.1996)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.07.1996)
Journal Article
Quinoline-substituted dihydroindoles as cysLT 1 (LTD 4 receptor) antagonists
Scott Sawyer, J., Jeff Thrasher, K., Bach, Nicholas J., Stengel, Peter W., Cockerham, Sandra L., Silbaugh, Steven A., Roman, Carlos R., Froelich, Larry L., Fleisch, Jerome H.
Published in Bioorganic & medicinal chemistry letters (1996)
Published in Bioorganic & medicinal chemistry letters (1996)
Get full text
Journal Article
Quinoline-substituted dihydroindoles as cysLT1 (LTD4 receptor) antagonists
Scott Sawyer, J., Jeff Thrasher, K., Bach, Nicholas J., Stengel, Peter W., Cockerham, Sandra L., Silbaugh, Steven A., Roman, Carlos R., Froelich, Larry L., Fleisch, Jerome H.
Published in Bioorganic & medicinal chemistry letters (01.02.1996)
Published in Bioorganic & medicinal chemistry letters (01.02.1996)
Get full text
Journal Article
Structural analogues of LY292728, a highly potent xanthone dicarboxylic acid leukotriene B4 receptor antagonist: spatial positioning of the secondary acid group
Sawyer, J.Scott, Schmittling, Elisabeth A., Bach, Nicholas J., Baker, S.Richard, Froelich, Larry L., Saussy, David L., Marder, Philip, Jackson, William T.
Published in Bioorganic & medicinal chemistry letters (08.09.1994)
Published in Bioorganic & medicinal chemistry letters (08.09.1994)
Get full text
Journal Article
Transgenic model for the discovery of novel human secretory non-pancreatic phospholipase A 2 inhibitors
Fox, Niles, Song, Min, Schrementi, James, Sharp, John D., White, Donald L., Snyder, David W., Hartley, Lawrence W., Carlson, Donald G., Bach, Nicholas J., Dillard, Robert D., Draheim, Susan E., Bobbitt, Jesse L., Fisher, Lawrence, Mihelich, Edward D.
Published in European journal of pharmacology (1996)
Published in European journal of pharmacology (1996)
Get full text
Journal Article
Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A 2 . 3. Indole-3-glyoxamides
Draheim, Susan E., Bach, Nicholas J., Dillard, Robert D., Berry, Dennis R., Carlson, Donald G., Chirgadze, Nickolay Y., Clawson, David K., Hartley, Lawrence W., Johnson, Lea M., Jones, Noel D., McKinney, Emma R., Mihelich, Edward D., Olkowski, Jennifer L., Schevitz, Richard W., Smith, Amy C., Snyder, David W., Sommers, Cynthia D., Wery, Jean-Pierre
Published in Journal of medicinal chemistry (01.01.1996)
Published in Journal of medicinal chemistry (01.01.1996)
Get full text
Journal Article