SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis
Jacobs, Robert T, Nare, Bakela, Wring, Stephen A, Orr, Matthew D, Chen, Daitao, Sligar, Jessica M, Jenks, Matthew X, Noe, Robert A, Bowling, Tana S, Mercer, Luke T, Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J, Yarlett, Nigel, Plattner, Jacob J, Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y-K, Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Published in PLoS neglected tropical diseases (01.06.2011)
Published in PLoS neglected tropical diseases (01.06.2011)
Get full text
Journal Article
Trypanocidal Activity of 8-Methyl-5′-{[(Z)-4-Aminobut-2-enyl]-(Methylamino)}Adenosine (Genz-644131), an Adenosylmethionine Decarboxylase Inhibitor
BACCHI, Cyrus J, BARKER, Robert H, RODRIGUEZ, Aixa, HIRTH, Bradford, RATTENDI, Donna, YARLETT, Nigel, HENDRICK, Clifford L, SYBERTZ, Edmund
Published in Antimicrobial Agents and Chemotherapy (01.08.2009)
Published in Antimicrobial Agents and Chemotherapy (01.08.2009)
Get full text
Journal Article
Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis
BARKER, Robert H, HANLAN LIU, RODRIGUEZ, Aixa, YARLETT, Nigel, KLINGER, Jeffrey D, SYBERTZ, Edmund, HIRTH, Bradford, CELATKA, Cassandra A, FITZPATRICK, Richard, YIBIN XIANG, WILLERT, Erin K, PHILLIPS, Margaret A, KAISER, Marcel, BACCHI, Cyrus J
Published in Antimicrobial Agents and Chemotherapy (01.05.2009)
Published in Antimicrobial Agents and Chemotherapy (01.05.2009)
Get full text
Journal Article
Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents
Vanden Eynde, Jean J, Mayence, Annie, Mottamal, Madhusoodanan, Bacchi, Cyrus J, Yarlett, Nigel, Kaiser, Marcel, Brun, Reto, Huang, Tien L
Published in Pharmaceuticals (Basel, Switzerland) (19.04.2016)
Published in Pharmaceuticals (Basel, Switzerland) (19.04.2016)
Get full text
Journal Article
Metabolism of an Alkyl Polyamine Analog by a Polyamine Oxidase from the Microsporidian Encephalitozoon cuniculi
BACCHI, Cyrus J, YARLETT, Nigel, FACIANE, Evangeline, XIANGDONG BI, RATTENDI, Donna, WEISS, Louis M, WOSTER, Patrick M
Published in Antimicrobial Agents and Chemotherapy (01.06.2009)
Published in Antimicrobial Agents and Chemotherapy (01.06.2009)
Get full text
Journal Article
Novel Trypanocidal Analogs of 5′-(Methylthio)-Adenosine
SUFRIN, Janice R, SPIESS, Arthur J, MARASCO, Canio J, RATTENDI, Donna, BACCHI, Cyrus J
Published in Antimicrobial Agents and Chemotherapy (01.01.2008)
Published in Antimicrobial Agents and Chemotherapy (01.01.2008)
Get full text
Journal Article
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides
Thompson, Andrew M., Marshall, Andrew J., Maes, Louis, Yarlett, Nigel, Bacchi, Cyrus J., Gaukel, Eric, Wring, Stephen A., Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Mowbray, Charles E., Denny, William A.
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
Get full text
Journal Article
In Memoriam: Michael Levandowsky (1935–2016)
Bacchi, Cyrus J., Gorrell, Thomas, McManus, George, Yarlett, Nigel
Published in The Journal of eukaryotic microbiology (01.07.2017)
Published in The Journal of eukaryotic microbiology (01.07.2017)
Get full text
Journal Article
Novel Synthetic Polyamines Are Effective in the Treatment of Experimental Microsporidiosis, an Opportunistic AIDS-Associated Infection
BACCHI, Cyrus J, WEISS, Louis M, YARLETT, Nigel, WITTNER, Murray, LANE, Schenella, FRYDMAN, Benjamin, VALASINAS, Aldonia, REDDY, Venodhar, SUN, Jerry S, MARTON, Laurence J, KHAN, Imitiaz A, MORETTO, Magali
Published in Antimicrobial Agents and Chemotherapy (01.01.2002)
Published in Antimicrobial Agents and Chemotherapy (01.01.2002)
Get full text
Journal Article
Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities
O’Sullivan, Mary C., Durham, Timothy B., Valdes, Hannah E., Dauer, Kelly L., Karney, Nicholas J., Forrestel, Andrew C., Bacchi, Cyrus J., Baker, Jerome F.
Published in Bioorganic & medicinal chemistry (01.03.2015)
Published in Bioorganic & medicinal chemistry (01.03.2015)
Get full text
Journal Article
Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis
Jacobs, Robert T, Plattner, Jacob J, Nare, Bakela, Wring, Stephen A, Chen, Daitao, Freund, Yvonne, Gaukel, Eric G, Orr, Matthew D, Perales, Joe B, Jenks, Matthew, Noe, Robert A, Sligar, Jessica M, Zhang, Yong-Kang, Bacchi, Cyrus J, Yarlett, Nigel, Don, Robert
Published in Future medicinal chemistry (01.08.2011)
Published in Future medicinal chemistry (01.08.2011)
Get more information
Journal Article
Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents
Ding, Dazhong, Zhao, Yaxue, Meng, Qingqing, Xie, Dongsheng, Nare, Bakela, Chen, Daitao, Bacchi, Cyrus J, Yarlett, Nigel, Zhang, Yong-Kang, Hernandez, Vincent, Xia, Yi, Freund, Yvonne, Abdulla, Maha, Ang, Kean-Hooi, Ratnam, Joseline, McKerrow, James H, Jacobs, Robert T, Zhou, Huchen, Plattner, Jacob J
Published in ACS medicinal chemistry letters (08.07.2010)
Published in ACS medicinal chemistry letters (08.07.2010)
Get full text
Journal Article
Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity
Huang, Tien L., Eynde, Jean Jacques Vanden, Mayence, Annie, Collins, Margaret S., Cushion, Melanie T., Rattendi, Donna, Londono, Indira, Mazumder, Lakshman, Bacchi, Cyrus J., Yarlett, Nigel
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Get full text
Journal Article
Antitrypanosomal Activity of a New Triazine Derivative, SIPI 1029, In Vitro and in Model Infections
BACCHI, C. J, VARGAS, M, RATTENDI, D, GOLDBERG, B, WEICHENG ZHOU
Published in Antimicrobial Agents and Chemotherapy (01.10.1998)
Published in Antimicrobial Agents and Chemotherapy (01.10.1998)
Get full text
Journal Article
SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei
Perales, Joe B., Freeman, Jennifer, Bacchi, Cyrus J., Bowling, Tana, Don, Robert, Gaukel, Eric, Mercer, Luke, Moore III, Joseph A., Nare, Bakela, Nguyen, Tien M., Noe, Robert A., Randolph, Ryan, Rewerts, Cindy, Wring, Stephen A., Yarlett, Nigel, Jacobs, Robert T.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Get full text
Journal Article