Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase
Sivaprakasam, Prasanna, Wang, Zhongyu, Meanwell, Nicholas A., Khan, Javed A., Langley, David R., Johnson, Stephen R., Li, Guo, Pendri, Annapurna, Connolly, Timothy P., Gao, Mian, Camac, Daniel M., Klakouski, Cheryl, Zvyaga, Tatyana, Cianci, Christopher, McAuliffe, Brian, Ding, Bo, Discotto, Linda, Krystal, Mark R., Jenkins, Susan, Peese, Kevin M., Narasimhulu Naidu, B.
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
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Journal Article
Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors
Naidu, B. Narasimhulu, Sorenson, Margaret E., Patel, Manoj, Ueda, Yasutsugu, Banville, Jacques, Beaulieu, Francis, Bollini, Sagarika, Dicker, Ira B., Higley, Helen, Lin, Zeyu, Pajor, Lori, Parker, Dawn D., Terry, Brian J., Zheng, Ming, Martel, Alain, Meanwell, Nicholas A., Krystal, Mark, Walker, Michael A.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Journal Article
Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts
Naidu, B. Narasimhulu, Sorenson, Margaret E., Bronson, Joanne J., Pucci, Michael J., Clark, Junius M., Ueda, Yasutsugu
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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Journal Article
Potent Long-Acting Inhibitors Targeting the HIV‑1 Capsid Based on a Versatile Quinazolin-4-one Scaffold
Gillis, Eric P., Parcella, Kyle, Bowsher, Michael, Cook, James H., Iwuagwu, Christiana, Naidu, B. Narasimhulu, Patel, Manoj, Peese, Kevin, Huang, Haichang, Valera, Lourdes, Wang, Chunfu, Kieltyka, Kasia, Parker, Dawn D., Simmermacher, Jean, Arnoult, Eric, Nolte, Robert T., Wang, Liping, Bender, John A., Frennesson, David B., Saulnier, Mark, Wang, Alan Xiangdong, Meanwell, Nicholas A., Belema, Makonen, Hanumegowda, Umesh, Jenkins, Susan, Krystal, Mark, Kadow, John F., Cockett, Mark, Fridell, Robert
Published in Journal of medicinal chemistry (09.02.2023)
Published in Journal of medicinal chemistry (09.02.2023)
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Journal Article
5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors
Peese, Kevin M, Allard, Christopher W, Connolly, Timothy, Johnson, Barry L, Li, Chen, Patel, Manoj, Sorensen, Margaret E, Walker, Michael A, Meanwell, Nicholas A, McAuliffe, Brian, Minassian, Beatrice, Krystal, Mark, Parker, Dawn D, Lewis, Hal A, Kish, Kevin, Zhang, Ping, Nolte, Robert T, Simmermacher, Jean, Jenkins, Susan, Cianci, Christopher, Naidu, B. Narasimhulu
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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Journal Article
Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV‑1 Integrase Inhibitors
Li, Guo, Meanwell, Nicholas A, Krystal, Mark R, Langley, David R, Naidu, B. Narasimhulu, Sivaprakasam, Prasanna, Lewis, Hal, Kish, Kevin, Khan, Javed A, Ng, Alicia, Trainor, George L, Cianci, Christopher, Dicker, Ira B, Walker, Michael A, Lin, Zeyu, Protack, Tricia, Discotto, Linda, Jenkins, Susan, Gerritz, Samuel W, Pendri, Annapurna
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
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Journal Article
Design, synthesis and SAR study of novel C2-pyrazolopyrimidine amides and amide isosteres as allosteric integrase inhibitors
Patel, Manoj, Cianci, Christopher, Allard, Christopher W., Parker, Dawn D., Simmermacher, Jean, Jenkins, Susan, Mcauliffe, Brian, Minassian, Beatrice, Discotto, Linda, Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
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Journal Article
Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV‑1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs
Naidu, B. Narasimhulu, Patel, Manoj, McAuliffe, Brian, Ding, Bo, Cianci, Christopher, Simmermacher, Jean, Jenkins, Susan, Parker, Dawn D, Sivaprakasam, Prasanna, Khan, Javed A, Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Krystal, Mark, Meanwell, Nicholas A, Kadow, John F
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Journal Article
Benzyl amide-ketoacid inhibitors of HIV-integrase
Walker, Michael A., Johnson, Timothy, Naidu, B. Narasimhulu, Banville, Jacques, Remillard, Roger, Plamondon, Serge, Martel, Alain, Li, Chen, Torri, Albert, Samanta, Himadri, Lin, Zeyu, Dicker, Ira, Krystal, Mark, Meanwell, Nicholas A.
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Journal Article
Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics
Naidu, B. Narasimhulu, Sorenson, Margaret E., Zhang, Yunhui, Kim, Oak K., Matiskella, John D., Wichtowski, John A., Connolly, Timothy P., Li, Wenying, Lam, Kin S., Bronson, Joanne J., Pucci, Michael J., Clark, Junius M., Ueda, Yasutsugu
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
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Journal Article
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors
Parcella, Kyle, Patel, Manoj, Tu, Yong, Eastman, Kyle, Peese, Kevin, Gillis, Eric, Belema, Makonen, Dicker, Ira B., McAuliffe, Brian, Ding, Bo, Falk, Paul, Simmermacher, Jean, Parker, Dawn D., Sivaprakasam, Prasanna, Khan, Javed A., Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Jenkins, Susan, Kadow, John F., Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in Bioorganic & medicinal chemistry (01.08.2022)
Published in Bioorganic & medicinal chemistry (01.08.2022)
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Journal Article
Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors
Patel, Manoj, Naidu, B. Narasimhulu, Dicker, Ira, Higley, Helen, Lin, Zeyu, Terry, Brian, Protack, Tricia, Krystal, Mark, Jenkins, Susan, Parker, Dawn, Panja, Chiradeep, Rampulla, Richard, Mathur, Arvind, Meanwell, Nicholas A., Walker, Michael A.
Published in Bioorganic & medicinal chemistry (01.07.2020)
Published in Bioorganic & medicinal chemistry (01.07.2020)
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Journal Article
Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11
Saulnier, Mark G, Balasubramanian, Balu N, Long, Byron H, Frennesson, David B, Ruediger, Edward, Zimmermann, Kurt, Eummer, Jeffrey T, St. Laurent, Denis R, Stoffan, Karen M, Naidu, B. Narasimhulu, Mahler, Mikael, Beaulieu, Francis, Bachand, Carol, Lee, Frank Y, Fairchild, Craig R, Stadnick, Linda K, Rose, William C, Solomon, Carola, Wong, Henry, Martel, Alain, Wright, John J, Kramer, Robert, Langley, David R, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
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Journal Article
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors
Peese, Kevin M., Naidu, B. Narasimhulu, Patel, Manoj, Li, Chen, Langley, David R., Terry, Brian, Protack, Tricia, Gali, Volodymyr, Lin, Zeyu, Samanta, Himadri K., Zheng, Ming, Jenkins, Susan, Dicker, Ira B., Krystal, Mark R., Meanwell, Nicholas A., Walker, Michael A.
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
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Journal Article
The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor
Naidu, B. Narasimhulu, Walker, Michael A., Sorenson, Margaret E., Ueda, Yasutsugu, Matiskella, John D., Connolly, Timothy P., Dicker, Ira B., Lin, Zeyu, Bollini, Sagarika, Terry, Brian J., Higley, Helen, Zheng, Ming, Parker, Dawn D., Wu, Dedong, Adams, Stephen, Krystal, Mark R., Meanwell, Nicholas A.
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
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Journal Article
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV‑1 Allosteric Integrase Inhibitor
Parcella, Kyle, Wang, Tao, Eastman, Kyle, Zhang, Zhongxing, Yin, Zhiwei, Patel, Manoj, Tu, Yong, Zheng, Barbara Zhizhen, Walker, Michael A., Saulnier, Mark G., Frennesson, David, Bowsher, Michael, Gillis, Eric, Peese, Kevin, Belema, Makonen, Cianci, Christopher, Dicker, Ira B., McAuliffe, Brian, Ding, Bo, Falk, Paul, Simmermacher, Jean, Parker, Dawn D., Sivaprakasam, Prasanna, Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Jenkins, Susan, Kadow, John F., Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in ACS medicinal chemistry letters (09.06.2022)
Published in ACS medicinal chemistry letters (09.06.2022)
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Journal Article
Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives
NARASIMHULU NAIDU, B, SORENSON, Margaret E, HUDYMA, Thomas, XIAOFAN ZHENG, YUNHUI ZHANG, BRONSON, Joanne J, PUCCI, Michael J, CLARK, Junius M, UEDA, Yasutsugu
Published in Bioorganic & medicinal chemistry letters (16.07.2004)
Published in Bioorganic & medicinal chemistry letters (16.07.2004)
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Journal Article
Novel semi-synthetic nocathiacin antibiotics: synthesis and antibacterial activity of bis- and mono- O-alkylated derivatives
Regueiro-Ren, Alicia, Naidu, B.Narasimhulu, Zheng, Xiaofan, Hudyma, Thomas W., Connolly, Timothy P., Matiskella, John D., Zhang, Yunhui, Kim, Oak K., Sorenson, Margaret E., Pucci, Michael, Clark, Junius, Bronson, Joanne J., Ueda, Yasutsugu
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
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Journal Article