Search Results - "BÜTTELMANN, Bernd" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

by Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk, Christoph, Guba, Wolfgang, Harrison, Anthony, Hartung, Thomas, Honer, Michael, Huwyler, Jörg, Kuratli, Martin, Niederhauser, Urs, Pähler, Axel, Peters, Jens-Uwe, Petersen, Ann, Prinssen, Eric, Ricci, Antonio, Rueher, Daniel, Rueher, Marianne, Schneider, Manfred, Spurr, Paul, Stoll, Theodor, Tännler, Daniel, Wichmann, Jürgen, Porter, Richard H, Wettstein, Joseph G, Lindemann, Lothar
Published in Journal of medicinal chemistry (12.02.2015)

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CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor

CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor

by Lindemann, Lothar, Jaeschke, Georg, Michalon, Aubin, Vieira, Eric, Honer, Michael, Spooren, Will, Porter, Richard, Hartung, Thomas, Kolczewski, Sabine, Büttelmann, Bernd, Flament, Christophe, Diener, Catherine, Fischer, Christophe, Gatti, Silvia, Prinssen, Eric P, Parrott, Neil, Hoffmann, Gerhard, Wettstein, Joseph G
Published in The Journal of pharmacology and experimental therapeutics (01.11.2011)

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Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

by ACHERMANN, Guido, BALLARD, Theresa M, KOBLET, Andreas, KNUST, Henner, KURT, Anke, MARTIN, James R, MASCIADRI, Raffaello, PORTER, Richard H. P, STADLER, Heinz, THOMAS, Andrew W, TRUBE, Gerhard, WICHMANN, Jürgen, BLASCO, Francesca, BROUTIN, Pierre-Emmanuel, BÜTTELMANN, Bernd, FISCHER, Holger, GRAF, Martin, HERNANDEZ, Maria-Clemencia, HILTY, Peter, KNOFLACH, Frédéric
Published in Bioorganic & medicinal chemistry letters (01.10.2009)

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Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists

by Jaeschke, Georg, Porter, Richard, Büttelmann, Bernd, Ceccarelli, Simona M., Guba, Wolfgang, Kuhn, Bernd, Kolczewski, Sabine, Huwyler, Jörg, Mutel, Vincent, Peters, Jens-Uwe, Ballard, Theresa, Prinssen, Eric, Vieira, Eric, Wichmann, Jürgen, Spooren, Will
Published in Bioorganic & medicinal chemistry letters (01.03.2007)

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Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

by Porter, Richard H P, Jaeschke, Georg, Spooren, Will, Ballard, Theresa M, Büttelmann, Bernd, Kolczewski, Sabine, Peters, Jens-Uwe, Prinssen, Eric, Wichmann, Jürgen, Vieira, Eric, Mühlemann, Andreas, Gatti, Silvia, Mutel, Vincent, Malherbe, Pari
Published in The Journal of pharmacology and experimental therapeutics (01.11.2005)

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Discovery of the imidazo[1,5- a][1,2,4]-triazolo[1,5- d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA A α5 inverse agonist series

Discovery of the imidazo[1,5- a][1,2,4]-triazolo[1,5- d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA A α5 inverse agonist series

by Achermann, Guido, Ballard, Theresa M., Blasco, Francesca, Broutin, Pierre-Emmanuel, Büttelmann, Bernd, Fischer, Holger, Graf, Martin, Hernandez, Maria-Clemencia, Hilty, Peter, Knoflach, Frédéric, Koblet, Andreas, Knust, Henner, Kurt, Anke, Martin, James R., Masciadri, Raffaello, Porter, Richard H.P., Stadler, Heinz, Thomas, Andrew W., Trube, Gerhard, Wichmann, Jürgen
Published in Bioorganic & medicinal chemistry letters (2009)

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2-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

2-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

by Büttelmann, Bernd, Alanine, Alexander, Bourson, Anne, Gill, Ramanjit, Heitz, Marie-Paule, Mutel, Vincent, Pinard, Emmanuel, Trube, Gerhard, Wyler, René
Published in Bioorganic & medicinal chemistry letters (10.03.2003)

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1-Benzyloxy-4,5-dihydro- 1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

1-Benzyloxy-4,5-dihydro- 1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

by Alanine, Alexander, Bourson, Anne, Büttelmann, Bernd, Gill, Ramanjit, Heitz, Marie-Paule, Mutel, Vincent, Pinard, Emmanuel, Trube, Gerhard, Wyler, René
Published in Bioorganic & medicinal chemistry letters (06.10.2003)

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Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

by Büttelmann, Bernd, Peters, Jens-Uwe, Ceccarelli, Simona, Kolczewski, Sabine, Vieira, Eric, Prinssen, Eric P., Spooren, Will, Schuler, Franz, Huwyler, Jörg, Porter, Richard H.P., Jaeschke, Georg
Published in Bioorganic & medicinal chemistry letters (01.04.2006)

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4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

by Pinard, Emmanuel, Alanine, Alexander, Bourson, Anne, Büttelmann, Bernd, Heitz, Marie-Paule, Mutel, a Ramanjit Gill, Vincent, Trube, Gerhard, Wyler, René
Published in Bioorganic & medicinal chemistry letters (16.09.2002)

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Journal Article

4-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1 H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists

4-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1 H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists

by Büttelmann, Bernd, Alanine, Alexander, Bourson, Anne, Gill, Ramanjit, Heitz, Marie-Paule, Mutel, Vincent, Pinard, Emmanuel, Trube, Gerhard, Wyler, René
Published in Bioorganic & medicinal chemistry letters (19.05.2003)

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Discovery of ( R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist

Discovery of ( R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist

by Pinard, Emmanuel, Alanine, Alexander, Bourson, Anne, Büttelmann, Bernd, Gill, Ramanjit, Heitz, Marie-Paule, Jaeschke, Georg, Mutel, Vincent, Trube, Gerhard, Wyler, René
Published in Bioorganic & medicinal chemistry letters (20.08.2001)

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Journal Article

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series

by Achermann, Guido, Ballard, Theresa M, Blasco, Francesca, Broutin, Pierre-Emmanuel, Büttelmann, Bernd, Fischer, Holger, Graf, Martin, Hernandez, Maria-Clemencia, Hilty, Peter, Knoflach, Frédéric, Koblet, Andreas, Knust, Henner, Kurt, Anke, Martin, James R, Masciadri, Raffaello, Porter, Richard H P, Stadler, Heinz, Thomas, Andrew W, Trube, Gerhard, Wichmann, Jürgen
Published in Bioorganic & medicinal chemistry letters (01.10.2009)

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Journal Article

Synthesis and rearrangement of 6H-imidazo[1,2-c]-quinazolin-5-ones

Synthesis and rearrangement of 6H-imidazo[1,2-c]-quinazolin-5-ones

by Arnold, W, Buttelmann, B, Heitz, MP, Wyler, R
Published in Heterocycles (1996)

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Journal Article

4-hydroxy-piperidine derivatives

4-hydroxy-piperidine derivatives

by Alanine, Alexander, Büttelmann, Bernd, Neidhart, Marie-Paule Heitz, Pinard, Emmanuel, Wyler, René
Year of Publication 19.03.2002

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Patent

NON-ANNELATED TYOPHENYLAMIDS AS INHIBITORS OF FATTY ACIDS FABP 4 AND / OR 5 BINDING PROTEINS

NON-ANNELATED TYOPHENYLAMIDS AS INHIBITORS OF FATTY ACIDS FABP 4 AND / OR 5 BINDING PROTEINS

by KYUNE Kholger, CHEKKARELLI Simona M, OBST ZANDER Ulrike, KUN Bernd, NAJDKHART Verner, BUTTELMANN Bernd, RIKHTER Khans
Year of Publication 16.03.2018

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Patent

TRIAZOLE AND IMIDAZOLE DERIVATIVES

TRIAZOLE AND IMIDAZOLE DERIVATIVES

by PINARD, EMMANUEL, WYLER, RENE, ALANINE, ALEXANDER, HEITZ NEIDHART, MARIE-PAULE, JAESCHKE, GEORG, BUTTELMANN, BERND
Year of Publication 30.09.2008

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Patent

QUINOLIN-4-YL DERIVATIVES

QUINOLIN-4-YL DERIVATIVES

by PINARD, EMMANUEL, WYLER, RENE, ALANINE, ALEXANDER, HEITZ NEIDHART, MARIE-PAULE, BURNER, SERGE, JAESCHKE, GEORG, BUTTELMANN, BERND
Year of Publication 20.05.2008

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Patent

THE USE OF ARYL-CYCLOHEXYLAMINE DERIVATIVES AGAINST CNS DISORDERS

THE USE OF ARYL-CYCLOHEXYLAMINE DERIVATIVES AGAINST CNS DISORDERS

by MARIE-PAULE HEITZ NEIDHART, EMMANUEL PINARD, BERND BUTTELMANN, RENE WYLER, ALEXANDER ALANINE
Year of Publication 31.10.2007

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Patent

ETHANESULFONYL-PIPERIDINE DERIVATIVES

ETHANESULFONYL-PIPERIDINE DERIVATIVES

by MARIE-PAULE HEITZ NEIDHART, EMMANUEL PINARD, GEORG JAESCHKE, SERGE BURNER, BERND BUTTELMANN, RENE WYLER, ALEXANDER ALANINE
Year of Publication 28.02.2007

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Patent

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