Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer
Lücking, Ulrich, Kosemund, Dirk, Böhnke, Niels, Lienau, Philip, Siemeister, Gerhard, Denner, Karsten, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Bömer, Ulf, Schäfer, Martina, Ince, Stuart, Mumberg, Dominik, Scholz, Arne, Izumi, Raquel, Hwang, Stuart, von Nussbaum, Franz
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models
Wengner, Antje M, Siemeister, Gerhard, Lücking, Ulrich, Lefranc, Julien, Wortmann, Lars, Lienau, Philip, Bader, Benjamin, Bömer, Ulf, Moosmayer, Dieter, Eberspächer, Uwe, Golfier, Sven, Schatz, Christoph A, Baumgart, Simon J, Haendler, Bernard, Lejeune, Pascale, Schlicker, Andreas, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik
Published in Molecular cancer therapeutics (01.01.2020)
Published in Molecular cancer therapeutics (01.01.2020)
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Journal Article
Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer
Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael
Published in ChemMedChem (08.11.2017)
Published in ChemMedChem (08.11.2017)
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Journal Article
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase
Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Journal Article
Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models
Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor
Lefranc, Julien, Schulze, Volker Klaus, Hillig, Roman Christian, Briem, Hans, Prinz, Florian, Mengel, Anne, Heinrich, Tobias, Balint, Jozsef, Rengachari, Srinivasan, Irlbacher, Horst, Stöckigt, Detlef, Bömer, Ulf, Bader, Benjamin, Gradl, Stefan Nikolaus, Nising, Carl Friedrich, von Nussbaum, Franz, Mumberg, Dominik, Panne, Daniel, Wengner, Antje Margret
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Journal Article
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21
Göricke, Fabian, Vu, Victoria, Smith, Leanna, Scheib, Ulrike, Böhm, Raphael, Akkilic, Namik, Wohlfahrt, Gerd, Weiske, Jörg, Bömer, Ulf, Brzezinka, Krzysztof, Lindner, Niels, Lienau, Philip, Gradl, Stefan, Beck, Hartmut, Brown, Peter J., Santhakumar, Vijayaratnam, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Schmees, Norbert, Petersen, Kirstin
Published in Journal of medicinal chemistry (09.03.2023)
Published in Journal of medicinal chemistry (09.03.2023)
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Journal Article
Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839
Bothe, Ulrich, Günther, Judith, Nubbemeyer, Reinhard, Siebeneicher, Holger, Ring, Sven, Bömer, Ulf, Peters, Michaele, Rausch, Alexandra, Denner, Karsten, Himmel, Herbert, Sutter, Andreas, Terebesi, Ildiko, Lange, Martin, Wengner, Antje M., Guimond, Nicolas, Thaler, Tobias, Platzek, Johannes, Eberspächer, Uwe, Schäfer, Martina, Steuber, Holger, Zollner, Thomas M., Steinmeyer, Andreas, Schmidt, Nicole
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
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Journal Article
A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy
Böhnke, Niels, Berger, Markus, Griebenow, Nils, Rottmann, Antje, Erkelenz, Michael, Hammer, Stefanie, Berndt, Sandra, Günther, Judith, Wengner, Antje M., Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah, Barak, Naomi, Bömer, Ulf, Hillig, Roman C., Eberspaecher, Uwe, Weiske, Jörg, Giese, Anja, Mumberg, Dominik, Nising, Carl Friedrich, Weinmann, Hilmar, Sommer, Anette
Published in Bioconjugate chemistry (15.06.2022)
Published in Bioconjugate chemistry (15.06.2022)
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Journal Article
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies
Berger, Markus, Wortmann, Lars, Buchgraber, Philipp, Lücking, Ulrich, Zitzmann-Kolbe, Sabine, Wengner, Antje M, Bader, Benjamin, Bömer, Ulf, Briem, Hans, Eis, Knut, Rehwinkel, Hartmut, Bartels, Florian, Moosmayer, Dieter, Eberspächer, Uwe, Lienau, Philip, Hammer, Stefanie, Schatz, Christoph A, Wang, Qiuwen, Wang, Qi, Mumberg, Dominik, Nising, Carl F, Siemeister, Gerhard
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Journal Article
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models
Lemos, Clara, Schulze, Volker K., Baumgart, Simon J., Nevedomskaya, Ekaterina, Heinrich, Tobias, Lefranc, Julien, Bader, Benjamin, Christ, Clara D., Briem, Hans, Kuhnke, Lara P., Holton, Simon J., Bömer, Ulf, Lienau, Philip, von Nussbaum, Franz, Nising, Carl F., Bauser, Marcus, Hägebarth, Andrea, Mumberg, Dominik, Haendler, Bernard
Published in Cellular oncology (Dordrecht) (01.06.2021)
Published in Cellular oncology (Dordrecht) (01.06.2021)
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Journal Article
High-Throughput Screening for Kinase Inhibitors
von Ahsen, Oliver, Bömer, Ulf
Published in Chembiochem : a European journal of chemical biology (01.03.2005)
Published in Chembiochem : a European journal of chemical biology (01.03.2005)
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Journal Article
Tom5 functionally links mitochondrial preprotein receptors to the general import pore
Pfanner, Nikolaus, Dietmeier, Klaus, Hönlinger, Angelika, Bömer, Ulf, Dekker, Peter J. T, Eckerskorn, Christoph, Lottspeich, Fritz, Kübrich, Michael
Published in Nature (London) (10.07.1997)
Published in Nature (London) (10.07.1997)
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Journal Article
BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumor activity
Santag, Susann, Siegel, Franziska, Wengner, Antje M, Lange, Claudia, Bömer, Ulf, Eis, Knut, Pühler, Florian, Lienau, Philip, Bergemann, Linda, Michels, Martin, von Nussbaum, Franz, Mumberg, Dominik, Petersen, Kirstin
Published in Cancer letters (01.04.2017)
Published in Cancer letters (01.04.2017)
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Journal Article
BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling‐dependent tumor growth in mouse models
Politz, Oliver, Siegel, Franziska, Bärfacker, Lars, Bömer, Ulf, Hägebarth, Andrea, Scott, William J., Michels, Martin, Ince, Stuart, Neuhaus, Roland, Meyer, Kirstin, Fernández‐Montalván, Amaury Ernesto, Liu, Ningshu, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl
Published in International journal of cancer (15.01.2017)
Published in International journal of cancer (15.01.2017)
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Journal Article
Discovery of Rogaratinib (BAY 1163877): a pan‐FGFR Inhibitor
Collin, Marie‐Pierre, Lobell, Mario, Hübsch, Walter, Brohm, Dirk, Schirok, Hartmut, Jautelat, Rolf, Lustig, Klemens, Bömer, Ulf, Vöhringer, Verena, Héroult, Mélanie, Grünewald, Sylvia, Hess‐Stumpp, Holger
Published in ChemMedChem (06.03.2018)
Published in ChemMedChem (06.03.2018)
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Journal Article
Abstract 5866: Discovery and profiling of a highly potent and selective ERK5 inhibitor: BAY-885
Lemos, Clara, Nguyen, Duy, Wortmann, Lars, Bömer, Ulf, Holton, Simon, Lechner, Christian, Prechtl, Stefan, Sülzle, Detlev, Siegel, Franziska, Mumberg, Dominik, Bauser, Marcus, Hägebarth, Andrea
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 2907: Identification and optimization of a novel NAMPT inhibitor-based ADC payload class for cancer therapy
Böhnke, Niels, Berger, Markus, Griebenow, Nils, Giese, Anja, Günther, Judith, Sommer, Anette, Hammer, Stefanie, Berndt, Sandra, Wengner, Antje M., Beier, Rudolf, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Rottmann, Antje, Erkelenz, Michael, Barak, Naomi, Bömer, Ulf, Mumber, Dominik, Kreft, Bertolt, Linden, Lars, Nising, Carl Friedrich, Weinmann, Hilmar
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 4851: Second generation 2,3-dihydroimidazo[1,2-c]quinazoline PI3K inhibitors: development of BAY 1082439, a novel balanced PI3Ká / PI3Kâ inhibitor
Scott, William J., Liu, Ningshu, Hägebarth, Andreas, Möwes, Manfred, Mönning, Ursula, Bömer, Ulf, Mumberg, Dominik, von Nussbaum, Franz, Brands, Michael, Lafranc, Julien
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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The Sorting Route of Cytochrome b 2Branches from the General Mitochondrial Import Pathway at the Preprotein Translocase of the Inner Membrane
Bömer, Ulf, Meijer, Michiel, Guiard, Bernard, Dietmeier, Klaus, Pfanner, Nikolaus, Rassow, Joachim
Published in The Journal of biological chemistry (01.11.1997)
Published in The Journal of biological chemistry (01.11.1997)
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