Parenteral platforms for tunable, long-acting administration of a highly hydrophobic antiretroviral drug
Akhavein, Nima, Baum, Marc M., Gunawardana, Manjula, Moss, John A., Calvez, Sandrine, Remedios-Chan, Mariana, Fanter, Rob, Lenhard, Steve, Rusk, Samantha, Azzarano, Leonard, McCoy, Deborah, Jucker, Beat, Johns, Brian, Burke, Matt, Velthuisen, Emile
Published in Scientific reports (21.05.2024)
Published in Scientific reports (21.05.2024)
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Preclinical Pharmacokinetic Properties of the P-Glycoprotein Inhibitor GF120918A (HCl salt of GF120918, 9,10-Dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the Mouse, Rat, Dog, and Monkey
Ward, Keith W, Azzarano, Leonard M
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)
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Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors
Hammond, Marlys, Washburn, David G., Hoang, Tram H., Manns, Sharada, Frazee, James S., Nakamura, Hiroko, Patterson, Jaclyn R., Trizna, Walter, Wu, Charlene, Azzarano, Leonard M., Nagilla, Rakesh, Nord, Melanie, Trejo, Rebecca, Head, Martha S., Zhao, Baoguang, Smallwood, Angela M., Hightower, Kendra, Laping, Nicholas J., Schnackenberg, Christine G., Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Comparison of N, N′-diarylsquaramides and N, N′-diarylureas as antagonists of the CXCR2 chemokine receptor
McCleland, Brent W., Davis, Roderick S., Palovich, Michael R., Widdowson, Katherine L., Werner, Michelle L., Burman, Miriam, Foley, James J., Schmidt, Dulcie B., Sarau, Henry M., Rogers, Martin, Salyers, Kevin L., Gorycki, Peter D., Roethke, Theresa J., Stelman, Gary J., Azzarano, Leonard M., Ward, Keith W., Busch-Petersen, Jakob
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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DEVELOPMENT OF AN IN VIVO PRECLINICAL SCREEN MODEL TO ESTIMATE ABSORPTION AND FIRST-PASS HEPATIC EXTRACTION OF XENOBIOTICS. II. USE OF KETOCONAZOLE TO IDENTIFY P-GLYCOPROTEIN/CYP3A-LIMITED BIOAVAILABILITY IN THE MONKEY
WARD, Keith W, STELMAN, Gary J, MORGAN, Jayme A, ZEIGLER, Kelli S, AZZARANO, Leonard M, KEHLER, Jonathan R, MCSURDY-FREED, Jeanelle E, PROKSCH, Joel W, SMITH, Brian R
Published in Drug metabolism and disposition (01.02.2004)
Published in Drug metabolism and disposition (01.02.2004)
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Improving the developability profile of pyrrolidine progesterone receptor partial agonists
Kallander, Lara S., Washburn, David G., Hoang, Tram H., Frazee, James S., Stoy, Patrick, Johnson, Latisha, Lu, Qing, Hammond, Marlys, Barton, Linda S., Patterson, Jaclyn R., Azzarano, Leonard M., Nagilla, Rakesh, Madauss, Kevin P., Williams, Shawn P., Stewart, Eugene L., Duraiswami, Chaya, Grygielko, Eugene T., Xu, Xiaoping, Laping, Nicholas J., Bray, Jeffrey D., Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
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Assessment of oral bioavailability enhancing approaches for SB-247083 using flow-through cell dissolution testing as one of the screens
Perng, Cherng-Yih, Kearney, Albert S, Palepu, Nagesh R, Smith, Brian R, Azzarano, Leonard M
Published in International journal of pharmaceutics (02.01.2003)
Published in International journal of pharmaceutics (02.01.2003)
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Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists
Miller, William H, Manley, Peter J, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Kwon, Chet, Ross, Stephen T, Samanen, James M, Takata, Dennis T, Uzinskas, Irene N, Yuan, Catherine C.K, Haltiwanger, R.Curtis, Gress, Catherine J, Lark, Michael W, Hwang, Shing-Mei, James, Ian E, Rieman, David J, Willette, Robert N, Yue, Tian-Li, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
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Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic
Miller, William H, Alberts, Doreen P, Bhatnagar, Pradip K, Bondinell, William E, Callahan, James F, Calvo, Raul R, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Keenan, Richard M, Kwon, Chet, Manley, Peter J, Newlander, Kenneth A, Ross, Stephen T, Samanen, James M, Uzinskas, Irene N, Venslavsky, Joseph W, Yuan, Catherine C.-K, Haltiwanger, R. Curtis, Gowen, Maxine, Hwang, Shing-Mei, James, Ian E, Lark, Michael W, Rieman, David J, Stroup, George B, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F
Published in Journal of medicinal chemistry (13.01.2000)
Published in Journal of medicinal chemistry (13.01.2000)
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Pharmacokinetics of SB-247083, a potent and selective endothelinA receptor antagonist, in the rat, dog, and monkey
Ward, Keith W., Azzarano, Leonard M., Morgan, Jayme A., Gould, Michael J., Perng, Cherng-Yih, Souder, Pamela R., Lundberg, David, Smith, Brian R.
Published in Biopharmaceutics & drug disposition (01.11.2002)
Published in Biopharmaceutics & drug disposition (01.11.2002)
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Pharmacokinetics of SB-247083, a potent and selective endothelin(A) receptor antagonist, in the rat, dog, and monkey
Ward, Keith W, Azzarano, Leonard M, Morgan, Jayme A, Gould, Michael J, Perng, Cherng-Yih, Souder, Pamela R, Lundberg, David, Smith, Brian R
Published in Biopharmaceutics & drug disposition (01.11.2002)
Published in Biopharmaceutics & drug disposition (01.11.2002)
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Preclinical Pharmacokinetics and Interspecies Scaling of a Novel Vitronectin Receptor Antagonist
WARD, K. W, AZZARANO, L. M, MUMAW, J. A, NEWLANDER, K. A, PIRHALLA, J. L, ROETHKE, T. J, SALYERS, K. L, SOUDER, P. R, STELMAN, G. J, SMITH, B. R, BONDINELL, W. E, COUSINS, R. D, HUFFMAN, W. F, JAKAS, D. R, KEENAN, R. M, KU, T. W, LUNDBERG, D, MILLER, W. H
Published in Drug metabolism and disposition (01.11.1999)
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Published in Drug metabolism and disposition (01.11.1999)
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SB-239063, a potent and selective inhibitor of p38 map kinase : Preclinical pharmacokinetics and species-specific reversible isomerization
WARD, Keith W, PROKSCH, Joel W, AZZARANO, Leonard M, SALYERS, Kevin L, MCSURDY-FREED, Jeanelle E, MOLNAR, Tina M, LEVY, Mark A, SMITH, Brian R
Published in Pharmaceutical research (01.09.2001)
Published in Pharmaceutical research (01.09.2001)
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Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model
Miller, William H., Bondinell, William E., Cousins, Russell D., Erhard, Karl F., Jakas, Dalia R., Keenan, Richard M., Ku, Thomas W., Newlander, Kenneth A., Ross, Stephen T., Haltiwanger, R.Curtis, Bradbeer, Jeremy, Drake, Fred H., Gowen, Maxine, Hoffman, Sandra J., Hwang, Shing-Mei, James, Ian E., Lark, Michael W., Lechowska, Beata, Rieman, David J., Stroup, George B., Vasko-Moser, Janice A., Zembryki, Denise L., Azzarano, Leonard M., Adams, Paula C., Salyers, Kevin L., Smith, Brian R., Ward, Keith W., Johanson, Kyung O., Huffaman, William F.
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
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