SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: Preclinical pharmacokinetics
WARD, K. W, PROKSCH, J. W, SALYERS, K. L, AZZARANO, L. M, MORGAN, J. A, ROETHKE, T. J, MCSURDY-FREED, J. E, LEVY, M. A, SMITH, B. R
Published in Xenobiotica (01.03.2002)
Published in Xenobiotica (01.03.2002)
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Preclinical pharmacokinetics of SB-203580, a potent inhibitor of p38 mitogen-activated protein kinase
Ward, K. W., Proksch, J. W., Azzarano, L. M., Mumaw, J. A., Roethke, T. J., Stelman, G. J., Walsh, M. J., Zeigler, K. S., McSurdy-Freed, J. E., Kehler, J. R, Chokshi, J., Levy, M. A., Smith, B. R.
Published in Xenobiotica (2001)
Published in Xenobiotica (2001)
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Preclinical Pharmacokinetics and Interspecies Scaling of a Novel Vitronectin Receptor Antagonist
WARD, K. W, AZZARANO, L. M, MUMAW, J. A, NEWLANDER, K. A, PIRHALLA, J. L, ROETHKE, T. J, SALYERS, K. L, SOUDER, P. R, STELMAN, G. J, SMITH, B. R, BONDINELL, W. E, COUSINS, R. D, HUFFMAN, W. F, JAKAS, D. R, KEENAN, R. M, KU, T. W, LUNDBERG, D, MILLER, W. H
Published in Drug metabolism and disposition (01.11.1999)
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Published in Drug metabolism and disposition (01.11.1999)
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Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic
Miller, William H, Alberts, Doreen P, Bhatnagar, Pradip K, Bondinell, William E, Callahan, James F, Calvo, Raul R, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Keenan, Richard M, Kwon, Chet, Manley, Peter J, Newlander, Kenneth A, Ross, Stephen T, Samanen, James M, Uzinskas, Irene N, Venslavsky, Joseph W, Yuan, Catherine C.-K, Haltiwanger, R. Curtis, Gowen, Maxine, Hwang, Shing-Mei, James, Ian E, Lark, Michael W, Rieman, David J, Stroup, George B, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F
Published in Journal of medicinal chemistry (13.01.2000)
Published in Journal of medicinal chemistry (13.01.2000)
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Apparent absolute oral bioavailability in excess of 100% for a vitronectin receptor antagonist (SB-265123) in rat. II. Studies implicating transporter-mediated intestinal secretion
Ward, K. W., Hardy, L. B., Kehler, J. R., Azzarano, L. M., Smith, B. R.
Published in Xenobiotica (01.04.2004)
Published in Xenobiotica (01.04.2004)
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Preclinical Pharmacokinetic Properties of the P-Glycoprotein Inhibitor GF120918A (HCl salt of GF120918, 9,10-Dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the Mouse, Rat, Dog, and Monkey
Ward, Keith W, Azzarano, Leonard M
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)
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Assessment of oral bioavailability enhancing approaches for SB-247083 using flow-through cell dissolution testing as one of the screens
Perng, Cherng-Yih, Kearney, Albert S, Palepu, Nagesh R, Smith, Brian R, Azzarano, Leonard M
Published in International journal of pharmaceutics (02.01.2003)
Published in International journal of pharmaceutics (02.01.2003)
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Journal Article
SB-242235, a selective inhibitor of p38 mitogenactivated protein kinase. I: Preclinical pharmacokinetics
Ward, K. W., Proksch, J. W., Salyers, K. L., Azzarano, L. M., Morgan, J. A., Roethke, T. J., McSurdy-Freed, J. E., Levy, M. A., Smith, B. R.
Published in Xenobiotica (01.01.2002)
Published in Xenobiotica (01.01.2002)
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SB-239063, a potent and selective inhibitor of p38 map kinase : Preclinical pharmacokinetics and species-specific reversible isomerization
WARD, Keith W, PROKSCH, Joel W, AZZARANO, Leonard M, SALYERS, Kevin L, MCSURDY-FREED, Jeanelle E, MOLNAR, Tina M, LEVY, Mark A, SMITH, Brian R
Published in Pharmaceutical research (01.09.2001)
Published in Pharmaceutical research (01.09.2001)
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Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model
Miller, William H., Bondinell, William E., Cousins, Russell D., Erhard, Karl F., Jakas, Dalia R., Keenan, Richard M., Ku, Thomas W., Newlander, Kenneth A., Ross, Stephen T., Haltiwanger, R.Curtis, Bradbeer, Jeremy, Drake, Fred H., Gowen, Maxine, Hoffman, Sandra J., Hwang, Shing-Mei, James, Ian E., Lark, Michael W., Lechowska, Beata, Rieman, David J., Stroup, George B., Vasko-Moser, Janice A., Zembryki, Denise L., Azzarano, Leonard M., Adams, Paula C., Salyers, Kevin L., Smith, Brian R., Ward, Keith W., Johanson, Kyung O., Huffaman, William F.
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
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DEVELOPMENT OF AN IN VIVO PRECLINICAL SCREEN MODEL TO ESTIMATE ABSORPTION AND FIRST-PASS HEPATIC EXTRACTION OF XENOBIOTICS. II. USE OF KETOCONAZOLE TO IDENTIFY P-GLYCOPROTEIN/CYP3A-LIMITED BIOAVAILABILITY IN THE MONKEY
WARD, Keith W, STELMAN, Gary J, MORGAN, Jayme A, ZEIGLER, Kelli S, AZZARANO, Leonard M, KEHLER, Jonathan R, MCSURDY-FREED, Jeanelle E, PROKSCH, Joel W, SMITH, Brian R
Published in Drug metabolism and disposition (01.02.2004)
Published in Drug metabolism and disposition (01.02.2004)
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Journal Article
Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists
Miller, William H, Manley, Peter J, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Kwon, Chet, Ross, Stephen T, Samanen, James M, Takata, Dennis T, Uzinskas, Irene N, Yuan, Catherine C.K, Haltiwanger, R.Curtis, Gress, Catherine J, Lark, Michael W, Hwang, Shing-Mei, James, Ian E, Rieman, David J, Willette, Robert N, Yue, Tian-Li, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
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Journal Article
Pharmacokinetics of SB-247083, a potent and selective endothelin(A) receptor antagonist, in the rat, dog, and monkey
Ward, Keith W, Azzarano, Leonard M, Morgan, Jayme A, Gould, Michael J, Perng, Cherng-Yih, Souder, Pamela R, Lundberg, David, Smith, Brian R
Published in Biopharmaceutics & drug disposition (01.11.2002)
Published in Biopharmaceutics & drug disposition (01.11.2002)
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