An asymmetric synthesis of differentially protected meso-2,6-diaminopimelic acid
Holcomb, Ryan C., Schow, Steven, Ayral-Kaloustian, S., Powell, Dennis
Published in Tetrahedron letters (19.09.1994)
Published in Tetrahedron letters (19.09.1994)
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Protein Farnesyltransferase Inhibitors
AYRAL-KALOUSTIAN, Semiramis, SALASKI, Edward J
Published in Current medicinal chemistry (01.05.2002)
Published in Current medicinal chemistry (01.05.2002)
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Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates
Levin, J.I., Chen, J.M., Cheung, K., Cole, D., Crago, C., Santos, E.Delos, Du, X., Khafizova, G., MacEwan, G., Niu, C., Salaski, E.J., Zask, A., Cummons, T., Sung, A., Xu, J., Zhang, Y., Xu, W., Ayral-Kaloustian, S., Jin, G., Cowling, R., Barone, D., Mohler, K.M., Black, R.A., Skotnicki, J.S.
Published in Bioorganic & medicinal chemistry letters (18.08.2003)
Published in Bioorganic & medicinal chemistry letters (18.08.2003)
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HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo
LOGANZO, Frank, DISCAFANI, Carolyn M, SINGANALLORE, Thiruvikraman, KHAFIZOVA, Gulnaz, PORUCHYNSKY, Marianne S, FOJO, Tito, NIEMAN, James A, AYRAL-KALOUSTIAN, Semiramis, ZASK, Arie, ANDERSEN, Raymond J, GREENBERGER, Lee M, ANNABLE, Tami, BEYER, Carl, MUSTO, Sylvia, HARI, Malathi, XINGZHI TAN, HARDY, Carolyn, HERNANDEZ, Richard, BAXTER, Michelle
Published in Cancer research (Chicago, Ill.) (15.04.2003)
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Published in Cancer research (Chicago, Ill.) (15.04.2003)
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Pegylated Wortmannin and 17-Hydroxywortmannin Conjugates as Phosphoinositide 3-Kinase Inhibitors Active in Human Tumor Xenograft Models
Zhu, Tianmin, Gu, Jianxin, Yu, Ker, Lucas, Judy, Cai, Ping, Tsao, Russ, Gong, Yumin, Li, Fangbiao, Chaudhary, Inder, Desai, Parimal, Ruppen, Mark, Fawzi, Mahdi, Gibbons, James, Ayral-Kaloustian, Semiramis, Skotnicki, Jerauld, Mansour, Tarek, Zask, Arie
Published in Journal of medicinal chemistry (23.02.2006)
Published in Journal of medicinal chemistry (23.02.2006)
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Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N-1-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]-N-1,3-dimethyl-L-valinamide (HTI-286)
Zask, A, Birnberg, G, Cheung, K, Kaplan, J, Niu, C, Norton, E, Suayan, R, Yamashita, A, Cole, D, Tang, ZL, Krishnamurthy, G, Williamson, R, Khafizova, G, Musto, S, Hernandez, R, Annable, T, Yang, XR, Discafani, C, Beyer, C, Greenberger, LM, Loganzo, F, Ayral-Kaloustian, S
Published in Journal of medicinal chemistry (09.09.2004)
Published in Journal of medicinal chemistry (09.09.2004)
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Journal Article
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors
Yu, Ker, Lucas, Judy, Zhu, Tianmin, Zask, Arie, Gaydos, Christine, Toral-Barza, Lourdes, Gu, Jianxin, Li, Fangbiao, Chaudhary, Inder, Cai, Ping, Lotvin, Jason, Petersen, Roseann, Ruppen, Mark, Fawzi, Mahdi, Ayral-Kaloustian, Semiramis, Skotnicki, Jerauld, Mansour, Tarek, Frost, Philip, Gibbons, James
Published in Cancer biology & therapy (01.05.2005)
Published in Cancer biology & therapy (01.05.2005)
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Journal Article
Two Photoaffinity Analogues of the Tripeptide, Hemiasterlin, Exclusively Label α-Tubulin
Nunes, Maria, Kaplan, Joshua, Wooters, Joseph, Hari, Malathi, Minnick, Albert A, May, Michael K, Shi, Celine, Musto, Sylvia, Beyer, Carl, Krishnamurthy, Girija, Qiu, Yongchang, Loganzo, Frank, Ayral-Kaloustian, Semiramis, Zask, Arie, Greenberger, Lee M
Published in Biochemistry (Easton) (10.05.2005)
Published in Biochemistry (Easton) (10.05.2005)
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Journal Article
Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in α-tubulin
Loganzo, Frank, Hari, Malathi, Annable, Tami, Tan, Xingzhi, Morilla, Daniel B, Musto, Sylvia, Zask, Arie, Kaplan, Joshua, Minnick, Jr, Albert A, May, Michael K, Ayral-Kaloustian, Semiramis, Poruchynsky, Marianne S, Fojo, Tito, Greenberger, Lee M
Published in Molecular cancer therapeutics (01.10.2004)
Published in Molecular cancer therapeutics (01.10.2004)
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Journal Article
D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors
Zask, Arie, Birnberg, Gary, Cheung, Katherine, Kaplan, Joshua, Niu, Chuan, Norton, Emily, Yamashita, Ayako, Beyer, Carl, Krishnamurthy, Girija, Greenberger, Lee M, Loganzo, Frank, Ayral-Kaloustian, Semiramis
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
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Benzodiazepine inhibitors of the MMPs and TACE. Part 2
Levin, Jeremy I, Nelson, Frances C, Delos Santos, Efren, Du, Mila T, MacEwan, Gloria, Chen, James M, Ayral-Kaloustian, Semiramis, Xu, Jun, Jin, Guixian, Cummons, Terri, Barone, Dauphine
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
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Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents
Niu, Chuan, Smith, Daniel, Zask, Arie, Loganzo, Frank, Discafani, Carolyn, Beyer, Carl, Greenberger, Lee, Ayral-Kaloustian, Semiramis
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
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165 POSTER Furan ring-opened 17-hydroxywortmannin analogs as phcsphoinositide 3-kinase inhibitors active in human tumor xenograft models
Zask, A., Kaplan, J., Lucas, J., Hollander, I., Li, F., Chaudhary, I., Ayral-Kaloustian, S., Yu, K.
Published in European journal of cancer supplements (01.11.2006)
Published in European journal of cancer supplements (01.11.2006)
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Anticancer Agents from Unique Natural Products Sources
Ireland, Chris, Aalbersberg, William, Andersen, Raymond, Ayral-Kaloustian, Semiramis, Berlinck, Roberto, Bernan, Valerie, Carter, Guy, Churchill, Alice, Clardy, Jon, Concepcion, Gisela, De Silva, E., Discafani, Carolyn, Fojo, Tito, Frost, Philip, Gibson, Donna, Greenberger, Lee, Greenstein, Michael, Harper, Mary Kay, Mallon, Robert, Loganzo, Frank, Nunes, Maria, Poruchynsky, Marianne, Zask, Arie
Published in Pharmaceutical biology (2003)
Published in Pharmaceutical biology (2003)
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COMPUESTO, COMPOSICION FARMACEUTICA Y METODOS PARA TRATAR UN TRASTORNO RELACIONADOS CON PI3K O CON MTOR, Y PROCESO PARA SINTETIZAR EL COMPUESTO
MALWITZ, D, VERHEIJEN, J, KAPLAN, J, AYRAL- KALOUSTIAN, S, YU, K, LEFEVER, M, NOWAK, PAWEL WOJCIECH, ZASK, A, RICHARD, D. J, CURRAN, K. J, COLE, DEREK CECIL, BURSAVICH, MATTHEW GREGORY
Year of Publication 01.07.2009
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Year of Publication 01.07.2009
Patent
Triazine compounds as PI3 kinase and mTOR inhibitors
ZASK ARIE, SANTOS EFREN G. DELOS, VERHEIJEN JEROEN C, CURRAN KEVIN J, SHI MENGXIAO, SANTOS OSVALDO DOS, MANSOUR TAREK S, CHEN ZECHENG, DEHNHARDT CHRISTOPH M, RICHARD DAVID J, GOPALSAMY ARIAMALA, AYRAL-KALOUSTIAN SEMIRAMIS, VENKATESAN ARANAPAKAM M, KAPLAN JOSHUA A
Year of Publication 24.12.2014
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Year of Publication 24.12.2014
Patent
Triazine compounds as P13 kinase and mTOR inhibitors
ZASK ARIE, VERHEIJEN JEROEN C, CURRAN KEVIN J, DOS SANTOS OSVALDO, DELOS SANTOS EFREN GUILLERMO, SHI MENGXIAO, MANSOUR TAREK S, CHEN ZECHENG, DEHNHARDT CHRISTOPH M, RICHARD DAVID J, GOPALSAMY ARIAMALA, AYRAL-KALOUSTIAN SEMIRAMIS, VENKATESAN ARANAPAKAM M, KAPLAN JOSHUA AARON
Year of Publication 17.09.2014
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Year of Publication 17.09.2014
Patent