The new normal: immunomodulatory agents against sepsis immune suppression
Hutchins, Noelle A, Unsinger, Jacqueline, Hotchkiss, Richard S, Ayala, Alfred
Published in Trends in molecular medicine (01.04.2014)
Published in Trends in molecular medicine (01.04.2014)
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The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients
Ward, Nicholas S, Casserly, Brian, Ayala, Alfred
Published in Clinics in chest medicine (01.12.2008)
Published in Clinics in chest medicine (01.12.2008)
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Journal Article
PAD4 Deficiency Leads to Decreased Organ Dysfunction and Improved Survival in a Dual Insult Model of Hemorrhagic Shock and Sepsis
Biron, Bethany M, Chung, Chun-Shiang, Chen, Yaping, Wilson, Zachary, Fallon, Eleanor A, Reichner, Jonathan S, Ayala, Alfred
Published in The Journal of immunology (1950) (01.03.2018)
Published in The Journal of immunology (1950) (01.03.2018)
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PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis
Huang, Xin, Venet, Fabienne, Wang, Yvonne L, Lepape, Alain, Yuan, Zhenglong, Chen, Yaping, Swan, Ryan, Kherouf, Hakim, Monneret, Guillaume, Chung, Chun-Shiang, Ayala, Alfred
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.2009)
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Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model
Biron, Bethany M., Chung, Chun-Shiang, O'Brien, Xian M., Chen, Yaping, Reichner, Jonathan S., Ayala, Alfred
Published in Journal of innate immunity (01.01.2017)
Published in Journal of innate immunity (01.01.2017)
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Journal Article
Biomarkers for Sepsis: What Is and What Might Be?
Biron, Bethany M., Ayala, Alfred, Lomas-Neira, Joanne L.
Published in Biomarker Insights (01.01.2015)
Published in Biomarker Insights (01.01.2015)
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Book Review
Identification of B7-H1 as a novel mediator of the innate immune/proinflammatory response as well as a possible myeloid cell prognostic biomarker in sepsis
Huang, Xin, Chen, Yaping, Chung, Chun-Shiang, Yuan, Zhenglong, Monaghan, Sean F, Wang, Fei, Ayala, Alfred
Published in The Journal of immunology (1950) (01.02.2014)
Published in The Journal of immunology (1950) (01.02.2014)
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Journal Article
Part II: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints
Libert, Claude, Ayala, Alfred, Bauer, Michael, Cavaillon, Jean-Marc, Deutschman, Clifford, Frostell, Claes, Knapp, Sylvia, Kozlov, Andrey V, Wang, Ping, Osuchowski, Marcin F, Remick, Daniel G
Published in Shock (Augusta, Ga.) (01.01.2019)
Published in Shock (Augusta, Ga.) (01.01.2019)
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Novel Role for PD-1:PD-L1 as Mediator of Pulmonary Vascular Endothelial Cell Functions in Pathogenesis of Indirect ARDS in Mice
Lomas-Neira, Joanne, Monaghan, Sean F, Huang, Xin, Fallon, Eleanor A, Chung, Chun-Shiang, Ayala, Alfred
Published in Frontiers in immunology (20.12.2018)
Published in Frontiers in immunology (20.12.2018)
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Journal Article
The Neonatal Innate Immune Response to Sepsis: Checkpoint Proteins as Novel Mediators of This Response and as Possible Therapeutic/Diagnostic Levers
Hensler, Emily, Petros, Habesha, Gray, Chyna C, Chung, Chun-Shiang, Ayala, Alfred, Fallon, Eleanor A
Published in Frontiers in immunology (04.07.2022)
Published in Frontiers in immunology (04.07.2022)
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Herpes virus entry mediator signaling blockade produces mortality in neonatal sepsis through induced cardiac dysfunction
Wakeley, Michelle E, Denning, Naomi-Liza, Jiang, Jihong, De Paepe, Monique E, Chung, Chun-Shiang, Wang, Ping, Ayala, Alfred
Published in Frontiers in immunology (07.05.2024)
Published in Frontiers in immunology (07.05.2024)
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Journal Article
Pathogenesis of indirect (secondary) acute lung injury
Perl, Mario, Lomas-Neira, Joanne, Venet, Fabienne, Chung, Chun-Shiang, Ayala, Alfred
Published in Expert review of respiratory medicine (01.02.2011)
Published in Expert review of respiratory medicine (01.02.2011)
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SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model
Jiang, Jihong, Hu, Baoji, Chung, Chun-Shiang, Chen, Yaping, Zhang, Yunhe, Tindal, Elizabeth W, Li, Jinbao, Ayala, Alfred
Published in Molecular medicine (Cambridge, Mass.) (21.09.2020)
Published in Molecular medicine (Cambridge, Mass.) (21.09.2020)
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BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction
Shubin, Nicholas J., Chung, Chun S., Heffernan, Daithi S., Irwin, Lydea R., Monaghan, Sean F., Ayala, Alfred
Published in Journal of leukocyte biology (01.09.2012)
Published in Journal of leukocyte biology (01.09.2012)
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Journal Article
Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD‐1
Tang, Lunxian, Bai, Jianwen, Chung, Chun‐Shiang, Lomas‐Neira, Joanne, Chen, Yaping, Huang, Xin, Ayala, Alfred
Published in Journal of leukocyte biology (01.11.2014)
Published in Journal of leukocyte biology (01.11.2014)
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Regulatory T cell populations in sepsis and trauma
Venet, Fabienne, Chung, Chun‐Shiang, Monneret, Guillaume, Huang, Xin, Horner, Brian, Garber, Megan, Ayala, Alfred
Published in Journal of leukocyte biology (01.03.2008)
Published in Journal of leukocyte biology (01.03.2008)
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Neutrophil-endothelial interactions mediate angiopoietin-2-associated pulmonary endothelial cell dysfunction in indirect acute lung injury in mice
Lomas-Neira, Joanne, Venet, Fabienne, Chung, Chun-Shiang, Thakkar, Rajan, Heffernan, Daithi, Ayala, Alfred
Published in American journal of respiratory cell and molecular biology (01.01.2014)
Published in American journal of respiratory cell and molecular biology (01.01.2014)
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Journal Article
Negative Immune Checkpoint Protein, VISTA, Regulates the CD4+ Treg Population During Sepsis Progression to Promote Acute Sepsis Recovery and Survival
Gray, Chyna C., Biron-Girard, Bethany, Wakeley, Michelle E., Chung, Chun-Shiang, Chen, Yaping, Quiles-Ramirez, Yael, Tolbert, Jessica D., Ayala, Alfred
Published in Frontiers in immunology (24.03.2022)
Published in Frontiers in immunology (24.03.2022)
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