Pharmacological targeting of the unfolded protein response for disease intervention
Hetz, Claudio, Axten, Jeffrey M., Patterson, John B.
Published in Nature chemical biology (01.08.2019)
Published in Nature chemical biology (01.08.2019)
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Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease
Mercado, Gabriela, Castillo, Valentina, Soto, Paulina, López, Nélida, Axten, Jeffrey M., Sardi, Sergio P., Hoozemans, Jeroen J.M., Hetz, Claudio
Published in Neurobiology of disease (01.04.2018)
Published in Neurobiology of disease (01.04.2018)
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Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice
Moreno, Julie A, Halliday, Mark, Molloy, Colin, Radford, Helois, Verity, Nicholas, Axten, Jeffrey M, Ortori, Catharine A, Willis, Anne E, Fischer, Peter M, Barrett, David A, Mallucci, Giovanna R
Published in Science translational medicine (09.10.2013)
Published in Science translational medicine (09.10.2013)
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Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Axten, Jeffrey M, Medina, Jesús R, Feng, Yanhong, Shu, Arthur, Romeril, Stuart P, Grant, Seth W, Li, William Hoi Hong, Heerding, Dirk A, Minthorn, Elisabeth, Mencken, Thomas, Atkins, Charity, Liu, Qi, Rabindran, Sridhar, Kumar, Rakesh, Hong, Xuan, Goetz, Aaron, Stanley, Thomas, Taylor, J. David, Sigethy, Scott D, Tomberlin, Ginger H, Hassell, Annie M, Kahler, Kirsten M, Shewchuk, Lisa M, Gampe, Robert T
Published in Journal of medicinal chemistry (23.08.2012)
Published in Journal of medicinal chemistry (23.08.2012)
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Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity
ATKINS, Charity, QI LIU, CHOUDHRY, Anthony E, ALSAID, Hasan, JUCKER, Beat M, AXTEN, Jeffrey M, KUMAR, Rakesh, MINTHORN, Elisabeth, ZHANG, Shu-Yun, FIGUEROA, David J, MOSS, Katherine, STANLEY, Thomas B, SANDERS, Brent, GOETZ, Aaron, GAUL, Nathan
Published in Cancer research (Chicago, Ill.) (15.03.2013)
Published in Cancer research (Chicago, Ill.) (15.03.2013)
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Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1
Najafov, Ayaz, Sommer, Eeva M, Axten, Jeffrey M, Deyoung, M Phillip, Alessi, Dario R
Published in Biochemical journal (15.01.2011)
Published in Biochemical journal (15.01.2011)
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Publisher Correction: Pharmacological targeting of the unfolded protein response for disease intervention
Hetz, Claudio, Axten, Jeffrey M., Patterson, John B.
Published in Nature chemical biology (01.11.2019)
Published in Nature chemical biology (01.11.2019)
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Journal Article
PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome
Grande, Valentina, Ornaghi, Francesca, Comerio, Liliana, Restelli, Elena, Masone, Antonio, Corbelli, Alessandro, Tolomeo, Daniele, Capone, Vanessa, Axten, Jeffrey M, Laping, Nicholas J, Fiordaliso, Fabio, Sallese, Michele, Chiesa, Roberto
Published in Human molecular genetics (15.07.2018)
Published in Human molecular genetics (15.07.2018)
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A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease
Douglas, Lisa E.J., Reihill, James A., Ho, Melisa W.Y., Axten, Jeffrey M., Campobasso, Nino, Schneck, Jessica L., Rendina, Alan R., Wilcoxen, Keith M., Martin, S. Lorraine
Published in Cell chemical biology (16.06.2022)
Published in Cell chemical biology (16.06.2022)
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Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development
Axten, Jeffrey M, Romeril, Stuart P, Shu, Arthur, Ralph, Jeffrey, Medina, Jesús R, Feng, Yanhong, Li, William Hoi Hong, Grant, Seth W, Heerding, Dirk A, Minthorn, Elisabeth, Mencken, Thomas, Gaul, Nathan, Goetz, Aaron, Stanley, Thomas, Hassell, Annie M, Gampe, Robert T, Atkins, Charity, Kumar, Rakesh
Published in ACS medicinal chemistry letters (10.10.2013)
Published in ACS medicinal chemistry letters (10.10.2013)
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Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy
Koren, Shon A, Hamm, Matthew J, Cloyd, Ryan, Fontaine, Sarah N, Chishti, Emad, Lanzillotta, Chiara, Rodriguez-Rivera, Jennifer, Ingram, Alexandria, Bell, Michelle, Galvis-Escobar, Sara M, Zulia, Nicholas, Di Domenico, Fabio, Duong, Duc, Seyfried, Nicholas T, Powell, David, Vandsburger, Moriel, Frolinger, Tal, Hartz, Anika M S, Koren, 3rd, John, Axten, Jeffrey M, Laping, Nicholas J, Abisambra, Jose F
Published in International journal of molecular sciences (26.01.2021)
Published in International journal of molecular sciences (26.01.2021)
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Journal Article
Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases
Miles, Timothy J., Axten, Jeffrey M., Barfoot, Christopher, Brooks, Gerald, Brown, Pamela, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Downie, David L., Eyrisch, Susanne, Gallagher, Timothy, Giordano, Ilaria, Gwynn, Michael N., Hennessy, Alan, Hoover, Jennifer, Huang, Jianzhong, Jones, Graham, Markwell, Roger, Miller, William H., Minthorn, Elizabeth A., Rittenhouse, Stephen, Seefeld, Mark, Pearson, Neil
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
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Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors
Medina, Jesús R, Becker, Christopher J, Blackledge, Charles W, Duquenne, Celine, Feng, Yanhong, Grant, Seth W, Heerding, Dirk, Li, William H, Miller, William H, Romeril, Stuart P, Scherzer, Daryl, Shu, Arthur, Bobko, Mark A, Chadderton, Antony R, Dumble, Melissa, Gardiner, Christine M, Gilbert, Seth, Liu, Qi, Rabindran, Sridhar K, Sudakin, Valery, Xiang, Hong, Brady, Pat G, Campobasso, Nino, Ward, Paris, Axten, Jeffrey M
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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Rapid synthesis of diversely functionalized 3,4,7-trisubstituted indoles
Grant, Seth W., Gallagher, Timothy F., Bobko, Mark A., Duquenne, Celine, Axten, Jeffrey M.
Published in Tetrahedron letters (29.06.2011)
Published in Tetrahedron letters (29.06.2011)
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Journal Article
TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis
Laping, Nicholas J., DeMartino, Michael P., Cottom, Joshua E., Axten, Jeffrey M., Emery, John G., Guss, Jeffrey H., Burman, Miriam, Foley, James J., Cheung, Mui, Oliff, Allen, Kumar, Sanjay
Published in Blood advances (12.12.2017)
Published in Blood advances (12.12.2017)
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The First Total Syntheses of Ircinol A, Ircinal A, and Manzamines A and D
Winkler, Jeffrey D, Axten, Jeffrey M
Published in Journal of the American Chemical Society (01.07.1998)
Published in Journal of the American Chemical Society (01.07.1998)
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Journal Article
Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery
Medina, Jesús R, Blackledge, Charles W, Heerding, Dirk A, Campobasso, Nino, Ward, Paris, Briand, Jacques, Wright, Lois, Axten, Jeffrey M
Published in ACS medicinal chemistry letters (11.11.2010)
Published in ACS medicinal chemistry letters (11.11.2010)
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Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity
Axten, Jeffrey M., Medina, Jesús R., Blackledge, Charles W., Duquenne, Céline, Grant, Seth W., Bobko, Mark A., Peng, Tony, Miller, William H., Pinckney, Theresa, Gallagher, Timothy F., Kulkarni, Swarupa, Lewandowski, Thomas, Van Aller, Glenn S., Zonis, Rimma, Ward, Paris, Campobasso, Nino
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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