Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets
Adnan-Awad, Shady, Kim, Daehong, Hohtari, Helena, Javarappa, Komal Kumar, Brandstoetter, Tania, Mayer, Isabella, Potdar, Swapnil, Heckman, Caroline A., Kytölä, Soili, Porkka, Kimmo, Doma, Eszter, Sexl, Veronika, Kankainen, Matti, Mustjoki, Satu
Published in Leukemia (01.07.2021)
Published in Leukemia (01.07.2021)
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Journal Article
RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses
Adnan Awad, Shady, Dufva, Olli, Ianevski, Aleksandr, Ghimire, Bishwa, Koski, Jan, Maliniemi, Pilvi, Thomson, Daniel, Schreiber, Andreas, Heckman, Caroline A., Koskenvesa, Perttu, Korhonen, Matti, Porkka, Kimmo, Branford, Susan, Aittokallio, Tero, Kankainen, Matti, Mustjoki, Satu
Published in Leukemia (01.04.2021)
Published in Leukemia (01.04.2021)
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Journal Article
Epigenetic modifier gene mutations in chronic myeloid leukemia (CML) at diagnosis are associated with risk of relapse upon treatment discontinuation
Adnan Awad, Shady, Brück, Oscar, Shanmuganathan, Naranie, Jarvinen, Timo, Lähteenmäki, Hanna, Klievink, Jay, Ibrahim, Hazem, Kytölä, Soili, Koskenvesa, Perttu, Hughes, Timothy P., Branford, Susan, Kankainen, Matti, Mustjoki, Satu
Published in Blood cancer journal (New York) (20.04.2022)
Published in Blood cancer journal (New York) (20.04.2022)
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Journal Article
Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia
Adnan Awad, Shady, Kankainen, Matti, Ojala, Teija, Koskenvesa, Perttu, Eldfors, Samuli, Ghimire, Bishwa, Kumar, Ashwini, Kytölä, Soili, Kamel, Mahmoud M., Heckman, Caroline A., Porkka, Kimmo, Mustjoki, Satu
Published in Blood advances (11.02.2020)
Published in Blood advances (11.02.2020)
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Journal Article
Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia
Adnan Awad, Shady, Dufva, Olli, Klievink, Jay, Karjalainen, Ella, Ianevski, Aleksandr, Pietarinen, Paavo, Kim, Daehong, Potdar, Swapnil, Wolf, Maija, Lotfi, Kourosh, Aittokallio, Tero, Wennerberg, Krister, Porkka, Kimmo, Mustjoki, Satu
Published in Cell reports. Medicine (21.05.2024)
Published in Cell reports. Medicine (21.05.2024)
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Journal Article
Targeting Apoptosis Pathways With BCL2 and MDM2 Inhibitors in Adult B‐cell Acute Lymphoblastic Leukemia
Hohtari, Helena, Kankainen, Matti, Adnan‐Awad, Shady, Yadav, Bhagwan, Potdar, Swapnil, Ianevski, Aleksandr, Dufva, Olli, Heckman, Caroline, Sexl, Veronika, Kytölä, Soili, Mustjoki, Satu, Porkka, Kimmo
Published in HemaSphere (01.03.2022)
Published in HemaSphere (01.03.2022)
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Journal Article
Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target
Dufva, Olli, Kankainen, Matti, Kelkka, Tiina, Sekiguchi, Nodoka, Awad, Shady Adnan, Eldfors, Samuli, Yadav, Bhagwan, Kuusanmäki, Heikki, Malani, Disha, Andersson, Emma I, Pietarinen, Paavo, Saikko, Leena, Kovanen, Panu E., Ojala, Teija, Lee, Dean A., Loughran, Thomas P., Nakazawa, Hideyuki, Suzumiya, Junji, Suzuki, Ritsuro, Ko, Young Hyeh, Kim, Won Seog, Chuang, Shih-Sung, Aittokallio, Tero, Chan, Wing C., Ohshima, Koichi, Ishida, Fumihiro, Mustjoki, Satu
Published in Nature communications (19.04.2018)
Published in Nature communications (19.04.2018)
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Journal Article
Assessment of bone marrow lymphocytic status during tyrosine kinase inhibitor therapy and its relation to therapy response in chronic myeloid leukaemia
El Missiry, Mohamed, Adnan Awad, Shady, Rajala, Hanna L, Al-Samadi, Ahmed, Ekblom, Marja, Markevän, Berit, Åstrand-Grundström, Ingbritt, Wold, Maren, Svedahl, Ellen Rabben, Juhl, Birgitte Ravn, Bjerrum, Ole Weis, Haulin, Inger, Porkka, Kimmo, Olsson-Strömberg, Ulla, Hjorth-Hansen, Henrik, Mustjoki, Satu
Published in Journal of cancer research and clinical oncology (01.05.2016)
Published in Journal of cancer research and clinical oncology (01.05.2016)
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Journal Article
P1228: GENOME‐WIDE CRISPR‐CAS9 SCREENING IDENTIFIES THERAPEUTIC TARGETS FOR MATURE T‐CELL MALIGNANCIES
Timonen, Sanna, Rebecca Gasparini, Vanessa, Piekkari, Ella, Dufva, Olli, Awad, Shady, Akimov, Yevhen, Jan, Jana, Braun, Till, Ianevski, Aleksandr, Kankainen, Matti, Klievink, Jay, Herling, Marco, Aittokallio, Tero, Mustjoki, Satu
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Journal Article
IDO1 Inhibition Reduces Immune Cell Exclusion Through Inducing Cell Migration While PD-1 Blockage Increases IL-6 and -8 Secretion From T Cells in Head and Neck Cancer
Sieviläinen, Meri, Saavalainen, Jordan, Adnan-Awad, Shady, Salo, Tuula, Al-Samadi, Ahmed
Published in Frontiers in immunology (14.03.2022)
Published in Frontiers in immunology (14.03.2022)
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Journal Article
Immunophenotypic Characterization of Cytogenetic Subgroups in Egyptian Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia
Adnan Awad, Shady, Kamel, Mahmoud M, Ayoub, Mahmoud A, Kamel, Ahmed M, Elnoshokaty, Essam H, El Hifnawi, Niveen
Published in Clinical lymphoma, myeloma and leukemia (01.08.2016)
Published in Clinical lymphoma, myeloma and leukemia (01.08.2016)
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Journal Article
A novel class of somatic mutations in blood detected preferentially in CD8 + cells
Valori, Miko, Jansson, Lilja, Kiviharju, Anna, Ellonen, Pekka, Rajala, Hanna, Awad, Shady Adnan, Mustjoki, Satu, Tienari, Pentti J
Published in Clinical immunology (Orlando, Fla.) (01.02.2017)
Published in Clinical immunology (Orlando, Fla.) (01.02.2017)
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Journal Article
miR-22 and miR-205 Drive Tumor Aggressiveness of Mucoepidermoid Carcinomas of Salivary Glands
Naakka, Erika, Barros-Filho, Mateus Camargo, Adnan-Awad, Shady, Al-Samadi, Ahmed, Marchi, Fábio Albuquerque, Kuasne, Hellen, Korelin, Katja, Suleymanova, Ilida, Brown, Amy Louise, Scapulatempo-Neto, Cristovam, Lourenço, Silvia Vanessa, Castilho, Rogério Moraes, Kowalski, Luiz Paulo, Mäkitie, Antti, Araújo, Vera Cavalcanti, Leivo, Ilmo, Rogatto, Silvia Regina, Salo, Tuula, Passador-Santos, Fabricio
Published in Frontiers in oncology (09.02.2022)
Published in Frontiers in oncology (09.02.2022)
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Immunophenotypic Characterization of Cytogenetic subgroups in Egyptian Pediatric B-Acute Lymphoblastic Leukemia Patients
Awad, Shady, MD, Kamel, Mahmoud M., MD, PhD, Ayoub, Mahmoud A., MD, PhD, Kamel, Ahmed M., MD, PhD, Elnoshokaty, Essam, MD, PhD, El Hifnawi, Niveen, MD, PhD
Published in Clinical lymphoma, myeloma and leukemia (01.09.2015)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2015)
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Journal Article
Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia
Bouillon, Anne-Sophie, Ventura Ferreira, Monica S., Awad, Shady Adnan, Richter, Johan, Hochhaus, Andreas, Kunzmann, Volker, Dengler, Jolanta, Janssen, Jeroen, Ossenkoppele, Gert, Westerweel, Peter E., te Boekhorst, Peter A.W., Mahon, Francois-Xavier, Hjorth-Hansen, Henrik, Isfort, Susanne, Fioretos, Thoas, Hummel, Sebastian, Schemionek, Mirle, Wilop, Stefan, Koschmieder, Steffen, Saußele, Susanne, Mustjoki, Satu, Beier, Fabian, Brümmendorf, Tim H.
Published in Blood advances (10.07.2018)
Published in Blood advances (10.07.2018)
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Web Resource
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Kuusanmäki, Heikki, Dufva, Olli, Vähä-Koskela, Markus, Leppä, Aino-Maija, Huuhtanen, Jani, Vänttinen, Ida, Nygren, Petra, Klievink, Jay, Bouhlal, Jonas, Pölönen, Petri, Zhang, Qi, Adnan-Awad, Shady, Mancebo-Pérez, Cristina, Saad, Joseph, Miettinen, Juho, Javarappa, Komal K., Aakko, Sofia, Ruokoranta, Tanja, Eldfors, Samuli, Heinäniemi, Merja, Theilgaard-Mönch, Kim, Wartiovaara-Kautto, Ulla, Keränen, Mikko, Porkka, Kimmo, Konopleva, Marina, Wennerberg, Krister, Kontro, Mika, Heckman, Caroline A., Mustjoki, Satu
Published in Blood (30.03.2023)
Published in Blood (30.03.2023)
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RUNX1 Mutations Identify an Entity of Blast Phase Chronic Myeloid Leukemia (BP-CML) Patients with Distinct Phenotype, Transcriptional Profile and Drug Vulnerabilities
Awad, Shady, Kankainen, Matti, Dufva, Olli, Heckman, Caroline A, Porkka, Kimmo, Mustjoki, Satu
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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