Compound Aggregation in Drug Discovery: Implementing a Practical NMR Assay for Medicinal Chemists
LaPlante, Steven R, Carson, Rebekah, Gillard, James, Aubry, Norman, Coulombe, René, Bordeleau, Sylvain, Bonneau, Pierre, Little, Michael, O’Meara, Jeff, Beaulieu, Pierre L
Published in Journal of medicinal chemistry (27.06.2013)
Published in Journal of medicinal chemistry (27.06.2013)
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Journal Article
Monitoring Drug Self-Aggregation and Potential for Promiscuity in Off-Target In Vitro Pharmacology Screens by a Practical NMR Strategy
LaPlante, Steven R, Aubry, Norman, Bolger, Gordon, Bonneau, Pierre, Carson, Rebekah, Coulombe, René, Sturino, Claudio, Beaulieu, Pierre L
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Journal Article
Solution Structure of Substrate-based Ligands When Bound to Hepatitis C Virus NS3 Protease Domain
LaPlante, S R, Cameron, D R, Aubry, N, Lefebvre, S, Kukolj, G, Maurice, R, Thibeault, D, Lamarre, D, Llinàs-Brunet, M
Published in The Journal of biological chemistry (25.06.1999)
Published in The Journal of biological chemistry (25.06.1999)
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Journal Article
Characterization of the Human Cytomegalovirus Protease As an Induced-Fit Serine Protease and the Implications to the Design of Mechanism-Based Inhibitors
LaPlante, Steven R, Bonneau, Pierre R, Aubry, Norman, Cameron, Dale R, Déziel, Robert, Grand-Maître, Chantal, Plouffe, Céline, Tong, Liang, Kawai, Stephen H
Published in Journal of the American Chemical Society (07.04.1999)
Published in Journal of the American Chemical Society (07.04.1999)
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Journal Article
Ligand Bioactive Conformation Plays a Critical Role in the Design of Drugs That Target the Hepatitis C Virus NS3 Protease
LaPlante, Steven R., Nar, Herbert, Lemke, Christopher T., Jakalian, Araz, Aubry, Norman, Kawai, Stephen H.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Determining the Predominant Conformations of Mortiamides A–D in Solution Using NMR Data and Molecular Modeling Tools
Franca, Tanos C. C., Goncalves, Arlan da Silva, Bérubé, Christopher, Voyer, Normand, Aubry, Norman, LaPlante, Steven R.
Published in ACS omega (25.07.2023)
Published in ACS omega (25.07.2023)
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Journal Article
Importance of Ligand Bioactive Conformation in the Discovery of Potent Indole-Diamide Inhibitors of the Hepatitis C Virus NS5B
LaPlante, Steven R, Gillard, James R, Jakalian, Araz, Aubry, Norman, Coulombe, René, Brochu, Christian, Tsantrizos, Youla S, Poirier, Martin, Kukolj, George, Beaulieu, Pierre L
Published in Journal of the American Chemical Society (03.11.2010)
Published in Journal of the American Chemical Society (03.11.2010)
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Journal Article
N- versus O-alkylation: Utilizing NMR methods to establish reliable primary structure determinations for drug discovery
LaPlante, Steven R., Bilodeau, François, Aubry, Norman, Gillard, James R., O’Meara, Jeff, Coulombe, René
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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Journal Article
RCM of Tripeptide Dienes Containing a Chiral Vinylcyclopropane Moiety: Impact of Different Ru-Based Catalysts on the Stereochemical Integrity of the Macrocyclic Products
Poirier, Martin, Aubry, Norman, Boucher, Colette, Ferland, Jean-Marie, LaPlante, Steve, Tsantrizos, Youla S
Published in Journal of organic chemistry (23.12.2005)
Published in Journal of organic chemistry (23.12.2005)
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Journal Article
Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics Strategy
LaPlante, Steven R., Jakalian, Araz, Aubry, Norman, Bousquet, Yves, Ferland, Jean-Marie, Gillard, James, Lefebvre, Sylvain, Poirier, Martin, Tsantrizos, Youla S., Kukolj, George, Beaulieu, Pierre L.
Published in Angewandte Chemie International Edition (20.08.2004)
Published in Angewandte Chemie International Edition (20.08.2004)
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Journal Article
Dimethylthiazolidine Carboxylic Acid as a Rigid P3 Unit in Inhibitors of Serine Proteases: Application to Two Targets
Kawai, Stephen H., Aubry, Norman, Duceppe, Jean-Simon, Llinàs-Brunet, Montse, LaPlante, Steven R.
Published in Chemical biology & drug design (01.11.2009)
Published in Chemical biology & drug design (01.11.2009)
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Journal Article
Quantifying trifluoroacetic acid as a counterion in drug discovery by 19F NMR and capillary electrophoresis
Little, Michael J., Aubry, Norman, Beaudoin, Marie-Eve, Goudreau, Nathalie, LaPlante, Steven R.
Published in Journal of pharmaceutical and biomedical analysis (12.03.2007)
Published in Journal of pharmaceutical and biomedical analysis (12.03.2007)
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Journal Article
RCM of tripeptide dienes containing a chiral vinylcyclopropane moiety : Impact of different ru-based catalysts on the stereochemical integrity of themacrocyclic products
POIRIER, Martin, AUBRY, Norman, BOUCHER, Colette, FERLAND, Jean-Marie, LAPLANTE, Steve, TSANTRIZOS, Youla S
Published in Journal of organic chemistry (2005)
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Published in Journal of organic chemistry (2005)
Journal Article
NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain
LaPlante, Steven R, Aubry, Norman, Bonneau, Pierre R, Kukolj, George, Lamarre, Daniel, Lefebvre, Sylvain, Li, Hong, Llinàs-Brunet, Montse, Plouffe, Céline, Cameron, Dale R
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Journal Article
Transferred 13C T1 Relaxation at Natural Isotopic Abundance: A Practical Method for Determining Site-Specific Changes in Ligand Flexibility upon Binding to a Macromolecule
LAPLANTE, Steven R., AUBRY, Norman, DéZIEL, Robert, NI, Feng, XU, Ping
Published in Journal of the American Chemical Society (20.12.2000)
Published in Journal of the American Chemical Society (20.12.2000)
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Journal Article
Transferred 13 C T 1 Relaxation at Natural Isotopic Abundance: A Practical Method for Determining Site-Specific Changes in Ligand Flexibility upon Binding to a Macromolecule
LaPlante, Steven R., Aubry, Norman, Déziel, Robert, Ni, Feng, Xu, Ping
Published in Journal of the American Chemical Society (01.12.2000)
Published in Journal of the American Chemical Society (01.12.2000)
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Journal Article
Human Cytomegalovirus Protease Complexes Its Substrate Recognition Sequences in an Extended Peptide Conformation
LaPlante, Steven R, Aubry, Norman, Bonneau, Pierre R, Cameron, Dale R, Lagacé, Lisette, Massariol, Marie-Josée, Montpetit, Hélène, Plouffe, Céline, Kawai, Stephen H, Fulton, Bruce D, Chen, Zhigang, Ni, Feng
Published in Biochemistry (Easton) (07.07.1998)
Published in Biochemistry (Easton) (07.07.1998)
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Journal Article
The Conformation of a Peptidyl Methyl Ketone Inhibitor Bound to the Human Cytomegalovirus Protease
LaPlante, Steven R., Cameron, Dale R., Aubry, Norman, Bonneau, Pierre R., Déziel, Robert, Grand-Maître, Chantal, Ogilvie, William W., Kawai, Stephen H.
Published in Angewandte Chemie International Edition (16.10.1998)
Published in Angewandte Chemie International Edition (16.10.1998)
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Journal Article
Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics Strategy
LaPlante, Steven R., Jakalian, Araz, Aubry, Norman, Bousquet, Yves, Ferland, Jean-Marie, Gillard, James, Lefebvre, Sylvain, Poirier, Martin, Tsantrizos, Youla S., Kukolj, George, Beaulieu, Pierre L.
Published in Angewandte Chemie (20.08.2004)
Published in Angewandte Chemie (20.08.2004)
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Journal Article
Transferred 13C T 1 Relaxation at Natural Isotopic Abundance: A Practical Method for Determining Site-Specific Changes in Ligand Flexibility upon Binding to a Macromolecule
LaPlante, Steven R, Aubry, Norman, Déziel, Robert, Ni, Feng, Xu, Ping
Published in Journal of the American Chemical Society (20.12.2000)
Published in Journal of the American Chemical Society (20.12.2000)
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Journal Article