Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration
Upadhya, Dinesh, Hattiangady, Bharathi, Castro, Olagide W., Shuai, Bing, Kodali, Maheedhar, Attaluri, Sahithi, Bates, Adrian, Dong, Yi, Zhang, Su-Chun, Prockop, Darwin J., Shetty, Ashok K.
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2019)
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Journal Article
Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus
Madhu, Leelavathi N., Kodali, Maheedhar, Attaluri, Sahithi, Shuai, Bing, Melissari, Laila, Rao, Xiaolan, Shetty, Ashok K.
Published in Redox biology (01.07.2021)
Published in Redox biology (01.07.2021)
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Journal Article
Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain
Kodali, Maheedhar, Castro, Olagide W, Kim, Dong-Ki, Thomas, Alicia, Shuai, Bing, Attaluri, Sahithi, Upadhya, Raghavendra, Gitai, Daniel, Madhu, Leelavathi N, Prockop, Darwin J, Shetty, Ashok K
Published in International journal of molecular sciences (26.12.2019)
Published in International journal of molecular sciences (26.12.2019)
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Journal Article
Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties
Upadhya, Raghavendra, Madhu, Leelavathi N., Attaluri, Sahithi, Gitaí, Daniel Leite Góes, Pinson, Marisa R, Kodali, Maheedhar, Shetty, Geetha, Zanirati, Gabriele, Kumar, Smrithi, Shuai, Bing, Weintraub, Susan T, Shetty, Ashok K.
Published in Journal of extracellular vesicles (01.01.2020)
Published in Journal of extracellular vesicles (01.01.2020)
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Journal Article
Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus
Ayyubova, Gunel, Kodali, Maheedhar, Upadhya, Raghavendra, Madhu, Leelavathi N, Attaluri, Sahithi, Somayaji, Yogish, Shuai, Bing, Rao, Shama, Shankar, Goutham, Shetty, Ashok K
Published in Journal of neuroinflammation (12.12.2023)
Published in Journal of neuroinflammation (12.12.2023)
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Journal Article
Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness
Attaluri, Sahithi, Upadhya, Raghavendra, Kodali, Maheedhar, Madhu, Leelavathi N, Upadhya, Dinesh, Shuai, Bing, Shetty, Ashok K
Published in Frontiers in immunology (29.04.2022)
Published in Frontiers in immunology (29.04.2022)
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Journal Article
Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus
Hussain, Tabish, Kil, Hyunsuk, Hattiangady, Bharathi, Lee, Jaeho, Kodali, Maheedhar, Shuai, Bing, Attaluri, Sahithi, Takata, Yoko, Shen, Jianjun, Abba, Martin C., Shetty, Ashok K., Aldaz, C. Marcelo
Published in Neurobiology of disease (01.01.2019)
Published in Neurobiology of disease (01.01.2019)
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Journal Article
Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness
Shetty, Geetha A, Hattiangady, Bharathi, Upadhya, Dinesh, Bates, Adrian, Attaluri, Sahithi, Shuai, Bing, Kodali, Maheedhar, Shetty, Ashok K
Published in Frontiers in molecular neuroscience (14.06.2017)
Published in Frontiers in molecular neuroscience (14.06.2017)
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Journal Article
A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling
Kodali, Maheedhar, Madhu, Leelavathi N, Reger, Roxanne L, Milutinovic, Bojana, Upadhya, Raghavendra, Attaluri, Sahithi, Shuai, Bing, Shankar, Goutham, Shetty, Ashok K
Published in Frontiers in molecular neuroscience (22.05.2023)
Published in Frontiers in molecular neuroscience (22.05.2023)
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Journal Article
Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice
Attaluri, Sahithi, Jaimes Gonzalez, Jenny, Kirmani, Maha, Vogel, Andrew D, Upadhya, Raghavendra, Kodali, Maheedhar, Madhu, Leelavathi N, Rao, Shama, Shuai, Bing, Babu, Roshni S, Huard, Charles, Shetty, Ashok K
Published in Frontiers in aging neuroscience (22.06.2023)
Published in Frontiers in aging neuroscience (22.06.2023)
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Journal Article
FDA-approved cannabidiol [Epidiolex®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis
Kodali, Maheedhar, Madhu, Leelavathi N., Kolla, Venkata Sai Vashishta, Attaluri, Sahithi, Huard, Charles, Somayaji, Yogish, Shuai, Bing, Jordan, Chase, Rao, Xiaolan, Shetty, Sanath, Shetty, Ashok K.
Published in Military medical research (22.08.2024)
Published in Military medical research (22.08.2024)
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Journal Article
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy
Upadhya, Dinesh, Attaluri, Sahithi, Liu, Yan, Hattiangady, Bharathi, Castro, Olagide W, Shuai, Bing, Dong, Yi, Zhang, Su-Chun, Shetty, Ashok K
Published in npj Regenerative medicine (01.08.2022)
Published in npj Regenerative medicine (01.08.2022)
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Journal Article
Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness
Shetty, Ashok K., Attaluri, Sahithi, Kodali, Maheedhar, Shuai, Bing, Shetty, Geetha A., Upadhya, Dinesh, Hattiangady, Bharathi, Madhu, Leelavathi N., Upadhya, Raghavendra, Bates, Adrian, Rao, Xiaolan
Published in Redox biology (01.01.2020)
Published in Redox biology (01.01.2020)
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Journal Article
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus
Kodali, Maheedhar, Attaluri, Sahithi, Madhu, Leelavathi N., Shuai, Bing, Upadhya, Raghavendra, Gonzalez, Jenny Jaimes, Rao, Xiaolan, Shetty, Ashok K.
Published in Aging cell (01.02.2021)
Published in Aging cell (01.02.2021)
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Journal Article
Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood
Madhu, Leelavathi N., Attaluri, Sahithi, Kodali, Maheedhar, Shuai, Bing, Upadhya, Raghavendra, Gitai, Daniel, Shetty, Ashok K.
Published in Brain, behavior, and immunity (01.10.2019)
Published in Brain, behavior, and immunity (01.10.2019)
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Journal Article
Moderate, intermittent voluntary exercise in a model of Gulf War Illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus
Kodali, Maheedhar, Mishra, Vikas, Hattiangady, Bharathi, Attaluri, Sahithi, Gonzalez, Jenny Jaimes, Shuai, Bing, Shetty, Ashok K.
Published in Brain, behavior, and immunity (01.10.2021)
Published in Brain, behavior, and immunity (01.10.2021)
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Journal Article
Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction
Kodali, Maheedhar, Madhu, Leelavathi N., Reger, Roxanne L., Milutinovic, Bojana, Upadhya, Raghavendra, Gonzalez, Jenny J., Attaluri, Sahithi, Shuai, Bing, Gitai, Daniel L.G., Rao, Shama, Choi, Jong M., Jung, Sung Y., Shetty, Ashok K.
Published in Brain, behavior, and immunity (01.02.2023)
Published in Brain, behavior, and immunity (01.02.2023)
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Journal Article
Chronobiology of limbic seizures: Potential mechanisms and prospects of chronotherapy for mesial temporal lobe epilepsy
Leite Góes Gitai, Daniel, de Andrade, Tiago Gomes, dos Santos, Ygor Daniel Ramos, Attaluri, Sahithi, Shetty, Ashok K.
Published in Neuroscience and biobehavioral reviews (01.03.2019)
Published in Neuroscience and biobehavioral reviews (01.03.2019)
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Journal Article
Transient CSF1R Inhibition in the Early Stage of AD Retains Homeostatic Microglia with Reduced Inflammasomes and Increased autophagy in the 5XFAD Model
Kodali, Maheedhar, Gonzalez, Jenny J, Oake, Chris, Huard, Charles, Somayaji, Yogish, Shuai, Bing, Madhu, Leelavathi N, Attaluri, Sahithi, Rao, Shama, Shankar, Goutham, Panda, Prashanta K, Hering, Catherine, Babu, Roshni S, Shetty, Ashok K
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Journal Article
FDA-approved cannabidiol Epidiolex® alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis
Kodali, Maheedhar, Madhu, Leelavathi N, Kolla, Venkata Sai Vashishta, Attaluri, Sahithi, Huard, Charles, Somayaji, Yogish, Shuai, Bing, Jordan, Chase, Rao, Xiaolan, Shetty, Sanath, Shetty, Ashok K
Published in Military medical research (22.08.2024)
Published in Military medical research (22.08.2024)
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Journal Article