Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor
Caravella, Justin A, Lin, Jian, Diebold, R. Bruce, Campbell, Ann-Marie, Ericsson, Anna, Gustafson, Gary, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Kershaw, Mark, Yao, Lili, Toms, Angela V, Barr, Kenneth J, Dinsmore, Christopher J, Walker, Duncan, Ashwell, Susan, Lu, Wei
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
Zabludoff, Sonya D, Deng, Chun, Grondine, Michael R, Sheehy, Adam M, Ashwell, Susan, Caleb, Benjamin L, Green, Stephen, Haye, Heather R, Horn, Candice L, Janetka, James W, Liu, Dongfang, Mouchet, Elizabeth, Ready, Shannon, Rosenthal, Judith L, Queva, Christophe, Schwartz, Gary K, Taylor, Karen J, Tse, Archie N, Walker, Graeme E, White, Anne M
Published in Molecular cancer therapeutics (01.09.2008)
Published in Molecular cancer therapeutics (01.09.2008)
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Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas
Oza, Vibha, Ashwell, Susan, Almeida, Lynsie, Brassil, Patrick, Breed, Jason, Deng, Chun, Gero, Thomas, Grondine, Michael, Horn, Candice, Ioannidis, Stephanos, Liu, Dongfang, Lyne, Paul, Newcombe, Nicholas, Pass, Martin, Read, Jon, Ready, Shannon, Rowsell, Siân, Su, Mei, Toader, Dorin, Vasbinder, Melissa, Yu, Dingwei, Yu, Yan, Xue, Yafeng, Zabludoff, Sonya, Janetka, James
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Keeping checkpoint kinases in line: new selective inhibitors in clinical trials
Ashwell, Susan, Janetka, James W, Zabludoff, Sonya
Published in Expert opinion on investigational drugs (01.09.2008)
Published in Expert opinion on investigational drugs (01.09.2008)
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Journal Article
Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration
Oza, Vibha, Ashwell, Susan, Brassil, Patrick, Breed, Jason, Deng, Chun, Ezhuthachan, Jay, Haye, Heather, Horn, Candice, Janetka, James, Lyne, Paul, Newcombe, Nicholas, Otterbien, Ludo, Pass, Martin, Read, Jon, Roswell, Sian, Su, Mei, Toader, Dorin, Yu, Dingwei, Yu, Yan, Valentine, Anna, Webborn, Peter, White, Ann, Zabludoff, Sonya, Zheng, Xiaolan
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors
Janetka, James W., Almeida, Lynsie, Ashwell, Susan, Brassil, Patrick J., Daly, Kevin, Deng, Chun, Gero, Thomas, Glynn, Roberta E., Horn, Candice L., Ioannidis, Stephanos, Lyne, Paul, Newcombe, Nicholas J., Oza, Vibha B., Pass, Martin, Springer, Stephanie K., Su, Mei, Toader, Dorin, Vasbinder, Melissa M., Yu, Dingwei, Yu, Yan, Zabludoff, Sonya D.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Journal Article
The identification and optimization of orally efficacious, small molecule VLA-4 antagonists
Huryn, Donna M, Konradi, Andrei W, Ashwell, Susan, Freedman, Stephen B, Lombardo, Louis J, Pleiss, Michael A, Thorsett, Eugene D, Yednock, Ted, Kennedy, Jeffrey D
Published in Current topics in medicinal chemistry (01.01.2004)
Published in Current topics in medicinal chemistry (01.01.2004)
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Journal Article
Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors
Lin, Jian, Lu, Wei, Caravella, Justin A, Campbell, Ann Marie, Diebold, R. Bruce, Ericsson, Anna, Fritzen, Edward, Gustafson, Gary R, Lancia, David R, Shelekhin, Tatiana, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Diep, Hien, Kershaw, Mark, Yao, Lili, Kauffman, Goss, Hubbs, Stephen E, Luke, George P, Toms, Angela V, Wang, Liann, Bair, Kenneth W, Barr, Kenneth J, Dinsmore, Christopher, Walker, Duncan, Ashwell, Susan
Published in Journal of medicinal chemistry (25.07.2019)
Published in Journal of medicinal chemistry (25.07.2019)
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Journal Article
Identification of Compounds with Nanomolar Binding Affinity for Checkpoint Kinase-1 Using Knowledge-Based Virtual Screening
Lyne, Paul D., Kenny, Peter W., Cosgrove, David A., Deng, Chun, Zabludoff, Sonya, Wendoloski, John J., Ashwell, Susan
Published in Journal of medicinal chemistry (08.04.2004)
Published in Journal of medicinal chemistry (08.04.2004)
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Journal Article
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors
Oza, Vibha, Ashwell, Susan, Brassil, Patrick, Breed, Jason, Ezhuthachan, Jaychandran, Deng, Chun, Grondine, Michael, Horn, Candice, Liu, DongFang, Lyne, Paul, Newcombe, Nicholas, Pass, Martin, Read, Jon, Su, Mei, Toader, Dorin, Yu, Dingwei, Yu, Yan, Zabludoff, Sonya
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
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Journal Article
Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents
Goteti, Kosalaram, Edwin Garner, C, Utley, Lucas, Dai, Jing, Ashwell, Susan, Moustakas, Demetri T, Gönen, Mithat, Schwartz, Gary K, Kern, Steven E, Zabludoff, Sonya, Brassil, Patrick J
Published in Cancer chemotherapy and pharmacology (01.07.2010)
Published in Cancer chemotherapy and pharmacology (01.07.2010)
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Journal Article
Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
Lu, Wei, Ashwell, Susan, Collis, Alan, Kelly, Patrick F, Walker, Duncan, Davis, Jeff, Thomson, Blythe
Year of Publication 23.04.2024
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Year of Publication 23.04.2024
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