Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling
Reilly, Louise, Howie, Jacqueline, Wypijewski, Krzysztof, Ashford, Michael L. J., Hilgemann, Donald W., Fuller, William
Published in The FASEB journal (01.11.2015)
Published in The FASEB journal (01.11.2015)
Get full text
Journal Article
Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes
McNeilly, Alison D., Gallagher, Jennifer R., Evans, Mark L., de Galan, Bastiaan E., Pedersen-Bjergaard, Ulrik, Thorens, Bernard, Dinkova-Kostova, Albena T., Huang, Jeffrey-T., Ashford, Michael L. J., McCrimmon, Rory J.
Published in Diabetologia (01.07.2023)
Published in Diabetologia (01.07.2023)
Get full text
Journal Article
The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection
Chen, Changwei, Gallagher, Jennifer R, Tarlton, Jamie, van Aalten, Lidy, Bray, Susan E, Ashford, Michael L J, McCrimmon, Rory J, Pearson, Ewan R, McNeilly, Alison D, Sutherland, Calum
Published in PloS one (01.07.2021)
Published in PloS one (01.07.2021)
Get full text
Journal Article
Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
Beall, C., Hamilton, D. L., Gallagher, J., Logie, L., Wright, K., Soutar, M. P., Dadak, S., Ashford, F. B., Haythorne, E., Du, Q., Jovanović, A., McCrimmon, R. J., Ashford, M. L. J.
Published in Diabetologia (01.09.2012)
Published in Diabetologia (01.09.2012)
Get full text
Journal Article
Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation
Meakin, Paul J, Morrison, Vicky L, Sneddon, Claire C, Savinko, Terhi, Uotila, Liisa, Jalicy, Susan M, Gabriel, Jennie L, Kang, Li, Ashford, Michael L J, Fagerholm, Susanna C
Published in PloS one (25.09.2015)
Published in PloS one (25.09.2015)
Get full text
Journal Article
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Mills, Evanna L, Ryan, Dylan G, Prag, Hiran A, Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P, Costa, Ana S H, Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C, King, Martin S, McGouran, Joanna F, Fischer, Roman, Kessler, Benedikt M, McGettrick, Anne F, Hughes, Mark M, Carroll, Richard G, Booty, Lee M, Knatko, Elena V, Meakin, Paul J, Ashford, Michael L J, Modis, Louise K, Brunori, Gino, Sévin, Daniel C, Fallon, Padraic G, Caldwell, Stuart T, Kunji, Edmund R S, Chouchani, Edward T, Frezza, Christian, Dinkova-Kostova, Albena T, Hartley, Richard C, Murphy, Michael P, O'Neill, Luke A
Published in Nature (London) (05.04.2018)
Published in Nature (London) (05.04.2018)
Get full text
Journal Article
Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes
Hamilton, D. Lee, Findlay, John A., Montagut, Gemma, Meakin, Paul J., Bestow, Dawn, Jalicy, Susan M., Ashford, Michael L. J.
Published in Diabetologia (01.08.2014)
Published in Diabetologia (01.08.2014)
Get full text
Journal Article
The beta secretase BACE1 regulates the expression of insulin receptor in the liver
Meakin, Paul J, Mezzapesa, Anna, Benabou, Eva, Haas, Mary E, Bonardo, Bernadette, Grino, Michel, Brunel, Jean-Michel, Desbois-Mouthon, Christèle, Biddinger, Sudha B, Govers, Roland, Ashford, Michael L J, Peiretti, Franck
Published in Nature communications (03.04.2018)
Published in Nature communications (03.04.2018)
Get full text
Journal Article
Substrate recognition by the cell surface palmitoyl transferase DHHC5
Howie, Jacqueline, Reilly, Louise, Fraser, Niall J., Walker, Julia M. Vlachaki, Wypijewski, Krzysztof J., Ashford, Michael L. J., Calaghan, Sarah C., McClafferty, Heather, Tian, Lijun, Shipston, Michael J., Boguslavskyi, Andrii, Shattock, Michael J., Fuller, William
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.2014)
Get full text
Journal Article
Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K+ channels
Ainscow, Edward K., Mirshamsi, Shirin, Tang, Teresa, Ashford, Michael L. J., Rutter, Guy A.
Published in The Journal of physiology (15.10.2002)
Published in The Journal of physiology (15.10.2002)
Get full text
Journal Article
Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation
McGuire, Victoria A, Ruiz-Zorrilla Diez, Tamara, Emmerich, Christoph H, Strickson, Sam, Ritorto, Maria Stella, Sutavani, Ruhcha V, Weiβ, Anne, Houslay, Kirsty F, Knebel, Axel, Meakin, Paul J, Phair, Iain R, Ashford, Michael L J, Trost, Matthias, Arthur, J Simon C
Published in Scientific reports (08.08.2016)
Published in Scientific reports (08.08.2016)
Get full text
Journal Article
The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis
Deldicque, Louise, Cani, Patrice D, Philp, Andrew, Raymackers, Jean-Marc, Meakin, Paul J, Ashford, Michael L J, Delzenne, Nathalie M, Francaux, Marc, Baar, Keith
Published in American journal of physiology: endocrinology and metabolism (01.11.2010)
Published in American journal of physiology: endocrinology and metabolism (01.11.2010)
Get full text
Journal Article
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
Ashford, M. L. J, Spanswick, D, Smith, M. A, Groppi, V. E, Logan, S. D
Published in Nature (London) (04.12.1997)
Published in Nature (London) (04.12.1997)
Get full text
Journal Article
Correction: Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes
McNeilly, Alison D., Gallagher, Jennifer R., Evans, Mark L., de Galan, Bastiaan E., Pedersen-Bjergaard, Ulrik, Thorens, Bernard, Dinkova-Kostova, Albena T., Huang, Jeffrey-T., Ashford, Michael L. J., McCrimmon, Rory J.
Published in Diabetologia (01.08.2024)
Published in Diabetologia (01.08.2024)
Get full text
Journal Article
Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances
Smith, Mark A., Hisadome, Kazunari, Al‐Qassab, Hind, Heffron, Helen, Withers, Dominic J., Ashford, Michael L. J.
Published in The Journal of physiology (15.01.2007)
Published in The Journal of physiology (15.01.2007)
Get full text
Journal Article
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice
Meakin, Paul J, Jalicy, Susan M, Montagut, Gemma, Allsop, David J P, Cavellini, Daniella L, Irvine, Stuart W, McGinley, Christopher, Liddell, Mary K, McNeilly, Alison D, Parmionova, Karolina, Liu, Yu-Ru, Bailey, Charlotte L S, Dale, J Kim, Heisler, Lora K, McCrimmon, Rory J, Ashford, Michael L J
Published in Scientific reports (08.01.2018)
Published in Scientific reports (08.01.2018)
Get full text
Journal Article
Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes
McNeilly, Alison D, Gallagher, Jennifer R, Dinkova-Kostova, Albena T, Hayes, John D, Sharkey, John, Ashford, Michael L J, McCrimmon, Rory J
Published in Diabetes (New York, N.Y.) (01.10.2016)
Published in Diabetes (New York, N.Y.) (01.10.2016)
Get full text
Journal Article