Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
de Calignon, Alix, Polydoro, Manuela, Suárez-Calvet, Marc, William, Christopher, Adamowicz, David H., Kopeikina, Kathy J., Pitstick, Rose, Sahara, Naruhiko, Ashe, Karen H., Carlson, George A., Spires-Jones, Tara L., Hyman, Bradley T.
Published in Neuron (Cambridge, Mass.) (23.02.2012)
Published in Neuron (Cambridge, Mass.) (23.02.2012)
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Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice
Gamache, Julia, Benzow, Kellie, Forster, Colleen, Kemper, Lisa, Hlynialuk, Chris, Furrow, Eva, Ashe, Karen H, Koob, Michael D
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Published in Nature communications (06.06.2019)
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Caspase-2 cleavage of tau reversibly impairs memory
Zhao, Xiaohui, Kotilinek, Linda A, Smith, Benjamin, Hlynialuk, Chris, Zahs, Kathleen, Ramsden, Martin, Cleary, James, Ashe, Karen H
Published in Nature medicine (01.11.2016)
Published in Nature medicine (01.11.2016)
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Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
Hoover, Brian R., Reed, Miranda N., Su, Jianjun, Penrod, Rachel D., Kotilinek, Linda A., Grant, Marianne K., Pitstick, Rose, Carlson, George A., Lanier, Lorene M., Yuan, Li-Lian, Ashe, Karen H., Liao, Dezhi
Published in Neuron (Cambridge, Mass.) (22.12.2010)
Published in Neuron (Cambridge, Mass.) (22.12.2010)
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Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration
Liu, Peng, Reed, Miranda N., Kotilinek, Linda A., Grant, Marianne K.O., Forster, Colleen L., Qiang, Wei, Shapiro, Samantha L., Reichl, John H., Chiang, Angie C.A., Jankowsky, Joanna L., Wilmot, Carrie M., Cleary, James P., Zahs, Kathleen R., Ashe, Karen H.
Published in Cell reports (Cambridge) (23.06.2015)
Published in Cell reports (Cambridge) (23.06.2015)
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Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies
Lo, Chih Hung, Lim, Colin Kin-Wye, Ding, Zhipeng, Wickramasinghe, Sanjula P., Braun, Anthony R., Ashe, Karen H., Rhoades, Elizabeth, Thomas, David D., Sachs, Jonathan N.
Published in Alzheimer's & dementia (01.11.2019)
Published in Alzheimer's & dementia (01.11.2019)
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Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)
Ramsden, Martin, Kotilinek, Linda, Forster, Colleen, Paulson, Jennifer, McGowan, Eileen, SantaCruz, Karen, Guimaraes, Aaron, Yue, Mei, Lewis, Jada, Carlson, George, Hutton, Michael, Ashe, Karen H
Published in The Journal of neuroscience (16.11.2005)
Published in The Journal of neuroscience (16.11.2005)
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Extended results of the Alzheimer’s disease anti-inflammatory prevention trial
Breitner, John C, Baker, Laura D, Montine, Thomas J, Meinert, Curtis L, Lyketsos, Constantine G, Ashe, Karen H, Brandt, Jason, Craft, Suzanne, Evans, Denis E, Green, Robert C, Ismail, M. Saleem, Martin, Barbara K, Mullan, Michael J, Sabbagh, Marwan, Tariot, Pierre N
Published in Alzheimer's & dementia (01.07.2011)
Published in Alzheimer's & dementia (01.07.2011)
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Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments
Grant, Marianne K O, Handoko, Maureen, Rozga, Malgorzata, Brinkmalm, Gunnar, Portelius, Erik, Blennow, Kaj, Ashe, Karen H, Zahs, Kathleen R, Liu, Peng
Published in PloS one (28.02.2019)
Published in PloS one (28.02.2019)
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Docosahexaenoic Acid Protects from Dendritic Pathology in an Alzheimer's Disease Mouse Model
Calon, Frédéric, Lim, Giselle P., Yang, Fusheng, Morihara, Takashi, Teter, Bruce, Ubeda, Oliver, Rostaing, Phillippe, Triller, Antoine, Salem, Norman, Ashe, Karen H., Frautschy, Sally A., Cole, Greg M.
Published in Neuron (Cambridge, Mass.) (02.09.2004)
Published in Neuron (Cambridge, Mass.) (02.09.2004)
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Region-specific Dissociation of Neuronal Loss and Neurofibrillary Pathology in a Mouse Model of Tauopathy
Spires, Tara L., Orne, Jennifer D., SantaCruz, Karen, Pitstick, Rose, Carlson, George A., Ashe, Karen H., Hyman, Bradley T.
Published in The American journal of pathology (01.05.2006)
Published in The American journal of pathology (01.05.2006)
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A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients
Liu, Peng, Smith, Benjamin R, Huang, Eric S, Mahesh, Abhishek, Vonsattel, Jean Paul G, Petersen, Ashley J, Gomez-Pastor, Rocio, Ashe, Karen H
Published in Acta neuropathologica communications (30.07.2019)
Published in Acta neuropathologica communications (30.07.2019)
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Alzheimer’s target still viable but untested
Ashe, Karen H.
Published in Science (American Association for the Advancement of Science) (26.08.2022)
Published in Science (American Association for the Advancement of Science) (26.08.2022)
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A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease
Smith, Benjamin R, Nelson, Kathryn M, Kemper, Lisa J, Leinonen-Wright, Kailee, Petersen, Ashley, Keene, C Dirk, Ashe, Karen H
Published in Acta neuropathologica communications (30.07.2019)
Published in Acta neuropathologica communications (30.07.2019)
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Aβ∗56 is a stable oligomer that impairs memory function in mice
Liu, Peng, Lapcinski, Ian P., Hlynialuk, Chris J.W., Steuer, Elizabeth L., Loude, Thomas J., Shapiro, Samantha L., Kemper, Lisa J., Ashe, Karen H.
Published in iScience (15.03.2024)
Published in iScience (15.03.2024)
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Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity
Ma, Huifang, Lesné, Sylvain, Kotilinek, Linda, Steidl-Nichols, Jill V, Sherman, Mathew, Younkin, Linda, Younkin, Steven, Forster, Colleen, Sergeant, Nicolas, Delacourte, André, Vassar, Robert, Citron, Martin, Kofuji, Paulo, Boland, Linda M, Ashe, Karen H
Published in Proceedings of the National Academy of Sciences - PNAS (08.05.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (08.05.2007)
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