Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives
Knight, W. B., Maycock, A. L., Green, B. G., Ashe, B. M., Gale, P., Weston, H., Finke, P. E., Hagmann, W. K., Shah, S. K., Doherty, J. B.
Published in Biochemistry (Easton) (01.06.1992)
Published in Biochemistry (Easton) (01.06.1992)
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Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones
Shah, Shrenik K, Dorn, Conrad P, Finke, Paul E, Hale, Jeffrey J, Hagmann, William K, Brause, Karen A, Chandler, Gilbert O, Kissinger, Amy L, Ashe, Bonnie M
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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PMN elastases: A comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors
Green, B.G., Weston, H., Ashe, B.M., Doherty, J., Finke, P., Hagmann, W., Lark, M., Mao, J., Maycock, A., Moore, V., Mumford, R., Shah, S., Walakovits, L., Knight, W.B.
Published in Archives of biochemistry and biophysics (01.04.1991)
Published in Archives of biochemistry and biophysics (01.04.1991)
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Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol
Finke, Paul E, Shah, Shrenik K, Ashe, Bonnie M, Ball, Richard G, Blacklock, Thomas J, Bonney, Robert J, Brause, Karen A, Chandler, Gilbert O, Cotton, Meredith
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase
Doherty, J B, Ashe, B M, Argenbright, L W, Barker, P L, Bonney, R J, Chandler, G O, Dahlgren, M E, Dorn, Jr, C P, Finke, P E, Firestone, R A
Published in Nature (London) (10.07.1986)
Published in Nature (London) (10.07.1986)
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Inhibition of elastase and other serine proteases by heterocyclic acylating agents
Zimmerman, M, Morman, H, Mulvey, D, Jones, H, Frankshun, R, Ashe, B M
Published in The Journal of biological chemistry (25.10.1980)
Published in The Journal of biological chemistry (25.10.1980)
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Selective inhibition of human leukocyte elastase and bovine alpha-chymotrypsin by novel heterocycles
Ashe, B M, Clark, R L, Jones, H, Zimmerman, M
Published in The Journal of biological chemistry (25.11.1981)
Published in The Journal of biological chemistry (25.11.1981)
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The discovery and biologic properties of cephalosporin-based inhibitors of PMN elastase
Davies, P, Ashe, B M, Bonney, R J, Dorn, C, Finke, P, Fletcher, D, Hanlon, W A, Humes, J L, Maycock, A, Mumford, R A
Published in Annals of the New York Academy of Sciences (01.05.1991)
Published in Annals of the New York Academy of Sciences (01.05.1991)
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Orally Active .beta.-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones
Finke, Paul E, Shah, Shrenik K, Fletcher, Daniel S, Ashe, Bonnie M, Brause, Karen A, Chandler, Gilbert O, Dellea, Pam S, Hand, Karen M, Maycock, Alan L
Published in Journal of medicinal chemistry (01.06.1995)
Published in Journal of medicinal chemistry (01.06.1995)
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Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site
Nakajima, K, Powers, J C, Ashe, B M, Zimmerman, M
Published in The Journal of biological chemistry (25.05.1979)
Published in The Journal of biological chemistry (25.05.1979)
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Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters
Doherty, James B, Ashe, Bonnie M, Barker, Peter L, Blacklock, Thomas J, Butcher, John W, Chandler, Gilbert O, Dahlgren, M. Ellen, Davies, Philip, Dorn, Conrad P
Published in Journal of medicinal chemistry (01.09.1990)
Published in Journal of medicinal chemistry (01.09.1990)
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Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides
Finke, Paul E, Ashe, Bonnie M, Knight, Wilson B, Maycock, Alan L, Navia, Manuel A, Shah, Shrenik K, Thompson, Kevan R, Underwood, Dennis J, Weston, Hazel
Published in Journal of medicinal chemistry (01.09.1990)
Published in Journal of medicinal chemistry (01.09.1990)
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Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins
Shah, Shrenik K, Brause, Karen A, Chandler, Gilbert O, Finke, Paul E, Ashe, Bonnie M, Weston, Hazel, Knight, Wilson B, Maycock, Alan L, Doherty, James B
Published in Journal of medicinal chemistry (01.09.1990)
Published in Journal of medicinal chemistry (01.09.1990)
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Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution
Hagmann, William K, Kissinger, Amy L, Shah, Shrenik K, Finke, Paul E, Dorn, Conrad P, Brause, Karen A, Ashe, Bonnie M, Weston, Hazel, Maycock, Alan L
Published in Journal of medicinal chemistry (01.03.1993)
Published in Journal of medicinal chemistry (01.03.1993)
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Proteinase activities of the golden hamster eggs and cells of the cumulus oophorus
Mumford, Richard A., Hartmann, John F., Ashe, Bonnie M., Zimmerman, Morris
Published in Developmental biology (30.01.1981)
Published in Developmental biology (30.01.1981)
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A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster
Fletcher, D S, Osinga, D G, Hand, K M, Dellea, P S, Ashe, B M, Mumford, R A, Davies, P, Hagmann, W, Finke, P E, Doherty, J B
Published in The American review of respiratory disease (01.03.1990)
Published in The American review of respiratory disease (01.03.1990)
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Orally active β-lactam inhibitors of human leukocyte elastase. III: Stereospecific synthesis and structure-activity relationships for 3,3-dialkylazetidin-2-ones
FINKE, P. E, SHAH, S. K, UNDERWOOD, D. J, WESTON, H, DAVIES, P, DOHERTY, J. B, FLETCHER, D. S, ASHE, B. M, BRAUSE, K. A, CHANDLER, G. O, DELLEA, P. S, HAND, K. M, MAYCOCK, A. L, OSINGA, D. G
Published in Journal of medicinal chemistry (1995)
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Published in Journal of medicinal chemistry (1995)
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Monocyclic β-lactam inhibitors of human leukocyte elastase. Stereospecific synthesis and activity of 3,4-disubstituted-2-azetidinones: Recent advances in the chemistry and biology of β-lactams and β-lactam antibiotics
SHAH, S. K, FINKE, P. E, BRAUSE, K. A, CHANDLER, G. O, ASHE, B. M, WESTON, H, MAYCOCK, A. L, MUMFORD, R. A, DOHERTY, J. B
Published in Bioorganic & medicinal chemistry letters (1993)
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Published in Bioorganic & medicinal chemistry letters (1993)
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