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Furukawa, Akihiro, Schwochert, Joshua, Pye, Cameron R., Asano, Daigo, Edmondson, Quinn D., Turmon, Alexandra C., Klein, Victoria G., Ono, Satoshi, Okada, Okimasa, Lokey, R. Scott
Published in Angewandte Chemie International Edition (23.11.2020)
Published in Angewandte Chemie International Edition (23.11.2020)
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Published in Chemical & pharmaceutical bulletin (01.11.2021)
Published in Chemical & pharmaceutical bulletin (01.11.2021)
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Discovery of a Novel Class of State-Dependent NaV1.7 Inhibitors for the Treatment of Neuropathic Pain
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Published in Chemical & pharmaceutical bulletin (01.07.2020)
Published in Chemical & pharmaceutical bulletin (01.07.2020)
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Discovery of a Novel Class of State-Dependent Na(V)1.7 Inhibitors for the Treatment of Neuropathic Pain
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Published in Chemical & pharmaceutical bulletin (01.07.2020)
Published in Chemical & pharmaceutical bulletin (01.07.2020)
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Renadirsen, a Novel 2′OMeRNA/ENA® Chimera Antisense Oligonucleotide, Induces Robust Exon 45 Skipping for Dystrophin In Vivo
Ito, Kentaro, Takakusa, Hideo, Kakuta, Masayo, Kanda, Akira, Takagi, Nana, Nagase, Hiroyuki, Watanabe, Nobuaki, Asano, Daigo, Goda, Ryoya, Masuda, Takeshi, Nakamura, Akifumi, Onishi, Yoshiyuki, Onoda, Toshio, Koizumi, Makoto, Takeshima, Yasuhiro, Matsuo, Masafumi, Takaishi, Kiyosumi
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Published in Current issues in molecular biology (25.09.2021)
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Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors
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Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Drug‐Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side‐Chain Lipophilicity
Furukawa, Akihiro, Schwochert, Joshua, Pye, Cameron R., Asano, Daigo, Edmondson, Quinn D., Turmon, Alexandra C., Klein, Victoria G., Ono, Satoshi, Okada, Okimasa, Lokey, R. Scott
Published in Angewandte Chemie (23.11.2020)
Published in Angewandte Chemie (23.11.2020)
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Establishment of Evaluation Method for siRNA Delivery Using Stable Cell Line Carrying the Luciferase Reporter Gene
Iijima, Ayako, Hachisu, Rei, Kobayashi, Hideo, Hashimoto, Kouichi, Asano, Daigo, Kikuchi, Hiroshi
Published in Biological & Pharmaceutical Bulletin (01.10.2007)
Published in Biological & Pharmaceutical Bulletin (01.10.2007)
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Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver
Asano, Daigo, Nakamura, Koichi, Nishiya, Yumi, Shiozawa, Hideyuki, Takakusa, Hideo, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Hamada, Takakazu, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Drug metabolism and disposition (01.01.2023)
Published in Drug metabolism and disposition (01.01.2023)
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Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase
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Published in Xenobiotica (02.09.2021)
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Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition
Akiu, Mayuko, Tsuji, Takashi, Sogawa, Yoshitaka, Terayama, Koji, Yokoyama, Mika, Tanaka, Jun, Asano, Daigo, Sakurai, Ken, Sergienko, Eduard, Sessions, E. Hampton, Gardell, Stephen J., Pinkerton, Anthony B., Nakamura, Tsuyoshi
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
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Tissue distribution of renadirsen sodium, a dystrophin exon-skipping antisense oligonucleotide, in heart and diaphragm after subcutaneous administration to cynomolgus monkeys
Yamamura, Naotoshi, Takakusa, Hideo, Asano, Daigo, Watanabe, Kyoko, Shibaya, Yukari, Yamanaka, Ryo, Fusegawa, Keiichi, Kanda, Akira, Nagase, Hiroyuki, Takaishi, Kiyosumi, Koizumi, Makoto, Takeshima, Yasuhiro, Matsuo, Masafumi
Published in Nucleosides, nucleotides & nucleic acids (10.08.2024)
Published in Nucleosides, nucleotides & nucleic acids (10.08.2024)
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Evaluation of species differences in the metabolism of the selective Na V 1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase
Asano, Daigo, Shibayama, Takahiro, Shiozawa, Hideyuki, Inoue, Shin-ichi, Shinozuka, Tsuyoshi, Murata, Shinji, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Xenobiotica (02.09.2021)
Published in Xenobiotica (02.09.2021)
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Drug-like properties in macrocycles above MW 1000: Backbone rigidity vs. side-chain lipophilicity
Furukawa, Akihiro, Schwochert, Joshua, Pye, Cameron R., Asano, Daigo, Edmondson, Quinn D., Turmon, Alexandra C., Klein, Victoria G., Ono, Satoshi, Okada, Okimasa, Lokey, R. Scott
Published in Angewandte Chemie International Edition (17.09.2020)
Published in Angewandte Chemie International Edition (17.09.2020)
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CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate
Asano, Daigo, Hamaue, Syoya, Zahir, Hamim, Shiozawa, Hideyuki, Nishiya, Yumi, Kimura, Takako, Kazui, Miho, Yamamura, Naotoshi, Ikeguchi, Marie, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Watanabe, Toshiyuki, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Drug metabolism and disposition (01.03.2022)
Published in Drug metabolism and disposition (01.03.2022)
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CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate
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Published in Drug metabolism and disposition (01.03.2022)
Published in Drug metabolism and disposition (01.03.2022)
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Discovery of DS-1971a, a Potent, Selective Na(V)1.7 Inhibitor
Shinozuka, Tsuyoshi, Kobayashi, Hiroyuki, Suzuki, Sayaka, Tanaka, Kyosuke, Karanjule, Narayan, Hayashi, Noriyuki, Tsuda, Toshifumi, Tokumaru, Eri, Inoue, Masahiro, Ueda, Kiyono, Kimoto, Hiroko, Domon, Yuki, Takahashi, Sakiko, Kubota, Kazufumi, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Sakakura, Tomoko, Takasuna, Kiyoshi, Abe, Yasuyuki, Watanabe, Toshiyuki, Kitano, Yutaka
Published in Journal of medicinal chemistry (24.09.2020)
Published in Journal of medicinal chemistry (24.09.2020)
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Journal Article
Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor
Shinozuka, Tsuyoshi, Kobayashi, Hiroyuki, Suzuki, Sayaka, Tanaka, Kyosuke, Karanjule, Narayan, Hayashi, Noriyuki, Tsuda, Toshifumi, Tokumaru, Eri, Inoue, Masahiro, Ueda, Kiyono, Kimoto, Hiroko, Domon, Yuki, Takahashi, Sakiko, Kubota, Kazufumi, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Sakakura, Tomoko, Takasuna, Kiyoshi, Abe, Yasuyuki, Watanabe, Toshiyuki, Kitano, Yutaka
Published in Journal of medicinal chemistry (24.09.2020)
Published in Journal of medicinal chemistry (24.09.2020)
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(18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study
Ogawa, Mikako, Ishino, Seigo, Mukai, Takahiro, Asano, Daigo, Teramoto, Noboru, Watabe, Hiroshi, Kudomi, Nobuyuki, Shiomi, Masashi, Magata, Yasuhiro, Iida, Hidehiro, Saji, Hideo
Published in The Journal of nuclear medicine (1978) (01.07.2004)
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Published in The Journal of nuclear medicine (1978) (01.07.2004)
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