Identification and Characterization of the First Small Molecule Inhibitor of MDMX
Reed, Damon, Shen, Ying, Shelat, Anang A., Arnold, Leggy A., Ferreira, Antonio M., Zhu, Fangyi, Mills, Nicholas, Smithson, David C., Regni, Catherine A., Bashford, Donald, Cicero, Samantha A., Schulman, Brenda A., Jochemsen, Aart G., Guy, R. Kiplin, Dyer, Michael A.
Published in The Journal of biological chemistry (02.04.2010)
Published in The Journal of biological chemistry (02.04.2010)
Get full text
Journal Article
Novel VDR antagonists based on the GW0742 scaffold
Teske, Kelly A., Bogart, Jonathan W., Arnold, Leggy A.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Get full text
Journal Article
surface on the androgen receptor that allosterically regulates coactivator binding
Estébanez-Perpiñá, Eva, Arnold, Alexander A, Nguyen, Phuong, Rodrigues, Edson Delgado, Mar, Ellena, Bateman, Raynard, Pallai, Peter, Shokat, Kevan M, Baxter, John D, Guy, R. Kiplin, Webb, Paul, Fletterick, Robert J
Published in Proceedings of the National Academy of Sciences - PNAS (09.10.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (09.10.2007)
Get full text
Journal Article
Dysregulation of tetrahydrobiopterin metabolism in myalgic encephalomyelitis/chronic fatigue syndrome by pentose phosphate pathway
Bulbule, Sarojini, Gottschalk, Carl Gunnar, Drosen, Molly E, Peterson, Daniel, Arnold, Leggy A, Roy, Avik
Published in Journal of central nervous system disease (01.07.2024)
Published in Journal of central nervous system disease (01.07.2024)
Get full text
Journal Article
A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABAA Receptor
Li, Guanguan, Nieman, Amanda N., Mian, Md Yeunus, Zahn, Nicolas M., Mikulsky, Brandon N., Poe, Michael M., Methuku, Kashi R., Liu, Yongfeng, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
Published in Molecules (Basel, Switzerland) (25.08.2020)
Published in Molecules (Basel, Switzerland) (25.08.2020)
Get full text
Journal Article
Identification and Quantification of MIDD0301 Metabolites
Roni, M S Rashid, Zahn, Nicolas M, Mikulsky, Brandon N, Webb, Daniel A, Mian, Md Yeunus, Knutson, Daniel E, Guthrie, Margaret L, Cook, James M, Stafford, Douglas C, Arnold, Leggy A
Published in Current drug metabolism (01.01.2021)
Published in Current drug metabolism (01.01.2021)
Get more information
Journal Article
Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays
Mukherjee, Sourav, Hanson, Alicia M, Shadrick, William R, Ndjomou, Jean, Sweeney, Noreena L, Hernandez, John J, Bartczak, Diana, Li, Kelin, Frankowski, Kevin J, Heck, Julie A, Arnold, Leggy A, Schoenen, Frank J, Frick, David N
Published in Nucleic acids research (01.09.2012)
Published in Nucleic acids research (01.09.2012)
Get full text
Journal Article
A fluorescence-based high throughput assay for the determination of small molecule−human serum albumin protein binding
McCallum, Megan M., Pawlak, Alan J., Shadrick, William R., Simeonov, Anton, Jadhav, Ajit, Yasgar, Adam, Maloney, David J., Arnold, Leggy A.
Published in Analytical and bioanalytical chemistry (01.03.2014)
Published in Analytical and bioanalytical chemistry (01.03.2014)
Get full text
Journal Article
Inhibition of a viral enzyme by a small-molecule dimer disruptor
Roels, Christina M, Guy, R Kiplin, Shahian, Tina, Lazic, Ana, Craik, Charles S, Velusamy, Priya, Arnold, Leggy A, Lee, Gregory M
Published in Nature chemical biology (01.09.2009)
Published in Nature chemical biology (01.09.2009)
Get full text
Journal Article
Discovery of the First Irreversible Small Molecule Inhibitors of the Interaction between the Vitamin D Receptor and Coactivators
Nandhikonda, Premchendar, Lynt, Wen Z, McCallum, Megan M, Ara, Tahniyath, Baranowski, Athena M, Yuan, Nina Y, Pearson, Dana, Bikle, Daniel D, Guy, R. Kiplin, Arnold, Leggy A
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
Get full text
Journal Article
Quantification of the Vitamin D Receptor−Coregulator Interaction
Teichert, Arnaud, Arnold, Leggy A, Otieno, Steve, Oda, Yuko, Augustinaite, Indre, Geistlinger, Tim R, Kriwacki, Richard W, Guy, R. Kiplin, Bikle, Daniel D
Published in Biochemistry (Easton) (24.02.2009)
Published in Biochemistry (Easton) (24.02.2009)
Get full text
Journal Article
Anticancer activity of VDR-coregulator inhibitor PS121912
Sidhu, Preetpal S., Teske, Kelly, Feleke, Belaynesh, Yuan, Nina Y., Guthrie, Margaret L., Fernstrum, Grant B., Vyas, Nishita D., Han, Lanlan, Preston, Joshua, Bogart, Jonathan W., Silvaggi, Nicholas R., Cook, James M., Singh, Rakesh K., Bikle, Daniel D., Arnold, Leggy A.
Published in Cancer chemotherapy and pharmacology (01.10.2014)
Published in Cancer chemotherapy and pharmacology (01.10.2014)
Get full text
Journal Article
Enantioselective Catalytic Conjugate Addition of Dialkylzinc Reagents using Copper–Phosphoramidite Complexes; Ligand Variation and Non-linear Effects
Arnold, Leggy A, Imbos, Rosalinde, Mandoli, Alessandro, de Vries, André H.M, Naasz, Robert, Feringa, Ben L
Published in Tetrahedron (28.04.2000)
Published in Tetrahedron (28.04.2000)
Get full text
Journal Article
Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression
Li, Guanguan, Stephen, Michael R., Kodali, Revathi, Zahn, Nicolas M., Poe, Michael M., Tiruveedhula, V. V. N. Phani Babu, Huber, Alec T., Schussman, Melissa K., Qualmann, Krista, Panhans, Cristina M., Raddatz, Nicholas J., Baker, David A., Prevot, Thomas D., Banasr, Mounira, Sibille, Etienne, Arnold, Leggy A., Cook, James M.
Published in ARKIVOC free online journal of organic chemistry (31.03.2018)
Published in ARKIVOC free online journal of organic chemistry (31.03.2018)
Get full text
Journal Article
Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model
Moore, Richard G, Lange, Thilo S, Robinson, Katina, Kim, Kyu K, Uzun, Alper, Horan, Timothy C, Kawar, Nada, Yano, Naohiro, Chu, Sharon R, Mao, Quanfu, Brard, Laurent, DePaepe, Monique E, Padbury, James F, Arnold, Leggy A, Brodsky, Alexander, Shen, Tun-Li, Singh, Rakesh K
Published in PloS one (03.04.2012)
Published in PloS one (03.04.2012)
Get full text
Journal Article